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Q91ZQ1

- PDE6C_MOUSE

UniProt

Q91ZQ1 - PDE6C_MOUSE

Protein

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Gene

Pde6c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei97 – 971cGMPBy similarity
    Binding sitei116 – 1161cGMPBy similarity
    Binding sitei176 – 1761cGMPBy similarity
    Active sitei562 – 5621Proton donorBy similarity
    Metal bindingi566 – 5661Divalent metal cation 1By similarity
    Metal bindingi602 – 6021Divalent metal cation 1By similarity
    Metal bindingi603 – 6031Divalent metal cation 1By similarity
    Metal bindingi603 – 6031Divalent metal cation 2By similarity
    Metal bindingi723 – 7231Divalent metal cation 1By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1724cGMPBy similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction, visible light Source: MGI
    2. retinal cone cell development Source: MGI
    3. sensory perception of light stimulus Source: MGI
    4. visual perception Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP, cGMP-binding, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC:3.1.4.35)
    Alternative name(s):
    cGMP phosphodiesterase 6C
    Gene namesi
    Name:Pde6c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:105956. Pde6c.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'PRO_0000226068Add
    BLAST
    Propeptidei859 – 8613Removed in mature formSequence AnalysisPRO_0000370789

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei858 – 8581Cysteine methyl esterSequence Analysis
    Lipidationi858 – 8581S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiQ91ZQ1.

    PTM databases

    PhosphoSiteiQ91ZQ1.

    Expressioni

    Gene expression databases

    BgeeiQ91ZQ1.
    GenevestigatoriQ91ZQ1.

    Interactioni

    Subunit structurei

    Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZQ1.
    SMRiQ91ZQ1. Positions 24-821.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini75 – 224150GAF 1Add
    BLAST
    Domaini256 – 433178GAF 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 GAF domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG290744.
    GeneTreeiENSGT00750000117253.
    HOGENOMiHOG000007069.
    HOVERGENiHBG053539.
    InParanoidiQ91ZQ1.
    KOiK13757.
    OMAiCGIRLFF.
    OrthoDBiEOG7BGHK1.
    PhylomeDBiQ91ZQ1.
    TreeFamiTF316499.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZQ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL    50
    PEMTQVEESA VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS 100
    CRARNGIPEV ASRLLNVTPT SKFEDNLVAP DREVVFPLDI GIVGWVAHVK 150
    KALNVSDVKK NSHFSDFMDK QTGYVTRNLL AVPIVAGKEV LAVVMAVNKI 200
    SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS QILMWSANKV 250
    FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE 300
    VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT 350
    YVAENGFICN MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV 400
    GVATFYNRKD GKPFDEHDEH ITETLTQFLG WSLLNTDTYE RVNKLESRKD 450
    IAQEMVMNLT KATPDEISSI LKFKEKLNVE VIEECEERQL LAILKEDLPD 500
    PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV PVEVLTRWMY 550
    TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF 600
    CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF 650
    QNLNKRQFET VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET 700
    IKYVTSDPTK KEVIMAMMMT ACDLSAITKP WEVQSQVALL VANEFWEQGD 750
    LERTVLQQQP IPMMDRSKKD ELPKLQVGFI DFVCTFVYKE FSRFHGEITP 800
    MLNGLQNNRV EWKSLAEEYE AKVKVTEEEA GKQEEEASDG KAATDLGGSA 850
    EDKKSKTCLM L 861
    Length:861
    Mass (Da):98,785
    Last modified:December 1, 2001 - v1
    Checksum:iC582D78114652B5B
    GO
    Isoform 2 (identifier: Q91ZQ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         737-761: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:836
    Mass (Da):95,906
    Checksum:iA8D60FAAFE6C9D9E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei737 – 76125Missing in isoform 2. 1 PublicationVSP_017422Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411063 mRNA. Translation: AAK96254.1.
    BC027050 mRNA. Translation: AAH27050.1.
    CCDSiCCDS37971.1. [Q91ZQ1-1]
    CCDS50431.1. [Q91ZQ1-2]
    RefSeqiNP_001164430.1. NM_001170959.1. [Q91ZQ1-2]
    NP_291092.1. NM_033614.2. [Q91ZQ1-1]
    UniGeneiMm.450141.

    Genome annotation databases

    EnsembliENSMUST00000025956; ENSMUSP00000025956; ENSMUSG00000024992. [Q91ZQ1-1]
    ENSMUST00000112329; ENSMUSP00000107948; ENSMUSG00000024992. [Q91ZQ1-2]
    GeneIDi110855.
    KEGGimmu:110855.
    UCSCiuc008hjf.2. mouse. [Q91ZQ1-1]
    uc012blg.1. mouse. [Q91ZQ1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411063 mRNA. Translation: AAK96254.1 .
    BC027050 mRNA. Translation: AAH27050.1 .
    CCDSi CCDS37971.1. [Q91ZQ1-1 ]
    CCDS50431.1. [Q91ZQ1-2 ]
    RefSeqi NP_001164430.1. NM_001170959.1. [Q91ZQ1-2 ]
    NP_291092.1. NM_033614.2. [Q91ZQ1-1 ]
    UniGenei Mm.450141.

    3D structure databases

    ProteinModelPortali Q91ZQ1.
    SMRi Q91ZQ1. Positions 24-821.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91ZQ1.

    Proteomic databases

    PRIDEi Q91ZQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025956 ; ENSMUSP00000025956 ; ENSMUSG00000024992 . [Q91ZQ1-1 ]
    ENSMUST00000112329 ; ENSMUSP00000107948 ; ENSMUSG00000024992 . [Q91ZQ1-2 ]
    GeneIDi 110855.
    KEGGi mmu:110855.
    UCSCi uc008hjf.2. mouse. [Q91ZQ1-1 ]
    uc012blg.1. mouse. [Q91ZQ1-2 ]

    Organism-specific databases

    CTDi 5146.
    MGIi MGI:105956. Pde6c.

    Phylogenomic databases

    eggNOGi NOG290744.
    GeneTreei ENSGT00750000117253.
    HOGENOMi HOG000007069.
    HOVERGENi HBG053539.
    InParanoidi Q91ZQ1.
    KOi K13757.
    OMAi CGIRLFF.
    OrthoDBi EOG7BGHK1.
    PhylomeDBi Q91ZQ1.
    TreeFami TF316499.

    Miscellaneous databases

    ChiTaRSi PDE6C. mouse.
    NextBioi 364793.
    PROi Q91ZQ1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91ZQ1.
    Genevestigatori Q91ZQ1.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A sequence alteration in Pde6c gene causes cone photoreceptor function loss (cpfl1) in mice."
      Chang B., Hawes N.L., Hurd R.E., Davisson M.T., Nusinowitz S., Heckenlively J.R.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.

    Entry informationi

    Entry nameiPDE6C_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZQ1
    Secondary accession number(s): Q8R0D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3