Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91ZR2

- SNX18_MOUSE

UniProt

Q91ZR2 - SNX18_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sorting nexin-18

Gene

Snx18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei302 – 3021Phosphatidylinositol 4,5-bisphosphateBy similarity
Binding sitei304 – 3041Phosphatidylinositol 4,5-bisphosphateBy similarity
Binding sitei328 – 3281Phosphatidylinositol 4,5-bisphosphateBy similarity
Binding sitei342 – 3421Phosphatidylinositol 4,5-bisphosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: MGI

GO - Biological processi

  1. endocytosis Source: UniProtKB
  2. intracellular protein transport Source: RefGenome
  3. mitotic cytokinesis Source: InterPro
  4. mitotic nuclear division Source: UniProtKB-KW
  5. positive regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
Sorting nexin-associated Golgi protein 1
Gene namesi
Name:Snx18
Synonyms:Snag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2137642. Snx18.

Subcellular locationi

Endomembrane system By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: RefGenome
  2. endosome Source: RefGenome
  3. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  4. growth cone Source: MGI
  5. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Sorting nexin-18PRO_0000213867Add
BLAST

Proteomic databases

MaxQBiQ91ZR2.
PaxDbiQ91ZR2.
PRIDEiQ91ZR2.

PTM databases

PhosphoSiteiQ91ZR2.

Expressioni

Gene expression databases

CleanExiMM_SNX18.
GenevestigatoriQ91ZR2.

Interactioni

Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FASLGP480234EBI-6879954,EBI-495538From a different organism.

Protein-protein interaction databases

IntActiQ91ZR2. 2 interactions.
MINTiMINT-5209459.
STRINGi10090.ENSMUSP00000104864.

Structurei

3D structure databases

ProteinModelPortaliQ91ZR2.
SMRiQ91ZR2. Positions 6-59, 253-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6161SH3PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 376111PXPROSITE-ProRule annotationAdd
BLAST
Domaini411 – 614204BARAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 BAR domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5391.
HOGENOMiHOG000261633.
HOVERGENiHBG009996.
InParanoidiQ91ZR2.
PhylomeDBiQ91ZR2.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR001452. SH3_domain.
IPR028646. SNX18.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]
PANTHERiPTHR10555:SF13. PTHR10555:SF13. 1 hit.
PfamiPF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF027744. Snx9. 1 hit.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL
110 120 130 140 150
LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD
160 170 180 190 200
DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS
210 220 230 240 250
APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR LREGWGQAVR
260 270 280 290 300
GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH
310 320 330 340 350
RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM
360 370 380 390 400
NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT
410 420 430 440 450
LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF
460 470 480 490 500
KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ
510 520 530 540 550
PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR RHVEEGKMEV
560 570 580 590 600
QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV
610
TQKLEEALHK YDSV
Length:614
Mass (Da):67,904
Last modified:December 1, 2001 - v1
Checksum:iBACED9D104571098
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF408408 mRNA. Translation: AAL02105.1.
UniGeneiMm.33721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF408408 mRNA. Translation: AAL02105.1 .
UniGenei Mm.33721.

3D structure databases

ProteinModelPortali Q91ZR2.
SMRi Q91ZR2. Positions 6-59, 253-613.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91ZR2. 2 interactions.
MINTi MINT-5209459.
STRINGi 10090.ENSMUSP00000104864.

PTM databases

PhosphoSitei Q91ZR2.

Proteomic databases

MaxQBi Q91ZR2.
PaxDbi Q91ZR2.
PRIDEi Q91ZR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2137642. Snx18.

Phylogenomic databases

eggNOGi COG5391.
HOGENOMi HOG000261633.
HOVERGENi HBG009996.
InParanoidi Q91ZR2.
PhylomeDBi Q91ZR2.

Miscellaneous databases

PROi Q91ZR2.
SOURCEi Search...

Gene expression databases

CleanExi MM_SNX18.
Genevestigatori Q91ZR2.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR001452. SH3_domain.
IPR028646. SNX18.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view ]
PANTHERi PTHR10555:SF13. PTHR10555:SF13. 1 hit.
Pfami PF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PIRSFi PIRSF027744. Snx9. 1 hit.
SMARTi SM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "SNAG1, a novel SH3 and PX domain containing protein."
    Cohn J.B., Bernstein A., Stanford W.L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiSNX18_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3