Q91ZU6 (DYST_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dystonin

Alternative name(s):
Bullous pemphigoid antigen 1
Short name=BPA
Dystonia musculorum protein
Hemidesmosomal plaque protein
Microtubule actin cross-linking factor 2

Gene names

Name:	Dst
Synonyms:	Bpag1, Macf2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	7389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. May regulate the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Ref.4 Ref.7 Ref.13 Ref.19 Isoform 5:plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Ref.4 Ref.7 Ref.13 Ref.19 Isoform 6:required for bundling actin filaments around the nucleus. Ref.4 Ref.7 Ref.13 Ref.19
Subunit structure	Homodimer. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Isoform 2 interacts (via N-terminus) with ACTN2. Isoform 2 interacts (via N-terminus) with PLEC (via N-terminus). Isoform 5 interacts (via N-terminus) with COL17A1 (via cytoplasmic region). Isoform 5 interacts (via N-terminus) with ITGB4 isoform beta-4a(via cytoplasmic region). Isoform 5 interacts (via N-terminus) with ERBB2IP (via C-terminus). Isoform 5 associates (via C-terminal) with KRT5-KRT14 (via rod region) intermadiate filaments of keratins By similarity. Isoform 2 and isoform 6 can homodimerize (via N-terminus). Isoform 2 interacts (via N-terminus) with PLEC (via N-terminus). Interacts with the neuronal intermediate filament protein, PRPH. Interacts with DES. Interacts with SYNE3. Ref.7 Ref.12 Ref.14 Ref.17 Ref.18
Subcellular location	Cytoplasm › cytoskeleton. Cell projection › axon. Membrane. Note: Associates with axonal microtubules at the growing distal tip and intermediate filaments, but not with actin cytoskeleton, in sensory neurons By similarity. Associates with intermediate filaments, acin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells. Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19 Isoform 1: Cytoplasm › cytoskeleton. Note: Colocalizes both cortical and cytoplasmic actin filaments. Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19 Isoform 2: Cell membrane › sarcolemma. Cytoplasm › myofibril › sarcomere › Z line. Cytoplasm › myofibril › sarcomere › H zone. Cytoplasm › cytoskeleton. Note: Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane. Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19 Isoform 5: Cytoplasm › cytoskeleton. Cell junction › hemidesmosome. Note: Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes By similarity. Localizes to actin and intermediate filaments cytoskeletons. Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19 Isoform 6: Nucleus. Nucleus envelope. Membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm › cytoskeleton. Note: Associates with actin cytoskeleton in sensory neurons By similarity. Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus. Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19 Isoform 7: Cytoplasm › cytoskeleton. Cytoplasm › cell cortex. Cell membrane; Lipid-anchor Ref.3 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19.
Tissue specificity	Isoform 1 and 2 are expressed in striated and heart muscle cells. Isoform 5 is expressed in the skin. Isoform 6 is expressed in sensory neural cells of the dorsal root ganglion and with low level in the skin (at protein level). Isoform 1 is expressed predominantly in the brain and spinal cord with low levels in the heart. Isoform 2 is predominantly expressed in muscle and heart and with low levels in the brain. Isoform 5 is expressed in the skin and with low levels in myoblast cells. Isoform 6 is expressed in neurons. Isoform 7 is expressed in lung and with low levels in the brain. Ref.1 Ref.2 Ref.4 Ref.9 Ref.10 Ref.14 Ref.17 Ref.18 Ref.19
Developmental stage	Isoform 1 is the major form expressed in the dorsal root ganglia at 14.5 dpc. Isoform 2 is predominantly expressed in the myocardium, skeletal muscles, bone cartilage and epithelia of the tongue at 14.5 dpc. Isoform 5 is expressed at high levels in the epidermis and mucosal epithelia of the digestive tracts at 14.5 dpc. Ref.1 Ref.2
Domain	Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermedaite filaments proteins and most likely involves recognition sites located in the rod domain of these keratins. The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends By similarity.
Disruption phenotype	Mice show progressive deterioration in motor function and sensory neurodegeneration. Exhibit axonal swellings packed with disorganized intermediate filaments (IFs) and microtubules. Show poorly defined Z lines and display a reduction in sarcomere length. Have increased accumulation of vesicles and severely disrupted retrograde axonal transport. In stratified epithelia, hemidesmosomes are normal but they lack the inner plate and have no cytoskeleton attached. Ref.9 Ref.11 Ref.12 Ref.13
Sequence similarities	Belongs to the plakin or cytolinker family. UniProtKB Q03001 Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 1 GAR domain. Contains 5 plectin repeats. Contains 1 SH3 domain. Contains 19 spectrin repeats.
Sequence caution	Isoform 6: The sequence AAC52231.1 differs from that shown. Reason: Frameshift at position 51.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Endoplasmic reticulum Intermediate filament Membrane Microtubule Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing
Domain	Coiled coil Repeat SH3 domain Transmembrane
Ligand	Actin-binding Calcium Metal-binding
Molecular function	Muscle protein
PTM	Lipoprotein Myristate Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from mutant phenotype PubMed 1634998. Source: MGI cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell cycle arrest Inferred from electronic annotation. Source: InterPro cytoplasmic microtubule organization Inferred from mutant phenotype Ref.11. Source: MGI intermediate filament cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB intracellular transport Inferred from direct assay Ref.14. Source: UniProtKB regulation of microtubule polymerization or depolymerization Inferred from mutant phenotype Ref.11. Source: MGI retrograde axon cargo transport Inferred from mutant phenotype Ref.13. Source: MGI
Cellular_component	H zone Inferred from direct assay Ref.19. Source: UniProtKB Z disc Inferred from direct assay Ref.18Ref.19. Source: UniProtKB actin cytoskeleton Inferred from direct assay Ref.11. Source: MGI axon Inferred from electronic annotation. Source: UniProtKB-SubCell cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from direct assay Ref.18. Source: UniProtKB cytoplasmic membrane-bounded vesicle Inferred from sequence orthology Ref.13. Source: MGI cytoplasmic side of plasma membrane Inferred from direct assay Ref.3. Source: UniProtKB endoplasmic reticulum membrane Inferred from direct assay Ref.17. Source: UniProtKB focal adhesion Inferred from direct assay Ref.14Ref.3. Source: UniProtKB hemidesmosome Inferred from direct assay PubMed 8707838. Source: MGI integral component of membrane Inferred from electronic annotation. Source: UniProtKB-KW intercalated disc Inferred from direct assay Ref.18. Source: UniProtKB intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.3. Source: UniProtKB microtubule cytoskeleton Inferred from direct assay Ref.11. Source: MGI microtubule plus-end Inferred from sequence or structural similarity. Source: UniProtKB neurofilament cytoskeleton Inferred from direct assay Ref.11. Source: MGI nuclear envelope Inferred from direct assay Ref.17. Source: UniProtKB nucleus Inferred from direct assay Ref.14Ref.3. Source: UniProtKB perinuclear endoplasmic reticulum Inferred from direct assay Ref.3. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay Ref.3. Source: UniProtKB sarcolemma Inferred from direct assay Ref.19. Source: UniProtKB stress fiber Inferred from direct assay Ref.14. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro microtubule binding Inferred from direct assay Ref.11. Source: MGI microtubule plus-end binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from physical interaction Ref.17Ref.18. Source: UniProtKB protein homodimerization activity Inferred from direct assay Ref.14. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Prph	P21807	3	EBI-446159,EBI-446227	From a different organism.

Alternative products

This entry describes 7 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 2 Ref.1 (identifier: Q91ZU6-1)

Also known as: BPAG1-b; BPAG1a1; dystonin-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 Ref.1 (identifier: Q91ZU6-2)

Also known as: BPAG1-a; BPAG1a2;

The sequence of this isoform differs from the canonical sequence as follows:
     1549-3557: Missing.

Isoform 3 (identifier: Q91ZU6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     7125-7130: Missing.
     7170-7193: Missing.
     7261-7261: K → KILHPLTRNYGKPWLANSKMSTPCKAAECPDFPVSSAE

Note: No experimental confirmation available.

Isoform 4 (identifier: Q91ZU6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     7170-7193: Missing.
     7261-7261: K → KILHPLTRNYGKPWLANSKMSTPCKAAECPDFPVSSAE

Note: No experimental confirmation available.

Isoform 5 Ref.1 (identifier: Q91ZU6-5)

Also known as: BPAG1-e;

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: MAGYLSPAAY...REKALRPEVE → MRISCPFIVVPLINSCISFSNESLDGH
     1432-1432: K → MKRSKENSEH...GISNLYYSSQ
     1433-7389: Missing.

Isoform 6 (identifier: Q91ZU6-6)

Also known as: BPAG1n; BPAG1-n1; BPAG1-n2; BPAG1a2; dystonin-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MAGYLSPAAYMYVEEQEYLQAYEDVLERYK → MIAAAFLVLL...PAERAVLRIA
     305-7389: Missing.

Note: Incomplete sequence. Transmembrane protein (helical transmembrane domain from amino acid 18 to 38).

Isoform 7 (identifier: Q91ZU6-8)

Also known as: BPAG1a3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: MAGYLSPAAY...GLIWTIILHF → MGNVCGCVRA...SKDAPRDDGC
     271-272: VK → KG
     273-7389: Missing.

