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Protein

Discoidin, CUB and LCCL domain-containing protein 2

Gene

Dcbld2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Discoidin, CUB and LCCL domain-containing protein 2
Alternative name(s):
Endothelial and smooth muscle cell-derived neuropilin-like protein
Gene namesi
Name:Dcbld2
Synonyms:Esdn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620543. Dcbld2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini64 – 523460ExtracellularSequence analysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence analysisAdd
BLAST
Topological domaini545 – 769225CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 6363Sequence analysisAdd
BLAST
Chaini64 – 769706Discoidin, CUB and LCCL domain-containing protein 2PRO_0000021080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 96By similarity
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 145By similarity
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi212 ↔ 234By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi289 ↔ 446By similarity
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence analysis
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence analysis
Modified residuei601 – 6011PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ91ZV2.
PRIDEiQ91ZV2.

Structurei

3D structure databases

ProteinModelPortaliQ91ZV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 184116CUBPROSITE-ProRule annotationAdd
BLAST
Domaini184 – 28299LCCLPROSITE-ProRule annotationAdd
BLAST
Domaini289 – 446158F5/8 type CPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi460 – 4634Poly-Pro

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 LCCL domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
HOGENOMiHOG000000681.
HOVERGENiHBG106294.
InParanoidiQ91ZV2.
PhylomeDBiQ91ZV2.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAPLRAA RSPQDPGGRA APAATGRAPL PSAGWCPLPP GRNSSSRPRL
60 70 80 90 100
LLLLLLLLPD AGAQKGDGCG HTVLGPESGT LTSINYPHTY PNSTVCKWEI
110 120 130 140 150
RVKTGERIRI KFGDFDIEDS DYCHLNYLKI FNGIGVSRTE IGKYCGLGLQ
160 170 180 190 200
MNQSIESKGS EITVLFMSGI HASGRGFLAS YSVIDKQDLI TCLDTVSNFL
210 220 230 240 250
EPEFSKYCPA GCLLPFAEIS GTIPHGYRDS SPLCMAGIHA GVVSDVLGGQ
260 270 280 290 300
ISVVISKGTP YYESSLANNV TSMVGYLSTS LFTFKTSGCY GTLGMESGVI
310 320 330 340 350
ADPQITASSV LEWTDHMGQE NSWKPEKARL RKPGPPWAAF ATDEHQWLQI
360 370 380 390 400
DLNKEKKITG IVTTGSTLIE HNYYVSAYRV LYSDDGQKWT VYREPGAAQD
410 420 430 440 450
KIFQGNKDYH KDVRNNFLPP IIARFIRVNP VQWQQKIAMK VELLGCQFTL
460 470 480 490 500
KGRLPKLTQP PPPRNSNNLK NTTVHPKLGR APKFTQALQP RSRNDLPLLP
510 520 530 540 550
AQTTATPDVK NTTVTPSVTK DVALAAVLVP VLVMALTTLI LILVCAWHWR
560 570 580 590 600
NRKKKAEGTY DLPHWDRAGW WKGVKQLLPA KSVEHEETPV RYSNSEVSHL
610 620 630 640 650
SPREVTTVLQ ADSAEYAQPL VGGIVGTLHQ RSTFKPEEGK EASYADLDPY
660 670 680 690 700
NAPVQEVYHA YAEPLPVTGP EYATPIVMDM SGHSTASVGL PSTSTFRTAG
710 720 730 740 750
NQPPALVGTY NTLLSRTDSC SSGQAQYDTP KGGKPAAAPE ELVYQVPQST
760
QEASGAGRDE KFDAFKETL
Length:769
Mass (Da):83,915
Last modified:December 1, 2001 - v1
Checksum:i5B7936C8FA063A93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387549 mRNA. Translation: AAL30180.1.
RefSeqiNP_569103.1. NM_130419.1.
UniGeneiRn.229591.

Genome annotation databases

GeneIDi155696.
KEGGirno:155696.
UCSCiRGD:620543. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387549 mRNA. Translation: AAL30180.1.
RefSeqiNP_569103.1. NM_130419.1.
UniGeneiRn.229591.

3D structure databases

ProteinModelPortaliQ91ZV2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ91ZV2.
PRIDEiQ91ZV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi155696.
KEGGirno:155696.
UCSCiRGD:620543. rat.

Organism-specific databases

CTDi131566.
RGDi620543. Dcbld2.

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
HOGENOMiHOG000000681.
HOVERGENiHBG106294.
InParanoidiQ91ZV2.
PhylomeDBiQ91ZV2.

Miscellaneous databases

NextBioi620923.
PROiQ91ZV2.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury."
    Kobuke K., Furukawa Y., Sugai M., Tanigaki K., Ohashi N., Matsumori A., Sasayama S., Honjo T., Tashiro K.
    J. Biol. Chem. 276:34105-34114(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiDCBD2_RAT
AccessioniPrimary (citable) accession number: Q91ZV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.