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Q91ZV7

- PLDX1_MOUSE

UniProt

Q91ZV7 - PLDX1_MOUSE

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Protein

Plexin domain-containing protein 1

Gene
Plxdc1, Tem7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a critical role in endothelial cell capillary morphogenesis.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. receptor activity Source: InterPro

GO - Biological processi

  1. spinal cord development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 7
Gene namesi
Name:Plxdc1
Synonyms:Tem7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919574. Plxdc1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein Reviewed prediction. Cell junctiontight junction By similarity
Note: Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 426407Extracellular Reviewed predictionAdd
BLAST
Transmembranei427 – 44721Helical; Reviewed predictionAdd
BLAST
Topological domaini448 – 50053Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: Ensembl
  5. plasma membrane Source: UniProtKB
  6. receptor complex Source: MGI
  7. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 500481Plexin domain-containing protein 1PRO_0000232752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ91ZV7.

PTM databases

PhosphoSiteiQ91ZV7.

Expressioni

Tissue specificityi

Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication

Gene expression databases

ArrayExpressiQ91ZV7.
BgeeiQ91ZV7.
CleanExiMM_PLXDC1.
GenevestigatoriQ91ZV7.

Interactioni

Subunit structurei

Interacts with NID1. May interact with CTTN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nid1P084602EBI-8280807,EBI-8280787From a different organism.

Protein-protein interaction databases

IntActiQ91ZV7. 1 interaction.
MINTiMINT-1891999.

Structurei

3D structure databases

ProteinModelPortaliQ91ZV7.
SMRiQ91ZV7. Positions 304-334.

Family & Domainsi

Sequence similaritiesi

Belongs to the plexin family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291117.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiA2A538.
OMAiVEDNHSY.
OrthoDBiEOG712TWH.
PhylomeDBiQ91ZV7.
TreeFamiTF314400.

Family and domain databases

InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view]
PfamiPF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR    50
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP 100
GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR 150
QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT 200
VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ 250
HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT 300
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ 350
EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL 400
NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH 450
PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC 500
Length:500
Mass (Da):55,635
Last modified:January 11, 2011 - v2
Checksum:i802D6865F8CA18BD
GO
Isoform 2 (identifier: Q91ZV7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: V → VALSLSPQ

Note: No experimental confirmation available.

Show »
Length:507
Mass (Da):56,332
Checksum:iC2D50B44561C3415
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei86 – 861V → VALSLSPQ in isoform 2. VSP_017975

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041Q → R in AAI14353. 1 Publication
Sequence conflicti248 – 2481S → P in AAI14353. 1 Publication
Sequence conflicti272 – 2721A → E in AAL11997. 1 Publication
Sequence conflicti272 – 2721A → E in AAI14353. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378760 mRNA. Translation: AAL11997.1.
AK010361 mRNA. Translation: BAB26881.1.
AK036144 mRNA. Translation: BAC29318.1.
AK153684 mRNA. Translation: BAE32144.1.
AL591209 Genomic DNA. Translation: CAM20410.1.
AL591209 Genomic DNA. Translation: CAM20411.1.
CH466556 Genomic DNA. Translation: EDL16106.1.
BC114352 mRNA. Translation: AAI14353.1.
CCDSiCCDS25333.1. [Q91ZV7-1]
CCDS48897.1. [Q91ZV7-2]
RefSeqiNP_001157080.1. NM_001163608.1. [Q91ZV7-2]
NP_082475.3. NM_028199.3. [Q91ZV7-1]
UniGeneiMm.39617.
Mm.482750.

Genome annotation databases

EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417. [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417. [Q91ZV7-2]
GeneIDi72324.
KEGGimmu:72324.
UCSCiuc007lfc.2. mouse. [Q91ZV7-1]
uc011ydx.1. mouse. [Q91ZV7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378760 mRNA. Translation: AAL11997.1 .
AK010361 mRNA. Translation: BAB26881.1 .
AK036144 mRNA. Translation: BAC29318.1 .
AK153684 mRNA. Translation: BAE32144.1 .
AL591209 Genomic DNA. Translation: CAM20410.1 .
AL591209 Genomic DNA. Translation: CAM20411.1 .
CH466556 Genomic DNA. Translation: EDL16106.1 .
BC114352 mRNA. Translation: AAI14353.1 .
CCDSi CCDS25333.1. [Q91ZV7-1 ]
CCDS48897.1. [Q91ZV7-2 ]
RefSeqi NP_001157080.1. NM_001163608.1. [Q91ZV7-2 ]
NP_082475.3. NM_028199.3. [Q91ZV7-1 ]
UniGenei Mm.39617.
Mm.482750.

3D structure databases

ProteinModelPortali Q91ZV7.
SMRi Q91ZV7. Positions 304-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91ZV7. 1 interaction.
MINTi MINT-1891999.

PTM databases

PhosphoSitei Q91ZV7.

Proteomic databases

PRIDEi Q91ZV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017561 ; ENSMUSP00000017561 ; ENSMUSG00000017417 . [Q91ZV7-1 ]
ENSMUST00000107565 ; ENSMUSP00000103191 ; ENSMUSG00000017417 . [Q91ZV7-2 ]
GeneIDi 72324.
KEGGi mmu:72324.
UCSCi uc007lfc.2. mouse. [Q91ZV7-1 ]
uc011ydx.1. mouse. [Q91ZV7-2 ]

Organism-specific databases

CTDi 57125.
MGIi MGI:1919574. Plxdc1.

Phylogenomic databases

eggNOGi NOG291117.
GeneTreei ENSGT00440000033408.
HOGENOMi HOG000234044.
HOVERGENi HBG079500.
InParanoidi A2A538.
OMAi VEDNHSY.
OrthoDBi EOG712TWH.
PhylomeDBi Q91ZV7.
TreeFami TF314400.

Miscellaneous databases

NextBioi 336020.
PROi Q91ZV7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91ZV7.
Bgeei Q91ZV7.
CleanExi MM_PLXDC1.
Genevestigatori Q91ZV7.

Family and domain databases

InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view ]
Pfami PF01437. PSI. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."
    Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryonic stem cell and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R."
    Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S., Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 64:8507-8511(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  7. "Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis."
    Wang X.Q., Sheibani N., Watson J.C.
    Microvasc. Res. 70:189-197(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  8. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
    Lee H.K., Seo I.A., Park H.K., Park H.T.
    FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NID1.

Entry informationi

Entry nameiPLDX1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZV7
Secondary accession number(s): A2A537
, A2A538, Q29R73, Q8BM20, Q9CWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi