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Protein

Probable UDP-sugar transporter protein SLC35A4

Gene

Slc35a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A4
Alternative name(s):
Complex leucine repeat protein
Solute carrier family 35 member A4
Gene namesi
Name:Slc35a4
Synonyms:CLRP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi628792. Slc35a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei249 – 271HelicalSequence analysisAdd BLAST23
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003377521 – 324Probable UDP-sugar transporter protein SLC35A4Add BLAST324

Proteomic databases

PaxDbiQ91ZR7.
PRIDEiQ91ZR7.

Expressioni

Tissue specificityi

Expressed in the kidney, lung, testis, and prostate. Expressed in the brain by sets of neurons, such as the pyramidal cells of the cortex, the Purkinje cells of the cerebellum, and the motoneurons of the brainstem.1 Publication

Developmental stagei

Expressed at E15; Expression is maintained until postnatal day 10 and decreases in adults.1 Publication

Gene expression databases

BgeeiENSRNOG00000002908.
GenevisibleiQ91ZR7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003878.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Leu6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ91ZR7.
KOiK15273.
OMAiALCHVNG.
OrthoDBiEOG091G0BN0.
PhylomeDBiQ91ZR7.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91ZR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEDGGMPG LARPKQARWT LMLFLSTAMY GAHAPFLALC HVDGRVPFRP
60 70 80 90 100
SSAVLLTELT KLLLCAFSLL VGWQTWPQGT PPWRQAAPFA LSALLYGANN
110 120 130 140 150
NLVIYLQRYM DPSTYQVLSN LKIGSTALLY CLCLGHRLSA RQGLALLLLM
160 170 180 190 200
AAGACYASGG FQEPGNTLPG PRSAAGARPM PLHITPLGLL LLILYCLISG
210 220 230 240 250
LSSVYTELIM KRQRLPLALQ NLFLYTFGVI LNLGLYAGSG PGPGFLEGFS
260 270 280 290 300
GWAVLVVLNQ AVNGLLMSAV MKHGSSITRL FIVSCSLVVN AVLSAVLLQL
310 320
QLTATFFLAA LLIGLAVCLY YGSP
Length:324
Mass (Da):34,705
Last modified:May 20, 2008 - v2
Checksum:iF66D814CD7CB77C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130Y → C in AAK96221 (PubMed:12124754).Curated1
Sequence conflicti137R → C in AAK96221 (PubMed:12124754).Curated1
Sequence conflicti260Q → H in AAK96221 (PubMed:12124754).Curated1
Sequence conflicti275S → I in AAK96221 (PubMed:12124754).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406814 mRNA. Translation: AAK96221.1.
BC085695 mRNA. Translation: AAH85695.1.
BC086986 mRNA. Translation: AAH86986.1.
RefSeqiNP_671481.2. NM_147140.2.
XP_006254590.1. XM_006254528.2.
XP_006254591.1. XM_006254529.3.
XP_008770241.1. XM_008772019.2.
UniGeneiRn.15468.

Genome annotation databases

EnsembliENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
GeneIDi257647.
KEGGirno:257647.
UCSCiRGD:628792. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406814 mRNA. Translation: AAK96221.1.
BC085695 mRNA. Translation: AAH85695.1.
BC086986 mRNA. Translation: AAH86986.1.
RefSeqiNP_671481.2. NM_147140.2.
XP_006254590.1. XM_006254528.2.
XP_006254591.1. XM_006254529.3.
XP_008770241.1. XM_008772019.2.
UniGeneiRn.15468.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003878.

Proteomic databases

PaxDbiQ91ZR7.
PRIDEiQ91ZR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003878; ENSRNOP00000003878; ENSRNOG00000002908.
GeneIDi257647.
KEGGirno:257647.
UCSCiRGD:628792. rat.

Organism-specific databases

CTDi113829.
RGDi628792. Slc35a4.

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154235.
HOVERGENiHBG108445.
InParanoidiQ91ZR7.
KOiK15273.
OMAiALCHVNG.
OrthoDBiEOG091G0BN0.
PhylomeDBiQ91ZR7.
TreeFamiTF315345.

Miscellaneous databases

PROiQ91ZR7.

Gene expression databases

BgeeiENSRNOG00000002908.
GenevisibleiQ91ZR7. RN.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A4_RAT
AccessioniPrimary (citable) accession number: Q91ZR7
Secondary accession number(s): Q5RKL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.