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Protein

Ankyrin repeat and SOCS box protein 9

Gene

Asb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei103 – 1031Essential for binding to CKBBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 9
Short name:
ASB-9
Gene namesi
Name:Asb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1916549. Asb9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Ankyrin repeat and SOCS box protein 9PRO_0000066941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91ZT8.
PaxDbiQ91ZT8.
PRIDEiQ91ZT8.

PTM databases

iPTMnetiQ91ZT8.
PhosphoSiteiQ91ZT8.
SwissPalmiQ91ZT8.

Expressioni

Gene expression databases

CleanExiMM_ASB9.
GenevisibleiQ91ZT8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033756.

Structurei

3D structure databases

ProteinModelPortaliQ91ZT8.
SMRiQ91ZT8. Positions 32-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6030ANK 1Add
BLAST
Repeati64 – 9330ANK 2Add
BLAST
Repeati97 – 12630ANK 3Add
BLAST
Repeati129 – 15830ANK 4Add
BLAST
Repeati162 – 19130ANK 5Add
BLAST
Repeati194 – 22330ANK 6Add
BLAST
Domaini236 – 29055SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ91ZT8.
KOiK10331.
OMAiHAACANF.
OrthoDBiEOG7J447G.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGEQRGRSD RPGGSPHLPF LSNPLMGDVV SDWSPLHDAA IHGCLLTLRN
60 70 80 90 100
LISQGWPVNI ITADHVSPLH EACLRGHLSC ASVLLSHGAQ VNGMTIDWRT
110 120 130 140 150
PLFNACVSGS QDCVNLLLQH GATPHPETEL ASPIHEAAKR GYVKCIESLA
160 170 180 190 200
AHGANIDYNI SHLGTPLYVA CKNQQVACAK KLLESGVSVN QGKGLDSPLH
210 220 230 240 250
VVARMSSVEL VHLLMDFGAN AQAKNADGKR PVDLVPLESP LIQIFLQNEG
260 270 280 290
PQSLRQLCRL RIRKCFGIRQ HHKISELLLP EDLKRFLLHL
Length:290
Mass (Da):31,656
Last modified:October 3, 2012 - v2
Checksum:i52FB9A086951BB42
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2751S → C in AAK97492 (PubMed:11509662).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398970 mRNA. Translation: AAK97492.1.
AK005878 mRNA. Translation: BAB24293.1.
AL772243 Genomic DNA. Translation: CAM16897.1.
CH466571 Genomic DNA. Translation: EDL40751.1.
BC061038 mRNA. Translation: AAH61038.1.
CCDSiCCDS30524.1.
RefSeqiNP_081303.1. NM_027027.2.
UniGeneiMm.79031.

Genome annotation databases

EnsembliENSMUST00000033756; ENSMUSP00000033756; ENSMUSG00000031384.
GeneIDi69299.
KEGGimmu:69299.
UCSCiuc009uvs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398970 mRNA. Translation: AAK97492.1.
AK005878 mRNA. Translation: BAB24293.1.
AL772243 Genomic DNA. Translation: CAM16897.1.
CH466571 Genomic DNA. Translation: EDL40751.1.
BC061038 mRNA. Translation: AAH61038.1.
CCDSiCCDS30524.1.
RefSeqiNP_081303.1. NM_027027.2.
UniGeneiMm.79031.

3D structure databases

ProteinModelPortaliQ91ZT8.
SMRiQ91ZT8. Positions 32-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033756.

PTM databases

iPTMnetiQ91ZT8.
PhosphoSiteiQ91ZT8.
SwissPalmiQ91ZT8.

Proteomic databases

MaxQBiQ91ZT8.
PaxDbiQ91ZT8.
PRIDEiQ91ZT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033756; ENSMUSP00000033756; ENSMUSG00000031384.
GeneIDi69299.
KEGGimmu:69299.
UCSCiuc009uvs.1. mouse.

Organism-specific databases

CTDi140462.
MGIiMGI:1916549. Asb9.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ91ZT8.
KOiK10331.
OMAiHAACANF.
OrthoDBiEOG7J447G.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi329063.
PROiQ91ZT8.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ASB9.
GenevisibleiQ91ZT8. MM.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Testis.

Entry informationi

Entry nameiASB9_MOUSE
AccessioniPrimary (citable) accession number: Q91ZT8
Secondary accession number(s): Q6GT43, Q9DAF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.