Note: Incomplete sequence. Probably myristoylated on Gly-2. Probably S-palmitoylated on Cys-5 and Cys-7. Mutagenesis of Gly-2 to Ala inhibits cortical localization. Mutagenesis of Cys-5 to Ser inhibits cortical localization. Mutagenesis of Cys-7 to Ser inhibits cortical localization.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 7389	7389	Dystonin		PRO_0000078141
Regions
	Domain	35 – 252	218	Actin-binding
	Domain	35 – 138	104	CH 1
	Domain	151 – 252	102	CH 2
	Repeat	701 – 801	101	Spectrin 1
	Domain	889 – 941	53	SH3
	Repeat	1582 – 1624	43	Plectin 1
	Repeat	1657 – 1701	45	Plectin 2
	Repeat	1772 – 1815	44	Plectin 3
	Repeat	1816 – 1844	29	Plectin 4
	Repeat	1848 – 1889	42	Plectin 5
	Repeat	3845 – 3925	81	Spectrin 2
	Repeat	3997 – 4079	83	Spectrin 3
	Repeat	4440 – 4548	109	Spectrin 4
	Repeat	4552 – 4657	106	Spectrin 5
	Repeat	4775 – 4877	103	Spectrin 6
	Repeat	5208 – 5315	108	Spectrin 7
	Repeat	5322 – 5423	102	Spectrin 8
	Repeat	5430 – 5532	103	Spectrin 9
	Repeat	5647 – 5751	105	Spectrin 10
	Repeat	5758 – 5856	99	Spectrin 11
	Repeat	6002 – 6082	81	Spectrin 12
	Repeat	6089 – 6191	103	Spectrin 13
	Repeat	6197 – 6300	104	Spectrin 14
	Repeat	6308 – 6410	103	Spectrin 15
	Repeat	6415 – 6519	105	Spectrin 16
	Repeat	6523 – 6629	107	Spectrin 17
	Repeat	6636 – 6736	101	Spectrin 18
	Repeat	6741 – 6844	104	Spectrin 19
	Domain	7015 – 7050	36	EF-hand 1
	Domain	7051 – 7086	36	EF-hand 2
	Domain	7091 – 7169	79	GAR
	Calcium binding	7028 – 7039	12	1 Potential
	Calcium binding	7064 – 7075	12	2 Potential
	Motif	1382 – 1388	7	Nuclear localization signal; in isoform 6
	Motif	7369 – 7372	4	Microtubule tip localization signal
	Compositional bias	2362 – 2422	61	Asp-rich
Amino acid modifications
	Modified residue	2857	1	Phosphoserine By similarity
	Modified residue	7250	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 381	381	MAGYL…RPEVE → MRISCPFIVVPLINSCISFS NESLDGH in isoform 5.		VSP_041541
	Alternative sequence	1 – 137	137	MAGYL…IILHF → MGNVCGCVRAEKEEPYFDPA KSPLSPEKYSPGRKYFRRKP CQKVVDDTEPVRQSSEREGK KGVSQPAGGQPAVSSGELPW EDPAASPTKEDAVQLGKRAA TEHGDQKPLPSSVDGYPHRV TVSSAQGRYSEVQVSIPDKI ISEEDSPPYCPETERHLDDV NSKHRTFLRKDNVSLSQTAA SSSPILCVTEKSLKNSALMG NLSRSCHSVLEQDSDERGHP FGVHRLQLTKRRCHSLSSGV SCVSKDAPRDDGC in isoform 7.		VSP_041542
	Alternative sequence	1 – 30	30	MAGYL…LERYK → MIAAAFLVLLRPYSIQCALF LLLLLLGTVATIVFFCCWHR KLQKGRHPMKSVFSGRSRSR DAALRSHHFRSEGFRASPRH IRRRVAAAAAARLEEVKPVV EVHHQSEQESSGRKRRIKKN SRVQPEFYHSVQGASTRRPS SGNASYRCSMSSSADFSDED DFSQKSGSASPAPGDTLPWN LPKHERSKRKIQGGSVLDPA ERAVLRIA in isoform 6.		VSP_041543
	Alternative sequence	271 – 272	2	VK → KG in isoform 7.		VSP_041544
	Alternative sequence	273 – 7389	7117	Missing in isoform 7.		VSP_041545
	Alternative sequence	305 – 7389	7085	Missing in isoform 6.		VSP_041546
	Alternative sequence	1432	1	K → MKRSKENSEHGAYSDLLQRQ RATMVENSKLTGKISELETM VAELKKQKSRVEEELPKVKE AAENELRKQQRNVEDIALQK LRAESEAKQYRRELETIVRE KEAAERELERVRQLTAEAEA RRAAVEENLRNFRSQLQENT FTRQTLEDHLRRKDSSLSDL EQQKRALVEELQRKRDHEEE LLRLVKQMERDLAFQKQVAE KQLKEKQKVELEARRKITEI QFSCRESAAVAQARPQREQG RQKEEELKQQVDELTLANRK AEKEMRELKYELSAVQLEKA SSEEKARLLKDKLDETNNTL KCLKEDLERKDQAQERYSQQ LRDLGGQLNQTTDKAEEVRQ EANDLKKIKHTYQLELESLH QEKGKLQREVDRVTRAHALA ERNIQCLNSQVHASRDEKDL SEERRRLCQRKSDHLKEEFE RSHAQLLQNIQAEKENNDKI QKLNKELEKSNECAETLKQK VDELTRQNNETKLMMQRIQA ESKNIVREKQAIQQRCEVLR IQADGFKDQLRNTNEHLHKQ TKTEQDFHRKIKSLEDDLAQ SQNLVSEFKQKCDQQSMIIQ KTEKEVRSLSAELSASKEEK RREEQKAQLQRAQVQELNDR LKRVQDELHLKTIEEQMTHR KMILLQEESDKFKRSADEFR KKMEKLMESKVVTETDLSGI KHDFVSLQRENFRAQENAKL WETNIRELERQLQCYREKMQ QGPPVEANHYQKCRRLEEEL LAQRREVENLKQKMDQQIKE HEHQLLRLQCEIQKKSTTQD HTFASAFDTAGRECHHPAEI SPGNSGHLNLKTRLPLSRWT QEPHQTEGKWPHRAAEQLPK EVQFRQPGAPLDRESSQPCY SEYFSQTSTELQITFDDKNP ITRLSELETMREQALHPSRP PVTYQDDKLERELVKLLTPL EIAKNKQCGMHTEVTTLKQE KRLGSSAGGWMLEGCRTSGG LKGDFLKKSVEPEASPSLDL NQACSVRDEEFQFQGLRHTV TGRQLVEAKLLDMRTVEQLR LGLKTVEEVQRSLSKFLTKA TSIAGLYLESSKEKMSFTSA AQKIIIDKMIALAFLEAQAA TGFIIDPVSGQTYCVEDAVL HGIVDPEFRSRLLEAEKAVL GYSHASKTLSVFQAMENRML DRKKGKHILEAQIASGGVID PVRGVRVPPEMAVQQGLLNN AVLQFLHEPSSNTRVFPNPN NKQALYYSELLQICVFDVDC QCFLLPFGEREISNLNIEKT HKIAVVDTKTGAELTAFEAF QRNLIDKGIYLELSGQQYQW KEATFFDSYGHPSHMLTDTK TGLQFNISEAVEQGTLDKAL VQKYQEGLTTLTELADFLLS KVVPKKDLHSPIAGYWLTAS GERISLLKASRRNLVDRVTA LRCLEAQICTGGIIDPLTGK KYRVAEALHRGLVDEGFAQQ LRQCELVITGISHPVSNKMM SVVEAVNANIISKEMGMRCL EFQYLTGGLIEPKVFSRLTI EEALHVGIIDVLIATRLKDQ KSYVRDIMCPQTKRKLTYKE ALEKADFDFHTGLKLLEVSE PLGTGISNLYYSSQ in isoform 5.		VSP_041547
	Alternative sequence	1433 – 7389	5957	Missing in isoform 5.		VSP_041548
	Alternative sequence	1549 – 3557	2009	Missing in isoform 1. Ref.1		VSP_041549
	Alternative sequence	7125 – 7130	6	Missing in isoform 3.		VSP_041550
	Alternative sequence	7170 – 7193	24	Missing in isoform 3 and isoform 4.		VSP_041551
	Alternative sequence	7261	1	K → KILHPLTRNYGKPWLANSKM STPCKAAECPDFPVSSAE in isoform 3 and isoform 4.		VSP_041552
Experimental info
	Mutagenesis	1385	1	R → A: Prevents isoform 6 from localizing to the nucleus; when associated with A-1386. Ref.14
	Mutagenesis	1386	1	R → A: Prevents isoform 6 from localizing to the nucleus; when associated with A-1385. Ref.14
	Sequence conflict	6193	1	T → A in AAK83383. Ref.1
	Sequence conflict	7097	1	G → E in BAC29753. Ref.6
	Sequence conflict	7097	1	G → E in BAC34695. Ref.6
	Sequence conflict	7241	1	G → A in BAC29753. Ref.6
	Sequence conflict	7241	1	G → A in BAC34695. Ref.6
Isoform 5:
	Sequence conflict	2325	1	G → D in BAB93448. Ref.7
	Sequence conflict	2416	1	A → T in BAB93448. Ref.7
	Sequence conflict	2530	1	K → Q in BAB93448. Ref.7
Isoform 6:
	Sequence conflict	101	1	E → K in AAC52231. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (BPAG1-b) (BPAG1a1) (dystonin-1) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BFED827ED8A88AAD	FASTA	7,389	833,638
	10 20 30 40 50 60 MAGYLSPAAY MYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 70 80 90 100 110 120 EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 130 140 150 160 170 180 GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW 190 200 210 220 230 240 RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 250 260 270 280 290 300 KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP 310 320 330 340 350 360 NNPLELKALY NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 370 380 390 400 410 420 EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA LQSDSKRLES 430 440 450 460 470 480 GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 490 500 510 520 530 540 SSVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS 550 560 570 580 590 600 SGMTSRLTPS VTPVYAPGFP SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 610 620 630 640 650 660 EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 670 680 690 700 710 720 SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE 730 740 750 760 770 780 SEVAYDWSER NSSVARKKSY HVELMRELEQ KEESIKAVQE IAEQLLLENH PARLTIEAYR 790 800 810 820 830 840 AAMQTQWSWI LQLCQCVEQH IQENSAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 850 860 870 880 890 900 HKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI 910 920 930 940 950 960 EITIYKDDEC VLANNSHRAK WKVISPTGNE AVVPSVCFTV PPPNKEAVDF ANRIEQQYQS 970 980 990 1000 1010 1020 VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE 1030 1040 1050 1060 1070 1080 DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE ESVYNLYISE VRNIRLRLES 1090 1100 1110 1120 1130 1140 CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELDRLKD DLGTITNKCE EFFSQAADSP 1150 1160 1170 1180 1190 1200 SVPALRSELS VVIQSLSQIY SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV 1210 1220 1230 1240 1250 1260 IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK 1270 1280 1290 1300 1310 1320 EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET TQRKIQENQP 1330 1340 1350 1360 1370 1380 ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVESQQK 1390 1400 1410 1420 1430 1440 SPVKRRRIQS SADLVIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ 1450 1460 1470 1480 1490 1500 HIEKAKELQK WVSNISKTLG DGEKAGKPLF SKQQMSSKEI STKKEQFSEA LQTTQIFLAK 1510 1520 1530 1540 1550 1560 HGDKLTEEER SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GESKVPEKPD KVIAGTINQT 1570 1580 1590 1600 1610 1620 TGEVLSVFQA VLRGLIDYET GIRLLEAQLV ITGLISPELR KCFDLRDAES HGLIDEQVLR 1630 1640 1650 1660 1670 1680 QLKELNRAKQ LISTASPTSI PVLDSLAQGM VSESMAIRVL EILLSAGPLL VPATGEHLTL 1690 1700 1710 1720 1730 1740 QQAFQQNLIS SALFSKVLER QDTCKDLIDP CTSEKVSLTD MVQRSILQEN TRMWLLPVRP 1750 1760 1770 1780 1790 1800 QEAGRITLKC GRSVSILRAA HEGLIDRETM FRLLGAQLLS GGLIDCNSGQ KMTVEEAVAE 1810 1820 1830 1840 1850 1860 GVIDRDTASS ILTYQVQTGG IVHSNPAKRL TVDEAVQCEL ITSSSALLVL EAQRGYVGLI 1870 1880 1890 1900 1910 1920 WPHSGEIFPT SSSLQQELIT NELASKILNG RQKIAALYIP ESSQVIGLDA AKQLGIIDNN 1930 1940 1950 1960 1970 1980 TASVLKDVKL PDKMPDLGDL EDCKNAKRWL SFCKFQPSTV HDYRQEEGGS DGEEPVTAQS 1990 2000 2010 2020 2030 2040 SEQTKKLFLS YLMVNSYMDA HTGQRLLLYD GDLDEAVSML LESCGAELGA DTSTRESLSV 2050 2060 2070 2080 2090 2100 LTIPDAFPDC ALSEEKHECS ADKCHYSHPG HKESLENAKW DMNEAFCKMG NNDSNGELPR 2110 2120 2130 2140 2150 2160 PENLADTTVV QKGSESPSRV RVPKPTSSST QPEGSVLRPE SGSILKGCKS QSEPVTKKYP 2170 2180 2190 2200 2210 2220 DGTNHSHFLT SETSRPCDSN EREDEENIQK GPSVFDYSPR LSALLSHDEL RQSQGRFSDT 2230 2240 2250 2260 2270 2280 STPQNTGYLC EASTLSPSDQ RVLADQSTRE KFQDRFLGIA AISVSLQGAP CGQKPVDTEC 2290 2300 2310 2320 2330 2340 SSSQVHYHSE ESMSDASAES GATRQTDESE KTGSKVEDNS CTMVPGGGSR NDNTSDCGPL 2350 2360 2370 2380 2390 2400 SHKGAIDAGD YETSLLAGQQ SDTATDSDSD DYFYDTPLFE DEDHDSLILQ GDDRDCLQPE 2410 2420 2430 2440 2450 2460 DYDTSLQEEN DRTPPPDDIF YDVMKEKENP EFPHGGMDES LGVENKVCCP QGFPVGIEKP 2470 2480 2490 2500 2510 2520 ELYLAGEKEF NSGGSEQLVE SVSESENPPG LWDSESDSLT EGEIIGRKER LGASLTPDGH 2530 2540 2550 2560 2570 2580 WRGDREECDT SRESQSDTDG VGSIQSSESY RPYMSDGSDL DEEDNGGRSS EDSGDGRGGQ 2590 2600 2610 2620 2630 2640 GVADEGGEPQ YQADPTQLYT AIRKEHGGET QNVSDMIPLD KTHSYSPLET QHGAGVFQPE 2650 2660 2670 2680 2690 2700 SAGKGGWDTE RSSHPELTTE ADEEDEASLS THMATKGVSL SNAEGTASEE IRLVQGPDSS 2710 2720 2730 2740 2750 2760 GILKAEDLEN VSPEISPSSD NIVRSEAELG GGASEDGHLS FTGSDRDQQG PGRGLVKGRD 2770 2780 2790 2800 2810 2820 GQSDKLVDET SIREMGFQKE GVLMSSPEEG GEEERDLEPF PNGSATESLN MGKSQVPPLL 