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Protein

CD209 antigen-like protein A

Gene

Cd209a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981CalciumBy similarity
Metal bindingi200 – 2001CalciumBy similarity
Metal bindingi202 – 2021Calcium; via carbonyl oxygenBy similarity
Metal bindingi205 – 2051CalciumBy similarity
Metal bindingi216 – 2161CalciumBy similarity
Metal bindingi217 – 2171CalciumBy similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: MGI
  • carbohydrate binding Source: MGI
  • carbohydrate derivative binding Source: MGI
  • mannose binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • virus receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein A
Alternative name(s):
Dendritic cell-specific ICAM-3-grabbing non-integrin
Short name:
DC-SIGN
CD_antigen: CD209
Gene namesi
Name:Cd209a
Synonyms:Cire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2157942. Cd209a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini73 – 238166ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238CD209 antigen-like protein APRO_0000046604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 119PROSITE-ProRule annotation
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 228PROSITE-ProRule annotation
Disulfide bondi207 ↔ 220PROSITE-ProRule annotation
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91ZX1.

PTM databases

PhosphoSiteiQ91ZX1.

Expressioni

Tissue specificityi

Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.2 Publications

Inductioni

Down-regulated upon activation of dendritic cells.1 Publication

Gene expression databases

BgeeiQ91ZX1.
CleanExiMM_CD209A.
ExpressionAtlasiQ91ZX1. baseline and differential.
GenevisibleiQ91ZX1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012847.

Structurei

3D structure databases

ProteinModelPortaliQ91ZX1.
SMRiQ91ZX1. Positions 74-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 229115C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267427.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG050992.
InParanoidiQ91ZX1.
KOiK06563.
OMAiWNDSATA.
OrthoDBiEOG79KPH7.
PhylomeDBiQ91ZX1.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS
60 70 80 90 100
QVPLALQVLF LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG
110 120 130 140 150
VDRLCRSCPW DWTHFQGSCY FFSVAQKSWN DSATACHNVG AQLVVIKSDE
160 170 180 190 200
EQNFLQQTSK KRGYTWMGLI DMSKESTWYW VDGSPLTLSF MKYWSKGEPN
210 220 230
NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK
Length:238
Mass (Da):27,149
Last modified:December 1, 2001 - v1
Checksum:i05C025FCF2E63DC2
GO
Isoform 2 (identifier: Q91ZX1-2) [UniParc]FASTAAdd to basket

Also known as: neck-less

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:211
Mass (Da):24,055
Checksum:i1AF2988F95FD9634
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 10127Missing in isoform 2. 1 PublicationVSP_010067Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA. Translation: AAL13234.1.
AF374470 mRNA. Translation: AAL27539.1.
AY049062 mRNA. Translation: AAK85825.1.
AK054139 mRNA. Translation: BAC35667.1.
AK171639 mRNA. Translation: BAE42579.1.
CCDSiCCDS22073.1. [Q91ZX1-1]
RefSeqiNP_573501.1. NM_133238.5. [Q91ZX1-1]
UniGeneiMm.32510.

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
GeneIDi170786.
KEGGimmu:170786.
UCSCiuc009ksq.2. mouse. [Q91ZX1-1]
uc012fyt.1. mouse. [Q91ZX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA. Translation: AAL13234.1.
AF374470 mRNA. Translation: AAL27539.1.
AY049062 mRNA. Translation: AAK85825.1.
AK054139 mRNA. Translation: BAC35667.1.
AK171639 mRNA. Translation: BAE42579.1.
CCDSiCCDS22073.1. [Q91ZX1-1]
RefSeqiNP_573501.1. NM_133238.5. [Q91ZX1-1]
UniGeneiMm.32510.

3D structure databases

ProteinModelPortaliQ91ZX1.
SMRiQ91ZX1. Positions 74-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012847.

PTM databases

PhosphoSiteiQ91ZX1.

Proteomic databases

PRIDEiQ91ZX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
GeneIDi170786.
KEGGimmu:170786.
UCSCiuc009ksq.2. mouse. [Q91ZX1-1]
uc012fyt.1. mouse. [Q91ZX1-2]

Organism-specific databases

CTDi170786.
MGIiMGI:2157942. Cd209a.

Phylogenomic databases

eggNOGiNOG267427.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000013222.
HOVERGENiHBG050992.
InParanoidiQ91ZX1.
KOiK06563.
OMAiWNDSATA.
OrthoDBiEOG79KPH7.
PhylomeDBiQ91ZX1.
TreeFamiTF333341.

Miscellaneous databases

NextBioi370415.
PROiQ91ZX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZX1.
CleanExiMM_CD209A.
ExpressionAtlasiQ91ZX1. baseline and differential.
GenevisibleiQ91ZX1. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells."
    Caminschi I., Lucas K.M., O'Keeffe M.A., Hochrein H., Laabi Y., Brodnicki T.C., Lew A.M., Shortman K., Wright M.D.
    Mol. Immunol. 38:365-373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Oviduct and Spleen.

Entry informationi

Entry nameiC209A_MOUSE
AccessioniPrimary (citable) accession number: Q91ZX1
Secondary accession number(s): Q3TAT9, Q91ZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by PubMed:11581173 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.