Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ice-structuring protein

Gene

AFPIII

Organism
Lycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lowers the blood freezing point. Contributes to protect fish blood from freezing at subzero sea water temperatures. Binds to nascent ice crystals and prevents further growth.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antifreeze proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring proteinUniRule annotation
Alternative name(s):
Antifreeze proteinUniRule annotation
Gene namesi
Name:AFPIIIImported
Synonyms:AFPIII-12Imported, AFPIII-14Imported, AFPIII-15Imported, AFPIII-16Imported, AFPIII-18Imported, AFPIII-2Imported, AFPIII-20Imported, AFPIII-22Imported, AFPIII-23Imported, AFPIII-27Imported, AFPIII-31Imported, AFPIII-5Imported, AFPIII-7Imported, AFPIII-8Imported
OrganismiLycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)Imported
Taxonomic identifieri8201 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesZoarcidaeLycodinaeLycodichthys

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222UniRule annotationAdd
BLAST
Chaini23 – 8765Ice-structuring proteinUniRule annotationPRO_5005144642Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92006.
SMRiQ92006. Positions 23-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8560AFP-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type-III AFP family.UniRule annotation
Contains 4 AFP-like domains.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

HOVERGENiHBG004237.

Family and domain databases

Gene3Di3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view]
PfamiPF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVVLTGLL FVLLCVDHMS SANKASVVAN QLIPINTALT LIMMKAEVVT
60 70 80
PMGIPAEDIP RIIGMQVNRA VPLGTTLMPD MVKNYEK
Length:87
Mass (Da):9,408
Last modified:November 1, 1996 - v1
Checksum:i0D14AB58D841A6C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20437 Genomic DNA. Translation: AAB60609.1.
U20438 Genomic DNA. Translation: AAB60610.1.
U20439 Genomic DNA. Translation: AAB60611.1.
DQ062451 mRNA. Translation: ABA41373.1.
GQ368892 Genomic DNA. Translation: ADJ80987.1.
GQ368893 Genomic DNA. Translation: ADJ80989.1.
JX844825 Genomic DNA. Translation: AFU88726.1.
JX844825 Genomic DNA. Translation: AFU88727.1.
JX844825 Genomic DNA. Translation: AFU88728.1.
JX844825 Genomic DNA. Translation: AFU88730.1.
JX844826 Genomic DNA. Translation: AFU88732.1.
JX844826 Genomic DNA. Translation: AFU88735.1.
JX844827 Genomic DNA. Translation: AFU88736.1.
JX844827 Genomic DNA. Translation: AFU88738.1.
JX844827 Genomic DNA. Translation: AFU88739.1.
JX844827 Genomic DNA. Translation: AFU88743.1.
JX844827 Genomic DNA. Translation: AFU88747.1.
JX844828 Genomic DNA. Translation: AFU88749.1.
JX844828 Genomic DNA. Translation: AFU88750.1.
JX844828 Genomic DNA. Translation: AFU88753.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20437 Genomic DNA. Translation: AAB60609.1.
U20438 Genomic DNA. Translation: AAB60610.1.
U20439 Genomic DNA. Translation: AAB60611.1.
DQ062451 mRNA. Translation: ABA41373.1.
GQ368892 Genomic DNA. Translation: ADJ80987.1.
GQ368893 Genomic DNA. Translation: ADJ80989.1.
JX844825 Genomic DNA. Translation: AFU88726.1.
JX844825 Genomic DNA. Translation: AFU88727.1.
JX844825 Genomic DNA. Translation: AFU88728.1.
JX844825 Genomic DNA. Translation: AFU88730.1.
JX844826 Genomic DNA. Translation: AFU88732.1.
JX844826 Genomic DNA. Translation: AFU88735.1.
JX844827 Genomic DNA. Translation: AFU88736.1.
JX844827 Genomic DNA. Translation: AFU88738.1.
JX844827 Genomic DNA. Translation: AFU88739.1.
JX844827 Genomic DNA. Translation: AFU88743.1.
JX844827 Genomic DNA. Translation: AFU88747.1.
JX844828 Genomic DNA. Translation: AFU88749.1.
JX844828 Genomic DNA. Translation: AFU88750.1.
JX844828 Genomic DNA. Translation: AFU88753.1.

3D structure databases

ProteinModelPortaliQ92006.
SMRiQ92006. Positions 23-86.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004237.

Family and domain databases

Gene3Di3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view]
PfamiPF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Antifreeze peptide heterogeneity in an antarctic eel pout includes an unusually large major variant comprised of two 7 kDa type III AFPs linked in tandem."
    Wang X., Devries A.L., Cheng C.-H.C.
    Biochim. Biophys. Acta 1247:163-172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  2. "Genomic basis for antifreeze peptide heterogeneity and abundance in an Antarctic eel pout: gene structures and organization."
    Wang X., DeVries A.L., Cheng C.H.
    Mol. Mar. Biol. Biotechnol. 4:135-147(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  3. Cheng-DeVries C.-H.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  4. "Nonhepatic origin of notothenioid antifreeze reveals pancreatic synthesis as common mechanism in polar fish freezing avoidance."
    Cheng C.H., Cziko P.A., Evans C.W.
    Proc. Natl. Acad. Sci. U.S.A. 103:10491-10496(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  5. "Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict."
    Deng C., Cheng C.H., Ye H., He X., Chen L.
    Proc. Natl. Acad. Sci. U.S.A. 107:21593-21598(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Deng C., Chen L.
    Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ92006_LYCDA
AccessioniPrimary (citable) accession number: Q92006
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.