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Protein
Submitted name:

Histamine H4 receptor

Gene

HRH4

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Histamine H4 receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HRH4Imported
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10923HelicalSequence analysisAdd
BLAST
Transmembranei129 – 15123HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19828HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32925HelicalSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1255160.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001751.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 358328G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
OMAiICIPLYI.
OrthoDBiEOG091G097A.
TreeFamiTF351747.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANNSTIAL TSIKISLTFL MSLLAIAIML GNVVVILAFI VDRNLRHRSN
60 70 80 90 100
YFFLNLAIAD FFVGAIAIPL YIPSSLTYWT SGKQACVFWL ITDYLLCTAS
110 120 130 140 150
VYNIVLISYD RYQSVSNAVW YRAQHSGTWK IATQMVAVWI FSFMTNGPMI
160 170 180 190 200
LISDSWQNST TECEPGFLKK WYFALPTSLL EFLIPILLVA YFSAHIYWSL
210 220 230 240 250
WKREKLSRCL SHPVLPSDSS SSDHGHSCRQ DPDSRATLPA RKETTASLGS
260 270 280 290 300
DKSRRKSSLL FSIRAYKNSN VIASKMGFLS HSDSLALQQR EHIELFRARK
310 320 330 340 350
LAKSLAILLA AFAICWAPYS LTTVIYSFFP ERNLTKSTWY HTAFWLQWFN
360 370 380
SFVNPFLYPL CHKRFQKAFL KILPVRRQST PPHNRSIST
Length:389
Mass (Da):44,512
Last modified:December 1, 2001 - v1
Checksum:i51AF32FD6F1C3E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02020635 Genomic DNA. No translation available.
AF358858 mRNA. Translation: AAK97379.1.
RefSeqiNP_001166218.1. NM_001172747.1.

Genome annotation databases

EnsembliENSCPOT00000001964; ENSCPOP00000001751; ENSCPOG00000001943.
GeneIDi100379272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02020635 Genomic DNA. No translation available.
AF358858 mRNA. Translation: AAK97379.1.
RefSeqiNP_001166218.1. NM_001172747.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001751.

Chemistry

ChEMBLiCHEMBL1255160.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000001964; ENSCPOP00000001751; ENSCPOG00000001943.
GeneIDi100379272.

Organism-specific databases

CTDi59340.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
OMAiICIPLYI.
OrthoDBiEOG091G097A.
TreeFamiTF351747.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91ZY3_CAVPO
AccessioniPrimary (citable) accession number: Q91ZY3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.