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Protein

2-acylglycerol O-acyltransferase 1

Gene

Mogat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine.1 Publication

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.1 Publication

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

  • 2-acylglycerol O-acyltransferase activity Source: MGI
  • diacylglycerol O-acyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.22. 3474.
UniPathwayiUPA00282.

Chemistry

SwissLipidsiSLP:000000300.

Names & Taxonomyi

Protein namesi
Recommended name:
2-acylglycerol O-acyltransferase 1 (EC:2.3.1.22)
Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 1
Short name:
MGAT1
Diacylglycerol acyltransferase 2-like protein 1
Monoacylglycerol O-acyltransferase 1
Gene namesi
Name:Mogat1
Synonyms:Dgat2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915643. Mogat1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353352-acylglycerol O-acyltransferase 1PRO_0000249059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91ZV4.
PaxDbiQ91ZV4.
PRIDEiQ91ZV4.

PTM databases

iPTMnetiQ91ZV4.
PhosphoSiteiQ91ZV4.

Expressioni

Tissue specificityi

Expressed at high level in kidney and stomach. Expressed at lower level in brown and white adipose tissue, uterus and liver. Not detected in small intestine.1 Publication

Gene expression databases

BgeeiQ91ZV4.
CleanExiMM_MOGAT1.
ExpressionAtlasiQ91ZV4. baseline and differential.
GenevisibleiQ91ZV4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012331.

Structurei

3D structure databases

ProteinModelPortaliQ91ZV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ91ZV4.
KOiK14458.
OMAiALTHGXG.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVEFAPLNT PLARCLQTAA VLQWVLSFLL LVQVCIGIMV MLVLYNYWFL
60 70 80 90 100
YIPYLVWFYY DWRTPEQGGR RWNWVQSWPV WKYFKEYFPI CLVKTQDLDP
110 120 130 140 150
GHNYIFGFHP HGIFVPGAFG NFCTKYSDFK KLFPGFTSYL HVAKIWFCFP
160 170 180 190 200
LFREYLMSNG PVSVSKESLS HVLSKDGGGN VSIIVLGGAK EALEAHPGTF
210 220 230 240 250
TLCIRQRKGF VKMALTHGAS LVPVFSFGEN DLYKQINNPK GSWLRTIQDA
260 270 280 290 300
MYDSMGVALP LIYARGIFQH YFGIMPYRKL IYTVVGRPIP VQQTLNPTSE
310 320 330
QIEELHQTYL EELKKLFNEH KGKYGIPEHE TLVFK
Length:335
Mass (Da):38,791
Last modified:July 27, 2011 - v2
Checksum:iA2691D9E6451AD30
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 862KE → FL in BAB22288 (PubMed:16141072).Curated
Sequence conflicti294 – 2941T → I in AAK84177 (PubMed:11481335).Curated
Sequence conflicti294 – 2941T → I in AAI06136 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384162 mRNA. Translation: AAK84177.1.
AK002693 mRNA. Translation: BAB22288.1.
AC158559 Genomic DNA. No translation available.
BC106135 mRNA. Translation: AAI06136.1.
CCDSiCCDS15085.1.
RefSeqiNP_080989.2. NM_026713.3.
XP_006497366.1. XM_006497303.2.
UniGeneiMm.41325.

Genome annotation databases

EnsembliENSMUST00000012331; ENSMUSP00000012331; ENSMUSG00000012187.
ENSMUST00000113524; ENSMUSP00000109152; ENSMUSG00000012187.
GeneIDi68393.
KEGGimmu:68393.
UCSCiuc007bqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384162 mRNA. Translation: AAK84177.1.
AK002693 mRNA. Translation: BAB22288.1.
AC158559 Genomic DNA. No translation available.
BC106135 mRNA. Translation: AAI06136.1.
CCDSiCCDS15085.1.
RefSeqiNP_080989.2. NM_026713.3.
XP_006497366.1. XM_006497303.2.
UniGeneiMm.41325.

3D structure databases

ProteinModelPortaliQ91ZV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012331.

Chemistry

SwissLipidsiSLP:000000300.

PTM databases

iPTMnetiQ91ZV4.
PhosphoSiteiQ91ZV4.

Proteomic databases

MaxQBiQ91ZV4.
PaxDbiQ91ZV4.
PRIDEiQ91ZV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012331; ENSMUSP00000012331; ENSMUSG00000012187.
ENSMUST00000113524; ENSMUSP00000109152; ENSMUSG00000012187.
GeneIDi68393.
KEGGimmu:68393.
UCSCiuc007bqk.1. mouse.

Organism-specific databases

CTDi116255.
MGIiMGI:1915643. Mogat1.

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ91ZV4.
KOiK14458.
OMAiALTHGXG.
TreeFamiTF314707.

Enzyme and pathway databases

UniPathwayiUPA00282.
BRENDAi2.3.1.22. 3474.

Miscellaneous databases

ChiTaRSiMogat1. mouse.
NextBioi327104.
PROiQ91ZV4.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZV4.
CleanExiMM_MOGAT1.
ExpressionAtlasiQ91ZV4. baseline and differential.
GenevisibleiQ91ZV4. MM.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
    Cases S., Stone S.J., Zhou P., Yen C.-L.E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Jr.
    J. Biol. Chem. 276:38870-38876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase."
    Yen C.-L.E., Stone S.J., Cases S., Zhou P., Farese R.V. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:8512-8517(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiMOGT1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZV4
Secondary accession number(s): E9QLA2, Q9DCL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: January 20, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.