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Q91ZV7

- PLDX1_MOUSE

UniProt

Q91ZV7 - PLDX1_MOUSE

Protein

Plexin domain-containing protein 1

Gene

Plxdc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Plays a critical role in endothelial cell capillary morphogenesis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. spinal cord development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin domain-containing protein 1
    Alternative name(s):
    Tumor endothelial marker 7
    Gene namesi
    Name:Plxdc1
    Synonyms:Tem7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919574. Plxdc1.

    Subcellular locationi

    Cell membrane Curated; Single-pass type I membrane protein Curated. Cell junctiontight junction By similarity
    Note: Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: Ensembl
    5. plasma membrane Source: UniProtKB
    6. receptor complex Source: MGI
    7. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 500481Plexin domain-containing protein 1PRO_0000232752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ91ZV7.

    PTM databases

    PhosphoSiteiQ91ZV7.

    Expressioni

    Tissue specificityi

    Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication

    Developmental stagei

    Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication

    Gene expression databases

    ArrayExpressiQ91ZV7.
    BgeeiQ91ZV7.
    CleanExiMM_PLXDC1.
    GenevestigatoriQ91ZV7.

    Interactioni

    Subunit structurei

    Interacts with NID1. May interact with CTTN.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Nid1P084602EBI-8280807,EBI-8280787From a different organism.

    Protein-protein interaction databases

    IntActiQ91ZV7. 1 interaction.
    MINTiMINT-1891999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZV7.
    SMRiQ91ZV7. Positions 304-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 426407ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini448 – 50053CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the plexin family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291117.
    GeneTreeiENSGT00440000033408.
    HOGENOMiHOG000234044.
    HOVERGENiHBG079500.
    InParanoidiA2A538.
    OMAiVEDNHSY.
    OrthoDBiEOG712TWH.
    PhylomeDBiQ91ZV7.
    TreeFamiTF314400.

    Family and domain databases

    InterProiIPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    [Graphical view]
    PfamiPF01437. PSI. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR    50
    ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP 100
    GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR 150
    QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT 200
    VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ 250
    HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT 300
    PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ 350
    EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL 400
    NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH 450
    PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC 500
    Length:500
    Mass (Da):55,635
    Last modified:January 11, 2011 - v2
    Checksum:i802D6865F8CA18BD
    GO
    Isoform 2 (identifier: Q91ZV7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         86-86: V → VALSLSPQ

    Note: No experimental confirmation available.

    Show »
    Length:507
    Mass (Da):56,332
    Checksum:iC2D50B44561C3415
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041Q → R in AAI14353. (PubMed:15489334)Curated
    Sequence conflicti248 – 2481S → P in AAI14353. (PubMed:15489334)Curated
    Sequence conflicti272 – 2721A → E in AAL11997. (PubMed:11559528)Curated
    Sequence conflicti272 – 2721A → E in AAI14353. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei86 – 861V → VALSLSPQ in isoform 2. 1 PublicationVSP_017975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378760 mRNA. Translation: AAL11997.1.
    AK010361 mRNA. Translation: BAB26881.1.
    AK036144 mRNA. Translation: BAC29318.1.
    AK153684 mRNA. Translation: BAE32144.1.
    AL591209 Genomic DNA. Translation: CAM20410.1.
    AL591209 Genomic DNA. Translation: CAM20411.1.
    CH466556 Genomic DNA. Translation: EDL16106.1.
    BC114352 mRNA. Translation: AAI14353.1.
    CCDSiCCDS25333.1. [Q91ZV7-1]
    CCDS48897.1. [Q91ZV7-2]
    RefSeqiNP_001157080.1. NM_001163608.1. [Q91ZV7-2]
    NP_082475.3. NM_028199.3. [Q91ZV7-1]
    UniGeneiMm.39617.
    Mm.482750.

    Genome annotation databases

    EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417. [Q91ZV7-1]
    ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417. [Q91ZV7-2]
    GeneIDi72324.
    KEGGimmu:72324.
    UCSCiuc007lfc.2. mouse. [Q91ZV7-1]
    uc011ydx.1. mouse. [Q91ZV7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378760 mRNA. Translation: AAL11997.1 .
    AK010361 mRNA. Translation: BAB26881.1 .
    AK036144 mRNA. Translation: BAC29318.1 .
    AK153684 mRNA. Translation: BAE32144.1 .
    AL591209 Genomic DNA. Translation: CAM20410.1 .
    AL591209 Genomic DNA. Translation: CAM20411.1 .
    CH466556 Genomic DNA. Translation: EDL16106.1 .
    BC114352 mRNA. Translation: AAI14353.1 .
    CCDSi CCDS25333.1. [Q91ZV7-1 ]
    CCDS48897.1. [Q91ZV7-2 ]
    RefSeqi NP_001157080.1. NM_001163608.1. [Q91ZV7-2 ]
    NP_082475.3. NM_028199.3. [Q91ZV7-1 ]
    UniGenei Mm.39617.
    Mm.482750.

    3D structure databases

    ProteinModelPortali Q91ZV7.
    SMRi Q91ZV7. Positions 304-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91ZV7. 1 interaction.
    MINTi MINT-1891999.

    PTM databases

    PhosphoSitei Q91ZV7.

    Proteomic databases

    PRIDEi Q91ZV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017561 ; ENSMUSP00000017561 ; ENSMUSG00000017417 . [Q91ZV7-1 ]
    ENSMUST00000107565 ; ENSMUSP00000103191 ; ENSMUSG00000017417 . [Q91ZV7-2 ]
    GeneIDi 72324.
    KEGGi mmu:72324.
    UCSCi uc007lfc.2. mouse. [Q91ZV7-1 ]
    uc011ydx.1. mouse. [Q91ZV7-2 ]

    Organism-specific databases

    CTDi 57125.
    MGIi MGI:1919574. Plxdc1.

    Phylogenomic databases

    eggNOGi NOG291117.
    GeneTreei ENSGT00440000033408.
    HOGENOMi HOG000234044.
    HOVERGENi HBG079500.
    InParanoidi A2A538.
    OMAi VEDNHSY.
    OrthoDBi EOG712TWH.
    PhylomeDBi Q91ZV7.
    TreeFami TF314400.

    Miscellaneous databases

    NextBioi 336020.
    PROi Q91ZV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91ZV7.
    Bgeei Q91ZV7.
    CleanExi MM_PLXDC1.
    Genevestigatori Q91ZV7.

    Family and domain databases

    InterProi IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    [Graphical view ]
    Pfami PF01437. PSI. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell surface tumor endothelial markers are conserved in mice and humans."
      Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
      Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum, Embryonic stem cell and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R."
      Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S., Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W., St Croix B.
      Cancer Res. 64:8507-8511(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    7. "Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis."
      Wang X.Q., Sheibani N., Watson J.C.
      Microvasc. Res. 70:189-197(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    8. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
      Lee H.K., Seo I.A., Park H.K., Park H.T.
      FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NID1.

    Entry informationi

    Entry nameiPLDX1_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZV7
    Secondary accession number(s): A2A537
    , A2A538, Q29R73, Q8BM20, Q9CWV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3