2830 2840 2850 2860 2870 2880 THTEELSHRG APHTTTMTTT MTLEGEAKNV QTGLTESPVL LETLAEIFDT PASKVTRADL 2890 2900 2910 2920 2930 2940 TSAVTASEMK SQVKEDSLTG GPEKETGPCT SLGHCDKCIH VDMLEPNEHT PSCALVAPPT 2950 2960 2970 2980 2990 3000 VKDNLCSVNN AGEKSVRPQE DWPPAAEVRL SDACVEESIS EGKAGILQFT PENSDSTLSR 3010 3020 3030 3040 3050 3060 LPHQSVAGWG KSADSVQARL PVSGVRHTSA DTLDVGCPQL ESSREKASAE EEPHRERALS 3070 3080 3090 3100 3110 3120 LKPQEREHHM LGFVEDGRSI LKSSLDKVHM NLQEVGDPSA GTGTKISIQN LIRRAILSEL 3130 3140 3150 3160 3170 3180 PNEVSNVPSH GISPISNSSE VRAESGGDPF CITSFLHLLK QNQPPQETPG ISELAKVLTQ 3190 3200 3210 3220 3230 3240 MDCDPEQRGL GSELLPPQLK NAFYKLLFDG YATEKDQAEA LGQTSCAVPK MAEEKPHVCS 3250 3260 3270 3280 3290 3300 DLRNKEGHHC PLNPQAVGEA EVEPFSVHIA ALPGGEKLGE LCSEPPEHSE STSGSKERSS 3310 3320 3330 3340 3350 3360 DGSSKEKCSN GLQQCLQHTE KMHEYLVLLQ DMKPPLDNQA SVESSLEALK SQLKQLEAFE 3370 3380 3390 3400 3410 3420 LGLAPIAVFL RKDLKLAEEF LKSFPSDLPR RHHEELSKSH QRLQNAFSSL SSVSSERMKL 3430 3440 3450 3460 3470 3480 IKLAINSEMS KLAVRHEDFL HKLTSYSDWV SEKSRSVKAI QTVNVQDTEL VKNSVKFLKN 3490 3500 3510 3520 3530 3540 VLADLSHTKM QLETTAFDVQ SFISDYAQDL SPSQSRQLLR LLNTTQKGFL DLQELVTTEA 3550 3560 3570 3580 3590 3600 DRLEALLQLE QELGHQKVVA ERQQEYREKL QGLCDLLTQT ENRLISNQEA FVIGDGTVEL 3610 3620 3630 3640 3650 3660 QKYQSKQEEL QRDMQGSTQA MEEIVRNTEL FLKESGDELS QADRALIEQK LNEVKMKCAQ 3670 3680 3690 3700 3710 3720 LNLKAEQSRK ELDKAVTTAL KEETEKVAAV RQLEESKTKI ENLLNWLSNV EEDSEGVWTK 3730 3740 3750 3760 3770 3780 HTQPMEQNGT YLHEGDSKLG AGEEDEVNGN LLETDAEGHS EATKGNLNQQ YEKVKAQHGK 3790 3800 3810 3820 3830 3840 IMAQHQAVLL ATQSAQVLLE KQGHYLSPEE KEKLQKNTQE LKVHYEKVLA ECEKKVKLTH 3850 3860 3870 3880 3890 3900 SLQEELEKFD TDYSEFEHWL QQSEQELANL EAGADDLSGL MDKLTRQKSF SEDVISHKGD 3910 3920 3930 3940 3950 3960 LRYITISGNR VIDAAKSCSK RDSDRIGKDS VETSATHREV QTKLDQVTDR FRSLYSKCSV 3970 3980 3990 4000 4010 4020 LGNNLKDLVD QYQQYEDASC GLLSGLQACE AKASKHLREP IALDPKNLQR QLEETKALQG 4030 4040 4050 4060 4070 4080 QISSQQVAVE KLKKTAEVLL DAKGSLLPAK NDIQKTLDDI VGRYDDLSKC VNERNEKLQI 4090 4100 4110 4120 4130 4140 TLTRSLSVQD ALDEMLDWMG SVESSLVKPG QVPLNSTALQ DLISKDTMLE QDITGRQSSI 4150 4160 4170 4180 4190 4200 NAMNEKVKTF IETTDPSTAS SLQAKMKDLS ARFSEASQKH KEKLAKMVEL KAKVEQFEKL 4210 4220 4230 4240 4250 4260 SDKLQTFLET QSQALTEVAM PGKDVPELSQ HMQESTAKFL EHRKDLEALH SLLKEISSHG 4270 4280 4290 4300 4310 4320 LPGDKALVFE KTNNLSRKFK EMEDTIQEKK DALSSCQEQL SAFQTLAQSL KTWIKETTKQ 4330 4340 4350 4360 4370 4380 VPVVKPSLGT EDLRKSLEET KKLQEKWNLK APEIHKASNS GVSLCNLLSA LISPAKAIAA 4390 4400 4410 4420 4430 4440 AKSGGVILNG EGTDTNTQDF LANKGLTSIK KDMTDISHSY EDLGLLLKDK IVELNTKLSK 4450 4460 4470 4480 4490 4500 LQKAQEESSA MMQWLEKMNK TASRWRQTPT PADTESVKLQ VEQNKSFEAE LKQNVNKVQE 4510 4520 4530 4540 4550 4560 LKDKLSELLE ENPEAPEAQS WKQALAEMDT KWQELNQLTM DRQQKLEESS NNLTQFQTTE 4570 4580 4590 4600 4610 4620 AQLKQWLMEK ELMVSVLGPL SIDPNMLNTQ KQQVQILLQE FDTRKPQYEQ LTAAGQGILS 4630 4640 4650 4660 4670 4680 RPGEDPSLHG IVNEQLEAVT QKWDNLTGQL RDRCDWIDQA IVKSTQYQSL LRSLSGTLTE 4690 4700 4710 4720 4730 4740 LDDKLSSGLT SGALPDAVNQ QLEAAQRLKQ EIEQQAPKIK EAQEVCEDLS ALVKEEYLKA 4750 4760 4770 4780 4790 4800 ELSRQLEGIL KSFKDIEQKT ENHVQHLQSA CASSHQFQQM SKDFQAWLDA KKEEQRDSPP 4810 4820 4830 4840 4850 4860 ISAKLDVLES LLNSQKDFGK TFTEQSNIYE KTISEGENLL LKTQGAEKAA LQLQLNTMKT 4870 4880 4890 4900 4910 4920 DWDRFRKQVK EREEKLKDSL EKALKYREQV ETLRPWIDRC QHSLDGVTFS LDPTESESSI 4930 4940 4950 4960 4970 4980 AELKSLQKEM DHHFGMLELL NNTANSLLSV CEVDKEAVTE ENQSLMEKVN RVTEQLQSKT 4990 5000 5010 5020 5030 5040 VSLENMAQKF KEFQEVSRDT QRQLQDTKEQ LEVHHSLGPQ AYSNKHLSVL QAQQKSLQTL 5050 5060 5070 5080 5090 5100 KQQVDEAKRL AQDLVVEAAD SKGTSDVLLQ AETLAEEHSE LSQQVDEKCS FLETKLQGLG 5110 5120 5130 5140 5150 5160 HFQNTIREMF SQFTECDDEL DGMAPVGRDA ETLRKQKACM QTFLKKLEAL MASNDSANRT 5170 5180 5190 5200 5210 5220 CKMMLATEET SPDLIGVKRD LEALSKQCNK LLDRAKTREE QVDGATEKLE EFHRKLEEFS 5230 5240 5250 5260 5270 5280 TLLQKAEEHE ESQGPVGTET ETINQQLDVF KVFQKEEIEP LQVKQQDVNW LGQGLIQSAA 5290 5300 5310 5320 5330 5340 ANTCTQGLEH DLDSVNSRWK TLNKKVAQRT SQLQEALLHC GRFQDALESL LSWMADTEEL 5350 5360 5370 5380 5390 5400 VANQKPPSAE FKVVKAQIQE QKLLQRLLED RKSTVEVIKR EGEKIAASAE PADRVKLTRQ 5410 5420 5430 5440 5450 5460 LSLLDSRWEA LLSRAEARNR QLEGISVVAQ EFHGTLEPLN EWLTAVEKKL ANSEPIGTQA 5470 5480 5490 5500 5510 5520 PKLEEQISQH KALQEDILLR KQSVDQALLN GLELLKQTTG DEVLIIQDKL EAIKARYKDI 5530 5540 5550 5560 5570 5580 TKLSADVAKT LEHALQLAGQ LQSMHKELCN WLDKVEVELL SYETQGLKGE AASQVQERQK 5590 5600 5610 5620 5630 5640 ELKNEVRSNK ALVDSLNEVS SALLELVPCR AKEGLEKTIA DDNEPLPDCE PTQSRHKVEE 5650 5660 5670 5680 5690 5700 IDAAILRSQQ FEQAADAELS WITETQKKLM SLGDIRLEQD QTSAQLQVQK AFTMDILRHK 5710 5720 5730 5740 5750 5760 DIIDELVTSG HKIMTTSGEE EKQSMKKKLD KVLKKYDAVC QINSERHLQL ERAQSLVSQF 5770 5780 5790 5800 5810 5820 WETYEELWPW LTETQRIISQ LPAPALEYET FERQQEEHRQ LRELIAEHKP HIDKMNKTGP 5830 5840 5850 5860 5870 5880 QLLELSPKEG IYIQEKYVAA DTLYSQIKED VKKRAVVLDE AISQSTQFHD KIDQILESLE 5890 5900 5910 5920 5930 5940 RIAERLRQPP SISAEVEKIK EQIGENKSVS VDMEKLQPLY ETLRQRGEEM IARSEGTEKD 5950 5960 5970 5980 5990 6000 VSARAVQDKL DQMVFIWGSI HTLVEEREAK LLDVMELAEK FWCDHMSLVV TIKDTQDFIR 6010 6020 6030 6040 6050 6060 DLEDPGIDPS VVKQQQEAAE AIREEIDGLQ EELDMVITLG SELIAACGEP DKPIVKKSID 6070 6080 6090 6100 6110 6120 ELNSAWDSLN KAWKDRVDRL EEAMQAAVQY QDGLQGIFDW VDIAGDKLAT MSPIGTDLET 6130 6140 6150 6160 6170 6180 VKQQIEELKQ FKSEAYQQQM EMERLNHQAE LLLKKVTEEA DKHTVQDPLM ELKLIWDSLD 6190 6200 6210 6220 6230 6240 ERIVSRQHKL EGTLLALGQF QHALDELLAW LTHTKGLLSE QKPVGGDPKA IEIELAKHHV 6250 6260 6270 6280 6290 6300 LQNDVLAHQS TVEAVNKAGN DLIESSEGEE ASNLQYKLRI LNQRWQDILE KTDQRKQQLD 6310 6320 6330 6340 6350 6360 SALRQAKGFH GEIEDLQQWL TDTERHLLAS KPLGGLPETA KEQLNAHMEV CTAFAIKEET 6370 6380 6390 6400 6410 6420 YKSLMLRGQQ MLARCPRSAE TNIDQDITNL KEKWESVKSK LNEKKTKLEE ALHLAMNFHN 6430 6440 6450 6460 6470 6480 SLQDFINWLT QAEQTLNVAS RPSLILDTIL FQIDEHKVFA NEVNSHREQI IELDKTGTHL 6490 6500 6510 6520 6530 6540 KYFSQKQDVV LIKNLLISVQ SRWEKVVQRL VERGRSLDEA RKRAKQFHEA WSKLMEWLEE 6550 6560 6570 6580 6590 6600 SEKSLDSELE IANDPDKIKA QLVQHKEFQK SLGGKHSVYD TTNRTGRSLK EKTSLADDNL 6610 6620 6630 6640 6650 6660 KLDNMLSELR DKWDTICGKS VERQNKLEEA LLFSGQFTDA LQALIDWLYR VEPQLAEDQP 6670 6680 6690 6700 6710 6720 VHGDIDLVMS LIDNHKVFQK ELGKRTSSVQ ALKRSARELI EGSRDDSSWV RVQMQELSTR 6730 6740 6750 6760 6770 6780 WETVCALSIS KQTRLESALQ QAEEFHSVVH TLLEWLAEAE QTLRFHGALP DDEDALRTLI 6790 6800 6810 6820 6830 6840 EQHKEFMKRL EEKRAELSKA TGMGDALLAV CHPDSITTIK HWITIIQARF EEVLAWAKQH 6850 6860 6870 6880 6890 6900 QQRLAGALAG LIAKQELLET LLAWLQWAET TLTEKDKEVI PQEIEEVKTL IAEHQTFMEE 6910 6920 6930 6940 6950 6960 MTRKQPDVDK VTKTYKRRAT DPPSLQSHIP VLDKGRAGRK RFPASGFYPS GSQTQIETKN 6970 6980 6990 7000 7010 7020 PRVNLLVSKW QQVWLLALER RRKLNDALDR LEELREFANF DFDIWRKKYM RWMNHKKSRV 7030 7040 7050 7060 7070 7080 MDFFRRIDKD QDGKITRQEF IDGILSSKFP TSRLEMSAVA DIFDRDGDGY IDYYEFVAAL 7090 7100 7110 7120 7130 7140 HPNKDAYKPI TDADKIGDEV TRQVAKCKCA KRFQVEQIGD NKYRFFLGNQ FGDSQQLRLV 7150 7160 7170 7180 7190 7200 RILRSTVMVR VGGGWMALDE FLVKNDPCRV HHHGSKMLRS ESNSSITATQ PTLAKGRTNM 7210 7220 7230 7240 7250 7260 ELREKFILAD GASQGMAAFR PRGRRSRPSS RGASPNRSTS GSSHACQAAS PPVPAAASTP 7270 7280 7290 7300 7310 7320 KGTPIQGSKL RLPGYLSGKG FHSGEDSALI TTAAARVRTQ FAESRKTPSR PGSRAGSKAG 7330 7340 7350 7360 7370 7380 SRASSRRGSD ASDFDISEIQ SVCSDVETVP QTHRPVPRAG SRPSTAKPSK IPTPQRRSPA SKLDKSSKR
	Isoform 1 (BPAG1-a) (BPAG1a2) [UniParc]. Checksum: E13CE8D1208B2BD5	FASTA	5,380	614,927
	10 20 30 40 50 60 MAGYLSPAAY MYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 70 80 90 100 110 120 EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 130 140 150 160 170 180 GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW 190 200 210 220 230 240 RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 250 260 270 280 290 300 KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP 310 320 330 340 350 360 NNPLELKALY NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 370 380 390 400 410 420 EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA LQSDSKRLES 430 440 450 460 470 480 GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 490 500 510 520 530 540 SSVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS 550 560 570 580 590 600 SGMTSRLTPS VTPVYAPGFP SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 610 620 630 640 650 660 EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 670 680 690 700 710 720 SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE 730 740 750 760 770 780 SEVAYDWSER NSSVARKKSY HVELMRELEQ KEESIKAVQE IAEQLLLENH PARLTIEAYR 790 800 810 820 830 840 AAMQTQWSWI LQLCQCVEQH IQENSAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 850 860 870 880 890 900 HKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI 910 920 930 940 950 960 EITIYKDDEC VLANNSHRAK WKVISPTGNE AVVPSVCFTV PPPNKEAVDF ANRIEQQYQS 970 980 990 1000 1010 1020 VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE 1030 1040 1050 1060 1070 1080 DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE ESVYNLYISE VRNIRLRLES 1090 1100 1110 1120 1130 1140 CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELDRLKD DLGTITNKCE EFFSQAADSP 1150 1160 1170 1180 1190 1200 SVPALRSELS VVIQSLSQIY SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV 1210 1220 1230 1240 1250 1260 IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK 1270 1280 1290 1300 1310 1320 EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET TQRKIQENQP 1330 1340 1350 1360 1370 1380 ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVESQQK 1390 1400 1410 1420 1430 1440 SPVKRRRIQS SADLVIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ 1450 1460 1470 1480 1490 1500 HIEKAKELQK WVSNISKTLG DGEKAGKPLF SKQQMSSKEI STKKEQFSEA LQTTQIFLAK 1510 1520 1530 1540 1550 1560 HGDKLTEEER SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GESKVPEKVV AERQQEYREK 1570 1580 1590 1600 1610 1620 LQGLCDLLTQ TENRLISNQE AFVIGDGTVE LQKYQSKQEE LQRDMQGSTQ AMEEIVRNTE 1630 1640 1650 1660 1670 1680 LFLKESGDEL SQADRALIEQ KLNEVKMKCA QLNLKAEQSR KELDKAVTTA LKEETEKVAA 1690 1700 1710 1720 1730 1740 VRQLEESKTK IENLLNWLSN VEEDSEGVWT KHTQPMEQNG TYLHEGDSKL GAGEEDEVNG 1750 1760 1770 1780 1790 1800 NLLETDAEGH SEATKGNLNQ QYEKVKAQHG