Reviewed, UniProtKB/Swiss-Prot Q91ZQ1 (PDE6C_MOUSE)

Names and origin

Protein names

Recommended name:
    Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
    EC=3.1.4.35
Alternative name(s):
    cGMP phosphodiesterase 6C

Gene names

Name:

Pde6c

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	861 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	cGMP
Molecular function	Hydrolase
PTM	Lipoprotein Methylation Prenylation
Gene Ontology (GO)
Biological process	phototransduction, visible light Inferred from mutant phenotype. Source: MGI signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	internal side of plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91ZQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91ZQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     737-761: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 858	858	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'		PRO_0000226068
	Propeptide	859 – 861	3	Removed in mature form Potential		PRO_0000370789
Regions
	Domain	75 – 224	150	GAF 1
	Domain	256 – 433	178	GAF 2
Amino acid modifications
	Modified residue	858	1	Cysteine methyl ester Potential
	Lipidation	858	1	S-geranylgeranyl cysteine By similarity
Natural variations
	Alternative sequence	737 – 761	25	Missing in isoform 2.		VSP_017422

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C582D78114652B5B	FASTA	861	98,785
	10 20 30 40 50 60 MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL PEMTQVEESA 70 80 90 100 110 120 VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS CRARNGIPEV ASRLLNVTPT 130 140 150 160 170 180 SKFEDNLVAP DREVVFPLDI GIVGWVAHVK KALNVSDVKK NSHFSDFMDK QTGYVTRNLL 190 200 210 220 230 240 AVPIVAGKEV LAVVMAVNKI SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS 250 260 270 280 290 300 QILMWSANKV FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE 310 320 330 340 350 360 VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT YVAENGFICN 370 380 390 400 410 420 MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV GVATFYNRKD GKPFDEHDEH 430 440 450 460 470 480 ITETLTQFLG WSLLNTDTYE RVNKLESRKD IAQEMVMNLT KATPDEISSI LKFKEKLNVE 490 500 510 520 530 540 VIEECEERQL LAILKEDLPD PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV 550 560 570 580 590 600 PVEVLTRWMY TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF 610 620 630 640 650 660 CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF QNLNKRQFET 670 680 690 700 710 720 VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET IKYVTSDPTK KEVIMAMMMT 730 740 750 760 770 780 ACDLSAITKP WEVQSQVALL VANEFWEQGD LERTVLQQQP IPMMDRSKKD ELPKLQVGFI 790 800 810 820 830 840 DFVCTFVYKE FSRFHGEITP MLNGLQNNRV EWKSLAEEYE AKVKVTEEEA GKQEEEASDG 850 860 KAATDLGGSA EDKKSKTCLM L
	Isoform 2. Checksum: A8D60FAAFE6C9D9E	FASTA	836	95,906
	10 20 30 40 50 60 MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL PEMTQVEESA 70 80 90 100 110 120 VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS CRARNGIPEV ASRLLNVTPT 130 140 150 160 170 180 SKFEDNLVAP DREVVFPLDI GIVGWVAHVK KALNVSDVKK NSHFSDFMDK QTGYVTRNLL 190 200 210 220 230 240 AVPIVAGKEV LAVVMAVNKI SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS 250 260 270 280 290 300 QILMWSANKV FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE 310 320 330 340 350 360 VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT YVAENGFICN 370 380 390 400 410 420 MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV GVATFYNRKD GKPFDEHDEH 430 440 450 460 470 480 ITETLTQFLG WSLLNTDTYE RVNKLESRKD IAQEMVMNLT KATPDEISSI LKFKEKLNVE 490 500 510 520 530 540 VIEECEERQL LAILKEDLPD PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV 550 560 570 580 590 600 PVEVLTRWMY TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF 610 620 630 640 650 660 CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF QNLNKRQFET 670 680 690 700 710 720 VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET IKYVTSDPTK KEVIMAMMMT 730 740 750 760 770 780 ACDLSAITKP WEVQSQPMMD RSKKDELPKL QVGFIDFVCT FVYKEFSRFH GEITPMLNGL 790 800 810 820 830 QNNRVEWKSL AEEYEAKVKV TEEEAGKQEE EASDGKAATD LGGSAEDKKS KTCLML

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A sequence alteration in Pde6c gene causes cone photoreceptor function loss (cpfl1) in mice." Chang B., Hawes N.L., Hurd R.E., Davisson M.T., Nusinowitz S., Heckenlively J.R. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Retina.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF411063 mRNA. Translation: AAK96254.1. BC027050 mRNA. Translation: AAH27050.1.
IPI	IPI00131299. IPI00742318.
RefSeq	NP_291092.1.
UniGene	Mm.450141
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q91ZQ1.
Proteomic databases
PRIDE	Q91ZQ1.
Genome annotation databases
Ensembl	ENSMUST00000025956; ENSMUSP00000025956; ENSMUSG00000024992; Mus musculus. [Genome view] ENSMUST00000112329; ENSMUSP00000107948; ENSMUSG00000024992; Mus musculus. [Genome view]
GeneID	110855.
KEGG	mmu:110855.
UCSC	uc008hjf.1. mouse.
Organism-specific databases
CTD	110855.
MGI	MGI:105956. Pde6c.
Phylogenomic databases
HOGENOM	Q91ZQ1.
HOVERGEN	Q91ZQ1.
OMA	DCEEKQL.
Enzyme and pathway databases
BRENDA	3.1.4.35. 244.
Gene expression databases
ArrayExpress	Q91ZQ1.
Bgee	Q91ZQ1.
Genevestigator	Q91ZQ1.
GermOnline	ENSMUSG00000024992. Mus musculus.
Family and domain databases
InterPro	IPR003018. GAF. IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. [Graphical view]
Pfam	PF01590. GAF. 2 hits. PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00065. GAF. 2 hits. SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	364793.
SOURCE	Search...

Entry information

Entry name

PDE6C_MOUSE

Accession

Primary (citable) accession number: Q91ZQ1
Secondary accession number(s): Q8R0D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)