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Q91ZR7 (S35A4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable UDP-sugar transporter protein SLC35A4
Alternative name(s):
Complex leucine repeat protein
Solute carrier family 35 member A4
Gene names
Name:Slc35a4
Synonyms:CLRP
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential. Golgi apparatus. Note: Punctate and perinuclear distribution throughout the cytoplasm.

Tissue specificity

Expressed in the kidney, lung, testis, and prostate. Expressed in the brain by sets of neurons, such as the pyramidal cells of the cortex, the Purkinje cells of the cerebellum, and the motoneurons of the brainstem. Ref.1

Developmental stage

Expressed at E15; Expression is maintained until postnatal day 10 and decreases in adults. Ref.1

Miscellaneous

Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Probable UDP-sugar transporter protein SLC35A4
PRO_0000337752

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane249 – 27123Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane302 – 32221Helical; Potential
Compositional bias144 – 1496Poly-Leu

Experimental info

Sequence conflict1301Y → C in AAK96221. Ref.1
Sequence conflict1371R → C in AAK96221. Ref.1
Sequence conflict2601Q → H in AAK96221. Ref.1
Sequence conflict2751S → I in AAK96221. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91ZR7 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: F66D814CD7CB77C6

FASTA32434,705
        10         20         30         40         50         60 
MSVEDGGMPG LARPKQARWT LMLFLSTAMY GAHAPFLALC HVDGRVPFRP SSAVLLTELT 

        70         80         90        100        110        120 
KLLLCAFSLL VGWQTWPQGT PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN 

       130        140        150        160        170        180 
LKIGSTALLY CLCLGHRLSA RQGLALLLLM AAGACYASGG FQEPGNTLPG PRSAAGARPM 

       190        200        210        220        230        240 
PLHITPLGLL LLILYCLISG LSSVYTELIM KRQRLPLALQ NLFLYTFGVI LNLGLYAGSG 

       250        260        270        280        290        300 
PGPGFLEGFS GWAVLVVLNQ AVNGLLMSAV MKHGSSITRL FIVSCSLVVN AVLSAVLLQL 

       310        320 
QLTATFFLAA LLIGLAVCLY YGSP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain."
Perez-Marquez J., Reguillo B., Paniagua R.
J. Neurobiol. 52:166-173(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"The nucleotide-sugar transporter family: a phylogenetic approach."
Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF406814 mRNA. Translation: AAK96221.1.
BC085695 mRNA. Translation: AAH85695.1.
BC086986 mRNA. Translation: AAH86986.1.
RefSeqNP_671481.2. NM_147140.2.
XP_006254590.1. XM_006254528.1.
XP_006254591.1. XM_006254529.1.
UniGeneRn.15468.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ91ZR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
GeneID257647.
KEGGrno:257647.
UCSCRGD:628792. rat.

Organism-specific databases

CTD113829.
RGD628792. Slc35a4.

Phylogenomic databases

eggNOGNOG302854.
GeneTreeENSGT00550000074563.
HOGENOMHOG000154235.
HOVERGENHBG108445.
InParanoidQ91ZR7.
KOK15273.
OMAVVVLIEL.
OrthoDBEOG7MSMQ1.
PhylomeDBQ91ZR7.
TreeFamTF315345.

Gene expression databases

GenevestigatorQ91ZR7.

Family and domain databases

InterProIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view]
PANTHERPTHR10231. PTHR10231. 1 hit.
PfamPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetSearch...

Other

NextBio624187.
PROQ91ZR7.

Entry information

Entry nameS35A4_RAT
AccessionPrimary (citable) accession number: Q91ZR7
Secondary accession number(s): Q5RKL6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families