KIMAQHQAVL LATQSAQVLL EKQGHYLSPE 1810 1820 1830 1840 1850 1860 EKEKLQKNTQ ELKVHYEKVL AECEKKVKLT HSLQEELEKF DTDYSEFEHW LQQSEQELAN 1870 1880 1890 1900 1910 1920 LEAGADDLSG LMDKLTRQKS FSEDVISHKG DLRYITISGN RVIDAAKSCS KRDSDRIGKD 1930 1940 1950 1960 1970 1980 SVETSATHRE VQTKLDQVTD RFRSLYSKCS VLGNNLKDLV DQYQQYEDAS CGLLSGLQAC 1990 2000 2010 2020 2030 2040 EAKASKHLRE PIALDPKNLQ RQLEETKALQ GQISSQQVAV EKLKKTAEVL LDAKGSLLPA 2050 2060 2070 2080 2090 2100 KNDIQKTLDD IVGRYDDLSK CVNERNEKLQ ITLTRSLSVQ DALDEMLDWM GSVESSLVKP 2110 2120 2130 2140 2150 2160 GQVPLNSTAL QDLISKDTML EQDITGRQSS INAMNEKVKT FIETTDPSTA SSLQAKMKDL 2170 2180 2190 2200 2210 2220 SARFSEASQK HKEKLAKMVE LKAKVEQFEK LSDKLQTFLE TQSQALTEVA MPGKDVPELS 2230 2240 2250 2260 2270 2280 QHMQESTAKF LEHRKDLEAL HSLLKEISSH GLPGDKALVF EKTNNLSRKF KEMEDTIQEK 2290 2300 2310 2320 2330 2340 KDALSSCQEQ LSAFQTLAQS LKTWIKETTK QVPVVKPSLG TEDLRKSLEE TKKLQEKWNL 2350 2360 2370 2380 2390 2400 KAPEIHKASN SGVSLCNLLS ALISPAKAIA AAKSGGVILN GEGTDTNTQD FLANKGLTSI 2410 2420 2430 2440 2450 2460 KKDMTDISHS YEDLGLLLKD KIVELNTKLS KLQKAQEESS AMMQWLEKMN KTASRWRQTP 2470 2480 2490 2500 2510 2520 TPADTESVKL QVEQNKSFEA ELKQNVNKVQ ELKDKLSELL EENPEAPEAQ SWKQALAEMD 2530 2540 2550 2560 2570 2580 TKWQELNQLT MDRQQKLEES SNNLTQFQTT EAQLKQWLME KELMVSVLGP LSIDPNMLNT 2590 2600 2610 2620 2630 2640 QKQQVQILLQ EFDTRKPQYE QLTAAGQGIL SRPGEDPSLH GIVNEQLEAV TQKWDNLTGQ 2650 2660 2670 2680 2690 2700 LRDRCDWIDQ AIVKSTQYQS LLRSLSGTLT ELDDKLSSGL TSGALPDAVN QQLEAAQRLK 2710 2720 2730 2740 2750 2760 QEIEQQAPKI KEAQEVCEDL SALVKEEYLK AELSRQLEGI LKSFKDIEQK TENHVQHLQS 2770 2780 2790 2800 2810 2820 ACASSHQFQQ MSKDFQAWLD AKKEEQRDSP PISAKLDVLE SLLNSQKDFG KTFTEQSNIY 2830 2840 2850 2860 2870 2880 EKTISEGENL LLKTQGAEKA ALQLQLNTMK TDWDRFRKQV KEREEKLKDS LEKALKYREQ 2890 2900 2910 2920 2930 2940 VETLRPWIDR CQHSLDGVTF SLDPTESESS IAELKSLQKE MDHHFGMLEL LNNTANSLLS 2950 2960 2970 2980 2990 3000 VCEVDKEAVT EENQSLMEKV NRVTEQLQSK TVSLENMAQK FKEFQEVSRD TQRQLQDTKE 3010 3020 3030 3040 3050 3060 QLEVHHSLGP QAYSNKHLSV LQAQQKSLQT LKQQVDEAKR LAQDLVVEAA DSKGTSDVLL 3070 3080 3090 3100 3110 3120 QAETLAEEHS ELSQQVDEKC SFLETKLQGL GHFQNTIREM FSQFTECDDE LDGMAPVGRD 3130 3140 3150 3160 3170 3180 AETLRKQKAC MQTFLKKLEA LMASNDSANR TCKMMLATEE TSPDLIGVKR DLEALSKQCN 3190 3200 3210 3220 3230 3240 KLLDRAKTRE EQVDGATEKL EEFHRKLEEF STLLQKAEEH EESQGPVGTE TETINQQLDV 3250 3260 3270 3280 3290 3300 FKVFQKEEIE PLQVKQQDVN WLGQGLIQSA AANTCTQGLE HDLDSVNSRW KTLNKKVAQR 3310 3320 3330 3340 3350 3360 TSQLQEALLH CGRFQDALES LLSWMADTEE LVANQKPPSA EFKVVKAQIQ EQKLLQRLLE 3370 3380 3390 3400 3410 3420 DRKSTVEVIK REGEKIAASA EPADRVKLTR QLSLLDSRWE ALLSRAEARN RQLEGISVVA 3430 3440 3450 3460 3470 3480 QEFHGTLEPL NEWLTAVEKK LANSEPIGTQ APKLEEQISQ HKALQEDILL RKQSVDQALL 3490 3500 3510 3520 3530 3540 NGLELLKQTT GDEVLIIQDK LEAIKARYKD ITKLSADVAK TLEHALQLAG QLQSMHKELC 3550 3560 3570 3580 3590 3600 NWLDKVEVEL LSYETQGLKG EAASQVQERQ KELKNEVRSN KALVDSLNEV SSALLELVPC 3610 3620 3630 3640 3650 3660 RAKEGLEKTI ADDNEPLPDC EPTQSRHKVE EIDAAILRSQ QFEQAADAEL SWITETQKKL 3670 3680 3690 3700 3710 3720 MSLGDIRLEQ DQTSAQLQVQ KAFTMDILRH KDIIDELVTS GHKIMTTSGE EEKQSMKKKL 3730 3740 3750 3760 3770 3780 DKVLKKYDAV CQINSERHLQ LERAQSLVSQ FWETYEELWP WLTETQRIIS QLPAPALEYE 3790 3800 3810 3820 3830 3840 TFERQQEEHR QLRELIAEHK PHIDKMNKTG PQLLELSPKE GIYIQEKYVA ADTLYSQIKE 3850 3860 3870 3880 3890 3900 DVKKRAVVLD EAISQSTQFH DKIDQILESL ERIAERLRQP PSISAEVEKI KEQIGENKSV 3910 3920 3930 3940 3950 3960 SVDMEKLQPL YETLRQRGEE MIARSEGTEK DVSARAVQDK LDQMVFIWGS IHTLVEEREA 3970 3980 3990 4000 4010 4020 KLLDVMELAE KFWCDHMSLV VTIKDTQDFI RDLEDPGIDP SVVKQQQEAA EAIREEIDGL 4030 4040 4050 4060 4070 4080 QEELDMVITL GSELIAACGE PDKPIVKKSI DELNSAWDSL NKAWKDRVDR LEEAMQAAVQ 4090 4100 4110 4120 4130 4140 YQDGLQGIFD WVDIAGDKLA TMSPIGTDLE TVKQQIEELK QFKSEAYQQQ MEMERLNHQA 4150 4160 4170 4180 4190 4200 ELLLKKVTEE ADKHTVQDPL MELKLIWDSL DERIVSRQHK LEGTLLALGQ FQHALDELLA 4210 4220 4230 4240 4250 4260 WLTHTKGLLS EQKPVGGDPK AIEIELAKHH VLQNDVLAHQ STVEAVNKAG NDLIESSEGE 4270 4280 4290 4300 4310 4320 EASNLQYKLR ILNQRWQDIL EKTDQRKQQL DSALRQAKGF HGEIEDLQQW LTDTERHLLA 4330 4340 4350 4360 4370 4380 SKPLGGLPET AKEQLNAHME VCTAFAIKEE TYKSLMLRGQ QMLARCPRSA ETNIDQDITN 4390 4400 4410 4420 4430 4440 LKEKWESVKS KLNEKKTKLE EALHLAMNFH NSLQDFINWL TQAEQTLNVA SRPSLILDTI 4450 4460 4470 4480 4490 4500 LFQIDEHKVF ANEVNSHREQ IIELDKTGTH LKYFSQKQDV VLIKNLLISV QSRWEKVVQR 4510 4520 4530 4540 4550 4560 LVERGRSLDE ARKRAKQFHE AWSKLMEWLE ESEKSLDSEL EIANDPDKIK AQLVQHKEFQ 4570 4580 4590 4600 4610 4620 KSLGGKHSVY DTTNRTGRSL KEKTSLADDN LKLDNMLSEL RDKWDTICGK SVERQNKLEE 4630 4640 4650 4660 4670 4680 ALLFSGQFTD ALQALIDWLY RVEPQLAEDQ PVHGDIDLVM SLIDNHKVFQ KELGKRTSSV 4690 4700 4710 4720 4730 4740 QALKRSAREL IEGSRDDSSW VRVQMQELST RWETVCALSI SKQTRLESAL QQAEEFHSVV 4750 4760 4770 4780 4790 4800 HTLLEWLAEA EQTLRFHGAL PDDEDALRTL IEQHKEFMKR LEEKRAELSK ATGMGDALLA 4810 4820 4830 4840 4850 4860 VCHPDSITTI KHWITIIQAR FEEVLAWAKQ HQQRLAGALA GLIAKQELLE TLLAWLQWAE 4870 4880 4890 4900 4910 4920 TTLTEKDKEV IPQEIEEVKT LIAEHQTFME EMTRKQPDVD KVTKTYKRRA TDPPSLQSHI 4930 4940 4950 4960 4970 4980 PVLDKGRAGR KRFPASGFYP SGSQTQIETK NPRVNLLVSK WQQVWLLALE RRRKLNDALD 4990 5000 5010 5020 5030 5040 RLEELREFAN FDFDIWRKKY MRWMNHKKSR VMDFFRRIDK DQDGKITRQE FIDGILSSKF 5050 5060 5070 5080 5090 5100 PTSRLEMSAV ADIFDRDGDG YIDYYEFVAA LHPNKDAYKP ITDADKIGDE VTRQVAKCKC 5110 5120 5130 5140 5150 5160 AKRFQVEQIG DNKYRFFLGN QFGDSQQLRL VRILRSTVMV RVGGGWMALD EFLVKNDPCR 5170 5180 5190 5200 5210 5220 VHHHGSKMLR SESNSSITAT QPTLAKGRTN MELREKFILA DGASQGMAAF RPRGRRSRPS 5230 5240 5250 5260 5270 5280 SRGASPNRST SGSSHACQAA SPPVPAAAST PKGTPIQGSK LRLPGYLSGK GFHSGEDSAL 5290 5300 5310 5320 5330 5340 ITTAAARVRT QFAESRKTPS RPGSRAGSKA GSRASSRRGS DASDFDISEI QSVCSDVETV 5350 5360 5370 5380 PQTHRPVPRA GSRPSTAKPS KIPTPQRRSP ASKLDKSSKR
	Isoform 3 [UniParc]. Checksum: B35C8666379E4313	FASTA	7,396	834,373
	10 20 30 40 50 60 MAGYLSPAAY MYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 70 80 90 100 110 120 EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 130 140 150 160 170 180 GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW 190 200 210 220 230 240 RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 250 260 270 280 290 300 KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP 310 320 330 340 350 360 NNPLELKALY NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 370 380 390 400 410 420 EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA LQSDSKRLES 430 440 450 460 470 480 GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 490 500 510 520 530 540 SSVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS 550 560 570 580 590 600 SGMTSRLTPS VTPVYAPGFP SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 610 620 630 640 650 660 EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 670 680 690 700 710 720 SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE 730 740 750 760 770 780 SEVAYDWSER NSSVARKKSY HVELMRELEQ KEESIKAVQE IAEQLLLENH PARLTIEAYR 790 800 810 820 830 840 AAMQTQWSWI LQLCQCVEQH IQENSAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 850 860 870 880 890 900 HKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI 910 920 930 940 950 960 EITIYKDDEC VLANNSHRAK WKVISPTGNE AVVPSVCFTV PPPNKEAVDF ANRIEQQYQS 970 980 990 1000 1010 1020 VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE 1030 1040 1050 1060 1070 1080 DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE ESVYNLYISE VRNIRLRLES 1090 1100 1110 1120 1130 1140 CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELDRLKD DLGTITNKCE EFFSQAADSP 1150 1160 1170 1180 1190 1200 SVPALRSELS VVIQSLSQIY SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV 1210 1220 1230 1240 1250 1260 IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK 1270 1280 1290 1300 1310 1320 EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET TQRKIQENQP 1330 1340 1350 1360 1370 1380 ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVESQQK 1390 1400 1410 1420 1430 1440 SPVKRRRIQS SADLVIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ 1450 1460 1470 1480 1490 1500 HIEKAKELQK WVSNISKTLG DGEKAGKPLF SKQQMSSKEI STKKEQFSEA LQTTQIFLAK 1510 1520 1530 1540 1550 1560 HGDKLTEEER SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GESKVPEKPD KVIAGTINQT 1570 1580 1590 1600 1610 1620 TGEVLSVFQA VLRGLIDYET GIRLLEAQLV ITGLISPELR KCFDLRDAES HGLIDEQVLR 1630 1640 1650 1660 1670 1680 QLKELNRAKQ LISTASPTSI PVLDSLAQGM VSESMAIRVL EILLSAGPLL VPATGEHLTL 1690 1700 1710 1720 1730 1740 QQAFQQNLIS SALFSKVLER QDTCKDLIDP CTSEKVSLTD MVQRSILQEN TRMWLLPVRP 1750 1760 1770 1780 1790 1800 QEAGRITLKC GRSVSILRAA HEGLIDRETM FRLLGAQLLS GGLIDCNSGQ KMTVEEAVAE 1810 1820 1830 1840 1850 1860 GVIDRDTASS ILTYQVQTGG IVHSNPAKRL TVDEAVQCEL ITSSSALLVL EAQRGYVGLI 1870 1880 1890 1900 1910 1920 WPHSGEIFPT SSSLQQELIT NELASKILNG RQKIAALYIP ESSQVIGLDA AKQLGIIDNN 1930 1940 1950 1960 1970 1980 TASVLKDVKL PDKMPDLGDL EDCKNAKRWL SFCKFQPSTV HDYRQEEGGS DGEEPVTAQS 1990 2000 2010 2020 2030 2040 SEQTKKLFLS YLMVNSYMDA HTGQRLLLYD GDLDEAVSML LESCGAELGA DTSTRESLSV 2050 2060 2070 2080 2090 2100 LTIPDAFPDC ALSEEKHECS ADKCHYSHPG HKESLENAKW DMNEAFCKMG NNDSNGELPR 2110 2120 2130 2140 2150 2160 PENLADTTVV QKGSESPSRV RVPKPTSSST QPEGSVLRPE SGSILKGCKS QSEPVTKKYP 2170 2180 2190 2200 2210 2220 DGTNHSHFLT SETSRPCDSN EREDEENIQK GPSVFDYSPR LSALLSHDEL RQSQGRFSDT 2230 2240 2250 2260 2270 2280 STPQNTGYLC EASTLSPSDQ RVLADQSTRE KFQDRFLGIA AISVSLQGAP CGQKPVDTEC 2290 2300 2310 2320 2330 2340 SSSQVHYHSE ESMSDASAES GATRQTDESE KTGSKVEDNS CTMVPGGGSR NDNTSDCGPL 2350 2360 2370 2380 2390 2400 SHKGAIDAGD YETSLLAGQQ SDTATDSDSD DYFYDTPLFE DEDHDSLILQ GDDRDCLQPE 2410 2420 2430 2440 2450 2460 DYDTSLQEEN DRTPPPDDIF YDVMKEKENP EFPHGGMDES LGVENKVCCP QGFPVGIEKP 2470 2480 2490 2500 2510 2520 ELYLAGEKEF NSGGSEQLVE SVSESENPPG LWDSESDSLT EGEIIGRKER LGASLTPDGH 2530 2540 2550 2560 2570 2580 WRGDREECDT SRESQSDTDG VGSIQSSESY RPYMSDGSDL DEEDNGGRSS EDSGDGRGGQ 2590 2600 2610 2620 2630 2640 GVADEGGEPQ YQADPTQLYT AIRKEHGGET QNVSDMIPLD KTHSYSPLET QHGAGVFQPE 2650 2660 2670 2680 2690 2700 SAGKGGWDTE RSSHPELTTE ADEEDEASLS THMATKGVSL SNAEGTASEE IRLVQGPDSS 2710 2720 2730 2740 2750 2760 GILKAEDLEN VSPEISPSSD NIVRSEAELG GGASEDGHLS FTGSDRDQQG PGRGLVKGRD 