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Q91ZR7

- S35A4_RAT

UniProt

Q91ZR7 - S35A4_RAT

Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

Slc35a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sugar:proton symporter activity Source: InterPro

    Keywords - Biological processi

    Sugar transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Alternative name(s):
    Complex leucine repeat protein
    Solute carrier family 35 member A4
    Gene namesi
    Name:Slc35a4
    Synonyms:CLRP
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi628792. Slc35a4.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus
    Note: Punctate and perinuclear distribution throughout the cytoplasm.

    GO - Cellular componenti

    1. Golgi membrane Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Probable UDP-sugar transporter protein SLC35A4PRO_0000337752Add
    BLAST

    Proteomic databases

    PRIDEiQ91ZR7.

    Expressioni

    Tissue specificityi

    Expressed in the kidney, lung, testis, and prostate. Expressed in the brain by sets of neurons, such as the pyramidal cells of the cortex, the Purkinje cells of the cerebellum, and the motoneurons of the brainstem.1 Publication

    Developmental stagei

    Expressed at E15; Expression is maintained until postnatal day 10 and decreases in adults.1 Publication

    Gene expression databases

    GenevestigatoriQ91ZR7.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 27123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 1496Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302854.
    GeneTreeiENSGT00550000074563.
    HOGENOMiHOG000154235.
    HOVERGENiHBG108445.
    InParanoidiQ91ZR7.
    KOiK15273.
    OMAiSSTERGF.
    OrthoDBiEOG7MSMQ1.
    PhylomeDBiQ91ZR7.
    TreeFamiTF315345.

    Family and domain databases

    InterProiIPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    [Graphical view]
    PANTHERiPTHR10231. PTHR10231. 1 hit.
    PfamiPF04142. Nuc_sug_transp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91ZR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVEDGGMPG LARPKQARWT LMLFLSTAMY GAHAPFLALC HVDGRVPFRP    50
    SSAVLLTELT KLLLCAFSLL VGWQTWPQGT PPWRQAAPFA LSALLYGANN 100
    NLVIYLQRYM DPSTYQVLSN LKIGSTALLY CLCLGHRLSA RQGLALLLLM 150
    AAGACYASGG FQEPGNTLPG PRSAAGARPM PLHITPLGLL LLILYCLISG 200
    LSSVYTELIM KRQRLPLALQ NLFLYTFGVI LNLGLYAGSG PGPGFLEGFS 250
    GWAVLVVLNQ AVNGLLMSAV MKHGSSITRL FIVSCSLVVN AVLSAVLLQL 300
    QLTATFFLAA LLIGLAVCLY YGSP 324
    Length:324
    Mass (Da):34,705
    Last modified:May 20, 2008 - v2
    Checksum:iF66D814CD7CB77C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301Y → C in AAK96221. (PubMed:12124754)Curated
    Sequence conflicti137 – 1371R → C in AAK96221. (PubMed:12124754)Curated
    Sequence conflicti260 – 2601Q → H in AAK96221. (PubMed:12124754)Curated
    Sequence conflicti275 – 2751S → I in AAK96221. (PubMed:12124754)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406814 mRNA. Translation: AAK96221.1.
    BC085695 mRNA. Translation: AAH85695.1.
    BC086986 mRNA. Translation: AAH86986.1.
    RefSeqiNP_671481.2. NM_147140.2.
    XP_006254590.1. XM_006254528.1.
    XP_006254591.1. XM_006254529.1.
    UniGeneiRn.15468.

    Genome annotation databases

    EnsembliENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
    GeneIDi257647.
    KEGGirno:257647.
    UCSCiRGD:628792. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406814 mRNA. Translation: AAK96221.1 .
    BC085695 mRNA. Translation: AAH85695.1 .
    BC086986 mRNA. Translation: AAH86986.1 .
    RefSeqi NP_671481.2. NM_147140.2.
    XP_006254590.1. XM_006254528.1.
    XP_006254591.1. XM_006254529.1.
    UniGenei Rn.15468.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q91ZR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003878 ; ENSRNOP00000003878 ; ENSRNOG00000002908 .
    GeneIDi 257647.
    KEGGi rno:257647.
    UCSCi RGD:628792. rat.

    Organism-specific databases

    CTDi 113829.
    RGDi 628792. Slc35a4.

    Phylogenomic databases

    eggNOGi NOG302854.
    GeneTreei ENSGT00550000074563.
    HOGENOMi HOG000154235.
    HOVERGENi HBG108445.
    InParanoidi Q91ZR7.
    KOi K15273.
    OMAi SSTERGF.
    OrthoDBi EOG7MSMQ1.
    PhylomeDBi Q91ZR7.
    TreeFami TF315345.

    Miscellaneous databases

    NextBioi 624187.
    PROi Q91ZR7.

    Gene expression databases

    Genevestigatori Q91ZR7.

    Family and domain databases

    InterProi IPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    [Graphical view ]
    PANTHERi PTHR10231. PTHR10231. 1 hit.
    Pfami PF04142. Nuc_sug_transp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain."
      Perez-Marquez J., Reguillo B., Paniagua R.
      J. Neurobiol. 52:166-173(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "The nucleotide-sugar transporter family: a phylogenetic approach."
      Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
      Biochimie 85:245-260(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiS35A4_RAT
    AccessioniPrimary (citable) accession number: Q91ZR7
    Secondary accession number(s): Q5RKL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3