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Q91ZX1

- C209A_MOUSE

UniProt

Q91ZX1 - C209A_MOUSE

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Protein
CD209 antigen-like protein A
Gene
Cd209a, Cire
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981Calcium By similarity
Metal bindingi200 – 2001Calcium By similarity
Metal bindingi202 – 2021Calcium; via carbonyl oxygen By similarity
Metal bindingi205 – 2051Calcium By similarity
Metal bindingi216 – 2161Calcium By similarity
Metal bindingi217 – 2171Calcium By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: MGI
  2. mannose binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein A
Alternative name(s):
Dendritic cell-specific ICAM-3-grabbing non-integrin
Short name:
DC-SIGN
CD_antigen: CD209
Gene namesi
Name:Cd209a
Synonyms:Cire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2157942. Cd209a.

Subcellular locationi

Membrane; Single-pass type II membrane protein Reviewed prediction 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini73 – 238166Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238CD209 antigen-like protein A
PRO_0000046604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 119 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 228 By similarity
Disulfide bondi207 ↔ 220 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91ZX1.

PTM databases

PhosphoSiteiQ91ZX1.

Expressioni

Tissue specificityi

Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.2 Publications

Inductioni

Down-regulated upon activation of dendritic cells.1 Publication

Gene expression databases

ArrayExpressiQ91ZX1.
BgeeiQ91ZX1.
CleanExiMM_CD209A.
GenevestigatoriQ91ZX1.

Structurei

3D structure databases

ProteinModelPortaliQ91ZX1.
SMRiQ91ZX1. Positions 74-230.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 229115C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267427.
GeneTreeiENSGT00750000117477.
HOGENOMiHOG000013222.
HOVERGENiHBG050992.
InParanoidiQ91ZX1.
KOiK06563.
OMAiWNDSATA.
OrthoDBiEOG79KPH7.
PhylomeDBiQ91ZX1.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS    50
QVPLALQVLF LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG 100
VDRLCRSCPW DWTHFQGSCY FFSVAQKSWN DSATACHNVG AQLVVIKSDE 150
EQNFLQQTSK KRGYTWMGLI DMSKESTWYW VDGSPLTLSF MKYWSKGEPN 200
NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK 238
Length:238
Mass (Da):27,149
Last modified:December 1, 2001 - v1
Checksum:i05C025FCF2E63DC2
GO
Isoform 2 (identifier: Q91ZX1-2) [UniParc]FASTAAdd to Basket

Also known as: neck-less

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:211
Mass (Da):24,055
Checksum:i1AF2988F95FD9634
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 10127Missing in isoform 2.
VSP_010067Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF373408 mRNA. Translation: AAL13234.1.
AF374470 mRNA. Translation: AAL27539.1.
AY049062 mRNA. Translation: AAK85825.1.
AK054139 mRNA. Translation: BAC35667.1.
AK171639 mRNA. Translation: BAE42579.1.
CCDSiCCDS22073.1. [Q91ZX1-1]
RefSeqiNP_573501.1. NM_133238.5. [Q91ZX1-1]
UniGeneiMm.32510.

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494. [Q91ZX1-1]
GeneIDi170786.
KEGGimmu:170786.
UCSCiuc009ksq.2. mouse. [Q91ZX1-1]
uc012fyt.1. mouse. [Q91ZX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR5

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF373408 mRNA. Translation: AAL13234.1 .
AF374470 mRNA. Translation: AAL27539.1 .
AY049062 mRNA. Translation: AAK85825.1 .
AK054139 mRNA. Translation: BAC35667.1 .
AK171639 mRNA. Translation: BAE42579.1 .
CCDSi CCDS22073.1. [Q91ZX1-1 ]
RefSeqi NP_573501.1. NM_133238.5. [Q91ZX1-1 ]
UniGenei Mm.32510.

3D structure databases

ProteinModelPortali Q91ZX1.
SMRi Q91ZX1. Positions 74-230.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91ZX1.

Proteomic databases

PRIDEi Q91ZX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012847 ; ENSMUSP00000012847 ; ENSMUSG00000031494 . [Q91ZX1-1 ]
GeneIDi 170786.
KEGGi mmu:170786.
UCSCi uc009ksq.2. mouse. [Q91ZX1-1 ]
uc012fyt.1. mouse. [Q91ZX1-2 ]

Organism-specific databases

CTDi 170786.
MGIi MGI:2157942. Cd209a.

Phylogenomic databases

eggNOGi NOG267427.
GeneTreei ENSGT00750000117477.
HOGENOMi HOG000013222.
HOVERGENi HBG050992.
InParanoidi Q91ZX1.
KOi K06563.
OMAi WNDSATA.
OrthoDBi EOG79KPH7.
PhylomeDBi Q91ZX1.
TreeFami TF333341.

Miscellaneous databases

NextBioi 370415.
PROi Q91ZX1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91ZX1.
Bgeei Q91ZX1.
CleanExi MM_CD209A.
Genevestigatori Q91ZX1.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells."
    Caminschi I., Lucas K.M., O'Keeffe M.A., Hochrein H., Laabi Y., Brodnicki T.C., Lew A.M., Shortman K., Wright M.D.
    Mol. Immunol. 38:365-373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Oviduct and Spleen.

Entry informationi

Entry nameiC209A_MOUSE
AccessioniPrimary (citable) accession number: Q91ZX1
Secondary accession number(s): Q3TAT9, Q91ZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by 1 Publication because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi