Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-4B

Gene

Rab4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8875656 MET receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4B
Gene namesi
Name:Rab4b
Synonyms:Rab4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105071 Rab4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211002 – 213Ras-related protein Rab-4BAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Modified residuei213Cysteine methyl esterBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ91ZR1
MaxQBiQ91ZR1
PaxDbiQ91ZR1
PRIDEiQ91ZR1

PTM databases

iPTMnetiQ91ZR1
PhosphoSitePlusiQ91ZR1

Expressioni

Gene expression databases

BgeeiENSMUSG00000053291
ExpressionAtlasiQ91ZR1 baseline and differential
GenevisibleiQ91ZR1 MM

Interactioni

Protein-protein interaction databases

IntActiQ91ZR1, 33 interactors
STRINGi10090.ENSMUSP00000090727

Structurei

3D structure databases

ProteinModelPortaliQ91ZR1
SMRiQ91ZR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086 Eukaryota
ENOG410XQ9X LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ91ZR1
KOiK07880
OMAiASQNICI
OrthoDBiEOG091G0QOB
PhylomeDBiQ91ZR1
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETYDFLFK FLVIGSAGTG KSCLLHQFIE NKFKQDSNHT IGVEFGSRVV
60 70 80 90 100
NVGGKTVKLQ IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNSLA
110 120 130 140 150
AWLTDARTLA SPNIVVILCG NKKDLDPERE VTFLEASRFA QENELMFLET
160 170 180 190 200
SALTGENVEE AFLKCARTIL NKIDSGELDP ERMGSGIQYG DISLRQLRQP
210
RSAQAVAPQP CGC
Length:213
Mass (Da):23,629
Last modified:April 26, 2004 - v2
Checksum:i0C3D76DC328B0018
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174D → G in AAL11725 (Ref. 1) Curated1
Sequence conflicti199 – 200QP → HA in AAL11725 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF408432 mRNA Translation: AAL11725.1
AK005314 mRNA Translation: BAB23948.1
BC007147 mRNA Translation: AAH07147.1
CCDSiCCDS21012.1
RefSeqiNP_083667.1, NM_029391.2
UniGeneiMm.482114

Genome annotation databases

EnsembliENSMUST00000093040; ENSMUSP00000090727; ENSMUSG00000053291
GeneIDi19342
KEGGimmu:19342
UCSCiuc009fvc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB4B_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health