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Protein

Sorting nexin-18

Gene

Snx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei302Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei304Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei328Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei342Phosphatidylinositol 4,5-bisphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
Sorting nexin-associated Golgi protein 1
Gene namesi
Name:Snx18
Synonyms:Snag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2137642. Snx18.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138671 – 614Sorting nexin-18Add BLAST614

Proteomic databases

EPDiQ91ZR2.
MaxQBiQ91ZR2.
PeptideAtlasiQ91ZR2.
PRIDEiQ91ZR2.

PTM databases

iPTMnetiQ91ZR2.
PhosphoSitePlusiQ91ZR2.

Expressioni

Gene expression databases

CleanExiMM_SNX18.

Interactioni

Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FASLGP480234EBI-6879954,EBI-495538From Homo sapiens.

Protein-protein interaction databases

IntActiQ91ZR2. 2 interactors.
MINTiMINT-5209459.

Structurei

3D structure databases

ProteinModelPortaliQ91ZR2.
SMRiQ91ZR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini266 – 376PXPROSITE-ProRule annotationAdd BLAST111
Domaini411 – 614BARAdd BLAST204

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000261633.
HOVERGENiHBG009996.
InParanoidiQ91ZR2.
PhylomeDBiQ91ZR2.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR001683. Phox.
IPR001452. SH3_domain.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
PfamiView protein in Pfam
PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
PIRSFiPIRSF027744. Snx9. 2 hits.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91ZR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL
110 120 130 140 150
LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD
160 170 180 190 200
DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS
210 220 230 240 250
APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR LREGWGQAVR
260 270 280 290 300
GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH
310 320 330 340 350
RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM
360 370 380 390 400
NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT
410 420 430 440 450
LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF
460 470 480 490 500
KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ
510 520 530 540 550
PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR RHVEEGKMEV
560 570 580 590 600
QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV
610
TQKLEEALHK YDSV
Length:614
Mass (Da):67,904
Last modified:December 1, 2001 - v1
Checksum:iBACED9D104571098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF408408 mRNA. Translation: AAL02105.1.
UniGeneiMm.33721.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSNX18_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families