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Q91ZR2

- SNX18_MOUSE

UniProt

Q91ZR2 - SNX18_MOUSE

Protein

Sorting nexin-18

Gene

Snx18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis By similarity. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei302 – 3021Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei304 – 3041Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei328 – 3281Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei342 – 3421Phosphatidylinositol 4,5-bisphosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. endocytosis Source: UniProtKB
    2. intracellular protein transport Source: RefGenome
    3. mitotic cytokinesis Source: InterPro
    4. mitotic nuclear division Source: UniProtKB-KW
    5. positive regulation of GTPase activity Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-18
    Alternative name(s):
    Sorting nexin-associated Golgi protein 1
    Gene namesi
    Name:Snx18
    Synonyms:Snag1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2137642. Snx18.

    Subcellular locationi

    Endomembrane system By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: RefGenome
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endosome Source: RefGenome
    4. endosome membrane Source: UniProtKB-SubCell
    5. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
    6. growth cone Source: MGI
    7. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Sorting nexin-18PRO_0000213867Add
    BLAST

    Proteomic databases

    MaxQBiQ91ZR2.
    PaxDbiQ91ZR2.
    PRIDEiQ91ZR2.

    PTM databases

    PhosphoSiteiQ91ZR2.

    Expressioni

    Gene expression databases

    CleanExiMM_SNX18.
    GenevestigatoriQ91ZR2.

    Interactioni

    Subunit structurei

    Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FASLGP480234EBI-6879954,EBI-495538From a different organism.

    Protein-protein interaction databases

    IntActiQ91ZR2. 2 interactions.
    MINTiMINT-5209459.
    STRINGi10090.ENSMUSP00000104864.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZR2.
    SMRiQ91ZR2. Positions 6-59, 253-613.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6161SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 376111PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini411 – 614204BARAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 BAR domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5391.
    HOGENOMiHOG000261633.
    HOVERGENiHBG009996.
    PhylomeDBiQ91ZR2.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR001452. SH3_domain.
    IPR028646. SNX18.
    IPR014536. Snx9_subfam.
    IPR019497. Sorting_nexin_WASP-bd-dom.
    [Graphical view]
    PANTHERiPTHR10555:SF13. PTHR10555:SF13. 1 hit.
    PfamiPF10456. BAR_3_WASP_bdg. 1 hit.
    PF00787. PX. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027744. Snx9. 1 hit.
    SMARTiSM00312. PX. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91ZR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL    50
    FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL 100
    LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD 150
    DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS 200
    APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR LREGWGQAVR 250
    GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH 300
    RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM 350
    NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT 400
    LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF 450
    KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ 500
    PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR RHVEEGKMEV 550
    QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV 600
    TQKLEEALHK YDSV 614
    Length:614
    Mass (Da):67,904
    Last modified:December 1, 2001 - v1
    Checksum:iBACED9D104571098
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF408408 mRNA. Translation: AAL02105.1.
    UniGeneiMm.33721.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF408408 mRNA. Translation: AAL02105.1 .
    UniGenei Mm.33721.

    3D structure databases

    ProteinModelPortali Q91ZR2.
    SMRi Q91ZR2. Positions 6-59, 253-613.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91ZR2. 2 interactions.
    MINTi MINT-5209459.
    STRINGi 10090.ENSMUSP00000104864.

    PTM databases

    PhosphoSitei Q91ZR2.

    Proteomic databases

    MaxQBi Q91ZR2.
    PaxDbi Q91ZR2.
    PRIDEi Q91ZR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2137642. Snx18.

    Phylogenomic databases

    eggNOGi COG5391.
    HOGENOMi HOG000261633.
    HOVERGENi HBG009996.
    PhylomeDBi Q91ZR2.

    Miscellaneous databases

    PROi Q91ZR2.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SNX18.
    Genevestigatori Q91ZR2.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR001452. SH3_domain.
    IPR028646. SNX18.
    IPR014536. Snx9_subfam.
    IPR019497. Sorting_nexin_WASP-bd-dom.
    [Graphical view ]
    PANTHERi PTHR10555:SF13. PTHR10555:SF13. 1 hit.
    Pfami PF10456. BAR_3_WASP_bdg. 1 hit.
    PF00787. PX. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027744. Snx9. 1 hit.
    SMARTi SM00312. PX. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SNAG1, a novel SH3 and PX domain containing protein."
      Cohn J.B., Bernstein A., Stanford W.L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiSNX18_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3