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Protein
Submitted name:

Cyclin A2

Gene

Ccna2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • organ regeneration Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  • regulation of G2/M transition of mitotic cell cycle Source: InterPro
  • response to estradiol Source: RGD
  • response to glucagon Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin A2Imported
Gene namesi
Name:Ccna2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621059. Ccna2.

Expressioni

Gene expression databases

GenevisibleiQ91ZX8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021156.

Structurei

3D structure databases

ProteinModelPortaliQ91ZX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG106244.
KOiK06627.
PhylomeDBiQ91ZX8.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015453. Cyclin_A_chordates.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF69. PTHR10177:SF69. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q91ZX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGIARQAGS ALLSQQEDQE NVNPEKVAPA QQPRAQAVLK AGKVRGPAPQ
60 70 80 90 100
QRLKTRRVAP LKDLPINDEH VPTVPSWKAV SKQPAFTIHV DEAEETQKRP
110 120 130 140 150
AERKETQCED ALAFSAAVSL PGARKPLVPL DYPMDGSFES PHAMDISIVL
160 170 180 190 200
EDEKPVNVNE VPDYHEDIHT YLGEMEVKCK PKVSYMKRQP DITNSMRAIL
210 220 230 240 250
VDWLVEVGEE YKLQNETLHL AVNYIDRFLF SMSALRGKLQ LVGTAAMLLA
260
SKFEEIYPPE VAEFV
Length:265
Mass (Da):29,619
Last modified:December 1, 2001 - v1
Checksum:iFACE7AC47D6A1289
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei265 – 2651Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367448 mRNA. Translation: AAK56923.1.
RefSeqiNP_446154.3. NM_053702.3.
UniGeneiRn.13094.

Genome annotation databases

GeneIDi114494.
KEGGirno:114494.
UCSCiRGD:621059. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367448 mRNA. Translation: AAK56923.1.
RefSeqiNP_446154.3. NM_053702.3.
UniGeneiRn.13094.

3D structure databases

ProteinModelPortaliQ91ZX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114494.
KEGGirno:114494.
UCSCiRGD:621059. rat.

Organism-specific databases

CTDi890.
RGDi621059. Ccna2.

Phylogenomic databases

HOVERGENiHBG106244.
KOiK06627.
PhylomeDBiQ91ZX8.

Miscellaneous databases

NextBioi618537.

Gene expression databases

GenevisibleiQ91ZX8. RN.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015453. Cyclin_A_chordates.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF69. PTHR10177:SF69. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase."
    Mitra S.K., Swarup G.
    Exp. Cell Res. 270:32-44(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LungImported.

Entry informationi

Entry nameiQ91ZX8_RAT
AccessioniPrimary (citable) accession number: Q91ZX8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.