Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91ZX1 (C209A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD209 antigen-like protein A
Alternative name(s):
Dendritic cell-specific ICAM-3-grabbing non-integrin
Short name=DC-SIGN
CD_antigen=CD209
Gene names
Name:Cd209a
Synonyms:Cire
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

Subcellular location

Membrane; Single-pass type II membrane protein Potential Ref.2.

Tissue specificity

Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow. Ref.1 Ref.2

Induction

Down-regulated upon activation of dendritic cells. Ref.2

Sequence similarities

Contains 1 C-type lectin domain.

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by Ref.1 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91ZX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91ZX1-2)

Also known as: neck-less;

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238CD209 antigen-like protein A
PRO_0000046604

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain73 – 238166Extracellular Potential
Domain115 – 229115C-type lectin

Sites

Metal binding1981Calcium By similarity
Metal binding2001Calcium By similarity
Metal binding2021Calcium; via carbonyl oxygen By similarity
Metal binding2051Calcium By similarity
Metal binding2161Calcium By similarity
Metal binding2171Calcium By similarity

Amino acid modifications

Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 119 By similarity
Disulfide bond136 ↔ 228 By similarity
Disulfide bond207 ↔ 220 By similarity

Natural variations

Alternative sequence75 – 10127Missing in isoform 2.
VSP_010067

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 05C025FCF2E63DC2

FASTA23827,149
        10         20         30         40         50         60 
MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS QVPLALQVLF 

        70         80         90        100        110        120 
LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG VDRLCRSCPW DWTHFQGSCY 

       130        140        150        160        170        180 
FFSVAQKSWN DSATACHNVG AQLVVIKSDE EQNFLQQTSK KRGYTWMGLI DMSKESTWYW 

       190        200        210        220        230 
VDGSPLTLSF MKYWSKGEPN NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK 

« Hide

Isoform 2 (neck-less) [UniParc].

Checksum: 1AF2988F95FD9634
Show »

FASTA21124,055

References

« Hide 'large scale' references
[1]"Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN."
Park C.G., Takahara K., Umemoto E., Yashima Y., Matsubara K., Matsuda Y., Clausen B.E., Inaba K., Steinman R.M.
Int. Immunol. 13:1283-1290(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells."
Caminschi I., Lucas K.M., O'Keeffe M.A., Hochrein H., Laabi Y., Brodnicki T.C., Lew A.M., Shortman K., Wright M.D.
Mol. Immunol. 38:365-373(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Oviduct and Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF373408 mRNA. Translation: AAL13234.1.
AF374470 mRNA. Translation: AAL27539.1.
AY049062 mRNA. Translation: AAK85825.1.
AK054139 mRNA. Translation: BAC35667.1.
AK171639 mRNA. Translation: BAE42579.1.
CCDSCCDS22073.1. [Q91ZX1-1]
RefSeqNP_573501.1. NM_133238.5. [Q91ZX1-1]
UniGeneMm.32510.

3D structure databases

ProteinModelPortalQ91ZX1.
SMRQ91ZX1. Positions 74-230.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91ZX1.

Proteomic databases

PRIDEQ91ZX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
GeneID170786.
KEGGmmu:170786.
UCSCuc009ksq.2. mouse. [Q91ZX1-1]
uc012fyt.1. mouse. [Q91ZX1-2]

Organism-specific databases

CTD170786.
MGIMGI:2157942. Cd209a.

Phylogenomic databases

eggNOGNOG267427.
GeneTreeENSGT00750000117477.
HOGENOMHOG000013222.
HOVERGENHBG050992.
InParanoidQ91ZX1.
KOK06563.
OMAWNDSATA.
OrthoDBEOG79KPH7.
PhylomeDBQ91ZX1.
TreeFamTF333341.

Gene expression databases

ArrayExpressQ91ZX1.
BgeeQ91ZX1.
CleanExMM_CD209A.
GenevestigatorQ91ZX1.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370415.
PROQ91ZX1.
SOURCESearch...

Entry information

Entry nameC209A_MOUSE
AccessionPrimary (citable) accession number: Q91ZX1
Secondary accession number(s): Q3TAT9, Q91ZW5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot