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Q91ZX1

- C209A_MOUSE

UniProt

Q91ZX1 - C209A_MOUSE

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Protein

CD209 antigen-like protein A

Gene

Cd209a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981CalciumBy similarity
Metal bindingi200 – 2001CalciumBy similarity
Metal bindingi202 – 2021Calcium; via carbonyl oxygenBy similarity
Metal bindingi205 – 2051CalciumBy similarity
Metal bindingi216 – 2161CalciumBy similarity
Metal bindingi217 – 2171CalciumBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: MGI
  2. mannose binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein A
Alternative name(s):
Dendritic cell-specific ICAM-3-grabbing non-integrin
Short name:
DC-SIGN
CD_antigen: CD209
Gene namesi
Name:Cd209a
Synonyms:Cire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2157942. Cd209a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini73 – 238166ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238CD209 antigen-like protein APRO_0000046604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 119PROSITE-ProRule annotation
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 228PROSITE-ProRule annotation
Disulfide bondi207 ↔ 220PROSITE-ProRule annotation
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91ZX1.

PTM databases

PhosphoSiteiQ91ZX1.

Expressioni

Tissue specificityi

Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.2 Publications

Inductioni

Down-regulated upon activation of dendritic cells.1 Publication

Gene expression databases

BgeeiQ91ZX1.
CleanExiMM_CD209A.
ExpressionAtlasiQ91ZX1. baseline and differential.
GenevestigatoriQ91ZX1.

Structurei

3D structure databases

ProteinModelPortaliQ91ZX1.
SMRiQ91ZX1. Positions 74-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 229115C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267427.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG050992.
InParanoidiQ91ZX1.
KOiK06563.
OMAiWNDSATA.
OrthoDBiEOG79KPH7.
PhylomeDBiQ91ZX1.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS
60 70 80 90 100
QVPLALQVLF LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG
110 120 130 140 150
VDRLCRSCPW DWTHFQGSCY FFSVAQKSWN DSATACHNVG AQLVVIKSDE
160 170 180 190 200
EQNFLQQTSK KRGYTWMGLI DMSKESTWYW VDGSPLTLSF MKYWSKGEPN
210 220 230
NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK
Length:238
Mass (Da):27,149
Last modified:December 1, 2001 - v1
Checksum:i05C025FCF2E63DC2
GO
Isoform 2 (identifier: Q91ZX1-2) [UniParc]FASTAAdd to Basket

Also known as: neck-less

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:211
Mass (Da):24,055
Checksum:i1AF2988F95FD9634
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 10127Missing in isoform 2. 1 PublicationVSP_010067Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA. Translation: AAL13234.1.
AF374470 mRNA. Translation: AAL27539.1.
AY049062 mRNA. Translation: AAK85825.1.
AK054139 mRNA. Translation: BAC35667.1.
AK171639 mRNA. Translation: BAE42579.1.
CCDSiCCDS22073.1. [Q91ZX1-1]
RefSeqiNP_573501.1. NM_133238.5. [Q91ZX1-1]
UniGeneiMm.32510.

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
GeneIDi170786.
KEGGimmu:170786.
UCSCiuc009ksq.2. mouse. [Q91ZX1-1]
uc012fyt.1. mouse. [Q91ZX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA. Translation: AAL13234.1 .
AF374470 mRNA. Translation: AAL27539.1 .
AY049062 mRNA. Translation: AAK85825.1 .
AK054139 mRNA. Translation: BAC35667.1 .
AK171639 mRNA. Translation: BAE42579.1 .
CCDSi CCDS22073.1. [Q91ZX1-1 ]
RefSeqi NP_573501.1. NM_133238.5. [Q91ZX1-1 ]
UniGenei Mm.32510.

3D structure databases

ProteinModelPortali Q91ZX1.
SMRi Q91ZX1. Positions 74-230.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91ZX1.

Proteomic databases

PRIDEi Q91ZX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012847 ; ENSMUSP00000012847 ; ENSMUSG00000031494 . [Q91ZX1-1 ]
GeneIDi 170786.
KEGGi mmu:170786.
UCSCi uc009ksq.2. mouse. [Q91ZX1-1 ]
uc012fyt.1. mouse. [Q91ZX1-2 ]

Organism-specific databases

CTDi 170786.
MGIi MGI:2157942. Cd209a.

Phylogenomic databases

eggNOGi NOG267427.
GeneTreei ENSGT00760000118924.
HOGENOMi HOG000013222.
HOVERGENi HBG050992.
InParanoidi Q91ZX1.
KOi K06563.
OMAi WNDSATA.
OrthoDBi EOG79KPH7.
PhylomeDBi Q91ZX1.
TreeFami TF333341.

Miscellaneous databases

NextBioi 370415.
PROi Q91ZX1.
SOURCEi Search...

Gene expression databases

Bgeei Q91ZX1.
CleanExi MM_CD209A.
ExpressionAtlasi Q91ZX1. baseline and differential.
Genevestigatori Q91ZX1.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells."
    Caminschi I., Lucas K.M., O'Keeffe M.A., Hochrein H., Laabi Y., Brodnicki T.C., Lew A.M., Shortman K., Wright M.D.
    Mol. Immunol. 38:365-373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Oviduct and Spleen.

Entry informationi

Entry nameiC209A_MOUSE
AccessioniPrimary (citable) accession number: Q91ZX1
Secondary accession number(s): Q3TAT9, Q91ZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by PubMed:11581173 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3