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Protein

Beta-synuclein

Gene

Sncb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal plasticity.By similarity

GO - Molecular functioni

GO - Biological processi

  • dopamine metabolic process Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • synapse organization Source: MGI
  • synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Gene namesi
Name:Sncb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1889011. Sncb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • Golgi apparatus Source: MGI
  • growth cone Source: Ensembl
  • inclusion body Source: MGI
  • mitochondrion Source: MGI
  • neuronal cell body Source: Ensembl
  • nucleoplasm Source: MGI
  • synapse Source: MGI
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Beta-synucleinPRO_0000286176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei117 – 1171Phosphoserine; by BARK1, CK2 and GRK5By similarity
Modified residuei118 – 1181PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91ZZ3.
PaxDbiQ91ZZ3.
PRIDEiQ91ZZ3.

2D gel databases

UCD-2DPAGEQ91ZZ3.

PTM databases

iPTMnetiQ91ZZ3.
PhosphoSiteiQ91ZZ3.

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

BgeeiQ91ZZ3.
CleanExiMM_SNCB.
GenevisibleiQ91ZZ3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91ZZ3. 1 interaction.
MINTiMINT-4122281.

Structurei

3D structure databases

ProteinModelPortaliQ91ZZ3.
SMRiQ91ZZ3. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 55143; approximateAdd
BLAST
Repeati56 – 66114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 66474 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ91ZZ3.
OMAiDSPQEEY.
OrthoDBiEOG7034KG.
PhylomeDBiQ91ZZ3.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q91ZZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTSGVVQG
60 70 80 90 100
VASVAEKTKE QASHLGGAVF SGAGNIAAAT GLVKKEEFPT DLKPEEVAQE
110 120 130
AAEEPLIEPL MEPEGESYED SPQEEYQEYE PEA
Length:133
Mass (Da):14,052
Last modified:December 1, 2001 - v1
Checksum:i8274D8A6A0D8E4D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348164, AF348162, AF348163 Genomic DNA. Translation: AAK83238.1.
BC019409 mRNA. Translation: AAH19409.1.
CCDSiCCDS36670.1.
RefSeqiNP_291088.1. NM_033610.2.
XP_006517078.1. XM_006517015.2.
XP_006517079.1. XM_006517016.2.
UniGeneiMm.200843.

Genome annotation databases

EnsembliENSMUST00000036825; ENSMUSP00000043074; ENSMUSG00000034891.
ENSMUST00000134110; ENSMUSP00000116296; ENSMUSG00000034891.
GeneIDi104069.
KEGGimmu:104069.
UCSCiuc007qpc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348164, AF348162, AF348163 Genomic DNA. Translation: AAK83238.1.
BC019409 mRNA. Translation: AAH19409.1.
CCDSiCCDS36670.1.
RefSeqiNP_291088.1. NM_033610.2.
XP_006517078.1. XM_006517015.2.
XP_006517079.1. XM_006517016.2.
UniGeneiMm.200843.

3D structure databases

ProteinModelPortaliQ91ZZ3.
SMRiQ91ZZ3. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZZ3. 1 interaction.
MINTiMINT-4122281.

PTM databases

iPTMnetiQ91ZZ3.
PhosphoSiteiQ91ZZ3.

2D gel databases

UCD-2DPAGEQ91ZZ3.

Proteomic databases

MaxQBiQ91ZZ3.
PaxDbiQ91ZZ3.
PRIDEiQ91ZZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036825; ENSMUSP00000043074; ENSMUSG00000034891.
ENSMUST00000134110; ENSMUSP00000116296; ENSMUSG00000034891.
GeneIDi104069.
KEGGimmu:104069.
UCSCiuc007qpc.1. mouse.

Organism-specific databases

CTDi6620.
MGIiMGI:1889011. Sncb.

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ91ZZ3.
OMAiDSPQEEY.
OrthoDBiEOG7034KG.
PhylomeDBiQ91ZZ3.
TreeFamiTF332776.

Miscellaneous databases

ChiTaRSiSncb. mouse.
PROiQ91ZZ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZZ3.
CleanExiMM_SNCB.
GenevisibleiQ91ZZ3. MM.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, chromosome location, and expression analysis of mouse beta-synuclein, a candidate for involvement in neurodegeneration."
    Sopher B.L., Koszdin K.L., McClain M.E., Myrick S.B., Martinez R.A., Smith A.C., La Spada A.R.
    Cytogenet. Cell Genet. 93:117-123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 60-84, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiSYUB_MOUSE
AccessioniPrimary (citable) accession number: Q91ZZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.