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Protein

CREB/ATF bZIP transcription factor

Gene

Crebzf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB/ATF bZIP transcription factor
Alternative name(s):
Host cell factor-binding transcription factor Zhangfei
Short name:
HCF-binding transcription factor Zhangfei
Tyrosine kinase-associated leucine zipper protein LAZip
Gene namesi
Name:Crebzf
Synonyms:Zf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2675296. Crebzf.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766461 – 358CREB/ATF bZIP transcription factorAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91ZR3.
PeptideAtlasiQ91ZR3.
PRIDEiQ91ZR3.

PTM databases

iPTMnetiQ91ZR3.
PhosphoSitePlusiQ91ZR3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051451.
CleanExiMM_CREBZF.
ExpressionAtlasiQ91ZR3. baseline and differential.
GenevisibleiQ91ZR3. MM.

Interactioni

Subunit structurei

Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EsrrgP625093EBI-5274001,EBI-5274019

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231418. 1 interactor.
IntActiQ91ZR3. 1 interactor.
STRINGi10090.ENSMUSP00000102824.

Structurei

3D structure databases

ProteinModelPortaliQ91ZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 271bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 230Basic motifBy similarity8
Regioni236 – 271Leucine-zipperBy similarityAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 310HCFC1-binding motif (HBM)By similarity4

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IF1I. Eukaryota.
ENOG4111T3W. LUCA.
GeneTreeiENSGT00390000016589.
HOGENOMiHOG000285965.
HOVERGENiHBG099107.
InParanoidiQ91ZR3.
OMAiDWHLDPG.
OrthoDBiEOG091G0Q2M.
PhylomeDBiQ91ZR3.
TreeFamiTF336153.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSLTKLLA ASGRDFPSRR DSREPPATRA PPREPSGAAA GAETPRPGSP
60 70 80 90 100
DREQPHGDGD GGEPEARSGS RGSVAVRAPA PSPLKMEEEE EDAIAMVPKE
110 120 130 140 150
EPEDMDFLSG LELADLLDPR QPDWHLEPGL SSPGPLSSSG GGSESGGLLR
160 170 180 190 200
GDDDDDTAAA EMQRFSDLLQ RLLNGIGGCS SGGDRGGGEK RRRKSPGAGG
210 220 230 240 250
GGANDGNQAA TKSPRKAAAA AARLNRLKKK EYVMGLESRV RGLAAENQEL
260 270 280 290 300
RAENRELGKR VQALQEESRY LRAVLANETG LARLLSRLSG VGLRLTTSLF
310 320 330 340 350
RDSPAGDHDY ALPVGKQPPE PREEDDAAGG VCLHVDKDKV SVEFCSACAR

KASSSLKM
Length:358
Mass (Da):37,825
Last modified:July 7, 2009 - v2
Checksum:iF7CC810EC242C24D
GO

Sequence cautioni

The sequence AAK51608 differs from that shown. Contaminating sequence. Sequence derived from chromosome 13 in the N-terminal part.Curated
The sequence AAL04512 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100322 Genomic DNA. No translation available.
AF408398 mRNA. Translation: AAL04512.1. Different initiation.
AF149050 mRNA. Translation: AAK51608.1. Sequence problems.
CCDSiCCDS40020.1.
RefSeqiNP_660133.2. NM_145151.3.
XP_006507669.1. XM_006507606.2.
UniGeneiMm.29496.

Genome annotation databases

EnsembliENSMUST00000061767; ENSMUSP00000050972; ENSMUSG00000051451.
GeneIDi233490.
KEGGimmu:233490.
UCSCiuc009ihl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100322 Genomic DNA. No translation available.
AF408398 mRNA. Translation: AAL04512.1. Different initiation.
AF149050 mRNA. Translation: AAK51608.1. Sequence problems.
CCDSiCCDS40020.1.
RefSeqiNP_660133.2. NM_145151.3.
XP_006507669.1. XM_006507606.2.
UniGeneiMm.29496.

3D structure databases

ProteinModelPortaliQ91ZR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231418. 1 interactor.
IntActiQ91ZR3. 1 interactor.
STRINGi10090.ENSMUSP00000102824.

PTM databases

iPTMnetiQ91ZR3.
PhosphoSitePlusiQ91ZR3.

Proteomic databases

PaxDbiQ91ZR3.
PeptideAtlasiQ91ZR3.
PRIDEiQ91ZR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061767; ENSMUSP00000050972; ENSMUSG00000051451.
GeneIDi233490.
KEGGimmu:233490.
UCSCiuc009ihl.2. mouse.

Organism-specific databases

CTDi58487.
MGIiMGI:2675296. Crebzf.

Phylogenomic databases

eggNOGiENOG410IF1I. Eukaryota.
ENOG4111T3W. LUCA.
GeneTreeiENSGT00390000016589.
HOGENOMiHOG000285965.
HOVERGENiHBG099107.
InParanoidiQ91ZR3.
OMAiDWHLDPG.
OrthoDBiEOG091G0Q2M.
PhylomeDBiQ91ZR3.
TreeFamiTF336153.

Miscellaneous databases

ChiTaRSiCrebzf. mouse.
PROiQ91ZR3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051451.
CleanExiMM_CREBZF.
ExpressionAtlasiQ91ZR3. baseline and differential.
GenevisibleiQ91ZR3. MM.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZHANG_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR3
Secondary accession number(s): Q91Y72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.