Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Relaxin receptor 2

Gene

Rxfp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).By similarity

Caution

By homology with the human sequence, it is uncertain whether Met-1 is the initiator.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • peptide hormone binding Source: Ensembl
  • protein-hormone receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-444821 Relaxin receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 2
Alternative name(s):
G-protein coupled receptor 106
G-protein coupled receptor affecting testicular descent
Leucine-rich repeat-containing G-protein coupled receptor 8
Relaxin family peptide receptor 2
Gene namesi
Name:Rxfp2
Synonyms:Gpr106, Great, Lgr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2153463 Rxfp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 399ExtracellularSequence analysisAdd BLAST399
Transmembranei400 – 420Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini421 – 438CytoplasmicSequence analysisAdd BLAST18
Transmembranei439 – 459Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini460 – 478ExtracellularSequence analysisAdd BLAST19
Transmembranei479 – 501Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini502 – 520CytoplasmicSequence analysisAdd BLAST19
Transmembranei521 – 541Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini542 – 575ExtracellularSequence analysisAdd BLAST34
Transmembranei576 – 596Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini597 – 622CytoplasmicSequence analysisAdd BLAST26
Transmembranei623 – 643Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini644 – 653ExtracellularSequence analysis10
Transmembranei654 – 674Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini675 – 737CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Rxfp2 seems to be a cause of impaired testicular descent (known as cryptorchidism).1 Publication

Chemistry databases

ChEMBLiCHEMBL3714702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697031 – 737Relaxin receptor 2Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 41By similarity
Disulfide bondi35 ↔ 54By similarity
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 63By similarity
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 556By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZZ5
PRIDEiQ91ZZ5

PTM databases

iPTMnetiQ91ZZ5
PhosphoSitePlusiQ91ZZ5

Expressioni

Tissue specificityi

Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart.

Gene expression databases

BgeeiENSMUSG00000053368
CleanExiMM_RXFP2
ExpressionAtlasiQ91ZZ5 baseline and differential
GenevisibleiQ91ZZ5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067897

Structurei

3D structure databases

ProteinModelPortaliQ91ZZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 64LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Repeati121 – 142LRR 1Add BLAST22
Repeati145 – 166LRR 2Add BLAST22
Repeati169 – 190LRR 3Add BLAST22
Repeati193 – 214LRR 4Add BLAST22
Repeati217 – 238LRR 5Add BLAST22
Repeati241 – 262LRR 6Add BLAST22
Repeati265 – 286LRR 7Add BLAST22
Repeati289 – 310LRR 8Add BLAST22
Repeati313 – 334LRR 9Add BLAST22
Repeati337 – 358LRR 10Add BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119088
HOGENOMiHOG000049056
HOVERGENiHBG026354
InParanoidiQ91ZZ5
KOiK04307
OMAiTAEVRNH
OrthoDBiEOG091G01UA
TreeFamiTF326185

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR008112 Relaxin_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF13855 LRR_8, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PR01739 RELAXINR
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00369 LRR_TYP, 10 hits
SUPFAMiSSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Q91ZZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLHVILL TEVKDFALAD SSMVAPLCPK GYFPCGNLTK CLPRAFHCDG
60 70 80 90 100
VDDCGNGADE DNCGDTSGWT TIFGTVHGNV NKVTLTQECF LSQYPQHCYC
110 120 130 140 150
RENELECVKA DLKAVPKVSS NVTLLSLKKN KIHRLPVKVF SRYTELRKIY
160 170 180 190 200
LQHNCITHIS RRAFLGLHNL QILYLSHNCI TSLRPGIFKD LHQLAWLILD
210 220 230 240 250
DNPITRISQK SFMGLNSLFF LSMVGNRLEA LPETLCAQMP QLNWVDLANN
260 270 280 290 300
GIKYITNSTF LTCDSLTVLF LPRNQIGFVP EKTFSSLKNL GELDLSSNMI
310 320 330 340 350
TKLPVHLFSD LHLLQKLNLS SNPLLYVHKN QFGSLKQLQS LDLERIEIPN
360 370 380 390 400
ISTGMFQPMK NLSHIYLKTF RYCSYVPHVR ICMPSTDGIS SSEDLLANGI
410 420 430 440 450
LRVSVWVIAF ITCVGNFLVI AVRSLIKAEN TTHAMSIKIL CCADCLMGVY
460 470 480 490 500
LFSVGVFDIK YRGQYQKYAL LWMESVPCRL LGFLATLSTE VSVLLLTFLT
510 520 530 540 550
LEKFLVIVFP FSNLRLGKRQ TAVALASIWV VGFLIAAVPF TREDYFGNFY
560 570 580 590 600
GKNGVCFPLH YDQAEDFGSR GYSLGIFLGV NLLAFLVIVI SYVTMFCSIH
610 620 630 640 650
KTALQTAEVR SHIGKEVAVA NRFFFIVFSD AICWIPVFVV KILSLLQVEI
660 670 680 690 700
PGTITSWIVV FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKPIFKV
710 720 730
KKKSLSASIV WTDESSLKLG VLSKIALGDS IMKPVSP
Length:737
Mass (Da):82,934
Last modified:July 27, 2011 - v2
Checksum:iAF60F63538061E49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222S → P in AAL08943 (PubMed:11353515).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346501 mRNA Translation: AAL08943.1
AC077689 Genomic DNA No translation available.
BC120741 mRNA Translation: AAI20742.1
CCDSiCCDS19886.1
RefSeqiNP_001276493.1, NM_001289564.1
NP_001276495.1, NM_001289566.1
NP_536716.2, NM_080468.2
UniGeneiMm.444643

Genome annotation databases

EnsembliENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368
GeneIDi140498
KEGGimmu:140498
UCSCiuc009ato.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRXFP2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZZ5
Secondary accession number(s): Q0VB90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health