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Q91ZV7 (PLDX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 7
Gene names
Name:Plxdc1
Synonyms:Tem7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a critical role in endothelial cell capillary morphogenesis. Ref.7

Subunit structure

Interacts with NID1. May interact with CTTN. Ref.6 Ref.8

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential. Cell junctiontight junction By similarity. Note: Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells By similarity.

Tissue specificity

Detected in brain. Highly expressed in Purkinje cells of the cerebellum. Ref.1

Developmental stage

Expression increases in endothelial cells undergoing capillary morphogenesis. Ref.7

Sequence similarities

Belongs to the plexin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Nid1P084602EBI-8280807,EBI-8280787From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91ZV7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91ZV7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: V → VALSLSPQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 500481Plexin domain-containing protein 1
PRO_0000232752

Regions

Topological domain20 – 426407Extracellular Potential
Transmembrane427 – 44721Helical; Potential
Topological domain448 – 50053Cytoplasmic Potential

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence861V → VALSLSPQ in isoform 2.
VSP_017975

Experimental info

Sequence conflict1041Q → R in AAI14353. Ref.5
Sequence conflict2481S → P in AAI14353. Ref.5
Sequence conflict2721A → E in AAL11997. Ref.1
Sequence conflict2721A → E in AAI14353. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 802D6865F8CA18BD

FASTA50055,635
        10         20         30         40         50         60 
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR ESPAQVLKPG 

        70         80         90        100        110        120 
KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP GEKQSQDLWV DLAVANRSHV 

       130        140        150        160        170        180 
KIHRILSSSH RQASRVVLSF DFPFYGHPLR QITIATGGFI FMGDMLHRML TATQYVAPLM 

       190        200        210        220        230        240 
ANFNPGYSDN STVAYFDNGT VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP 

       250        260        270        280        290        300 
MAVLDISSAQ HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT 

       310        320        330        340        350        360 
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ EAEGKTCEDF 

       370        380        390        400        410        420 
QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL NPYAEGDGLP DHSSPKSKGP 

       430        440        450        460        470        480 
PVHLGTIVGI VLAVLLVAAI ILAGIYISGH PNSNAALFFI ERRPHHWPAM KFHNHPNHST 

       490        500 
YTEVEPSGHE KEGFVEAEQC 

« Hide

Isoform 2 [UniParc].

Checksum: C2D50B44561C3415
Show »

FASTA50756,332

References

« Hide 'large scale' references
[1]"Cell surface tumor endothelial markers are conserved in mice and humans."
Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cerebellum, Embryonic stem cell and Thymus.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R."
Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S., Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W., St Croix B.
Cancer Res. 64:8507-8511(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[7]"Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis."
Wang X.Q., Sheibani N., Watson J.C.
Microvasc. Res. 70:189-197(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[8]"Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
Lee H.K., Seo I.A., Park H.K., Park H.T.
FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NID1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378760 mRNA. Translation: AAL11997.1.
AK010361 mRNA. Translation: BAB26881.1.
AK036144 mRNA. Translation: BAC29318.1.
AK153684 mRNA. Translation: BAE32144.1.
AL591209 Genomic DNA. Translation: CAM20410.1.
AL591209 Genomic DNA. Translation: CAM20411.1.
CH466556 Genomic DNA. Translation: EDL16106.1.
BC114352 mRNA. Translation: AAI14353.1.
RefSeqNP_001157080.1. NM_001163608.1.
NP_082475.3. NM_028199.3.
UniGeneMm.39617.
Mm.482750.

3D structure databases

ProteinModelPortalQ91ZV7.
SMRQ91ZV7. Positions 304-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91ZV7. 1 interaction.
MINTMINT-1891999.

PTM databases

PhosphoSiteQ91ZV7.

Proteomic databases

PRIDEQ91ZV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417. [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417. [Q91ZV7-2]
GeneID72324.
KEGGmmu:72324.
UCSCuc007lfc.2. mouse. [Q91ZV7-1]
uc011ydx.1. mouse. [Q91ZV7-2]

Organism-specific databases

CTD57125.
MGIMGI:1919574. Plxdc1.

Phylogenomic databases

eggNOGNOG291117.
GeneTreeENSGT00440000033408.
HOGENOMHOG000234044.
HOVERGENHBG079500.
InParanoidA2A538.
OMAVEDNHSY.
OrthoDBEOG712TWH.
PhylomeDBQ91ZV7.
TreeFamTF314400.

Gene expression databases

ArrayExpressQ91ZV7.
BgeeQ91ZV7.
CleanExMM_PLXDC1.
GenevestigatorQ91ZV7.

Family and domain databases

InterProIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view]
PfamPF01437. PSI. 1 hit.
[Graphical view]
SMARTSM00423. PSI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio336020.
PROQ91ZV7.
SOURCESearch...

Entry information

Entry namePLDX1_MOUSE
AccessionPrimary (citable) accession number: Q91ZV7
Secondary accession number(s): A2A537 expand/collapse secondary AC list , A2A538, Q29R73, Q8BM20, Q9CWV5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot