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Protein

Ankyrin repeat and SOCS box protein 6

Gene

Asb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 6
Short name:
ASB-6
Gene namesi
Name:Asb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919573. Asb6.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669341 – 418Ankyrin repeat and SOCS box protein 6Add BLAST418

Proteomic databases

EPDiQ91ZU1.
MaxQBiQ91ZU1.
PaxDbiQ91ZU1.
PRIDEiQ91ZU1.

PTM databases

iPTMnetiQ91ZU1.
PhosphoSitePlusiQ91ZU1.

Expressioni

Tissue specificityi

Detected in adipocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000039483.
CleanExiMM_ASB6.
ExpressionAtlasiQ91ZU1. baseline and differential.
GenevisibleiQ91ZU1. MM.

Interactioni

Subunit structurei

Binds APS. Identified in a complex with TCEB1 and TCEB2. Interacts with CUL5 and RNF7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi215308. 3 interactors.
STRINGi10090.ENSMUSP00000043462.

Structurei

3D structure databases

ProteinModelPortaliQ91ZU1.
SMRiQ91ZU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 95ANK 1Add BLAST31
Repeati100 – 129ANK 2Add BLAST30
Repeati134 – 164ANK 3Add BLAST31
Repeati168 – 203ANK 4Add BLAST36
Repeati224 – 253ANK 5Add BLAST30
Repeati258 – 287ANK 6Add BLAST30
Domaini358 – 413SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000006784.
HOGENOMiHOG000231756.
HOVERGENiHBG037329.
InParanoidiQ91ZU1.
KOiK10328.
OMAiFCFQVTQ.
OrthoDBiEOG091G07QG.
PhylomeDBiQ91ZU1.
TreeFamiTF330837.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLHGFRRI IFEYQPLVDA ILGALGIQDL ERQEPLDDSA SSEESRILVL
60 70 80 90 100
TELLEQKAHS PFYQEGVSNA LLKMAELGLT RAAAVLLQSG ANLNFEDPVT
110 120 130 140 150
YYTALHIAVL RNQPDMVELL VRHGADINRR DRIHESSPLD LASEEPERLP
160 170 180 190 200
CLQRLLDLGA DVNAADKNGK TALLHALASS DGVQIHNTEN IRLLLEGGAD
210 220 230 240 250
VKATTKDGDT VFTCIIFLLG ETVCGDKEEA PMINRFCFQV TQLLLAHGAD
260 270 280 290 300
PSECPAHESL THICLKSFKL HFPLLCFLLE SGAAYNCSLH GASCWSGFNL
310 320 330 340 350
VFERLCSHPG CAEDDSHIEL LHKAETVLDL MVTSSQRLQL PENLNIHPVG
360 370 380 390 400
SLAGKIQALH ASLRQLESYP PPLKHLCRVS IRLCLRPWPV DTKVKALPLP
410
DRLKWYLLSA HSDTQDTC
Length:418
Mass (Da):46,276
Last modified:December 1, 2001 - v1
Checksum:i04ADE4CC0CF6E964
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189E → D in AAH19192 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398967 mRNA. Translation: AAK97489.1.
BC019192 mRNA. Translation: AAH19192.1.
CCDSiCCDS38096.1.
RefSeqiNP_579924.1. NM_133346.2.
UniGeneiMm.27656.

Genome annotation databases

EnsembliENSMUST00000041726; ENSMUSP00000043462; ENSMUSG00000039483.
GeneIDi72323.
KEGGimmu:72323.
UCSCiuc008jcx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398967 mRNA. Translation: AAK97489.1.
BC019192 mRNA. Translation: AAH19192.1.
CCDSiCCDS38096.1.
RefSeqiNP_579924.1. NM_133346.2.
UniGeneiMm.27656.

3D structure databases

ProteinModelPortaliQ91ZU1.
SMRiQ91ZU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215308. 3 interactors.
STRINGi10090.ENSMUSP00000043462.

PTM databases

iPTMnetiQ91ZU1.
PhosphoSitePlusiQ91ZU1.

Proteomic databases

EPDiQ91ZU1.
MaxQBiQ91ZU1.
PaxDbiQ91ZU1.
PRIDEiQ91ZU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041726; ENSMUSP00000043462; ENSMUSG00000039483.
GeneIDi72323.
KEGGimmu:72323.
UCSCiuc008jcx.1. mouse.

Organism-specific databases

CTDi140459.
MGIiMGI:1919573. Asb6.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000006784.
HOGENOMiHOG000231756.
HOVERGENiHBG037329.
InParanoidiQ91ZU1.
KOiK10328.
OMAiFCFQVTQ.
OrthoDBiEOG091G07QG.
PhylomeDBiQ91ZU1.
TreeFamiTF330837.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ91ZU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039483.
CleanExiMM_ASB6.
ExpressionAtlasiQ91ZU1. baseline and differential.
GenevisibleiQ91ZU1. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB6_MOUSE
AccessioniPrimary (citable) accession number: Q91ZU1
Secondary accession number(s): Q8VEC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.