2770 2780 2790 2800 2810 2820 GQSDKLVDET SIREMGFQKE GVLMSSPEEG GEEERDLEPF PNGSATESLN MGKSQVPPLL 2830 2840 2850 2860 2870 2880 THTEELSHRG APHTTTMTTT MTLEGEAKNV QTGLTESPVL LETLAEIFDT PASKVTRADL 2890 2900 2910 2920 2930 2940 TSAVTASEMK SQVKEDSLTG GPEKETGPCT SLGHCDKCIH VDMLEPNEHT PSCALVAPPT 2950 2960 2970 2980 2990 3000 VKDNLCSVNN AGEKSVRPQE DWPPAAEVRL SDACVEESIS EGKAGILQFT PENSDSTLSR 3010 3020 3030 3040 3050 3060 LPHQSVAGWG KSADSVQARL PVSGVRHTSA DTLDVGCPQL ESSREKASAE EEPHRERALS 3070 3080 3090 3100 3110 3120 LKPQEREHHM LGFVEDGRSI LKSSLDKVHM NLQEVGDPSA GTGTKISIQN LIRRAILSEL 3130 3140 3150 3160 3170 3180 PNEVSNVPSH GISPISNSSE VRAESGGDPF CITSFLHLLK QNQPPQETPG ISELAKVLTQ 3190 3200 3210 3220 3230 3240 MDCDPEQRGL GSELLPPQLK NAFYKLLFDG YATEKDQAEA LGQTSCAVPK MAEEKPHVCS 3250 3260 3270 3280 3290 3300 DLRNKEGHHC PLNPQAVGEA EVEPFSVHIA ALPGGEKLGE LCSEPPEHSE STSGSKERSS 3310 3320 3330 3340 3350 3360 DGSSKEKCSN GLQQCLQHTE KMHEYLVLLQ DMKPPLDNQA SVESSLEALK SQLKQLEAFE 3370 3380 3390 3400 3410 3420 LGLAPIAVFL RKDLKLAEEF LKSFPSDLPR RHHEELSKSH QRLQNAFSSL SSVSSERMKL 3430 3440 3450 3460 3470 3480 IKLAINSEMS KLAVRHEDFL HKLTSYSDWV SEKSRSVKAI QTVNVQDTEL VKNSVKFLKN 3490 3500 3510 3520 3530 3540 VLADLSHTKM QLETTAFDVQ SFISDYAQDL SPSQSRQLLR LLNTTQKGFL DLQELVTTEA 3550 3560 3570 3580 3590 3600 DRLEALLQLE QELGHQKVVA ERQQEYREKL QGLCDLLTQT ENRLISNQEA FVIGDGTVEL 3610 3620 3630 3640 3650 3660 QKYQSKQEEL QRDMQGSTQA MEEIVRNTEL FLKESGDELS QADRALIEQK LNEVKMKCAQ 3670 3680 3690 3700 3710 3720 LNLKAEQSRK ELDKAVTTAL KEETEKVAAV RQLEESKTKI ENLLNWLSNV EEDSEGVWTK 3730 3740 3750 3760 3770 3780 HTQPMEQNGT YLHEGDSKLG AGEEDEVNGN LLETDAEGHS EATKGNLNQQ YEKVKAQHGK 3790 3800 3810 3820 3830 3840 IMAQHQAVLL ATQSAQVLLE KQGHYLSPEE KEKLQKNTQE LKVHYEKVLA ECEKKVKLTH 3850 3860 3870 3880 3890 3900 SLQEELEKFD TDYSEFEHWL QQSEQELANL EAGADDLSGL MDKLTRQKSF SEDVISHKGD 3910 3920 3930 3940 3950 3960 LRYITISGNR VIDAAKSCSK RDSDRIGKDS VETSATHREV QTKLDQVTDR FRSLYSKCSV 3970 3980 3990 4000 4010 4020 LGNNLKDLVD QYQQYEDASC GLLSGLQACE AKASKHLREP IALDPKNLQR QLEETKALQG 4030 4040 4050 4060 4070 4080 QISSQQVAVE KLKKTAEVLL DAKGSLLPAK NDIQKTLDDI VGRYDDLSKC VNERNEKLQI 4090 4100 4110 4120 4130 4140 TLTRSLSVQD ALDEMLDWMG SVESSLVKPG QVPLNSTALQ DLISKDTMLE QDITGRQSSI 4150 4160 4170 4180 4190 4200 NAMNEKVKTF IETTDPSTAS SLQAKMKDLS ARFSEASQKH KEKLAKMVEL KAKVEQFEKL 4210 4220 4230 4240 4250 4260 SDKLQTFLET QSQALTEVAM PGKDVPELSQ HMQESTAKFL EHRKDLEALH SLLKEISSHG 4270 4280 4290 4300 4310 4320 LPGDKALVFE KTNNLSRKFK EMEDTIQEKK DALSSCQEQL SAFQTLAQSL KTWIKETTKQ 4330 4340 4350 4360 4370 4380 VPVVKPSLGT EDLRKSLEET KKLQEKWNLK APEIHKASNS GVSLCNLLSA LISPAKAIAA 4390 4400 4410 4420 4430 4440 AKSGGVILNG EGTDTNTQDF LANKGLTSIK KDMTDISHSY EDLGLLLKDK IVELNTKLSK 4450 4460 4470 4480 4490 4500 LQKAQEESSA MMQWLEKMNK TASRWRQTPT PADTESVKLQ VEQNKSFEAE LKQNVNKVQE 4510 4520 4530 4540 4550 4560 LKDKLSELLE ENPEAPEAQS WKQALAEMDT KWQELNQLTM DRQQKLEESS NNLTQFQTTE 4570 4580 4590 4600 4610 4620 AQLKQWLMEK ELMVSVLGPL SIDPNMLNTQ KQQVQILLQE FDTRKPQYEQ LTAAGQGILS 4630 4640 4650 4660 4670 4680 RPGEDPSLHG IVNEQLEAVT QKWDNLTGQL RDRCDWIDQA IVKSTQYQSL LRSLSGTLTE 4690 4700 4710 4720 4730 4740 LDDKLSSGLT SGALPDAVNQ QLEAAQRLKQ EIEQQAPKIK EAQEVCEDLS ALVKEEYLKA 4750 4760 4770 4780 4790 4800 ELSRQLEGIL KSFKDIEQKT ENHVQHLQSA CASSHQFQQM SKDFQAWLDA KKEEQRDSPP 4810 4820 4830 4840 4850 4860 ISAKLDVLES LLNSQKDFGK TFTEQSNIYE KTISEGENLL LKTQGAEKAA LQLQLNTMKT 4870 4880 4890 4900 4910 4920 DWDRFRKQVK EREEKLKDSL EKALKYREQV ETLRPWIDRC QHSLDGVTFS LDPTESESSI 4930 4940 4950 4960 4970 4980 AELKSLQKEM DHHFGMLELL NNTANSLLSV CEVDKEAVTE ENQSLMEKVN RVTEQLQSKT 4990 5000 5010 5020 5030 5040 VSLENMAQKF KEFQEVSRDT QRQLQDTKEQ LEVHHSLGPQ AYSNKHLSVL QAQQKSLQTL 5050 5060 5070 5080 5090 5100 KQQVDEAKRL AQDLVVEAAD SKGTSDVLLQ AETLAEEHSE LSQQVDEKCS FLETKLQGLG 5110 5120 5130 5140 5150 5160 HFQNTIREMF SQFTECDDEL DGMAPVGRDA ETLRKQKACM QTFLKKLEAL MASNDSANRT 5170 5180 5190 5200 5210 5220 CKMMLATEET SPDLIGVKRD LEALSKQCNK LLDRAKTREE QVDGATEKLE EFHRKLEEFS 5230 5240 5250 5260 5270 5280 TLLQKAEEHE ESQGPVGTET ETINQQLDVF KVFQKEEIEP LQVKQQDVNW LGQGLIQSAA 5290 5300 5310 5320 5330 5340 ANTCTQGLEH DLDSVNSRWK TLNKKVAQRT SQLQEALLHC GRFQDALESL LSWMADTEEL 5350 5360 5370 5380 5390 5400 VANQKPPSAE FKVVKAQIQE QKLLQRLLED RKSTVEVIKR EGEKIAASAE PADRVKLTRQ 5410 5420 5430 5440 5450 5460 LSLLDSRWEA LLSRAEARNR QLEGISVVAQ EFHGTLEPLN EWLTAVEKKL ANSEPIGTQA 5470 5480 5490 5500 5510 5520 PKLEEQISQH KALQEDILLR KQSVDQALLN GLELLKQTTG DEVLIIQDKL EAIKARYKDI 5530 5540 5550 5560 5570 5580 TKLSADVAKT LEHALQLAGQ LQSMHKELCN WLDKVEVELL SYETQGLKGE AASQVQERQK 5590 5600 5610 5620 5630 5640 ELKNEVRSNK ALVDSLNEVS SALLELVPCR AKEGLEKTIA DDNEPLPDCE PTQSRHKVEE 5650 5660 5670 5680 5690 5700 IDAAILRSQQ FEQAADAELS WITETQKKLM SLGDIRLEQD QTSAQLQVQK AFTMDILRHK 5710 5720 5730 5740 5750 5760 DIIDELVTSG HKIMTTSGEE EKQSMKKKLD KVLKKYDAVC QINSERHLQL ERAQSLVSQF 5770 5780 5790 5800 5810 5820 WETYEELWPW LTETQRIISQ LPAPALEYET FERQQEEHRQ LRELIAEHKP HIDKMNKTGP 5830 5840 5850 5860 5870 5880 QLLELSPKEG IYIQEKYVAA DTLYSQIKED VKKRAVVLDE AISQSTQFHD KIDQILESLE 5890 5900 5910 5920 5930 5940 RIAERLRQPP SISAEVEKIK EQIGENKSVS VDMEKLQPLY ETLRQRGEEM IARSEGTEKD 5950 5960 5970 5980 5990 6000 VSARAVQDKL DQMVFIWGSI HTLVEEREAK LLDVMELAEK FWCDHMSLVV TIKDTQDFIR 6010 6020 6030 6040 6050 6060 DLEDPGIDPS VVKQQQEAAE AIREEIDGLQ EELDMVITLG SELIAACGEP DKPIVKKSID 6070 6080 6090 6100 6110 6120 ELNSAWDSLN KAWKDRVDRL EEAMQAAVQY QDGLQGIFDW VDIAGDKLAT MSPIGTDLET 6130 6140 6150 6160 6170 6180 VKQQIEELKQ FKSEAYQQQM EMERLNHQAE LLLKKVTEEA DKHTVQDPLM ELKLIWDSLD 6190 6200 6210 6220 6230 6240 ERIVSRQHKL EGTLLALGQF QHALDELLAW LTHTKGLLSE QKPVGGDPKA IEIELAKHHV 6250 6260 6270 6280 6290 6300 LQNDVLAHQS TVEAVNKAGN DLIESSEGEE ASNLQYKLRI LNQRWQDILE KTDQRKQQLD 6310 6320 6330 6340 6350 6360 SALRQAKGFH GEIEDLQQWL TDTERHLLAS KPLGGLPETA KEQLNAHMEV CTAFAIKEET 6370 6380 6390 6400 6410 6420 YKSLMLRGQQ MLARCPRSAE TNIDQDITNL KEKWESVKSK LNEKKTKLEE ALHLAMNFHN 6430 6440 6450 6460 6470 6480 SLQDFINWLT QAEQTLNVAS RPSLILDTIL FQIDEHKVFA NEVNSHREQI IELDKTGTHL 6490 6500 6510 6520 6530 6540 KYFSQKQDVV LIKNLLISVQ SRWEKVVQRL VERGRSLDEA RKRAKQFHEA WSKLMEWLEE 6550 6560 6570 6580 6590 6600 SEKSLDSELE IANDPDKIKA QLVQHKEFQK SLGGKHSVYD TTNRTGRSLK EKTSLADDNL 6610 6620 6630 6640 6650 6660 KLDNMLSELR DKWDTICGKS VERQNKLEEA LLFSGQFTDA LQALIDWLYR VEPQLAEDQP 6670 6680 6690 6700 6710 6720 VHGDIDLVMS LIDNHKVFQK ELGKRTSSVQ ALKRSARELI EGSRDDSSWV RVQMQELSTR 6730 6740 6750 6760 6770 6780 WETVCALSIS KQTRLESALQ QAEEFHSVVH TLLEWLAEAE QTLRFHGALP DDEDALRTLI 6790 6800 6810 6820 6830 6840 EQHKEFMKRL EEKRAELSKA TGMGDALLAV CHPDSITTIK HWITIIQARF EEVLAWAKQH 6850 6860 6870 6880 6890 6900 QQRLAGALAG LIAKQELLET LLAWLQWAET TLTEKDKEVI PQEIEEVKTL IAEHQTFMEE 6910 6920 6930 6940 6950 6960 MTRKQPDVDK VTKTYKRRAT DPPSLQSHIP VLDKGRAGRK RFPASGFYPS GSQTQIETKN 6970 6980 6990 7000 7010 7020 PRVNLLVSKW QQVWLLALER RRKLNDALDR LEELREFANF DFDIWRKKYM RWMNHKKSRV 7030 7040 7050 7060 7070 7080 MDFFRRIDKD QDGKITRQEF IDGILSSKFP TSRLEMSAVA DIFDRDGDGY IDYYEFVAAL 7090 7100 7110 7120 7130 7140 HPNKDAYKPI TDADKIGDEV TRQVAKCKCA KRFQVEQIGD NKYRFGDSQQ LRLVRILRST 7150 7160 7170 7180 7190 7200 VMVRVGGGWM ALDEFLVKND PCRAKGRTNM ELREKFILAD GASQGMAAFR PRGRRSRPSS 7210 7220 7230 7240 7250 7260 RGASPNRSTS GSSHACQAAS PPVPAAASTP KILHPLTRNY GKPWLANSKM STPCKAAECP 7270 7280 7290 7300 7310 7320 DFPVSSAEGT PIQGSKLRLP GYLSGKGFHS GEDSALITTA AARVRTQFAE SRKTPSRPGS 7330 7340 7350 7360 7370 7380 RAGSKAGSRA SSRRGSDASD FDISEIQSVC SDVETVPQTH RPVPRAGSRP STAKPSKIPT 7390 PQRRSPASKL DKSSKR
	Isoform 4 [UniParc]. Checksum: 23266E5A1EF3BFED	FASTA	7,402	835,080
	10 20 30 40 50 60 MAGYLSPAAY MYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 70 80 90 100 110 120 EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 130 140 150 160 170 180 GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW 190 200 210 220 230 240 RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 250 260 270 280 290 300 KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP 310 320 330 340 350 360 NNPLELKALY NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 370 380 390 400 410 420 EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA LQSDSKRLES 430 440 450 460 470 480 GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 490 500 510 520 530 540 SSVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS 550 560 570 580 590 600 SGMTSRLTPS VTPVYAPGFP SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 610 620 630 640 650 660 EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 670 680 690 700 710 720 SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE 730 740 750 760 770 780 SEVAYDWSER NSSVARKKSY HVELMRELEQ KEESIKAVQE IAEQLLLENH PARLTIEAYR 790 800 810 820 830 840 AAMQTQWSWI LQLCQCVEQH IQENSAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 850 860 870 880 890 900 HKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI 910 920 930 940 950 960 EITIYKDDEC VLANNSHRAK WKVISPTGNE AVVPSVCFTV PPPNKEAVDF ANRIEQQYQS 970 980 990 1000 1010 1020 VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE 1030 1040 1050 1060 1070 1080 DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE ESVYNLYISE VRNIRLRLES 1090 1100 1110 1120 1130 1140 CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELDRLKD DLGTITNKCE EFFSQAADSP 1150 1160 1170 1180 1190 1200 SVPALRSELS VVIQSLSQIY SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV 1210 1220 1230 1240 1250 1260 IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK 1270 1280 1290 1300 1310 1320 EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET TQRKIQENQP 1330 1340 1350 1360 1370 1380 ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVESQQK 1390 1400 1410 1420 1430 1440 SPVKRRRIQS SADLVIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ 1450 1460 1470 1480 1490 1500 HIEKAKELQK WVSNISKTLG DGEKAGKPLF SKQQMSSKEI STKKEQFSEA LQTTQIFLAK 1510 1520 1530 1540 1550 1560 HGDKLTEEER SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GESKVPEKPD KVIAGTINQT 1570 1580 1590 1600 1610 1620 TGEVLSVFQA VLRGLIDYET GIRLLEAQLV ITGLISPELR KCFDLRDAES HGLIDEQVLR 1630 1640 1650 1660 1670 1680 QLKELNRAKQ LISTASPTSI PVLDSLAQGM VSESMAIRVL EILLSAGPLL VPATGEHLTL 1690 1700 1710 1720 1730 1740 QQAFQQNLIS SALFSKVLER QDTCKDLIDP CTSEKVSLTD