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Reviewed, UniProtKB/Swiss-Prot Q91ZV4 (MOGT1_MOUSE)

Last modified February 9, 2010. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    2-acylglycerol O-acyltransferase 1
    EC=2.3.1.22
Alternative name(s):
    Monoacylglycerol O-acyltransferase 1
    Acyl CoA:monoacylglycerol acyltransferase 1
      Short name=MGAT1
    Diacylglycerol acyltransferase 2-like protein 1
Gene names
Name: Mogat1
Synonyms: Dgat2l1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine. Ref.4

Catalytic activity

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. Ref.4

Pathway

Glycerolipid metabolism; triacylglycerol biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable Ref.4.

Tissue specificity

Expressed at high level in kidney and stomach. Expressed at lower level in brown and white adipose tissue, uterus and liver. Not detected in small intestine. Ref.4

Sequence similarities

Belongs to the diacylglycerol acyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3353352-acylglycerol O-acyltransferase 1
PRO_0000249059

Regions

Transmembrane24 – 4421 Potential
Transmembrane104 – 12421 Potential

Amino acid modifications

Glycosylation1801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict85 – 862KE → FL in BAB22288. Ref.2
Sequence conflict2941I → T in BAB22288. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q91ZV4-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A27297B6DD51AD30

FASTA33538,803
        10         20         30         40         50         60 
MMVEFAPLNT PLARCLQTAA VLQWVLSFLL LVQVCIGIMV MLVLYNYWFL YIPYLVWFYY 

        70         80         90        100        110        120 
DWRTPEQGGR RWNWVQSWPV WKYFKEYFPI CLVKTQDLDP GHNYIFGFHP HGIFVPGAFG 

       130        140        150        160        170        180 
NFCTKYSDFK KLFPGFTSYL HVAKIWFCFP LFREYLMSNG PVSVSKESLS HVLSKDGGGN 

       190        200        210        220        230        240 
VSIIVLGGAK EALEAHPGTF TLCIRQRKGF VKMALTHGAS LVPVFSFGEN DLYKQINNPK 

       250        260        270        280        290        300 
GSWLRTIQDA MYDSMGVALP LIYARGIFQH YFGIMPYRKL IYTVVGRPIP VQQILNPTSE 

       310        320        330 
QIEELHQTYL EELKKLFNEH KGKYGIPEHE TLVFK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
Cases S., Stone S.J., Zhou P., Yen C.-L.E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Jr.
J. Biol. Chem. 276:38870-38876(2001) [PubMed: 11481335] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[4]"Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase."
Yen C.-L.E., Stone S.J., Cases S., Zhou P., Farese R.V. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:8512-8517(2002) [PubMed: 12077311] [Abstract]
Cited for: CATALYTIC ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF384162 mRNA. Translation: AAK84177.1.
AK002693 mRNA. Translation: BAB22288.1.
BC106135 mRNA. Translation: AAI06136.1.
IPIIPI00121027.
RefSeqNP_080989.2.
UniGeneMm.41325

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ91ZV4.

Proteomic databases

PRIDEQ91ZV4.

Genome annotation databases

EnsemblENSMUST00000012331; ENSMUSP00000012331; ENSMUSG00000012187; Mus musculus. [Genome view]
ENSMUST00000113524; ENSMUSP00000109152; ENSMUSG00000012187; Mus musculus. [Genome view]
GeneID68393.
KEGGmmu:68393.
UCSCuc007bqk.1. mouse.

Organism-specific databases

CTD68393.
MGIMGI:1915643. Mogat1.

Phylogenomic databases

HOGENOMHBG561030.
HOVERGENQ91ZV4.
InParanoidQ91ZV4.
PhylomeDBQ91ZV4.

Enzyme and pathway databases

BRENDA2.3.1.22. 244.

Gene expression databases

ArrayExpressQ91ZV4.
BgeeQ91ZV4.
CleanExMM_MOGAT1.
GenevestigatorQ91ZV4.
GermOnlineENSMUSG00000012187. Mus musculus.

Family and domain databases

InterProIPR007130. DAGAT.
[Graphical view]
PANTHERPTHR12317. DAGAT. 1 hit.
ProtoNetSearch...

Other Resources

NextBio327104.
SOURCESearch...

Entry information

Entry nameMOGT1_MOUSE
AccessionPrimary (citable) accession number: Q91ZV4
Secondary accession number(s): Q9DCL0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 1, 2001
Last modified: February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents