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Protein

Ankyrin repeat and SOCS box protein 7

Gene

Asb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 7
Short name:
ASB-7
Gene namesi
Name:Asb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2152835. Asb7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ankyrin repeat and SOCS box protein 7PRO_0000066937Add
BLAST

Proteomic databases

PaxDbiQ91ZU0.
PRIDEiQ91ZU0.

PTM databases

iPTMnetiQ91ZU0.
PhosphoSiteiQ91ZU0.

Expressioni

Gene expression databases

CleanExiMM_ASB7.
ExpressionAtlasiQ91ZU0. baseline and differential.
GenevisibleiQ91ZU0. MM.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122395.

Structurei

3D structure databases

ProteinModelPortaliQ91ZU0.
SMRiQ91ZU0. Positions 18-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4230ANK 1Add
BLAST
Repeati46 – 7530ANK 2Add
BLAST
Repeati80 – 10930ANK 3Add
BLAST
Repeati116 – 14530ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati180 – 20829ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Domaini265 – 31854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000013024.
HOVERGENiHBG037171.
InParanoidiQ91ZU0.
KOiK10329.
OMAiDHSANID.
OrthoDBiEOG790G10.
TreeFamiTF331695.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL
60 70 80 90 100
LHFSAARGKE RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM
110 120 130 140 150
LESEYRSDII NAKSNDGWTP LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG
160 170 180 190 200
TTPLQLAIIR ERSSCVKILL DHNANIDIQN GFLLRYAVIK SNHSYCRMFL
210 220 230 240 250
QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT NTRNYEGQTP
260 270 280 290 300
LAVSISISGS SRPCLDFLQD VTRQPRTLQD LCRIKIRQCI GLQNLKLLDE
310
LPIAKVMKDY LKHKFDDI
Length:318
Mass (Da):35,984
Last modified:October 3, 2012 - v2
Checksum:iF725AF4F350DF83E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731R → S in AAK97490 (PubMed:11509662).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398968 mRNA. Translation: AAK97490.1.
AC115761 Genomic DNA. No translation available.
AC120791 Genomic DNA. No translation available.
CH466543 Genomic DNA. Translation: EDL07214.1.
CCDSiCCDS21346.1.
RefSeqiNP_536691.2. NM_080443.2.
XP_006540630.1. XM_006540567.2.
UniGeneiMm.34785.

Genome annotation databases

EnsembliENSMUST00000124899; ENSMUSP00000122395; ENSMUSG00000030509.
GeneIDi117589.
KEGGimmu:117589.
UCSCiuc009hhn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398968 mRNA. Translation: AAK97490.1.
AC115761 Genomic DNA. No translation available.
AC120791 Genomic DNA. No translation available.
CH466543 Genomic DNA. Translation: EDL07214.1.
CCDSiCCDS21346.1.
RefSeqiNP_536691.2. NM_080443.2.
XP_006540630.1. XM_006540567.2.
UniGeneiMm.34785.

3D structure databases

ProteinModelPortaliQ91ZU0.
SMRiQ91ZU0. Positions 18-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122395.

PTM databases

iPTMnetiQ91ZU0.
PhosphoSiteiQ91ZU0.

Proteomic databases

PaxDbiQ91ZU0.
PRIDEiQ91ZU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124899; ENSMUSP00000122395; ENSMUSG00000030509.
GeneIDi117589.
KEGGimmu:117589.
UCSCiuc009hhn.3. mouse.

Organism-specific databases

CTDi140460.
MGIiMGI:2152835. Asb7.

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000013024.
HOVERGENiHBG037171.
InParanoidiQ91ZU0.
KOiK10329.
OMAiDHSANID.
OrthoDBiEOG790G10.
TreeFamiTF331695.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ91ZU0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ASB7.
ExpressionAtlasiQ91ZU0. baseline and differential.
GenevisibleiQ91ZU0. MM.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiASB7_MOUSE
AccessioniPrimary (citable) accession number: Q91ZU0
Secondary accession number(s): G3UVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.