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Q91ZQ1 (PDE6C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

EC=3.1.4.35
Alternative name(s):
cGMP phosphodiesterase 6C
Gene names
Name:Pde6c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length861 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Subunit structure

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 2 GAF domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91ZQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91ZQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     737-761: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
PRO_0000226068
Propeptide859 – 8613Removed in mature form Potential
PRO_0000370789

Regions

Domain75 – 224150GAF 1
Domain256 – 433178GAF 2
Nucleotide binding169 – 1724cGMP By similarity

Sites

Active site5621Proton donor By similarity
Metal binding5661Divalent metal cation 1 By similarity
Metal binding6021Divalent metal cation 1 By similarity
Metal binding6031Divalent metal cation 1 By similarity
Metal binding6031Divalent metal cation 2 By similarity
Metal binding7231Divalent metal cation 1 By similarity
Binding site971cGMP By similarity
Binding site1161cGMP By similarity
Binding site1761cGMP By similarity

Amino acid modifications

Modified residue8581Cysteine methyl ester Potential
Lipidation8581S-geranylgeranyl cysteine By similarity

Natural variations

Alternative sequence737 – 76125Missing in isoform 2.
VSP_017422

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C582D78114652B5B

FASTA86198,785
        10         20         30         40         50         60 
MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL PEMTQVEESA 

        70         80         90        100        110        120 
VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS CRARNGIPEV ASRLLNVTPT 

       130        140        150        160        170        180 
SKFEDNLVAP DREVVFPLDI GIVGWVAHVK KALNVSDVKK NSHFSDFMDK QTGYVTRNLL 

       190        200        210        220        230        240 
AVPIVAGKEV LAVVMAVNKI SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS 

       250        260        270        280        290        300 
QILMWSANKV FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE 

       310        320        330        340        350        360 
VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT YVAENGFICN 

       370        380        390        400        410        420 
MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV GVATFYNRKD GKPFDEHDEH 

       430        440        450        460        470        480 
ITETLTQFLG WSLLNTDTYE RVNKLESRKD IAQEMVMNLT KATPDEISSI LKFKEKLNVE 

       490        500        510        520        530        540 
VIEECEERQL LAILKEDLPD PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV 

       550        560        570        580        590        600 
PVEVLTRWMY TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF 

       610        620        630        640        650        660 
CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF QNLNKRQFET 

       670        680        690        700        710        720 
VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET IKYVTSDPTK KEVIMAMMMT 

       730        740        750        760        770        780 
ACDLSAITKP WEVQSQVALL VANEFWEQGD LERTVLQQQP IPMMDRSKKD ELPKLQVGFI 

       790        800        810        820        830        840 
DFVCTFVYKE FSRFHGEITP MLNGLQNNRV EWKSLAEEYE AKVKVTEEEA GKQEEEASDG 

       850        860 
KAATDLGGSA EDKKSKTCLM L 

« Hide

Isoform 2 [UniParc].

Checksum: A8D60FAAFE6C9D9E
Show »

FASTA83695,906

References

« Hide 'large scale' references
[1]"A sequence alteration in Pde6c gene causes cone photoreceptor function loss (cpfl1) in mice."
Chang B., Hawes N.L., Hurd R.E., Davisson M.T., Nusinowitz S., Heckenlively J.R.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411063 mRNA. Translation: AAK96254.1.
BC027050 mRNA. Translation: AAH27050.1.
RefSeqNP_001164430.1. NM_001170959.1.
NP_291092.1. NM_033614.2.
UniGeneMm.450141.

3D structure databases

ProteinModelPortalQ91ZQ1.
SMRQ91ZQ1. Positions 24-821.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91ZQ1.

Proteomic databases

PRIDEQ91ZQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025956; ENSMUSP00000025956; ENSMUSG00000024992. [Q91ZQ1-1]
ENSMUST00000112329; ENSMUSP00000107948; ENSMUSG00000024992. [Q91ZQ1-2]
GeneID110855.
KEGGmmu:110855.
UCSCuc008hjf.2. mouse. [Q91ZQ1-1]
uc012blg.1. mouse. [Q91ZQ1-2]

Organism-specific databases

CTD5146.
MGIMGI:105956. Pde6c.

Phylogenomic databases

eggNOGNOG290744.
GeneTreeENSGT00750000117253.
HOGENOMHOG000007069.
HOVERGENHBG053539.
InParanoidQ91ZQ1.
KOK13757.
OMAIVMGKEV.
OrthoDBEOG7BGHK1.
PhylomeDBQ91ZQ1.
TreeFamTF316499.

Gene expression databases

BgeeQ91ZQ1.
GenevestigatorQ91ZQ1.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003018. GAF.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDE6C. mouse.
NextBio364793.
PROQ91ZQ1.
SOURCESearch...

Entry information

Entry namePDE6C_MOUSE
AccessionPrimary (citable) accession number: Q91ZQ1
Secondary accession number(s): Q8R0D4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot