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Protein

Ankyrin repeat and SOCS box protein 8

Gene

Asb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 8
Short name:
ASB-8
Gene namesi
Name:Asb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1925791. Asb8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Ankyrin repeat and SOCS box protein 8PRO_0000066939Add
BLAST

Proteomic databases

EPDiQ91ZT9.
PaxDbiQ91ZT9.
PRIDEiQ91ZT9.

PTM databases

iPTMnetiQ91ZT9.
PhosphoSiteiQ91ZT9.

Expressioni

Gene expression databases

BgeeiQ91ZT9.
CleanExiMM_ASB8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057864.

Structurei

3D structure databases

ProteinModelPortaliQ91ZT9.
SMRiQ91ZT9. Positions 24-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 8130ANK 1Add
BLAST
Repeati85 – 11329ANK 2Add
BLAST
Repeati117 – 14630ANK 3Add
BLAST
Repeati150 – 17930ANK 4Add
BLAST
Domaini235 – 28854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000034088.
HOVERGENiHBG001430.
InParanoidiQ91ZT9.
KOiK10330.
OrthoDBiEOG7BS49X.
TreeFamiTF332452.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT
60 70 80 90 100
HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAERDEAC
110 120 130 140 150
VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN
160 170 180 190 200
NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLKGQTPISR LVALLVRGLG
210 220 230 240 250
TEKEDSCFEL LHRAVGQFEL RKNGIMPREV TKDQQLCEKL TVLCSAPGTL
260 270 280
KTLARYAVRR SLGLQYLPDA VKGLPLPVSL KDYLLLLE
Length:288
Mass (Da):31,735
Last modified:December 1, 2001 - v1
Checksum:i363727C6EB46CB1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961R → K in AAH25106 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398969 mRNA. Translation: AAK97491.1.
BC025106 mRNA. Translation: AAH25106.1.
CCDSiCCDS27787.1.
RefSeqiNP_001164181.1. NM_001170710.1.
NP_001164182.1. NM_001170711.1.
NP_084397.3. NM_030121.4.
XP_006521605.1. XM_006521542.2.
XP_011244077.1. XM_011245775.1.
UniGeneiMm.200766.

Genome annotation databases

GeneIDi78541.
KEGGimmu:78541.
UCSCiuc007xlx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398969 mRNA. Translation: AAK97491.1.
BC025106 mRNA. Translation: AAH25106.1.
CCDSiCCDS27787.1.
RefSeqiNP_001164181.1. NM_001170710.1.
NP_001164182.1. NM_001170711.1.
NP_084397.3. NM_030121.4.
XP_006521605.1. XM_006521542.2.
XP_011244077.1. XM_011245775.1.
UniGeneiMm.200766.

3D structure databases

ProteinModelPortaliQ91ZT9.
SMRiQ91ZT9. Positions 24-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057864.

PTM databases

iPTMnetiQ91ZT9.
PhosphoSiteiQ91ZT9.

Proteomic databases

EPDiQ91ZT9.
PaxDbiQ91ZT9.
PRIDEiQ91ZT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78541.
KEGGimmu:78541.
UCSCiuc007xlx.2. mouse.

Organism-specific databases

CTDi140461.
MGIiMGI:1925791. Asb8.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000034088.
HOVERGENiHBG001430.
InParanoidiQ91ZT9.
KOiK10330.
OrthoDBiEOG7BS49X.
TreeFamiTF332452.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi349057.
PROiQ91ZT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZT9.
CleanExiMM_ASB8.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASB8_MOUSE
AccessioniPrimary (citable) accession number: Q91ZT9
Secondary accession number(s): Q8R178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.