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Q91ZR2

- SNX18_MOUSE

UniProt

Q91ZR2 - SNX18_MOUSE

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Protein

Sorting nexin-18

Gene
Snx18, Snag1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis By similarity. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei302 – 3021Phosphatidylinositol 4,5-bisphosphate By similarity
Binding sitei304 – 3041Phosphatidylinositol 4,5-bisphosphate By similarity
Binding sitei328 – 3281Phosphatidylinositol 4,5-bisphosphate By similarity
Binding sitei342 – 3421Phosphatidylinositol 4,5-bisphosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: MGI
  2. protein binding Source: IntAct

GO - Biological processi

  1. endocytosis Source: UniProtKB
  2. intracellular protein transport Source: RefGenome
  3. mitotic cytokinesis Source: InterPro
  4. mitotic nuclear division Source: UniProtKB-KW
  5. positive regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
Sorting nexin-associated Golgi protein 1
Gene namesi
Name:Snx18
Synonyms:Snag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2137642. Snx18.

Subcellular locationi

Endomembrane system; Peripheral membrane protein; Cytoplasmic side By similarity. Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation By similarity.

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: RefGenome
  2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  3. endosome Source: RefGenome
  4. endosome membrane Source: UniProtKB-SubCell
  5. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  6. growth cone Source: MGI
  7. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Sorting nexin-18PRO_0000213867Add
BLAST

Proteomic databases

MaxQBiQ91ZR2.
PaxDbiQ91ZR2.
PRIDEiQ91ZR2.

PTM databases

PhosphoSiteiQ91ZR2.

Expressioni

Gene expression databases

CleanExiMM_SNX18.
GenevestigatoriQ91ZR2.

Interactioni

Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
FASLGP480234EBI-6879954,EBI-495538From a different organism.

Protein-protein interaction databases

IntActiQ91ZR2. 2 interactions.
MINTiMINT-5209459.
STRINGi10090.ENSMUSP00000104864.

Structurei

3D structure databases

ProteinModelPortaliQ91ZR2.
SMRiQ91ZR2. Positions 6-59, 253-613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6161SH3Add
BLAST
Domaini266 – 376111PXAdd
BLAST
Domaini411 – 614204BARAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate By similarity.

Sequence similaritiesi

Belongs to the sorting nexin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5391.
HOGENOMiHOG000261633.
HOVERGENiHBG009996.
PhylomeDBiQ91ZR2.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR001452. SH3_domain.
IPR028646. SNX18.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]
PANTHERiPTHR10555:SF13. PTHR10555:SF13. 1 hit.
PfamiPF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF027744. Snx9. 1 hit.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZR2-1 [UniParc]FASTAAdd to Basket

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MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL    50
FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL 100
LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD 150
DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS 200
APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR LREGWGQAVR 250
GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH 300
RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM 350
NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT 400
LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF 450
KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ 500
PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR RHVEEGKMEV 550
QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV 600
TQKLEEALHK YDSV 614
Length:614
Mass (Da):67,904
Last modified:December 1, 2001 - v1
Checksum:iBACED9D104571098
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF408408 mRNA. Translation: AAL02105.1.
UniGeneiMm.33721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF408408 mRNA. Translation: AAL02105.1 .
UniGenei Mm.33721.

3D structure databases

ProteinModelPortali Q91ZR2.
SMRi Q91ZR2. Positions 6-59, 253-613.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91ZR2. 2 interactions.
MINTi MINT-5209459.
STRINGi 10090.ENSMUSP00000104864.

PTM databases

PhosphoSitei Q91ZR2.

Proteomic databases

MaxQBi Q91ZR2.
PaxDbi Q91ZR2.
PRIDEi Q91ZR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2137642. Snx18.

Phylogenomic databases

eggNOGi COG5391.
HOGENOMi HOG000261633.
HOVERGENi HBG009996.
PhylomeDBi Q91ZR2.

Miscellaneous databases

PROi Q91ZR2.
SOURCEi Search...

Gene expression databases

CleanExi MM_SNX18.
Genevestigatori Q91ZR2.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR001452. SH3_domain.
IPR028646. SNX18.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view ]
PANTHERi PTHR10555:SF13. PTHR10555:SF13. 1 hit.
Pfami PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PIRSFi PIRSF027744. Snx9. 1 hit.
SMARTi SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "SNAG1, a novel SH3 and PX domain containing protein."
    Cohn J.B., Bernstein A., Stanford W.L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiSNX18_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi