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Protein

Histamine H4 receptor

Gene

Hrh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H4 receptor
Short name:
H4R
Short name:
HH4R
Gene namesi
Name:Hrh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620631. Hrh4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence analysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini41 – 5212CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 8714ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 13123CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini153 – 17422ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini196 – 306111CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini328 – 34316ExtracellularSequence analysisAdd
BLAST
Transmembranei344 – 36421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini365 – 39127CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4468.
GuidetoPHARMACOLOGYi265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Histamine H4 receptorPRO_0000303239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi87 ↔ 166PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZY1.
PRIDEiQ91ZY1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022744.

Chemistry

BindingDBiQ91ZY1.

Structurei

3D structure databases

ProteinModelPortaliQ91ZY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ91ZY1.
KOiK04152.
PhylomeDBiQ91ZY1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESNGTDVL PLTAQVPLAF LMSLLAFAIT IGNAVVILAF VADRNLRHRS
60 70 80 90 100
NYFFLNLAIS DFFVGVISIP LYIPHTLFNW NFGSGICMFW LITDYLLCTA
110 120 130 140 150
SVYSIVLISY DRYQSVSNAV RYRAQHTGIL KIVAQMVAVW ILAFLVNGPM
160 170 180 190 200
ILASDSWKNS TNTEECEPGF VTEWYILAIT AFLEFLLPVS LVVYFSVQIY
210 220 230 240 250
WSLWKRGSLS RCPSHAGFIA TSSRGTGHSR RTGLACRTSL PGLKEPAASL
260 270 280 290 300
HSESPRGKSS LLVSLRTHMS GSIIAFKVGS FCRSESPVLH QREHVELLRG
310 320 330 340 350
RKLARSLAVL LSAFAICWAP YCLFTIVLST YRRGERPKSI WYSIAFWLQW
360 370 380 390
FNSLINPFLY PLCHRRFQKA FWKILCVTKQ PAPSQTQSVS S
Length:391
Mass (Da):44,023
Last modified:December 1, 2001 - v1
Checksum:iC707BA6E39CFED41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358860 mRNA. Translation: AAK97381.1.
RefSeqiNP_571984.1. NM_131909.1.
UniGeneiRn.162272.

Genome annotation databases

GeneIDi170704.
KEGGirno:170704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358860 mRNA. Translation: AAK97381.1.
RefSeqiNP_571984.1. NM_131909.1.
UniGeneiRn.162272.

3D structure databases

ProteinModelPortaliQ91ZY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022744.

Chemistry

BindingDBiQ91ZY1.
ChEMBLiCHEMBL4468.
GuidetoPHARMACOLOGYi265.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ91ZY1.
PRIDEiQ91ZY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170704.
KEGGirno:170704.

Organism-specific databases

CTDi59340.
RGDi620631. Hrh4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ91ZY1.
KOiK04152.
PhylomeDBiQ91ZY1.

Miscellaneous databases

PROiQ91ZY1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008102. Histamine_H4_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01726. HISTAMINEH4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of human, mouse, rat, and guinea pig histamine H4 receptor suggests substantial species variation."
    Liu C., Wilson S., Kuei C., Lovenberg T.W.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiHRH4_RAT
AccessioniPrimary (citable) accession number: Q91ZY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.