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Q91ZR2 (SNX18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-18
Alternative name(s):
Sorting nexin-associated Golgi protein 1
Gene names
Name:Snx18
Synonyms:Snag1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length614 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis By similarity. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane By similarity.

Subunit structure

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex By similarity.

Subcellular location

Endomembrane system; Peripheral membrane protein; Cytoplasmic side By similarity. Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation By similarity.

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 BAR domain.

Contains 1 PX (phox homology) domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Endocytosis
Mitosis
Protein transport
Transport
   Cellular componentCell membrane
Cytoplasmic vesicle
Endosome
Membrane
   DomainSH3 domain
   LigandLipid-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

intracellular protein transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

mitotic cytokinesis

Inferred from electronic annotation. Source: InterPro

mitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

endosome

Inferred from Biological aspect of Ancestor. Source: RefGenome

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

extrinsic component of cytoplasmic side of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

growth cone

Inferred from direct assay PubMed 21339182. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 21339182. Source: MGI

   Molecular_functionphosphatidylinositol binding

Inferred from direct assay PubMed 21339182. Source: MGI

protein binding

Inferred from physical interaction PubMed 17761170. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FASLGP480234EBI-6879954,EBI-495538From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 614614Sorting nexin-18
PRO_0000213867

Regions

Domain1 – 6161SH3
Domain266 – 376111PX
Domain411 – 614204BAR

Sites

Binding site3021Phosphatidylinositol 4,5-bisphosphate By similarity
Binding site3041Phosphatidylinositol 4,5-bisphosphate By similarity
Binding site3281Phosphatidylinositol 4,5-bisphosphate By similarity
Binding site3421Phosphatidylinositol 4,5-bisphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91ZR2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BACED9D104571098

FASTA61467,904
        10         20         30         40         50         60 
MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL FPASYVQVIR 

        70         80         90        100        110        120 
APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL LQPQASPGSF QPPGAGFPYG 

       130        140        150        160        170        180 
GGALQPSPQQ LYGGYQASLG SDDDWDDEWD DSSTVADEPG ALGSGAYPDL DGSSSAGGGA 

       190        200        210        220        230        240 
AGRYRLSTRS DLSLGSRGVS APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR 

       250        260        270        280        290        300 
LREGWGQAVR GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH 

       310        320        330        340        350        360 
RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM NHMASHPVLA 

       370        380        390        400        410        420 
QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD LQEVESKIDG 

       430        440        450        460        470        480 
FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN 

       490        500        510        520        530        540 
QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR 

       550        560        570        580        590        600 
RHVEEGKMEV QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV 

       610 
TQKLEEALHK YDSV 

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References

[1]"SNAG1, a novel SH3 and PX domain containing protein."
Cohn J.B., Bernstein A., Stanford W.L.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF408408 mRNA. Translation: AAL02105.1.
UniGeneMm.33721.

3D structure databases

ProteinModelPortalQ91ZR2.
SMRQ91ZR2. Positions 6-59, 253-613.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91ZR2. 2 interactions.
MINTMINT-5209459.
STRING10090.ENSMUSP00000104864.

PTM databases

PhosphoSiteQ91ZR2.

Proteomic databases

MaxQBQ91ZR2.
PaxDbQ91ZR2.
PRIDEQ91ZR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:2137642. Snx18.

Phylogenomic databases

eggNOGCOG5391.
HOGENOMHOG000261633.
HOVERGENHBG009996.
PhylomeDBQ91ZR2.

Gene expression databases

CleanExMM_SNX18.
GenevestigatorQ91ZR2.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
IPR001452. SH3_domain.
IPR028646. SNX18.
IPR014536. Snx9_subfam.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]
PANTHERPTHR10555:SF13. PTHR10555:SF13. 1 hit.
PfamPF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFPIRSF027744. Snx9. 1 hit.
SMARTSM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ91ZR2.
SOURCESearch...

Entry information

Entry nameSNX18_MOUSE
AccessionPrimary (citable) accession number: Q91ZR2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot