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Protein

Cation channel sperm-associated protein 1

Gene

Catsper1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.5 Publications

Enzyme regulationi

In contrast to the human ortholog, not activated by progesterone.1 Publication

GO - Molecular functioni

  • calcium activated cation channel activity Source: InterPro
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • calcium ion transport Source: MGI
  • cell differentiation Source: UniProtKB-KW
  • flagellated sperm motility Source: MGI
  • fusion of sperm to egg plasma membrane Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • multicellular organism development Source: UniProtKB-KW
  • regulation of calcium ion transport Source: MGI
  • regulation of cilium beat frequency involved in ciliary motility Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Developmental protein, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Differentiation, Ion transport, Spermatogenesis, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-1300642. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.3. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 1
Short name:
CatSper1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2179947. Catsper1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 349CytoplasmicSequence analysisAdd BLAST349
Transmembranei350 – 370Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini371 – 383ExtracellularSequence analysisAdd BLAST13
Transmembranei384 – 404Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini405 – 417CytoplasmicSequence analysisAdd BLAST13
Transmembranei418 – 438Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini439 – 447ExtracellularSequence analysis9
Transmembranei448 – 468Helical; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini469 – 485CytoplasmicSequence analysisAdd BLAST17
Transmembranei486 – 506Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini507 – 521ExtracellularSequence analysisAdd BLAST15
Intramembranei522 – 542Helical; Pore-formingSequence analysisAdd BLAST21
Topological domaini543 – 552ExtracellularSequence analysis10
Transmembranei553 – 573Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini574 – 686CytoplasmicSequence analysisAdd BLAST113

GO - Cellular componenti

  • CatSper complex Source: UniProtKB
  • motile cilium Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. In mice lacking Catsper1, sperm lacks CatSper2 protein, while in mice lacking CatSper1, sperm lacks CatSper1 protein, suggesting that stable expression of CatSper1 protein requires CatSper2 and vice versa.1 Publication

Chemistry databases

GuidetoPHARMACOLOGYi388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956751 – 686Cation channel sperm-associated protein 1Add BLAST686

Proteomic databases

PaxDbiQ91ZR5.
PRIDEiQ91ZR5.

PTM databases

iPTMnetiQ91ZR5.
PhosphoSitePlusiQ91ZR5.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

Detected only after round spermatids are produced at approximatly day 18.2 Publications

Gene expression databases

BgeeiENSMUSG00000038498.
CleanExiMM_CATSPER1.
GenevisibleiQ91ZR5. MM.

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity (By similarity). Component of the CatSper complex. Interacts with CATSPER3 and CATSPER4.By similarityCurated4 Publications

Protein-protein interaction databases

BioGridi230434. 6 interactors.
DIPiDIP-60800N.
STRINGi10090.ENSMUSP00000045430.

Structurei

3D structure databases

ProteinModelPortaliQ91ZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 255His-richAdd BLAST244