MVQRSILQEN TRMWLLPVRP 1750 1760 1770 1780 1790 1800 QEAGRITLKC GRSVSILRAA HEGLIDRETM FRLLGAQLLS GGLIDCNSGQ KMTVEEAVAE 1810 1820 1830 1840 1850 1860 GVIDRDTASS ILTYQVQTGG IVHSNPAKRL TVDEAVQCEL ITSSSALLVL EAQRGYVGLI 1870 1880 1890 1900 1910 1920 WPHSGEIFPT SSSLQQELIT NELASKILNG RQKIAALYIP ESSQVIGLDA AKQLGIIDNN 1930 1940 1950 1960 1970 1980 TASVLKDVKL PDKMPDLGDL EDCKNAKRWL SFCKFQPSTV HDYRQEEGGS DGEEPVTAQS 1990 2000 2010 2020 2030 2040 SEQTKKLFLS YLMVNSYMDA HTGQRLLLYD GDLDEAVSML LESCGAELGA DTSTRESLSV 2050 2060 2070 2080 2090 2100 LTIPDAFPDC ALSEEKHECS ADKCHYSHPG HKESLENAKW DMNEAFCKMG NNDSNGELPR 2110 2120 2130 2140 2150 2160 PENLADTTVV QKGSESPSRV RVPKPTSSST QPEGSVLRPE SGSILKGCKS QSEPVTKKYP 2170 2180 2190 2200 2210 2220 DGTNHSHFLT SETSRPCDSN EREDEENIQK GPSVFDYSPR LSALLSHDEL RQSQGRFSDT 2230 2240 2250 2260 2270 2280 STPQNTGYLC EASTLSPSDQ RVLADQSTRE KFQDRFLGIA AISVSLQGAP CGQKPVDTEC 2290 2300 2310 2320 2330 2340 SSSQVHYHSE ESMSDASAES GATRQTDESE KTGSKVEDNS CTMVPGGGSR NDNTSDCGPL 2350 2360 2370 2380 2390 2400 SHKGAIDAGD YETSLLAGQQ SDTATDSDSD DYFYDTPLFE DEDHDSLILQ GDDRDCLQPE 2410 2420 2430 2440 2450 2460 DYDTSLQEEN DRTPPPDDIF YDVMKEKENP EFPHGGMDES LGVENKVCCP QGFPVGIEKP 2470 2480 2490 2500 2510 2520 ELYLAGEKEF NSGGSEQLVE SVSESENPPG LWDSESDSLT EGEIIGRKER LGASLTPDGH 2530 2540 2550 2560 2570 2580 WRGDREECDT SRESQSDTDG VGSIQSSESY RPYMSDGSDL DEEDNGGRSS EDSGDGRGGQ 2590 2600 2610 2620 2630 2640 GVADEGGEPQ YQADPTQLYT AIRKEHGGET QNVSDMIPLD KTHSYSPLET QHGAGVFQPE 2650 2660 2670 2680 2690 2700 SAGKGGWDTE RSSHPELTTE ADEEDEASLS THMATKGVSL SNAEGTASEE IRLVQGPDSS 2710 2720 2730 2740 2750 2760 GILKAEDLEN VSPEISPSSD NIVRSEAELG GGASEDGHLS FTGSDRDQQG PGRGLVKGRD 2770 2780 2790 2800 2810 2820 GQSDKLVDET SIREMGFQKE GVLMSSPEEG GEEERDLEPF PNGSATESLN MGKSQVPPLL 2830 2840 2850 2860 2870 2880 THTEELSHRG APHTTTMTTT MTLEGEAKNV QTGLTESPVL LETLAEIFDT PASKVTRADL 2890 2900 2910 2920 2930 2940 TSAVTASEMK SQVKEDSLTG GPEKETGPCT SLGHCDKCIH VDMLEPNEHT PSCALVAPPT 2950 2960 2970 2980 2990 3000 VKDNLCSVNN AGEKSVRPQE DWPPAAEVRL SDACVEESIS EGKAGILQFT PENSDSTLSR 3010 3020 3030 3040 3050 3060 LPHQSVAGWG KSADSVQARL PVSGVRHTSA DTLDVGCPQL ESSREKASAE EEPHRERALS 3070 3080 3090 3100 3110 3120 LKPQEREHHM LGFVEDGRSI LKSSLDKVHM NLQEVGDPSA GTGTKISIQN LIRRAILSEL 3130 3140 3150 3160 3170 3180 PNEVSNVPSH GISPISNSSE VRAESGGDPF CITSFLHLLK QNQPPQETPG ISELAKVLTQ 3190 3200 3210 3220 3230 3240 MDCDPEQRGL GSELLPPQLK NAFYKLLFDG YATEKDQAEA LGQTSCAVPK MAEEKPHVCS 3250 3260 3270 3280 3290 3300 DLRNKEGHHC PLNPQAVGEA EVEPFSVHIA ALPGGEKLGE LCSEPPEHSE STSGSKERSS 3310 3320 3330 3340 3350 3360 DGSSKEKCSN GLQQCLQHTE KMHEYLVLLQ DMKPPLDNQA SVESSLEALK SQLKQLEAFE 3370 3380 3390 3400 3410 3420 LGLAPIAVFL RKDLKLAEEF LKSFPSDLPR RHHEELSKSH QRLQNAFSSL SSVSSERMKL 3430 3440 3450 3460 3470 3480 IKLAINSEMS KLAVRHEDFL HKLTSYSDWV SEKSRSVKAI QTVNVQDTEL VKNSVKFLKN 3490 3500 3510 3520 3530 3540 VLADLSHTKM QLETTAFDVQ SFISDYAQDL SPSQSRQLLR LLNTTQKGFL DLQELVTTEA 3550 3560 3570 3580 3590 3600 DRLEALLQLE QELGHQKVVA ERQQEYREKL QGLCDLLTQT ENRLISNQEA FVIGDGTVEL 3610 3620 3630 3640 3650 3660 QKYQSKQEEL QRDMQGSTQA MEEIVRNTEL FLKESGDELS QADRALIEQK LNEVKMKCAQ 3670 3680 3690 3700 3710 3720 LNLKAEQSRK ELDKAVTTAL KEETEKVAAV RQLEESKTKI ENLLNWLSNV EEDSEGVWTK 3730 3740 3750 3760 3770 3780 HTQPMEQNGT YLHEGDSKLG AGEEDEVNGN LLETDAEGHS EATKGNLNQQ YEKVKAQHGK 3790 3800 3810 3820 3830 3840 IMAQHQAVLL ATQSAQVLLE KQGHYLSPEE KEKLQKNTQE LKVHYEKVLA ECEKKVKLTH 3850 3860 3870 3880 3890 3900 SLQEELEKFD TDYSEFEHWL QQSEQELANL EAGADDLSGL MDKLTRQKSF SEDVISHKGD 3910 3920 3930 3940 3950 3960 LRYITISGNR VIDAAKSCSK RDSDRIGKDS VETSATHREV QTKLDQVTDR FRSLYSKCSV 3970 3980 3990 4000 4010 4020 LGNNLKDLVD QYQQYEDASC GLLSGLQACE AKASKHLREP IALDPKNLQR QLEETKALQG 4030 4040 4050 4060 4070 4080 QISSQQVAVE KLKKTAEVLL DAKGSLLPAK NDIQKTLDDI VGRYDDLSKC VNERNEKLQI 4090 4100 4110 4120 4130 4140 TLTRSLSVQD ALDEMLDWMG SVESSLVKPG QVPLNSTALQ DLISKDTMLE QDITGRQSSI 4150 4160 4170 4180 4190 4200 NAMNEKVKTF IETTDPSTAS SLQAKMKDLS ARFSEASQKH KEKLAKMVEL KAKVEQFEKL 4210 4220 4230 4240 4250 4260 SDKLQTFLET QSQALTEVAM PGKDVPELSQ HMQESTAKFL EHRKDLEALH SLLKEISSHG 4270 4280 4290 4300 4310 4320 LPGDKALVFE KTNNLSRKFK EMEDTIQEKK DALSSCQEQL SAFQTLAQSL KTWIKETTKQ 4330 4340 4350 4360 4370 4380 VPVVKPSLGT EDLRKSLEET KKLQEKWNLK APEIHKASNS GVSLCNLLSA LISPAKAIAA 4390 4400 4410 4420 4430 4440 AKSGGVILNG EGTDTNTQDF LANKGLTSIK KDMTDISHSY EDLGLLLKDK IVELNTKLSK 4450 4460 4470 4480 4490 4500 LQKAQEESSA MMQWLEKMNK TASRWRQTPT PADTESVKLQ VEQNKSFEAE LKQNVNKVQE 4510 4520 4530 4540 4550 4560 LKDKLSELLE ENPEAPEAQS WKQALAEMDT KWQELNQLTM DRQQKLEESS NNLTQFQTTE 4570 4580 4590 4600 4610 4620 AQLKQWLMEK ELMVSVLGPL SIDPNMLNTQ KQQVQILLQE FDTRKPQYEQ LTAAGQGILS 4630 4640 4650 4660 4670 4680 RPGEDPSLHG IVNEQLEAVT QKWDNLTGQL RDRCDWIDQA IVKSTQYQSL LRSLSGTLTE 4690 4700 4710 4720 4730 4740 LDDKLSSGLT SGALPDAVNQ QLEAAQRLKQ EIEQQAPKIK EAQEVCEDLS ALVKEEYLKA 4750 4760 4770 4780 4790 4800 ELSRQLEGIL KSFKDIEQKT ENHVQHLQSA CASSHQFQQM SKDFQAWLDA KKEEQRDSPP 4810 4820 4830 4840 4850 4860 ISAKLDVLES LLNSQKDFGK TFTEQSNIYE KTISEGENLL LKTQGAEKAA LQLQLNTMKT 4870 4880 4890 4900 4910 4920 DWDRFRKQVK EREEKLKDSL EKALKYREQV ETLRPWIDRC QHSLDGVTFS LDPTESESSI 4930 4940 4950 4960 4970 4980 AELKSLQKEM DHHFGMLELL NNTANSLLSV CEVDKEAVTE ENQSLMEKVN RVTEQLQSKT 4990 5000 5010 5020 5030 5040 VSLENMAQKF KEFQEVSRDT QRQLQDTKEQ LEVHHSLGPQ AYSNKHLSVL QAQQKSLQTL 5050 5060 5070 5080 5090 5100 KQQVDEAKRL AQDLVVEAAD SKGTSDVLLQ AETLAEEHSE LSQQVDEKCS FLETKLQGLG 5110 5120 5130 5140 5150 5160 HFQNTIREMF SQFTECDDEL DGMAPVGRDA ETLRKQKACM QTFLKKLEAL MASNDSANRT 5170 5180 5190 5200 5210 5220 CKMMLATEET SPDLIGVKRD LEALSKQCNK LLDRAKTREE QVDGATEKLE EFHRKLEEFS 5230 5240 5250 5260 5270 5280 TLLQKAEEHE ESQGPVGTET ETINQQLDVF KVFQKEEIEP LQVKQQDVNW LGQGLIQSAA 5290 5300 5310 5320 5330 5340 ANTCTQGLEH DLDSVNSRWK TLNKKVAQRT SQLQEALLHC GRFQDALESL LSWMADTEEL 5350 5360 5370 5380 5390 5400 VANQKPPSAE FKVVKAQIQE QKLLQRLLED RKSTVEVIKR EGEKIAASAE PADRVKLTRQ 5410 5420 5430 5440 5450 5460 LSLLDSRWEA LLSRAEARNR QLEGISVVAQ EFHGTLEPLN EWLTAVEKKL ANSEPIGTQA 5470 5480 5490 5500 5510 5520 PKLEEQISQH KALQEDILLR KQSVDQALLN GLELLKQTTG DEVLIIQDKL EAIKARYKDI 5530 5540 5550 5560 5570 5580 TKLSADVAKT LEHALQLAGQ LQSMHKELCN WLDKVEVELL SYETQGLKGE AASQVQERQK 5590 5600 5610 5620 5630 5640 ELKNEVRSNK ALVDSLNEVS SALLELVPCR AKEGLEKTIA DDNEPLPDCE PTQSRHKVEE 5650 5660 5670 5680 5690 5700 IDAAILRSQQ FEQAADAELS WITETQKKLM SLGDIRLEQD QTSAQLQVQK AFTMDILRHK 5710 5720 5730 5740 5750 5760 DIIDELVTSG HKIMTTSGEE EKQSMKKKLD KVLKKYDAVC QINSERHLQL ERAQSLVSQF 5770 5780 5790 5800 5810 5820 WETYEELWPW LTETQRIISQ LPAPALEYET FERQQEEHRQ LRELIAEHKP HIDKMNKTGP 5830 5840 5850 5860 5870 5880 QLLELSPKEG IYIQEKYVAA DTLYSQIKED VKKRAVVLDE AISQSTQFHD KIDQILESLE 5890 5900 5910 5920 5930 5940 RIAERLRQPP SISAEVEKIK EQIGENKSVS VDMEKLQPLY ETLRQRGEEM IARSEGTEKD 5950 5960 5970 5980 5990 6000 VSARAVQDKL DQMVFIWGSI HTLVEEREAK LLDVMELAEK FWCDHMSLVV TIKDTQDFIR 6010 6020 6030 6040 6050 6060 DLEDPGIDPS VVKQQQEAAE AIREEIDGLQ EELDMVITLG SELIAACGEP DKPIVKKSID 6070 6080 6090 6100 6110 6120 ELNSAWDSLN KAWKDRVDRL EEAMQAAVQY QDGLQGIFDW VDIAGDKLAT MSPIGTDLET 6130 6140 6150 6160 6170 6180 VKQQIEELKQ FKSEAYQQQM EMERLNHQAE LLLKKVTEEA DKHTVQDPLM ELKLIWDSLD 6190 6200 6210 6220 6230 6240 ERIVSRQHKL EGTLLALGQF QHALDELLAW LTHTKGLLSE QKPVGGDPKA IEIELAKHHV 6250 6260 6270 6280 6290 6300 LQNDVLAHQS TVEAVNKAGN DLIESSEGEE ASNLQYKLRI LNQRWQDILE KTDQRKQQLD 6310 6320 6330 6340 6350 6360 SALRQAKGFH GEIEDLQQWL TDTERHLLAS KPLGGLPETA KEQLNAHMEV CTAFAIKEET 6370 6380 6390 6400 6410 6420 YKSLMLRGQQ MLARCPRSAE TNIDQDITNL KEKWESVKSK LNEKKTKLEE ALHLAMNFHN 6430 6440 6450 6460 6470 6480 SLQDFINWLT QAEQTLNVAS RPSLILDTIL FQIDEHKVFA NEVNSHREQI IELDKTGTHL 6490 6500 6510 6520 6530 6540 KYFSQKQDVV LIKNLLISVQ SRWEKVVQRL VERGRSLDEA RKRAKQFHEA WSKLMEWLEE 6550 6560 6570 6580 6590 6600 SEKSLDSELE IANDPDKIKA QLVQHKEFQK SLGGKHSVYD TTNRTGRSLK EKTSLADDNL 6610 6620 6630 6640 6650 6660 KLDNMLSELR DKWDTICGKS VERQNKLEEA LLFSGQFTDA LQALIDWLYR VEPQLAEDQP 6670 6680 6690 6700 6710 6720 VHGDIDLVMS LIDNHKVFQK ELGKRTSSVQ ALKRSARELI EGSRDDSSWV RVQMQELSTR 6730 6740 6750 6760 6770 6780 WETVCALSIS KQTRLESALQ QAEEFHSVVH TLLEWLAEAE QTLRFHGALP DDEDALRTLI 6790 6800 6810 6820 6830 6840 EQHKEFMKRL EEKRAELSKA TGMGDALLAV CHPDSITTIK HWITIIQARF EEVLAWAKQH 6850 6860 6870 6880 6890 6900 QQRLAGALAG LIAKQELLET LLAWLQWAET TLTEKDKEVI PQEIEEVKTL IAEHQTFMEE 6910 6920 6930 6940 6950 6960 MTRKQPDVDK VTKTYKRRAT DPPSLQSHIP VLDKGRAGRK RFPASGFYPS GSQTQIETKN 6970 6980 6990 7000 7010 7020 PRVNLLVSKW QQVWLLALER RRKLNDALDR LEELREFANF DFDIWRKKYM RWMNHKKSRV 7030 7040 7050 7060 7070 7080 MDFFRRIDKD QDGKITRQEF IDGILSSKFP TSRLEMSAVA DIFDRDGDGY IDYYEFVAAL 7090 7100 7110 7120 7130 7140 HPNKDAYKPI TDADKIGDEV TRQVAKCKCA KRFQVEQIGD NKYRFFLGNQ FGDSQQLRLV 7150 7160 7170 7180 7190 7200 RILRSTVMVR VGGGWMALDE FLVKNDPCRA KGRTNMELRE KFILADGASQ GMAAFRPRGR 7210 7220 7230 7240 7250 7260 RSRPSSRGAS PNRSTSGSSH ACQAASPPVP AAASTPKILH PLTRNYGKPW LANSKMSTPC 7270 7280 7290 7300 7310 7320 KAAECPDFPV SSAEGTPIQG SKLRLPGYLS GKGFHSGEDS ALITTAAARV RTQFAESRKT 7330 7340 7350 7360 7370 7380 PSRPGSRAGS KAGSRASSRR GSDASDFDIS EIQSVCSDVE TVPQTHRPVP RAGSRPSTAK 7390 7400 PSKIPTPQRR SPASKLDKSS KR
	Isoform 5 (BPAG1-e) [UniParc]. Checksum: 56CA2AC3D1215E91	FASTA	2,611	301,692
