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Protein

Homologous-pairing protein 2 homolog

Gene

Psmc3ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription.By similarity1 Publication

GO - Molecular functioni

  • androgen receptor binding Source: RGD
  • DBD domain binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • estrogen receptor binding Source: RGD
  • glucocorticoid receptor binding Source: RGD
  • ligand-dependent nuclear receptor transcription coactivator activity Source: RGD
  • protein dimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • thyroid hormone receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homologous-pairing protein 2 homolog
Alternative name(s):
Nuclear receptor coactivator GT198
PSMC3-interacting protein
Proteasome 26S ATPase subunit 3-interacting protein
Gene namesi
Name:Psmc3ip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621885. Psmc3ip.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Homologous-pairing protein 2 homologPRO_0000314137Add
BLAST

Post-translational modificationi

Phosphorylated by PKA, PKC and MAPK.1 Publication

Proteomic databases

PaxDbiQ91ZY6.
PRIDEiQ91ZY6.

PTM databases

iPTMnetiQ91ZY6.
PhosphoSiteiQ91ZY6.

Interactioni

Subunit structurei

Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1 (By similarity). Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA.By similarity1 Publication

GO - Molecular functioni

  • androgen receptor binding Source: RGD
  • DBD domain binding Source: RGD
  • estrogen receptor binding Source: RGD
  • glucocorticoid receptor binding Source: RGD
  • protein dimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • thyroid hormone receptor binding Source: RGD

Protein-protein interaction databases

BioGridi250872. 1 interaction.
STRINGi10116.ENSRNOP00000027159.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 11729Interaction with NR3C1, homodimerization and transcriptional activation almost abolished when missingAdd
BLAST
Regioni118 – 18265DNA bindingBy similarityAdd
BLAST
Regioni118 – 18265Interaction with NR3C1 decreased when missingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili93 – 15361Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HOP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4603. Eukaryota.
ENOG410XT3U. LUCA.
HOGENOMiHOG000005789.
HOVERGENiHBG105257.
InParanoidiQ91ZY6.
KOiK06695.
PhylomeDBiQ91ZY6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR010776. TBPIP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR15938. PTHR15938. 1 hit.
PfamiPF07106. TBPIP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91ZY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSRAEAAA GAPGIVLRYL QEQNRPYSAQ DVFGNLQKEH GLGKAAVVKA
60 70 80 90 100
LDQLAQQGKI KEKTYGKQKI YFADQDQFDT VSDADLHSLD ASIMALTAKV
110 120 130 140 150
QGLQQSCRHM EAELKELTSA LTTPEMQTEI QELKKECARY TERLKNIKAA
160 170 180 190 200
TNHVTPEEKE KVYRERQKYC KEWRKRKRMT TELCDAILEG YPKSKKQFFE
210
EVGIETDEDH NVTLPNP
Length:217
Mass (Da):24,768
Last modified:December 1, 2001 - v1
Checksum:i422C1F1ED22EAD63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352812 mRNA. Translation: AAL23906.1.
RefSeqiNP_604453.2. NM_134458.2.
UniGeneiRn.144650.

Genome annotation databases

GeneIDi140938.
KEGGirno:140938.
UCSCiRGD:621885. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352812 mRNA. Translation: AAL23906.1.
RefSeqiNP_604453.2. NM_134458.2.
UniGeneiRn.144650.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250872. 1 interaction.
STRINGi10116.ENSRNOP00000027159.

PTM databases

iPTMnetiQ91ZY6.
PhosphoSiteiQ91ZY6.

Proteomic databases

PaxDbiQ91ZY6.
PRIDEiQ91ZY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140938.
KEGGirno:140938.
UCSCiRGD:621885. rat.

Organism-specific databases

CTDi29893.
RGDi621885. Psmc3ip.

Phylogenomic databases

eggNOGiKOG4603. Eukaryota.
ENOG410XT3U. LUCA.
HOGENOMiHOG000005789.
HOVERGENiHBG105257.
InParanoidiQ91ZY6.
KOiK06695.
PhylomeDBiQ91ZY6.

Miscellaneous databases

NextBioi620826.
PROiQ91ZY6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR010776. TBPIP.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR15938. PTHR15938. 1 hit.
PfamiPF07106. TBPIP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors."
    Ko L., Cardona G.R., Henrion-Caude A., Chin W.W.
    Mol. Cell. Biol. 22:357-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NR3C1; ESR2; THRB AND RXRA, REGION, PHOSPHORYLATION, FUNCTION.
    Tissue: Pituitary.

Entry informationi

Entry nameiHOP2_RAT
AccessioniPrimary (citable) accession number: Q91ZY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.