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP4H. Eukaryota.
ENOG410Y55D. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000112051.
InParanoidiQ91ZR5.
KOiK16889.
OMAiQLSHKSH.
OrthoDBiEOG091G0KAS.
PhylomeDBiQ91ZR5.
TreeFamiTF329330.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR028746. CatSper1.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PANTHERiPTHR10037:SF216. PTHR10037:SF216. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSSRRDES YHETHPGSLD PSHQSHPHPH PHPTLHRPNQ GGVYYDSPQH
60 70 80 90 100
GMFQQPYQQH GGFHQQNELQ HLREFSDSHD NAFSHHSYQQ DRAGVSTLPN
110 120 130 140 150
NISHAYGGSH PLAESQHSGG PQSGPRIDPN HHPHQDDPHR PSEPLSHPSS
160 170 180 190 200
TGSHQGTTHQ QYHERSHHLN PQQNRDHADT ISYRSSTRFY RSHAPFSRQE
210 220 230 240 250
RPHLHADHHH EGHHAHSHHG EHPHHKEQRH YHGDHMHHHI HHRSPSASQL
260 270 280 290 300
SHKSHSTLAT SPSHVGSKST ASGARYTFGA RSQIFGKAQS RESLRESASL
310 320 330 340 350
SEGEDHVQKR KKAQRAHKKA HTGNIFQLLW EKISHLLLGL QQMILSLTQS
360 370 380 390 400
LGFETFIFIV VCLNTVILVA QTFTELEIRG EWYFMVLDSI FLSIYVLEAV
410 420 430 440 450
LKLIALGLEY FYDPWNNLDF FIMVMAVLDF VLLQINSLSY SFYNHSLFRI
460 470 480 490 500
LKVFKSMRAL RAIRVLRRLS ILTSLHEVAG TLSGSLPSIT AILTLMFTCL
510 520 530 540 550
FLFSVVLRAL FQDSDPKRFQ NIFTTLFTLF TMLTLDDWSL IYIDNRAQGA
560 570 580 590 600
WYIIPILMIY IVIQYFIFLN LVIAVLVDNF QMALLKGLEK VKLEQAARVH
610 620 630 640 650
EKLLDDSLTD LNKADANAQM TEEALKMQLI EGMFGNMTVK QRVLHFQFLQ
660 670 680
LVAAVEQHQQ KFRSQAYVID ELVDMAFEAG DDDYGK
Length:686
Mass (Da):78,706
Last modified:December 1, 2001 - v1
Checksum:i2E85FFE72B3147BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25S → SHP in strain: 72. 1
Natural varianti52M → R in strain: 2, 47 and 58. 1 Publication1
Natural varianti160Missing in strain: 47. 1 Publication1
Natural varianti270T → I in strain: 72. 1 Publication1
Natural varianti276Y → S in strain: 72. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF407332 mRNA. Translation: AAL14104.1.
DQ021482 Genomic DNA. Translation: AAY63820.1.
DQ021483 Genomic DNA. Translation: AAY63821.1.
DQ021484 Genomic DNA. Translation: AAY63822.1.
DQ021485 Genomic DNA. Translation: AAY63823.1.
DQ021486 Genomic DNA. Translation: AAY63824.1.
DQ021488 Genomic DNA. Translation: AAY63826.1.
DQ021489 Genomic DNA. Translation: AAY63827.1.
DQ021490 Genomic DNA. Translation: AAY63828.1.
DQ021491 Genomic DNA. Translation: AAY63829.1.
DQ021492 Genomic DNA. Translation: AAY63830.1.
CCDSiCCDS29456.1.
RefSeqiNP_647462.1. NM_139301.2.
UniGeneiMm.87321.

Genome annotation databases

EnsembliENSMUST00000043380; ENSMUSP00000045430; ENSMUSG00000038498.
GeneIDi225865.
KEGGimmu:225865.
UCSCiuc008gcp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF407332 mRNA. Translation: AAL14104.1.
DQ021482 Genomic DNA. Translation: AAY63820.1.
DQ021483 Genomic DNA. Translation: AAY63821.1.
DQ021484 Genomic DNA. Translation: AAY63822.1.
DQ021485 Genomic DNA. Translation: AAY63823.1.
DQ021486 Genomic DNA. Translation: AAY63824.1.
DQ021488 Genomic DNA. Translation: AAY63826.1.
DQ021489 Genomic DNA. Translation: AAY63827.1.
DQ021490 Genomic DNA. Translation: AAY63828.1.
DQ021491 Genomic DNA. Translation: AAY63829.1.
DQ021492 Genomic DNA. Translation: AAY63830.1.
CCDSiCCDS29456.1.
RefSeqiNP_647462.1. NM_139301.2.
UniGeneiMm.87321.

3D structure databases

ProteinModelPortaliQ91ZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230434. 6 interactors.
DIPiDIP-60800N.
STRINGi10090.ENSMUSP00000045430.

Chemistry databases

GuidetoPHARMACOLOGYi388.

Protein family/group databases

TCDBi1.A.1.19.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ91ZR5.
PhosphoSitePlusiQ91ZR5.

Proteomic databases

PaxDbiQ91ZR5.
PRIDEiQ91ZR5.

Protocols and materials databases

DNASUi225865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043380; ENSMUSP00000045430; ENSMUSG00000038498.
GeneIDi225865.
KEGGimmu:225865.
UCSCiuc008gcp.1. mouse.

Organism-specific databases

CTDi117144.
MGIiMGI:2179947. Catsper1.

Phylogenomic databases

eggNOGiENOG410IP4H. Eukaryota.
ENOG410Y55D. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000112051.
InParanoidiQ91ZR5.
KOiK16889.
OMAiQLSHKSH.
OrthoDBiEOG091G0KAS.
PhylomeDBiQ91ZR5.
TreeFamiTF329330.

Enzyme and pathway databases

ReactomeiR-MMU-1300642. Sperm Motility And Taxes.

Miscellaneous databases

PROiQ91ZR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038498.
CleanExiMM_CATSPER1.
GenevisibleiQ91ZR5. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR028746. CatSper1.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PANTHERiPTHR10037:SF216. PTHR10037:SF216. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTSR1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR5
Secondary accession number(s): Q4PZC3
, Q4PZC4, Q4PZC5, Q4PZC6, Q4PZD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.