Q91ZV4 (MOGT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 65.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 2-acylglycerol O-acyltransferase 1 EC=2.3.1.22 Alternative name(s): Acyl-CoA:monoacylglycerol acyltransferase 1 Short name=MGAT1 Diacylglycerol acyltransferase 2-like protein 1 Monoacylglycerol O-acyltransferase 1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 335 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine. Ref.5 |
| Catalytic activity | Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. Ref.5 |
| Pathway | |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein Probable Ref.5. |
| Tissue specificity | Expressed at high level in kidney and stomach. Expressed at lower level in brown and white adipose tissue, uterus and liver. Not detected in small intestine. Ref.5 |
| Sequence similarities | Belongs to the diacylglycerol acyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycerol metabolism Lipid metabolism Lipid synthesis |
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Acyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | diacylglycerol biosynthetic process Inferred from direct assay Ref.5. Source: MGI glycerol metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW membrane fractionInferred from direct assay Ref.5. Source: MGI |
| Molecular function | 2-acylglycerol O-acyltransferase activity Inferred from direct assay Ref.5. Source: MGI diacylglycerol O-acyltransferase activityInferred from direct assay Ref.5. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 335 | 335 | 2-acylglycerol O-acyltransferase 1 | PRO_0000249059 | |||||
Regions | |||||||||
| Transmembrane | 24 – 44 | 21 | Helical; Potential | ||||||
| Transmembrane | 104 – 124 | 21 | Helical; Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 180 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 85 – 86 | 2 | KE → FL in BAB22288. Ref.2 | ||||||
| Sequence conflict | 294 | 1 | T → I in AAK84177. Ref.1 | ||||||
| Sequence conflict | 294 | 1 | T → I in AAI06136. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF384162 mRNA. Translation: AAK84177.1. AK002693 mRNA. Translation: BAB22288.1. AC158559 Genomic DNA. No translation available. BC106135 mRNA. Translation: AAI06136.1. |
| IPI | IPI00121027. |
| RefSeq | NP_080989.2. NM_026713.3. |
| UniGene | Mm.41325. |
3D structure databases | |
| ProteinModelPortal | Q91ZV4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q91ZV4. |
Proteomic databases | |
| PRIDE | Q91ZV4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000012331; ENSMUSP00000012331; ENSMUSG00000012187. ENSMUST00000113524; ENSMUSP00000109152; ENSMUSG00000012187. |
| GeneID | 68393. |
| KEGG | mmu:68393. |
| UCSC | uc007bqk.1. mouse. |
Organism-specific databases | |
| CTD | 116255. |
| MGI | MGI:1915643. Mogat1. |
Phylogenomic databases | |
| GeneTree | ENSGT00550000074276. |
| HOGENOM | HBG561030. |
| HOVERGEN | HBG065791. |
| InParanoid | Q91ZV4. |
| OrthoDB | EOG4BP1C4. |
| PhylomeDB | Q91ZV4. |
Gene expression databases | |
| ArrayExpress | Q91ZV4. |
| Bgee | Q91ZV4. |
| CleanEx | MM_MOGAT1. |
| Genevestigator | Q91ZV4. |
| GermOnline | ENSMUSG00000012187. Mus musculus. |
Family and domain databases | |
| InterPro | IPR007130. DAGAT. [Graphical view] |
| KO | K14458. |
| PANTHER | PTHR12317. DAGAT. 1 hit. |
| Pfam | PF03982. DAGAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 327104. |
| SOURCE | Search... |
Entry information
| Entry name | MOGT1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q91ZV4 Secondary accession number(s): E9QLA2, Q9DCL0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with