	10 20 30 40 50 60 MRISCPFIVV PLINSCISFS NESLDGHRLD MLQQIATRVQ RDSVSCEDKL ILARNALQSD 70 80 90 100 110 120 SKRLESGVQF QNEAEIAGYI LECENLLRQH VIDVQILIDG KYYQADQLVQ RVAKLRDEIM 130 140 150 160 170 180 ALRNECSSVY SKGRMLTTEQ TKLMISGITQ SLNSGFAQTL HPSLNSGLTQ SLTPSLTSSS 190 200 210 220 230 240 VTSGLSSGMT SRLTPSVTPV YAPGFPSVVA PNFSLGVEPN SLQTLKLMQI RKPLLKSSLL 250 260 270 280 290 300 DQNLTEEEVN MKFVQDLLNW VDEMQVQLDR TEWGSDLPSV ESHLENHKNV HRAIEEFESS 310 320 330 340 350 360 LKEAKISEIQ MTAPLKLSYT DKLHRLESQY AKLLNTSRNQ ERHLDTLHNF VTRATNELIW 370 380 390 400 410 420 LNEKEESEVA YDWSERNSSV ARKKSYHVEL MRELEQKEES IKAVQEIAEQ LLLENHPARL 430 440 450 460 470 480 TIEAYRAAMQ TQWSWILQLC QCVEQHIQEN SAYFEFFNDA KEATDYLRNL KDAIQRKYSC 490 500 510 520 530 540 DRSSSIHKLE DLVQESMEKE ELLQYRSVVA GLMGRAKTVV QLKPRNPDNP LKTSIPIKAI 550 560 570 580 590 600 CDYRQIEITI YKDDECVLAN NSHRAKWKVI SPTGNEAVVP SVCFTVPPPN KEAVDFANRI 610 620 630 640 650 660 EQQYQSVLTL WHESHINMKS VVSWHYLVNE IDRIRASNVA SIKTMLPGEH QQVLSNLQSR 670 680 690 700 710 720 LEDFLEDSQE SQIFSGSDIS QLEKEVSVCR KYYQELLKSA EREEQEESVY NLYISEVRNI 730 740 750 760 770 780 RLRLESCEDR LIRQIRTPLE RDDLHESMLR ITEQEKLKKE LDRLKDDLGT ITNKCEEFFS 790 800 810 820 830 840 QAADSPSVPA LRSELSVVIQ SLSQIYSMSS TYIEKLKTVN LVLKNTQAAE ALVKLYETKL 850 860 870 880 890 900 CEEEAVIADK NNIENLMSTL KQWRSEVDEK REVFHALEDE LQKAKAISDE MFKTHKERDL 910 920 930 940 950 960 DFDWHKEKAD QLVERWQSVH VQIDNRLRDL EGIGKSLKHY RDSYHPLDDW IQHIETTQRK 970 980 990 1000 1010 1020 IQENQPENSK ALALQLNQQK MLVSEIEVKQ SKMDECQKYS EQYSAAVKDY ELQTMTYRAM 1030 1040 1050 1060 1070 1080 VESQQKSPVK RRRIQSSADL VIQEFMDLRT RYTALVTLMT QYIKFAGDSL KRLEEEEMKR 1090 1100 1110 1120 1130 1140 SKENSEHGAY SDLLQRQRAT MVENSKLTGK ISELETMVAE LKKQKSRVEE ELPKVKEAAE 1150 1160 1170 1180 1190 1200 NELRKQQRNV EDIALQKLRA ESEAKQYRRE LETIVREKEA AERELERVRQ LTAEAEARRA 1210 1220 1230 1240 1250 1260 AVEENLRNFR SQLQENTFTR QTLEDHLRRK DSSLSDLEQQ KRALVEELQR KRDHEEELLR 1270 1280 1290 1300 1310 1320 LVKQMERDLA FQKQVAEKQL KEKQKVELEA RRKITEIQFS CRESAAVAQA RPQREQGRQK 1330 1340 1350 1360 1370 1380 EEELKQQVDE LTLANRKAEK EMRELKYELS AVQLEKASSE EKARLLKDKL DETNNTLKCL 1390 1400 1410 1420 1430 1440 KEDLERKDQA QERYSQQLRD LGGQLNQTTD KAEEVRQEAN DLKKIKHTYQ LELESLHQEK 1450 1460 1470 1480 1490 1500 GKLQREVDRV TRAHALAERN IQCLNSQVHA SRDEKDLSEE RRRLCQRKSD HLKEEFERSH 1510 1520 1530 1540 1550 1560 AQLLQNIQAE KENNDKIQKL NKELEKSNEC AETLKQKVDE LTRQNNETKL MMQRIQAESK 1570 1580 1590 1600 1610 1620 NIVREKQAIQ QRCEVLRIQA DGFKDQLRNT NEHLHKQTKT EQDFHRKIKS LEDDLAQSQN 1630 1640 1650 1660 1670 1680 LVSEFKQKCD QQSMIIQKTE KEVRSLSAEL SASKEEKRRE EQKAQLQRAQ VQELNDRLKR 1690 1700 1710 1720 1730 1740 VQDELHLKTI EEQMTHRKMI LLQEESDKFK RSADEFRKKM EKLMESKVVT ETDLSGIKHD 1750 1760 1770 1780 1790 1800 FVSLQRENFR AQENAKLWET NIRELERQLQ CYREKMQQGP PVEANHYQKC RRLEEELLAQ 1810 1820 1830 1840 1850 1860 RREVENLKQK MDQQIKEHEH QLLRLQCEIQ KKSTTQDHTF ASAFDTAGRE CHHPAEISPG 1870 1880 1890 1900 1910 1920 NSGHLNLKTR LPLSRWTQEP HQTEGKWPHR AAEQLPKEVQ FRQPGAPLDR ESSQPCYSEY 1930 1940 1950 1960 1970 1980 FSQTSTELQI TFDDKNPITR LSELETMREQ ALHPSRPPVT YQDDKLEREL VKLLTPLEIA 1990 2000 2010 2020 2030 2040 KNKQCGMHTE VTTLKQEKRL GSSAGGWMLE GCRTSGGLKG DFLKKSVEPE ASPSLDLNQA 2050 2060 2070 2080 2090 2100 CSVRDEEFQF QGLRHTVTGR QLVEAKLLDM RTVEQLRLGL KTVEEVQRSL SKFLTKATSI 2110 2120 2130 2140 2150 2160 AGLYLESSKE KMSFTSAAQK IIIDKMIALA FLEAQAATGF IIDPVSGQTY CVEDAVLHGI 2170 2180 2190 2200 2210 2220 VDPEFRSRLL EAEKAVLGYS HASKTLSVFQ AMENRMLDRK KGKHILEAQI ASGGVIDPVR 2230 2240 2250 2260 2270 2280 GVRVPPEMAV QQGLLNNAVL QFLHEPSSNT RVFPNPNNKQ ALYYSELLQI CVFDVDCQCF 2290 2300 2310 2320 2330 2340 LLPFGEREIS NLNIEKTHKI AVVDTKTGAE LTAFEAFQRN LIDKGIYLEL SGQQYQWKEA 2350 2360 2370 2380 2390 2400 TFFDSYGHPS HMLTDTKTGL QFNISEAVEQ GTLDKALVQK YQEGLTTLTE LADFLLSKVV 2410 2420 2430 2440 2450 2460 PKKDLHSPIA GYWLTASGER ISLLKASRRN LVDRVTALRC LEAQICTGGI IDPLTGKKYR 2470 2480 2490 2500 2510 2520 VAEALHRGLV DEGFAQQLRQ CELVITGISH PVSNKMMSVV EAVNANIISK EMGMRCLEFQ 2530 2540 2550 2560 2570 2580 YLTGGLIEPK VFSRLTIEEA LHVGIIDVLI ATRLKDQKSY VRDIMCPQTK RKLTYKEALE 2590 2600 2610 KADFDFHTGL KLLEVSEPLG TGISNLYYSS Q
	Isoform 6 (BPAG1n) (BPAG1-n1) (BPAG1-n2) (BPAG1a2) (dystonin-2) [UniParc]. Checksum: A40496BA1F6125BD	FASTA	482	55,058
	10 20 30 40 50 60 MIAAAFLVLL RPYSIQCALF LLLLLLGTVA TIVFFCCWHR KLQKGRHPMK SVFSGRSRSR 70 80 90 100 110 120 DAALRSHHFR SEGFRASPRH IRRRVAAAAA ARLEEVKPVV EVHHQSEQES SGRKRRIKKN 130 140 150 160 170 180 SRVQPEFYHS VQGASTRRPS SGNASYRCSM SSSADFSDED DFSQKSGSAS PAPGDTLPWN 190 200 210 220 230 240 LPKHERSKRK IQGGSVLDPA ERAVLRIADE RDKVQKKTFT KWINQHLMKV RKHVNDLYED 250 260 270 280 290 300 LRDGHNLISL LEVLSGDTLP REKGRMRFHR LQNVQIALDY LKRRQVKLVN IRNDDITDGN 310 320 330 340 350 360 PKLTLGLIWT IILHFQISDI HVTGESEDMS AKERLLLWTQ QATEGYAGVR CENFTTCWRD 370 380 390 400 410 420 GKLFNAIIHK YRPDLIDMNT VAVQSNLANL EHAFYVAEKI GVIRLLDPED VDVSSPDEKS 430 440 450 460 470 480 VITYVSSLYD AFPKVPEGGE GIGANDVEVK WIEYQNMVNY LIQWIRHHVV TMSERTFPNN PL
	Isoform 7 (BPAG1a3) [UniParc]. Checksum: 7258EC5F1E2DA4E7	FASTA	388	42,618
	10 20 30 40 50 60 MGNVCGCVRA EKEEPYFDPA KSPLSPEKYS PGRKYFRRKP CQKVVDDTEP VRQSSEREGK 70 80 90 100 110 120 KGVSQPAGGQ PAVSSGELPW EDPAASPTKE DAVQLGKRAA TEHGDQKPLP SSVDGYPHRV 130 140 150 160 170 180 TVSSAQGRYS EVQVSIPDKI ISEEDSPPYC PETERHLDDV NSKHRTFLRK DNVSLSQTAA 190 200 210 220 230 240 SSSPILCVTE KSLKNSALMG NLSRSCHSVL EQDSDERGHP FGVHRLQLTK RRCHSLSSGV 250 260 270 280 290 300 SCVSKDAPRD DGCQISDIHV TGESEDMSAK ERLLLWTQQA TEGYAGVRCE NFTTCWRDGK 310 320 330 340 350 360 LFNAIIHKYR PDLIDMNTVA VQSNLANLEH AFYVAEKIGV IRLLDPEDVD VSSPDEKSVI 370 380 TYVSSLYDAF PKVPEGGEGI GANDVEKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The BPAG1 locus: alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles." Leung C.L., Zheng M., Prater S.M., Liem R.K.H. J. Cell Biol. 154:691-697(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ALTERNATIVE SPLICING. Strain: BALB/c. Tissue: Epithelium, Muscle and Neuron.
[2]	"The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1." Brown A., Bernier G., Mathieu M., Rossant J., Kothary R. Nat. Genet. 10:301-306(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-511 (ISOFORM 2), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Brain.
[3]	"A Bpag1 isoform involved in cytoskeletal organization surrounding the nucleus." Young K.G., Pinheiro B., Kothary R. Exp. Cell Res. 312:121-134(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304 (ISOFORM 6), ALTERNATIVE SPLICING (ISOFORMS 2 AND 6), SUBCELLULAR LOCATION (ISOFORMS 2 AND 6). Strain: C3H.
[4]	"Dissecting the sequence specific functions of alternative N-terminal isoforms of mouse bullous pemphigoid antigen 1." Jefferson J.J., Leung C.L., Liem R.K. Exp. Cell Res. 312:2712-2725(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-270 (ISOFORM 7), ALTERNATIVE SPLICING (ISOFORMS 1; 6 AND 7), FUNCTION OF ISOFORMS 1; 6 AND 7, PALMITOYLATION, MYRISTOYLATION, MUTAGENESIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: C57BL/6 X CBA.
[5]	"Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily." Jefferson J.J., Ciatto C., Shapiro L., Liem R.K. J. Mol. Biol. 366:244-257(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 580-584; 1043-1047 AND 1053-1057, X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 580-803.
[6]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6693-7389 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6870-7389 (ISOFORM 4). Strain: C57BL/6J. Tissue: Fetal skin and Fetal spinal cord.
[7]	"The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons." Leung C.L., Sun D., Liem R.K. J. Cell Biol. 144:435-446(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH PRPH. Strain: BALB/c.
[8]	"Molecular network in NGF-mediated neural differentiation." Kubo Y., Ohba M., Iwashita S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Strain: Swiss Webster / NIH.
[9]	"Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration." Guo L., Degenstein L., Dowling J., Yu Q.C., Wollmann R., Perman B., Fuchs E. Cell 81:233-243(1995) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 5), DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION (ISOFORM 5), TISSUE SPECIFICITY.
[10]	"An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Yang Y., Dowling J., Yu Q.C., Kouklis P., Cleveland D.W., Fuchs E. Cell 86:655-665(1996) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 5 AND 6), SUBCELLULAR LOCATION (ISOFORMS 5 AND 6), TISSUE SPECIFICITY.
[11]	"Integrators of the cytoskeleton that stabilize microtubules." Yang Y., Bauer C., Strasser G., Wollman R., Julien J.P., Fuchs E. Cell 98:229-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[12]	"Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture." Dalpe G., Mathieu M., Comtois A., Zhu E., Wasiak S., De Repentigny Y., Leclerc N., Kothary R. Dev. Biol. 210:367-380(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DES, DISRUPTION PHENOTYPE.
[13]	"BPAG1n4 is essential for retrograde axonal transport in sensory neurons." Liu J.J., Ding J., Kowal A.S., Nardine T., Allen E., Delcroix J.D., Wu C., Mobley W., Fuchs E., Yang Y. J. Cell Biol. 163:223-229(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[14]	"Bpag1 localization to actin filaments and to the nucleus is regulated by its N-terminus." Young K.G., Pool M., Kothary R. J. Cell Sci. 116:4543-4555(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 2; 5 AND 6), HOMODIMERIZATION, MUTAGENESIS OF ARG-1385 AND ARG-1386, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[15]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Brain.
[16]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[17]	"Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons." Young K.G., Kothary R. Exp. Cell Res. 314:2750-2761(2008) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 6), INTERACTION WITH SYNE3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[18]	"BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin." Steiner-Champliaud M.F., Schneider Y., Favre B., Paulhe F., Praetzel-Wunder S., Faulkner G., Konieczny P., Raith M., Wiche G., Adebola A., Liem R.K., Langbein L., Sonnenberg A., Fontao L., Borradori L. Exp. Cell Res. 316:297-313(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INTERACTION WITH PLEC, SUBCELLULAR LOCATION (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[19]	"Hearts of dystonia musculorum mice display normal morphological and histological features but show signs of cardiac stress." Boyer J.G., Bhanot K., Kothary R., Boudreau-Lariviere C. PLoS ONE 5:E9465-E9465(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION OF ISOFORM 2, SUBCELLULAR LOCATION (ISOFORM 2), TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF396877 mRNA. Translation: AAK83382.1.
AF396878 mRNA. Translation: AAK83383.1.
AF396879 mRNA. Translation: AAK83384.1.
U22452 mRNA. Translation: AAC52230.1.
U25158 mRNA. Translation: AAC52231.1. Frameshift.
DQ023311 mRNA. Translation: AAY46942.1.
DQ463750 mRNA. Translation: ABF00406.1.
AK051626 mRNA. Translation: BAC34695.1.
AK037206 mRNA. Translation: BAC29753.1.
AF115383 mRNA. Translation: AAD22959.1.
AB085694 mRNA. Translation: BAB93448.1.

