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Protein

Histamine H4 receptor

Gene

Hrh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H4 receptor
Short name:
H4R
Short name:
HH4R
Gene namesi
Name:Hrh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2429635. Hrh4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence analysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini41 – 5212CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 8714ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 13123CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini153 – 17422ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini196 – 306111CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini328 – 34316ExtracellularSequence analysisAdd
BLAST
Transmembranei344 – 36421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini365 – 39127CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • synapse Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5657.
GuidetoPHARMACOLOGYi265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Histamine H4 receptorPRO_0000303238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi87 ↔ 166PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZY2.
PRIDEiQ91ZY2.

PTM databases

iPTMnetiQ91ZY2.

Expressioni

Gene expression databases

BgeeiQ91ZY2.
CleanExiMM_HRH4.
GenevisibleiQ91ZY2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041061.

Chemistry

BindingDBiQ91ZY2.

Structurei

3D structure databases

ProteinModelPortaliQ91ZY2.
SMRiQ91ZY2. Positions 15-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ91ZY2.
KOiK04152.
OMAiKGCEPGF.
OrthoDBiEOG7XWPNM.
PhylomeDBiQ91ZY2.
TreeFamiTF351747.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESNSTGIL PPAAQVPLAF LMSSFAFAIM VGNAVVILAF VVDRNLRHRS
60 70 80 90 100
NYFFLNLAIS DFLVGLISIP LYIPHVLFNW NFGSGICMFW LITDYLLCTA
110 120 130 140 150
SVYNIVLISY DRYQSVSNAV SYRAQHTGIM KIVAQMVAVW ILAFLVNGPM
160 170 180 190 200
ILASDSWKNS TNTKDCEPGF VTEWYILTIT MLLEFLLPVI SVAYFNVQIY
210 220 230 240 250
WSLWKRRALS RCPSHAGFST TSSSASGHLH RAGVACRTSN PGLKESAASR
260 270 280 290 300
HSESPRRKSS ILVSLRTHMN SSITAFKVGS FWRSESAALR QREYAELLRG
310 320 330 340 350
RKLARSLAIL LSAFAICWAP YCLFTIVLST YPRTERPKSV WYSIAFWLQW
360 370 380 390
FNSFVNPFLY PLCHRRFQKA FWKILCVTKQ PALSQNQSVS S
Length:391
Mass (Da):44,249
Last modified:December 1, 2001 - v1
Checksum:i59EC73CB5214C5E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358859 mRNA. Translation: AAK97380.1.
CCDSiCCDS29069.1.
RefSeqiNP_694727.1. NM_153087.2.
UniGeneiMm.207073.

Genome annotation databases

EnsembliENSMUST00000041676; ENSMUSP00000041061; ENSMUSG00000037346.
GeneIDi225192.
KEGGimmu:225192.
UCSCiuc008edb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358859 mRNA. Translation: AAK97380.1.
CCDSiCCDS29069.1.
RefSeqiNP_694727.1. NM_153087.2.
UniGeneiMm.207073.

3D structure databases

ProteinModelPortaliQ91ZY2.
SMRiQ91ZY2. Positions 15-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041061.

Chemistry

BindingDBiQ91ZY2.
ChEMBLiCHEMBL5657.
GuidetoPHARMACOLOGYi265.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ91ZY2.

Proteomic databases

PaxDbiQ91ZY2.
PRIDEiQ91ZY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041676; ENSMUSP00000041061; ENSMUSG00000037346.
GeneIDi225192.
KEGGimmu:225192.
UCSCiuc008edb.1. mouse.

Organism-specific databases

CTDi59340.
MGIiMGI:2429635. Hrh4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ91ZY2.
KOiK04152.
OMAiKGCEPGF.
OrthoDBiEOG7XWPNM.
PhylomeDBiQ91ZY2.
TreeFamiTF351747.

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ91ZY2.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZY2.
CleanExiMM_HRH4.
GenevisibleiQ91ZY2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of human, mouse, rat, and guinea pig histamine H4 receptor suggests substantial species variation."
    Liu C., Wilson S., Kuei C., Lovenberg T.W.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.

Entry informationi

Entry nameiHRH4_MOUSE
AccessioniPrimary (citable) accession number: Q91ZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.