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Protein

Unconventional myosin-Ic

Gene

Myo1c

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPBy similarity1
Binding sitei61ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 113ATPBy similarity10
Nucleotide bindingi157 – 161ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Short name:
aMIb
Gene namesi
Name:Myo1c
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003694121 – 1028Unconventional myosin-IcAdd BLAST1028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei348N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Expressioni

Tissue specificityi

Expressed in brain and the sacculus of the internal ear.1 Publication

Interactioni

Subunit structurei

Interacts (via its IQ motifs) with calmodulin.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ92002
SMRiQ92002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 696Myosin motorPROSITE-ProRule annotationAdd BLAST685
Domaini699 – 728IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini722 – 751IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini850 – 1024TH1PROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni573 – 595Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

Q92002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESALTARDR VGVQDFVLLE NYTSEAAFIE NLRKRFKENL IYTYIGSVLV
60 70 80 90 100
SVNPYKELEI YSKQHMERYR GVSFYEVSPH IYAIADNSYR SLRTERKDQC
110 120 130 140 150
ILISGESGAG KTEASKKILQ YYAVTCPVSD QVETVKDRLL QSNPVLEAFG
160 170 180 190 200
NAKTLRNDNS SRFGKYMDVQ FDYKGAPVGG HILNYLLEKS RVVHQNHGER
210 220 230 240 250
NFHIFYQLLE GGEEDLLRRL GLDKNAQNYQ YLIKGQCARV SSINDKNDWK
260 270 280 290 300
VVRRALSIIN FNDDDIEELL SIVASVLHLG NVQFATDEHG HAQVTTENQI
310 320 330 340 350
KYLARLLSVD STVLRESLIH KKIIAKGEEL NSPLNLEQAA YARDALAKAI
360 370 380 390 400
YGRTFSWLVS KINKSLAYKG TDMHKLGSAS VIGLLDIYGF EVFQHNSFEQ
410 420 430 440 450
FCINFCNEKL QQLFIELTLK SEQDEYESEG IAWEPVQYFN NKIICDLVEE
460 470 480 490 500
KFKGIISILD EECLRPGEAT DMTFLEKLED TVKNHPHFVT HKLGDQKTRK
510 520 530 540 550
VLGRDEFRLL HYAGEVNYSV AGFLDKNNDL LFRNLKEVMC DSGNPIAHQC
560 570 580 590 600
FNRSELTDKK RPETAATQFK NSLSKLMEIL MSKQPSYVRC IKPNDAKQPA
610 620 630 640 650
RFDEVLIRHQ VKYLGLIENV RVRRAGFAYR RKYEIFLQRY KSLCPDTWPN
660 670 680 690 700
WDGRAMDGVA VLVKSLGYKP EEYKMGRTKI FIRFPKTLFA TEDALEVRKH
710 720 730 740 750
SIATFLQARW RGYHQRQKFL HMKHSAVEIQ SWWRGTIGRR KAAKRKWAVD
760 770 780 790 800
VVRRFIKGFI YRNQPRCTEN EYFLDYIRYS FLMTLYRNQP KSVLDKSWPV
810 820 830 840 850
PPPSLREASE LLREMCMNNM VWKYCRRINP EWKQQLEQKV VASEIFKDKK
860 870 880 890 900
DNYPQSVPRL FINTRLGNDE INTKILQQLE SQTLTYAVPV VKYDRKGYKP
910 920 930 940 950
RRRQLLLTQN AAYLVEEAKM KQRIDYANLT GISVSSLSDN LFVLHVKCED
960 970 980 990 1000
NKQKGDAILQ SDHVIETLTK VAITAEKINN ININQGSIKF TVGPGKEGII
1010 1020
DFTAGSELLI AKAKNGHLSV VAPRLNSR
Length:1,028
Mass (Da):118,831
Last modified:November 1, 1996 - v1
Checksum:iD15F6F99B68A90AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14382 mRNA Translation: AAA65091.1
U14549 mRNA Translation: AAA57192.1
PIRiI51173

Similar proteinsi

Entry informationi

Entry nameiMYO1C_LITCT
AccessioniPrimary (citable) accession number: Q92002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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