PIR

A60776.
I49290.
I49298.

UniGene

Mm.336625.
Mm.478284.
Mm.487428.

3D structure databases

PDBe
RCSB-PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2IAK	X-ray	3.00	A	580-803	[»]

ProteinModelPortal

Q91ZU6.

SMR

Q91ZU6. Positions 31-255, 268-479, 583-1051, 1553-1927, 4476-4570, 5208-5532, 6115-6480, 7098-7170.

ModBase

Search...

MobiDB

Search...

Protein-protein interaction databases

IntAct

Q91ZU6. 5 interactions.

MINT

MINT-1861530.

STRING

10090.ENSMUSP00000095392.

Chemistry

ChEMBL

CHEMBL2176789.

2D gel databases

REPRODUCTION-2DPAGE

IPI00230689.
IPI00230690.
IPI00284272.

Proteomic databases

MaxQB

Q91ZU6.

PaxDb

Q91ZU6.

PRIDE

Q91ZU6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

UCSC

uc007aof.1. mouse. [Q91ZU6-6]

Organism-specific databases

MGI

MGI:104627. Dst.

Phylogenomic databases

eggNOG

COG5069.

HOVERGEN

HBG031127.

PhylomeDB

Q91ZU6.

Gene expression databases

CleanEx

MM_DST.

Genevestigator

Q91ZU6.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.
1.10.418.10. 2 hits.
3.30.920.20. 1 hit.
3.90.1290.10. 3 hits.

InterPro

IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR003108. GAS2_dom.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]

Pfam

PF00307. CH. 2 hits.
PF13499. EF-hand_7. 1 hit.
PF02187. GAS2. 1 hit.
PF00681. Plectin. 5 hits.
PF00435. Spectrin. 18 hits.
[Graphical view]

SMART

SM00033. CH. 2 hits.
SM00054. EFh. 2 hits.
SM00243. GAS2. 1 hit.
SM00250. PLEC. 9 hits.
SM00150. SPEC. 32 hits.
[Graphical view]

SUPFAM

SSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
SSF75399. SSF75399. 2 hits.

PROSITE

PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51460. GAR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DST. mouse.

EvolutionaryTrace

Q91ZU6.

NextBio

284082.

PRO

Q91ZU6.

SOURCE

Search...

Entry information

Entry name

DYST_MOUSE

Accession

Primary (citable) accession number: Q91ZU6
Secondary accession number(s): Q1KP04 , Q3I6J6, Q60824, Q60845, Q8K5D4, Q91ZU7, Q91ZU8, Q9WU50

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	December 1, 2001
Last modified:	July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program