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Protein

Ankyrin repeat and SOCS box protein 10

Gene

Asb10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 10
Short name:
ASB-10
Gene namesi
Name:Asb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2152836. Asb10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Ankyrin repeat and SOCS box protein 10PRO_0000066943Add
BLAST

Proteomic databases

PaxDbiQ91ZT7.
PRIDEiQ91ZT7.

PTM databases

PhosphoSiteiQ91ZT7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038204.
CleanExiMM_ASB10.
ExpressionAtlasiQ91ZT7. baseline and differential.
GenevisibleiQ91ZT7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041539.

Structurei

3D structure databases

ProteinModelPortaliQ91ZT7.
SMRiQ91ZT7. Positions 38-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati115 – 14430ANK 1Add
BLAST
Repeati147 – 17630ANK 2Add
BLAST
Repeati180 – 20930ANK 3Add
BLAST
Repeati214 – 24330ANK 4Add
BLAST
Repeati247 – 28943ANK 5Add
BLAST
Repeati293 – 32230ANK 6Add
BLAST
Repeati326 – 36136ANK 7Add
BLAST
Domaini412 – 46756SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ91ZT7.
KOiK10332.
OMAiNNANTEC.
OrthoDBiEOG091G0711.
PhylomeDBiQ91ZT7.
TreeFamiTF323921.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMSWSPEEC RDQGEPQGDR YSLCAKLVEK PDRGSEEHLE PGLGPIIIRS
60 70 80 90 100
ASGPTLAFWQ AVLVGDVGSV SRILSDSSTG LAPDSIFDTS DPERWRDYRF
110 120 130 140 150
NIRALRLWSL TYEEELTTPL HVAASRGHTE VLELLLRRRA KPDSAPGGRT
160 170 180 190 200
ALHEACSAGH AACVRVLLVA GADPNTLDQD GKRPLHLCRG PGILECVELL
210 220 230 240 250
LKFGAQVDGR TEDEEETPLH IAARLGHVEL ADLLLRWGAC PDVRNSEGWT
260 270 280 290 300
PLLAACDIRC QSPKDAEATT NRCFQLCRLL LSVGADADAA NQDKQRPLHL
310 320 330 340 350
ACRHGHSAVV QLLLSCGVNA NAMDYGGHTP LHCALLGPTT AVAHSPEHTV
360 370 380 390 400
RDLLNHGAVR VWPGALPKVL DRWCMSPRTI EVLMNTYRVV QLPEEAKGLV
410 420 430 440 450
PPEILQKYHG FYSSLFALVR QPRSLQHLCR CALRSHLEGC LPHALPRLPL
460
PPRMLRFLQL DFEDLLY
Length:467
Mass (Da):51,583
Last modified:December 1, 2001 - v1
Checksum:i7DF5BCFDD2EAA4AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398971 mRNA. Translation: AAK97493.1.
AK028538 mRNA. Translation: BAC25997.1.
AK052929 mRNA. Translation: BAC35206.1.
BC141311 mRNA. Translation: AAI41312.1.
BC141313 mRNA. Translation: AAI41314.1.
CCDSiCCDS19124.1.
RefSeqiNP_001297405.1. NM_001310476.1.
NP_536692.1. NM_080444.5.
UniGeneiMm.207071.

Genome annotation databases

EnsembliENSMUST00000048302; ENSMUSP00000041539; ENSMUSG00000038204.
GeneIDi117590.
KEGGimmu:117590.
UCSCiuc008wry.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398971 mRNA. Translation: AAK97493.1.
AK028538 mRNA. Translation: BAC25997.1.
AK052929 mRNA. Translation: BAC35206.1.
BC141311 mRNA. Translation: AAI41312.1.
BC141313 mRNA. Translation: AAI41314.1.
CCDSiCCDS19124.1.
RefSeqiNP_001297405.1. NM_001310476.1.
NP_536692.1. NM_080444.5.
UniGeneiMm.207071.

3D structure databases

ProteinModelPortaliQ91ZT7.
SMRiQ91ZT7. Positions 38-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041539.

PTM databases

PhosphoSiteiQ91ZT7.

Proteomic databases

PaxDbiQ91ZT7.
PRIDEiQ91ZT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048302; ENSMUSP00000041539; ENSMUSG00000038204.
GeneIDi117590.
KEGGimmu:117590.
UCSCiuc008wry.1. mouse.

Organism-specific databases

CTDi136371.
MGIiMGI:2152836. Asb10.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000011960.
HOGENOMiHOG000232066.
HOVERGENiHBG073573.
InParanoidiQ91ZT7.
KOiK10332.
OMAiNNANTEC.
OrthoDBiEOG091G0711.
PhylomeDBiQ91ZT7.
TreeFamiTF323921.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ91ZT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038204.
CleanExiMM_ASB10.
ExpressionAtlasiQ91ZT7. baseline and differential.
GenevisibleiQ91ZT7. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB10_MOUSE
AccessioniPrimary (citable) accession number: Q91ZT7
Secondary accession number(s): B2RUP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.