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Protein

Plexin domain-containing protein 1

Gene

Plxdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in endothelial cell capillary morphogenesis.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 7
Gene namesi
Name:Plxdc1
Synonyms:Tem7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919574. Plxdc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 426ExtracellularSequence analysisAdd BLAST407
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 500CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • dendrite Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: UniProtKB
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000023275220 – 500Plexin domain-containing protein 1Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZV7.
PeptideAtlasiQ91ZV7.
PRIDEiQ91ZV7.

PTM databases

iPTMnetiQ91ZV7.
PhosphoSitePlusiQ91ZV7.

Expressioni

Tissue specificityi

Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000017417.
CleanExiMM_PLXDC1.
ExpressionAtlasiQ91ZV7. baseline and differential.
GenevisibleiQ91ZV7. MM.

Interactioni

Subunit structurei

Interacts with NID1. May interact with CTTN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nid1P084602EBI-8280807,EBI-8280787From a different organism.

Protein-protein interaction databases

IntActiQ91ZV7. 1 interactor.
MINTiMINT-1891999.
STRINGi10090.ENSMUSP00000103191.

Structurei

3D structure databases

ProteinModelPortaliQ91ZV7.
SMRiQ91ZV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ91ZV7.
OMAiVEDNHSY.
OrthoDBiEOG091G0827.
PhylomeDBiQ91ZV7.
TreeFamiTF314400.

Family and domain databases

InterProiIPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031153. PLXDC1.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF10. PTHR13055:SF10. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR
60 70 80 90 100
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP
110 120 130 140 150
GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR
160 170 180 190 200
QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT
210 220 230 240 250
VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ
260 270 280 290 300
HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT
310 320 330 340 350
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ
360 370 380 390 400
EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL
410 420 430 440 450
NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH
460 470 480 490 500
PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC
Length:500
Mass (Da):55,635
Last modified:January 11, 2011 - v2
Checksum:i802D6865F8CA18BD
GO
Isoform 2 (identifier: Q91ZV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: V → VALSLSPQ

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):56,332
Checksum:iC2D50B44561C3415
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104Q → R in AAI14353 (PubMed:15489334).Curated1
Sequence conflicti248S → P in AAI14353 (PubMed:15489334).Curated1
Sequence conflicti272A → E in AAL11997 (PubMed:11559528).Curated1
Sequence conflicti272A → E in AAI14353 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01797586V → VALSLSPQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378760 mRNA. Translation: AAL11997.1.
AK010361 mRNA. Translation: BAB26881.1.
AK036144 mRNA. Translation: BAC29318.1.
AK153684 mRNA. Translation: BAE32144.1.
AL591209 Genomic DNA. Translation: CAM20410.1.
AL591209 Genomic DNA. Translation: CAM20411.1.
CH466556 Genomic DNA. Translation: EDL16106.1.
BC114352 mRNA. Translation: AAI14353.1.
CCDSiCCDS25333.1. [Q91ZV7-1]
CCDS48897.1. [Q91ZV7-2]
RefSeqiNP_001157080.1. NM_001163608.1. [Q91ZV7-2]
NP_082475.3. NM_028199.3. [Q91ZV7-1]
UniGeneiMm.39617.
Mm.482750.

Genome annotation databases

EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417. [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417. [Q91ZV7-2]
GeneIDi72324.
KEGGimmu:72324.
UCSCiuc007lfc.2. mouse. [Q91ZV7-1]
uc011ydx.1. mouse. [Q91ZV7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378760 mRNA. Translation: AAL11997.1.
AK010361 mRNA. Translation: BAB26881.1.
AK036144 mRNA. Translation: BAC29318.1.
AK153684 mRNA. Translation: BAE32144.1.
AL591209 Genomic DNA. Translation: CAM20410.1.
AL591209 Genomic DNA. Translation: CAM20411.1.
CH466556 Genomic DNA. Translation: EDL16106.1.
BC114352 mRNA. Translation: AAI14353.1.
CCDSiCCDS25333.1. [Q91ZV7-1]
CCDS48897.1. [Q91ZV7-2]
RefSeqiNP_001157080.1. NM_001163608.1. [Q91ZV7-2]
NP_082475.3. NM_028199.3. [Q91ZV7-1]
UniGeneiMm.39617.
Mm.482750.

3D structure databases

ProteinModelPortaliQ91ZV7.
SMRiQ91ZV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZV7. 1 interactor.
MINTiMINT-1891999.
STRINGi10090.ENSMUSP00000103191.

PTM databases

iPTMnetiQ91ZV7.
PhosphoSitePlusiQ91ZV7.

Proteomic databases

PaxDbiQ91ZV7.
PeptideAtlasiQ91ZV7.
PRIDEiQ91ZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417. [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417. [Q91ZV7-2]
GeneIDi72324.
KEGGimmu:72324.
UCSCiuc007lfc.2. mouse. [Q91ZV7-1]
uc011ydx.1. mouse. [Q91ZV7-2]

Organism-specific databases

CTDi57125.
MGIiMGI:1919574. Plxdc1.

Phylogenomic databases

eggNOGiKOG3848. Eukaryota.
ENOG410Y7ZQ. LUCA.
GeneTreeiENSGT00440000033408.
HOGENOMiHOG000234044.
HOVERGENiHBG079500.
InParanoidiQ91ZV7.
OMAiVEDNHSY.
OrthoDBiEOG091G0827.
PhylomeDBiQ91ZV7.
TreeFamiTF314400.

Miscellaneous databases

PROiQ91ZV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017417.
CleanExiMM_PLXDC1.
ExpressionAtlasiQ91ZV7. baseline and differential.
GenevisibleiQ91ZV7. MM.

Family and domain databases

InterProiIPR002165. Plexin_repeat.
IPR031152. PLXDC.
IPR031153. PLXDC1.
[Graphical view]
PANTHERiPTHR13055. PTHR13055. 1 hit.
PTHR13055:SF10. PTHR13055:SF10. 1 hit.
PfamiPF01437. PSI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLDX1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZV7
Secondary accession number(s): A2A537
, A2A538, Q29R73, Q8BM20, Q9CWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.