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Protein

Unconventional myosin-Ic

Gene

Myo1c

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPBy similarity1
Binding sitei61ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 113ATPBy similarity10
Nucleotide bindingi157 – 161ATPBy similarity5

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Short name:
aMIb
Gene namesi
Name:Myo1c
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cell projectionruffle By similarity
  • Cytoplasmic vesicle By similarity
  • Cell projectionstereocilium membrane 1 Publication

  • Note: Detected in stereocilia at the insertions of stereocilia into the apical surface of the cell, near the side plaques of tip links and near the tops of the tip links.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003694121 – 1028Unconventional myosin-IcAdd BLAST1028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei348N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Expressioni

Tissue specificityi

Expressed in brain and the sacculus of the internal ear.1 Publication

Interactioni

Subunit structurei

Interacts (via its IQ motifs) with calmodulin.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 696Myosin motorAdd BLAST685
Domaini699 – 728IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini722 – 751IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini850 – 1024TH1PROSITE-ProRule annotationAdd BLAST175

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESALTARDR VGVQDFVLLE NYTSEAAFIE NLRKRFKENL IYTYIGSVLV
60 70 80 90 100
SVNPYKELEI YSKQHMERYR GVSFYEVSPH IYAIADNSYR SLRTERKDQC
110 120 130 140 150
ILISGESGAG KTEASKKILQ YYAVTCPVSD QVETVKDRLL QSNPVLEAFG
160 170 180 190 200
NAKTLRNDNS SRFGKYMDVQ FDYKGAPVGG HILNYLLEKS RVVHQNHGER
210 220 230 240 250
NFHIFYQLLE GGEEDLLRRL GLDKNAQNYQ YLIKGQCARV SSINDKNDWK
260 270 280 290 300
VVRRALSIIN FNDDDIEELL SIVASVLHLG NVQFATDEHG HAQVTTENQI
310 320 330 340 350
KYLARLLSVD STVLRESLIH KKIIAKGEEL NSPLNLEQAA YARDALAKAI
360 370 380 390 400
YGRTFSWLVS KINKSLAYKG TDMHKLGSAS VIGLLDIYGF EVFQHNSFEQ
410 420 430 440 450
FCINFCNEKL QQLFIELTLK SEQDEYESEG IAWEPVQYFN NKIICDLVEE
460 470 480 490 500
KFKGIISILD EECLRPGEAT DMTFLEKLED TVKNHPHFVT HKLGDQKTRK
510 520 530 540 550
VLGRDEFRLL HYAGEVNYSV AGFLDKNNDL LFRNLKEVMC DSGNPIAHQC
560 570 580 590 600
FNRSELTDKK RPETAATQFK NSLSKLMEIL MSKQPSYVRC IKPNDAKQPA
610 620 630 640 650
RFDEVLIRHQ VKYLGLIENV RVRRAGFAYR RKYEIFLQRY KSLCPDTWPN
660 670 680 690 700
WDGRAMDGVA VLVKSLGYKP EEYKMGRTKI FIRFPKTLFA TEDALEVRKH
710 720 730 740 750
SIATFLQARW RGYHQRQKFL HMKHSAVEIQ SWWRGTIGRR KAAKRKWAVD
760 770 780 790 800
VVRRFIKGFI YRNQPRCTEN EYFLDYIRYS FLMTLYRNQP KSVLDKSWPV
810 820 830 840 850
PPPSLREASE LLREMCMNNM VWKYCRRINP EWKQQLEQKV VASEIFKDKK
860 870 880 890 900
DNYPQSVPRL FINTRLGNDE INTKILQQLE SQTLTYAVPV VKYDRKGYKP
910 920 930 940 950
RRRQLLLTQN AAYLVEEAKM KQRIDYANLT GISVSSLSDN LFVLHVKCED
960 970 980 990 1000
NKQKGDAILQ SDHVIETLTK VAITAEKINN ININQGSIKF TVGPGKEGII
1010 1020
DFTAGSELLI AKAKNGHLSV VAPRLNSR
Length:1,028
Mass (Da):118,831
Last modified:November 1, 1996 - v1
Checksum:iD15F6F99B68A90AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14382 mRNA. Translation: AAA65091.1.
U14549 mRNA. Translation: AAA57192.1.
PIRiI51173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14382 mRNA. Translation: AAA65091.1.
U14549 mRNA. Translation: AAA57192.1.
PIRiI51173.

3D structure databases

ProteinModelPortaliQ92002.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1C_LITCT
AccessioniPrimary (citable) accession number: Q92002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.