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Protein

Zinc finger and BTB domain-containing protein 14

Gene

ZBTB14

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 30228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 33028C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35828C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38628C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41529C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 14
Alternative name(s):
Zinc finger protein 161 homolog
Short name:
Zfp-161
Zinc finger protein 5
Short name:
ZF5
Gene namesi
Name:ZBTB14
Synonyms:ZFP161
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Zinc finger and BTB domain-containing protein 14PRO_0000047319Add
BLAST

Proteomic databases

PaxDbiQ92010.

Interactioni

Subunit structurei

Interacts with ZBTB21.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023787.

Structurei

3D structure databases

ProteinModelPortaliQ92010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10267BTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6617Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi153 – 17826Asp/Glu-rich (acidic)Add
BLAST

Domaini

The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 30228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 33028C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35828C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38628C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41529C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiQ92010.
PhylomeDBiQ92010.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFFISMSET IKYNDDDHKT VFLKTLNEQR LEGEFCDIAI VVEDVKFRAH
60 70 80 90 100
RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV
110 120 130 140 150
KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPEENTQSK SKYCLKINRP
160 170 180 190 200
IGEPNDTQDD EVEEIGDHDD SPSDVTVEGT PPSQEDGKSP TTTLRVQEAI
210 220 230 240 250
LKELGSEEVR KVNCYGQEVE SMETTESKDL GSQTPQALTF NDGISEVKDE
260 270 280 290 300
QTPGWTTAAG DMKFEYLLYG HREHIVCQAC GKTFSDEARL RKHEKLHTAD
310 320 330 340 350
RPFVCEMCTK GFTTQAHLKE HLKIHTGYKP YSCEVCGKSF IRAPDLKKHE
360 370 380 390 400
RVHSNERPFA CHMCDKAFKH KSHLKDHERR HRGEKPFVCG SCTKAFAKAS
410 420 430 440
DLKRHENNMH SERKQVTTAN SIQSETEQLQ AAAMAREAEQ QLETIACS
Length:448
Mass (Da):51,050
Last modified:November 1, 1996 - v1
Checksum:i8DF0FA3D8580412A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51641 mRNA. Translation: AAB38388.1.
U51640 Genomic DNA. Translation: AAB38387.1.
PIRiS71427.
RefSeqiNP_990492.1. NM_205161.1.
UniGeneiGga.2147.

Genome annotation databases

GeneIDi396070.
KEGGigga:396070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51641 mRNA. Translation: AAB38388.1.
U51640 Genomic DNA. Translation: AAB38387.1.
PIRiS71427.
RefSeqiNP_990492.1. NM_205161.1.
UniGeneiGga.2147.

3D structure databases

ProteinModelPortaliQ92010.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023787.

Proteomic databases

PaxDbiQ92010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396070.
KEGGigga:396070.

Organism-specific databases

CTDi7541.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiQ92010.
PhylomeDBiQ92010.

Miscellaneous databases

NextBioi20816129.
PROiQ92010.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic and cDNA structures of the gene encoding the chicken ZF5 DNA binding protein."
    Bhathal H.S., Stumph W.E.
    Biochim. Biophys. Acta 1308:114-118(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiZBT14_CHICK
AccessioniPrimary (citable) accession number: Q92010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.