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Protein

Relaxin receptor 2

Gene

Rxfp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).By similarity

GO - Molecular functioni

  • peptide hormone binding Source: Ensembl
  • protein-hormone receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 2
Alternative name(s):
G-protein coupled receptor 106
G-protein coupled receptor affecting testicular descent
Leucine-rich repeat-containing G-protein coupled receptor 8
Relaxin family peptide receptor 2
Gene namesi
Name:Rxfp2
Synonyms:Gpr106, Great, Lgr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2153463. Rxfp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 399399ExtracellularSequence analysisAdd
BLAST
Transmembranei400 – 42021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini421 – 43818CytoplasmicSequence analysisAdd
BLAST
Transmembranei439 – 45921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini460 – 47819ExtracellularSequence analysisAdd
BLAST
Transmembranei479 – 50123Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini502 – 52019CytoplasmicSequence analysisAdd
BLAST
Transmembranei521 – 54121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini542 – 57534ExtracellularSequence analysisAdd
BLAST
Transmembranei576 – 59621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini597 – 62226CytoplasmicSequence analysisAdd
BLAST
Transmembranei623 – 64321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini644 – 65310ExtracellularSequence analysis
Transmembranei654 – 67421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini675 – 73763CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Rxfp2 seems to be a cause of impaired testicular descent (known as cryptorchidism).

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Relaxin receptor 2PRO_0000069703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 41By similarity
Disulfide bondi35 ↔ 54By similarity
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi48 ↔ 63By similarity
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence analysis
Disulfide bondi478 ↔ 556By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZZ5.
PRIDEiQ91ZZ5.

PTM databases

PhosphoSiteiQ91ZZ5.

Expressioni

Tissue specificityi

Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart.

Gene expression databases

BgeeiQ91ZZ5.
CleanExiMM_RXFP2.
ExpressionAtlasiQ91ZZ5. baseline and differential.
GenevisibleiQ91ZZ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067897.

Structurei

3D structure databases

ProteinModelPortaliQ91ZZ5.
SMRiQ91ZZ5. Positions 22-64, 98-399, 407-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 6438LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Repeati121 – 14222LRR 1Add
BLAST
Repeati145 – 16622LRR 2Add
BLAST
Repeati169 – 19022LRR 3Add
BLAST
Repeati193 – 21422LRR 4Add
BLAST
Repeati217 – 23822LRR 5Add
BLAST
Repeati241 – 26222LRR 6Add
BLAST
Repeati265 – 28622LRR 7Add
BLAST
Repeati289 – 31022LRR 8Add
BLAST
Repeati313 – 33422LRR 9Add
BLAST
Repeati337 – 35822LRR 10Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ91ZZ5.
KOiK04307.
OMAiKMFLPMG.
OrthoDBiEOG77DJ5W.
TreeFamiTF326185.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLHVILL TEVKDFALAD SSMVAPLCPK GYFPCGNLTK CLPRAFHCDG
60 70 80 90 100
VDDCGNGADE DNCGDTSGWT TIFGTVHGNV NKVTLTQECF LSQYPQHCYC
110 120 130 140 150
RENELECVKA DLKAVPKVSS NVTLLSLKKN KIHRLPVKVF SRYTELRKIY
160 170 180 190 200
LQHNCITHIS RRAFLGLHNL QILYLSHNCI TSLRPGIFKD LHQLAWLILD
210 220 230 240 250
DNPITRISQK SFMGLNSLFF LSMVGNRLEA LPETLCAQMP QLNWVDLANN
260 270 280 290 300
GIKYITNSTF LTCDSLTVLF LPRNQIGFVP EKTFSSLKNL GELDLSSNMI
310 320 330 340 350
TKLPVHLFSD LHLLQKLNLS SNPLLYVHKN QFGSLKQLQS LDLERIEIPN
360 370 380 390 400
ISTGMFQPMK NLSHIYLKTF RYCSYVPHVR ICMPSTDGIS SSEDLLANGI
410 420 430 440 450
LRVSVWVIAF ITCVGNFLVI AVRSLIKAEN TTHAMSIKIL CCADCLMGVY
460 470 480 490 500
LFSVGVFDIK YRGQYQKYAL LWMESVPCRL LGFLATLSTE VSVLLLTFLT
510 520 530 540 550
LEKFLVIVFP FSNLRLGKRQ TAVALASIWV VGFLIAAVPF TREDYFGNFY
560 570 580 590 600
GKNGVCFPLH YDQAEDFGSR GYSLGIFLGV NLLAFLVIVI SYVTMFCSIH
610 620 630 640 650
KTALQTAEVR SHIGKEVAVA NRFFFIVFSD AICWIPVFVV KILSLLQVEI
660 670 680 690 700
PGTITSWIVV FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKPIFKV
710 720 730
KKKSLSASIV WTDESSLKLG VLSKIALGDS IMKPVSP
Length:737
Mass (Da):82,934
Last modified:July 27, 2011 - v2
Checksum:iAF60F63538061E49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221S → P in AAL08943 (PubMed:11353515).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346501 mRNA. Translation: AAL08943.1.
AC077689 Genomic DNA. No translation available.
BC120741 mRNA. Translation: AAI20742.1.
CCDSiCCDS19886.1.
RefSeqiNP_001276493.1. NM_001289564.1.
NP_001276495.1. NM_001289566.1.
NP_536716.2. NM_080468.2.
XP_006504972.1. XM_006504909.2.
UniGeneiMm.444643.

Genome annotation databases

EnsembliENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368.
GeneIDi140498.
KEGGimmu:140498.
UCSCiuc009ato.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346501 mRNA. Translation: AAL08943.1.
AC077689 Genomic DNA. No translation available.
BC120741 mRNA. Translation: AAI20742.1.
CCDSiCCDS19886.1.
RefSeqiNP_001276493.1. NM_001289564.1.
NP_001276495.1. NM_001289566.1.
NP_536716.2. NM_080468.2.
XP_006504972.1. XM_006504909.2.
UniGeneiMm.444643.

3D structure databases

ProteinModelPortaliQ91ZZ5.
SMRiQ91ZZ5. Positions 22-64, 98-399, 407-689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067897.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ91ZZ5.

Proteomic databases

PaxDbiQ91ZZ5.
PRIDEiQ91ZZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368.
GeneIDi140498.
KEGGimmu:140498.
UCSCiuc009ato.1. mouse.

Organism-specific databases

CTDi122042.
MGIiMGI:2153463. Rxfp2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ91ZZ5.
KOiK04307.
OMAiKMFLPMG.
OrthoDBiEOG77DJ5W.
TreeFamiTF326185.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-444821. Relaxin receptors.

Miscellaneous databases

NextBioi369832.
PROiQ91ZZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZZ5.
CleanExiMM_RXFP2.
ExpressionAtlasiQ91ZZ5. baseline and differential.
GenevisibleiQ91ZZ5. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRXFP2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZZ5
Secondary accession number(s): Q0VB90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

By homology with the human sequence, it is uncertain whether Met-1 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.