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Protein

Melanoma inhibitory activity protein 2

Gene

Mia2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage.By similarity

GO - Biological processi

  • cholesterol homeostasis Source: MGI
  • triglyceride homeostasis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma inhibitory activity protein 2
Gene namesi
Name:Mia2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2159614. Mia2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 517495Melanoma inhibitory activity protein 2PRO_0000019032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZV0.
PRIDEiQ91ZV0.

PTM databases

PhosphoSiteiQ91ZV0.

Expressioni

Tissue specificityi

Highly expressed in liver and weakly in testis.

Developmental stagei

Expression is seen at E12.5 and E14.5 embryonic stages.

Gene expression databases

BgeeiQ91ZV0.
CleanExiMM_MIA2.
GenevisibleiQ91ZV0. MM.

Structurei

3D structure databases

ProteinModelPortaliQ91ZV0.
SMRiQ91ZV0. Positions 27-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11795SH3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 297201Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IIF2. Eukaryota.
ENOG41118PB. LUCA.
GeneTreeiENSGT00530000063635.
HOGENOMiHOG000220907.
HOVERGENiHBG049225.
InParanoidiQ91ZV0.
OMAiGDLECEX.
OrthoDBiEOG7R833J.
PhylomeDBiQ91ZV0.
TreeFamiTF332724.

Family and domain databases

InterProiIPR029782. MIA2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23158:SF42. PTHR23158:SF42. 1 hit.
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVSVQRIL LLVVSLAKCL EGTKLLAHLK KCGDLECETL ISRVLALRDY
60 70 80 90 100
TGPDCRYLNF TTGEEISVYV KLGGDREDLW AGSKGKDFGF FPRDAVEIEE
110 120 130 140 150
VFISEEVEMP TKSDFLCLLG EGYIFGSEQS ELNSEDDEEH MYPYEKDEDQ
160 170 180 190 200
NYNIYEGDFQ PEPDLYAAAE GTLLEDQIPA SEAPDDFRFS SEWKAWEGAG
210 220 230 240 250
SQGGGEQDYT ADSDQDLPSL SKPERQGWFG LGTEEAEEKV FESDTEPTQE
260 270 280 290 300
LALEEESDLE KLHSGEPQVE LEQEPKSETL EFSSVPDEEY ELESETESIL
310 320 330 340 350
KPQASGWFGE GLTSYLGFGN EEAGLELLSK ESNPPLQDIP SSVPPDEEVP
360 370 380 390 400
APCREISTDK EDAVINDSSV LSPSWFYYGF GMLGFTNADE DNIVSDKGEN
410 420 430 440 450
EDGEVDNLKH PIGSDFDPEK EQERKIVTVE TEDQAGTESV LEKTDESGSM
460 470 480 490 500
QYLKKFFDNP WGFQSLPEDT ELPFSKKMLD QDDIVENDKI EELSTENSPT
510
GSMKDPVMLA SRYVLSG
Length:517
Mass (Da):57,777
Last modified:June 1, 2003 - v2
Checksum:iDCD459082827A781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390177 mRNA. Translation: AAL26992.2.
CCDSiCCDS25934.1.
RefSeqiNP_796295.1. NM_177321.2.
UniGeneiMm.213215.

Genome annotation databases

EnsembliENSMUST00000021384; ENSMUSP00000021384; ENSMUSG00000035349.
GeneIDi338320.
KEGGimmu:338320.
UCSCiuc007nqc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390177 mRNA. Translation: AAL26992.2.
CCDSiCCDS25934.1.
RefSeqiNP_796295.1. NM_177321.2.
UniGeneiMm.213215.

3D structure databases

ProteinModelPortaliQ91ZV0.
SMRiQ91ZV0. Positions 27-117.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91ZV0.

Proteomic databases

PaxDbiQ91ZV0.
PRIDEiQ91ZV0.

Protocols and materials databases

DNASUi338320.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021384; ENSMUSP00000021384; ENSMUSG00000035349.
GeneIDi338320.
KEGGimmu:338320.
UCSCiuc007nqc.1. mouse.

Organism-specific databases

CTDi117153.
MGIiMGI:2159614. Mia2.

Phylogenomic databases

eggNOGiENOG410IIF2. Eukaryota.
ENOG41118PB. LUCA.
GeneTreeiENSGT00530000063635.
HOGENOMiHOG000220907.
HOVERGENiHBG049225.
InParanoidiQ91ZV0.
OMAiGDLECEX.
OrthoDBiEOG7R833J.
PhylomeDBiQ91ZV0.
TreeFamiTF332724.

Miscellaneous databases

NextBioi400089.
PROiQ91ZV0.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZV0.
CleanExiMM_MIA2.
GenevisibleiQ91ZV0. MM.

Family and domain databases

InterProiIPR029782. MIA2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23158:SF42. PTHR23158:SF42. 1 hit.
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes."
    Bosserhoff A.K., Moser M., Schoelmerich J., Buettner R., Hellerbrand C.
    J. Biol. Chem. 278:15225-15231(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver and Pancreas.

Entry informationi

Entry nameiMIA2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.