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Protein

Nuclear factor 7, brain

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that determines dorsal-ventral body axis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 18541RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 26042B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 7, brain
Short name:
xNF7
Short name:
xNF7-B
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252335. xnf7.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Nuclear factor 7, brainPRO_0000055977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031Phosphothreonine; by CDK11 Publication

Post-translational modificationi

Threonine (predominantly) and serine residues are phosphorylated during oocyte maturation, when CDK1 is active.1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ92021.

Expressioni

Tissue specificityi

At the neurula stage, high expression in dorsal embryo region including neural folds and somites. Also high expression in adult brain (CNS) and low expression in oocytes.2 Publications

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi99195. 5 interactions.
IntActiQ92021. 1 interaction.

Structurei

Secondary structure

1
609
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi237 – 2426Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FRENMR-A219-260[»]
ProteinModelPortaliQ92021.
SMRiQ92021. Positions 222-260.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92021.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini413 – 609197B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili278 – 37194Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 18541RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 26042B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG001357.
KOiK12015.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR025995. Tudor-knot.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF11717. Tudor-knot. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 1 hit.
SM00298. CHROMO. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEEGADDG EQGEEEVLVV NVGSTYPCKR SDGSQHDAEI VKVRYNKQAG
60 70 80 90 100
REEYYAHYVG LNRRQNEWVD KSRLVLTKPP KEGETNGTDQ EVTDTAEQPD
110 120 130 140 150
SKTPQKRKIE EPEPEPKKAK VEEKDASKNA SSLGAAGDFA EELTCPLCVE
160 170 180 190 200
LFKDPVMVAC GHNFCRSCID KAWEGQSSFA CPECRESITD RKYTINRVLA
210 220 230 240 250
NLAKKAACTP VTPVEKKTRP LEKCSEHDER LKLYCKDDGT LSCVICRDSL
260 270 280 290 300
KHASHNFLPI LDAVGVYREE LSAIVAPLEA SLKVTEQLSS EQSDKIEQHN
310 320 330 340 350
KNMSQYKEHI TSEFEKLHKF LREREEKLLE QLKEQGENLL TEMENNLVKM
360 370 380 390 400
QESQDAIKKT ISLAKERMED TDSISFLMDI KAFIDKCQEQ QRAVISTGNT
410 420 430 440 450
LLSKELCQGT FKGPIQYIMW KELKSVVIPS LTPMLLDPTS AHPNLHLSDG
460 470 480 490 500
LTSVRYGENK LSLPDNPKRF SQCILVLGSQ GFDSGRHYWE VEVGDKTAWD
510 520 530 540 550
VGMASESSNR KGKIKLNPKN GYWAIWLRNG NAYKALESPS KSLSLSSHPR
560 570 580 590 600
KIGVYVDYEG GQISFYNADD MTIIYTFNAT FTEKLYPYLS PFLHDSGKNV

DPLRFVHNK
Length:609
Mass (Da):68,876
Last modified:November 1, 1996 - v1
Checksum:i088C8312B45C78F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64515 mRNA. Translation: AAB20269.1.
M63705 mRNA. Translation: AAA49995.1.
PIRiA43906.
RefSeqiNP_001081473.1. NM_001088004.1.
UniGeneiXl.1352.

Genome annotation databases

GeneIDi397856.
KEGGixla:397856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64515 mRNA. Translation: AAB20269.1.
M63705 mRNA. Translation: AAA49995.1.
PIRiA43906.
RefSeqiNP_001081473.1. NM_001088004.1.
UniGeneiXl.1352.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FRENMR-A219-260[»]
ProteinModelPortaliQ92021.
SMRiQ92021. Positions 222-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi99195. 5 interactions.
IntActiQ92021. 1 interaction.

PTM databases

iPTMnetiQ92021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397856.
KEGGixla:397856.

Organism-specific databases

CTDi397856.
XenbaseiXB-GENE-6252335. xnf7.

Phylogenomic databases

HOVERGENiHBG001357.
KOiK12015.

Miscellaneous databases

EvolutionaryTraceiQ92021.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR025995. Tudor-knot.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF11717. Tudor-knot. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 1 hit.
SM00298. CHROMO. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cloning and characterization of a maternally expressed novel zinc finger nuclear phosphoprotein (xnf7) in Xenopus laevis."
    Reddy B.A., Kloc M., Etkin L.D.
    Dev. Biol. 148:107-116(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION AT THR-103.
    Tissue: Brain1 Publication.
  2. "Two forms of Xenopus nuclear factor 7 have overlapping spatial but different temporal patterns of expression during development."
    Gong S.-G., Reddy B.A., Etkin L.D.
    Mech. Dev. 52:305-318(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  3. "Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development."
    Borden K.L.B., Lally J.M., Martin S.R., O'Reilly N.J., Etkin L.D., Freemont P.S.
    EMBO J. 14:5947-5956(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 219-260.

Entry informationi

Entry nameiNF7B_XENLA
AccessioniPrimary (citable) accession number: Q92021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.