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Q91ZX1

- C209A_MOUSE

UniProt

Q91ZX1 - C209A_MOUSE

Protein

CD209 antigen-like protein A

Gene

Cd209a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi198 – 1981CalciumBy similarity
    Metal bindingi200 – 2001CalciumBy similarity
    Metal bindingi202 – 2021Calcium; via carbonyl oxygenBy similarity
    Metal bindingi205 – 2051CalciumBy similarity
    Metal bindingi216 – 2161CalciumBy similarity
    Metal bindingi217 – 2171CalciumBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: MGI
    2. mannose binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Calcium, Lectin, Mannose-binding, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD209 antigen-like protein A
    Alternative name(s):
    Dendritic cell-specific ICAM-3-grabbing non-integrin
    Short name:
    DC-SIGN
    CD_antigen: CD209
    Gene namesi
    Name:Cd209a
    Synonyms:Cire
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2157942. Cd209a.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238CD209 antigen-like protein APRO_0000046604Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi108 ↔ 119PROSITE-ProRule annotation
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 228PROSITE-ProRule annotation
    Disulfide bondi207 ↔ 220PROSITE-ProRule annotation
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ91ZX1.

    PTM databases

    PhosphoSiteiQ91ZX1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.2 Publications

    Inductioni

    Down-regulated upon activation of dendritic cells.1 Publication

    Gene expression databases

    ArrayExpressiQ91ZX1.
    BgeeiQ91ZX1.
    CleanExiMM_CD209A.
    GenevestigatoriQ91ZX1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZX1.
    SMRiQ91ZX1. Positions 74-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 238166ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 229115C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267427.
    GeneTreeiENSGT00750000117477.
    HOGENOMiHOG000013222.
    HOVERGENiHBG050992.
    InParanoidiQ91ZX1.
    KOiK06563.
    OMAiWNDSATA.
    OrthoDBiEOG79KPH7.
    PhylomeDBiQ91ZX1.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZX1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS    50
    QVPLALQVLF LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG 100
    VDRLCRSCPW DWTHFQGSCY FFSVAQKSWN DSATACHNVG AQLVVIKSDE 150
    EQNFLQQTSK KRGYTWMGLI DMSKESTWYW VDGSPLTLSF MKYWSKGEPN 200
    NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK 238
    Length:238
    Mass (Da):27,149
    Last modified:December 1, 2001 - v1
    Checksum:i05C025FCF2E63DC2
    GO
    Isoform 2 (identifier: Q91ZX1-2) [UniParc]FASTAAdd to Basket

    Also known as: neck-less

    The sequence of this isoform differs from the canonical sequence as follows:
         75-101: Missing.

    Show »
    Length:211
    Mass (Da):24,055
    Checksum:i1AF2988F95FD9634
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 10127Missing in isoform 2. 1 PublicationVSP_010067Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF373408 mRNA. Translation: AAL13234.1.
    AF374470 mRNA. Translation: AAL27539.1.
    AY049062 mRNA. Translation: AAK85825.1.
    AK054139 mRNA. Translation: BAC35667.1.
    AK171639 mRNA. Translation: BAE42579.1.
    CCDSiCCDS22073.1. [Q91ZX1-1]
    RefSeqiNP_573501.1. NM_133238.5. [Q91ZX1-1]
    UniGeneiMm.32510.

    Genome annotation databases

    EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
    GeneIDi170786.
    KEGGimmu:170786.
    UCSCiuc009ksq.2. mouse. [Q91ZX1-1]
    uc012fyt.1. mouse. [Q91ZX1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    SIGNR5

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF373408 mRNA. Translation: AAL13234.1 .
    AF374470 mRNA. Translation: AAL27539.1 .
    AY049062 mRNA. Translation: AAK85825.1 .
    AK054139 mRNA. Translation: BAC35667.1 .
    AK171639 mRNA. Translation: BAE42579.1 .
    CCDSi CCDS22073.1. [Q91ZX1-1 ]
    RefSeqi NP_573501.1. NM_133238.5. [Q91ZX1-1 ]
    UniGenei Mm.32510.

    3D structure databases

    ProteinModelPortali Q91ZX1.
    SMRi Q91ZX1. Positions 74-230.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91ZX1.

    Proteomic databases

    PRIDEi Q91ZX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012847 ; ENSMUSP00000012847 ; ENSMUSG00000031494 . [Q91ZX1-1 ]
    GeneIDi 170786.
    KEGGi mmu:170786.
    UCSCi uc009ksq.2. mouse. [Q91ZX1-1 ]
    uc012fyt.1. mouse. [Q91ZX1-2 ]

    Organism-specific databases

    CTDi 170786.
    MGIi MGI:2157942. Cd209a.

    Phylogenomic databases

    eggNOGi NOG267427.
    GeneTreei ENSGT00750000117477.
    HOGENOMi HOG000013222.
    HOVERGENi HBG050992.
    InParanoidi Q91ZX1.
    KOi K06563.
    OMAi WNDSATA.
    OrthoDBi EOG79KPH7.
    PhylomeDBi Q91ZX1.
    TreeFami TF333341.

    Miscellaneous databases

    NextBioi 370415.
    PROi Q91ZX1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91ZX1.
    Bgeei Q91ZX1.
    CleanExi MM_CD209A.
    Genevestigatori Q91ZX1.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells."
      Caminschi I., Lucas K.M., O'Keeffe M.A., Hochrein H., Laabi Y., Brodnicki T.C., Lew A.M., Shortman K., Wright M.D.
      Mol. Immunol. 38:365-373(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Oviduct and Spleen.

    Entry informationi

    Entry nameiC209A_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZX1
    Secondary accession number(s): Q3TAT9, Q91ZW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by PubMed:11581173 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3