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Protein

CREB/ATF bZIP transcription factor

Gene

Crebzf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB/ATF bZIP transcription factor
Alternative name(s):
Host cell factor-binding transcription factor Zhangfei
Short name:
HCF-binding transcription factor Zhangfei
Tyrosine kinase-associated leucine zipper protein LAZip
Gene namesi
Name:Crebzf
Synonyms:Zf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2675296 Crebzf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766461 – 358CREB/ATF bZIP transcription factorAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91ZR3
PaxDbiQ91ZR3
PeptideAtlasiQ91ZR3
PRIDEiQ91ZR3

PTM databases

iPTMnetiQ91ZR3
PhosphoSitePlusiQ91ZR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000051451
CleanExiMM_CREBZF
ExpressionAtlasiQ91ZR3 baseline and differential
GenevisibleiQ91ZR3 MM

Interactioni

Subunit structurei

Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity. Interacts with CREB3; the interaction occurs only in combination with HCFC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EsrrgP625093EBI-5274001,EBI-5274019

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2314181 interactor.
IntActiQ91ZR3 1 interactor.
STRINGi10090.ENSMUSP00000102824

Structurei

3D structure databases

ProteinModelPortaliQ91ZR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 271bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 230Basic motifBy similarity8
Regioni236 – 271Leucine-zipperBy similarityAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 310HCFC1-binding motif (HBM)By similarity4

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IF1I Eukaryota
ENOG4111T3W LUCA
GeneTreeiENSGT00390000016589
HOGENOMiHOG000285965
HOVERGENiHBG099107
InParanoidiQ91ZR3
KOiK21548
OMAiDWHLDPG
OrthoDBiEOG091G0Q2M
PhylomeDBiQ91ZR3
TreeFamiTF336153

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q91ZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSLTKLLA ASGRDFPSRR DSREPPATRA PPREPSGAAA GAETPRPGSP
60 70 80 90 100
DREQPHGDGD GGEPEARSGS RGSVAVRAPA PSPLKMEEEE EDAIAMVPKE
110 120 130 140 150
EPEDMDFLSG LELADLLDPR QPDWHLEPGL SSPGPLSSSG GGSESGGLLR
160 170 180 190 200
GDDDDDTAAA EMQRFSDLLQ RLLNGIGGCS SGGDRGGGEK RRRKSPGAGG
210 220 230 240 250
GGANDGNQAA TKSPRKAAAA AARLNRLKKK EYVMGLESRV RGLAAENQEL
260 270 280 290 300
RAENRELGKR VQALQEESRY LRAVLANETG LARLLSRLSG VGLRLTTSLF
310 320 330 340 350
RDSPAGDHDY ALPVGKQPPE PREEDDAAGG VCLHVDKDKV SVEFCSACAR

KASSSLKM
Length:358
Mass (Da):37,825
Last modified:July 7, 2009 - v2
Checksum:iF7CC810EC242C24D
GO

Sequence cautioni

The sequence AAK51608 differs from that shown. Contaminating sequence. Sequence derived from chromosome 13 in the N-terminal part.Curated
The sequence AAL04512 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100322 Genomic DNA No translation available.
AF408398 mRNA Translation: AAL04512.1 Different initiation.
AF149050 mRNA Translation: AAK51608.1 Sequence problems.
CCDSiCCDS40020.1
RefSeqiNP_660133.2, NM_145151.3
XP_006507669.1, XM_006507606.2
UniGeneiMm.29496

Genome annotation databases

EnsembliENSMUST00000061767; ENSMUSP00000050972; ENSMUSG00000051451
GeneIDi233490
KEGGimmu:233490
UCSCiuc009ihl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZHANG_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR3
Secondary accession number(s): Q91Y72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome