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Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

Slc35a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sugar:proton symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A4
Alternative name(s):
Complex leucine repeat protein
Solute carrier family 35 member A4
Gene namesi
Name:Slc35a4
Synonyms:CLRP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi628792. Slc35a4.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Golgi apparatus
Note: Punctate and perinuclear distribution throughout the cytoplasm.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei249 – 27123HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Probable UDP-sugar transporter protein SLC35A4PRO_0000337752Add
BLAST

Proteomic databases

PRIDEiQ91ZR7.

Expressioni

Tissue specificityi

Expressed in the kidney, lung, testis, and prostate. Expressed in the brain by sets of neurons, such as the pyramidal cells of the cortex, the Purkinje cells of the cerebellum, and the motoneurons of the brainstem.1 Publication

Developmental stagei

Expressed at E15; Expression is maintained until postnatal day 10 and decreases in adults.1 Publication

Gene expression databases

GenevestigatoriQ91ZR7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 1496Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302854.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ91ZR7.
KOiK15273.
OMAiFLALCHV.
OrthoDBiEOG7MSMQ1.
PhylomeDBiQ91ZR7.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91ZR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEDGGMPG LARPKQARWT LMLFLSTAMY GAHAPFLALC HVDGRVPFRP
60 70 80 90 100
SSAVLLTELT KLLLCAFSLL VGWQTWPQGT PPWRQAAPFA LSALLYGANN
110 120 130 140 150
NLVIYLQRYM DPSTYQVLSN LKIGSTALLY CLCLGHRLSA RQGLALLLLM
160 170 180 190 200
AAGACYASGG FQEPGNTLPG PRSAAGARPM PLHITPLGLL LLILYCLISG
210 220 230 240 250
LSSVYTELIM KRQRLPLALQ NLFLYTFGVI LNLGLYAGSG PGPGFLEGFS
260 270 280 290 300
GWAVLVVLNQ AVNGLLMSAV MKHGSSITRL FIVSCSLVVN AVLSAVLLQL
310 320
QLTATFFLAA LLIGLAVCLY YGSP
Length:324
Mass (Da):34,705
Last modified:May 19, 2008 - v2
Checksum:iF66D814CD7CB77C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301Y → C in AAK96221 (PubMed:12124754).Curated
Sequence conflicti137 – 1371R → C in AAK96221 (PubMed:12124754).Curated
Sequence conflicti260 – 2601Q → H in AAK96221 (PubMed:12124754).Curated
Sequence conflicti275 – 2751S → I in AAK96221 (PubMed:12124754).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406814 mRNA. Translation: AAK96221.1.
BC085695 mRNA. Translation: AAH85695.1.
BC086986 mRNA. Translation: AAH86986.1.
RefSeqiNP_671481.2. NM_147140.2.
XP_006254590.1. XM_006254528.1.
XP_006254591.1. XM_006254529.2.
XP_008770241.1. XM_008772019.1.
UniGeneiRn.15468.

Genome annotation databases

EnsembliENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
GeneIDi257647.
KEGGirno:257647.
UCSCiRGD:628792. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406814 mRNA. Translation: AAK96221.1.
BC085695 mRNA. Translation: AAH85695.1.
BC086986 mRNA. Translation: AAH86986.1.
RefSeqiNP_671481.2. NM_147140.2.
XP_006254590.1. XM_006254528.1.
XP_006254591.1. XM_006254529.2.
XP_008770241.1. XM_008772019.1.
UniGeneiRn.15468.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ91ZR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
GeneIDi257647.
KEGGirno:257647.
UCSCiRGD:628792. rat.

Organism-specific databases

CTDi113829.
RGDi628792. Slc35a4.

Phylogenomic databases

eggNOGiNOG302854.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ91ZR7.
KOiK15273.
OMAiFLALCHV.
OrthoDBiEOG7MSMQ1.
PhylomeDBiQ91ZR7.
TreeFamiTF315345.

Miscellaneous databases

NextBioi624187.
PROiQ91ZR7.

Gene expression databases

GenevestigatoriQ91ZR7.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain."
    Perez-Marquez J., Reguillo B., Paniagua R.
    J. Neurobiol. 52:166-173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The nucleotide-sugar transporter family: a phylogenetic approach."
    Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.
    Biochimie 85:245-260(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiS35A4_RAT
AccessioniPrimary (citable) accession number: Q91ZR7
Secondary accession number(s): Q5RKL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: May 19, 2008
Last modified: January 6, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.