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Protein

Vacuole membrane protein 1

Gene

Vmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion (By similarity). Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.By similarity4 Publications

GO - Biological processi

Keywordsi

Biological processAutophagy, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
Transmembrane protein 49
Gene namesi
Name:Vmp1
Synonyms:Tmem49
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi70367 Vmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 109ExtracellularSequence analysisAdd BLAST11
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 250CytoplasmicSequence analysisAdd BLAST120
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 273ExtracellularSequence analysis2
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305CytoplasmicSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 363ExtracellularSequence analysisAdd BLAST37
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 406CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002845492 – 406Vacuole membrane protein 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ91ZQ0
PRIDEiQ91ZQ0

PTM databases

iPTMnetiQ91ZQ0
PhosphoSitePlusiQ91ZQ0

Expressioni

Tissue specificityi

Highly expressed in intestine, kidney, ovary and placenta, moderately expressed in liver, lung, stomach, thymus, brain, and testis and slightly expressed in control thyroid and retina. Strongly expressed in pancreas (acinar cells) during acute pancreatitis.1 Publication

Inductioni

Overexpressed only in pancreas during acute pancreatitis. Up-regulated by starvation. Up-regulated following MTOR-inhibition by rapamycin.1 Publication

Gene expression databases

BgeeiENSRNOG00000003967
GenevisibleiQ91ZQ0 RN

Interactioni

Subunit structurei

Interacts with TJP1 (By similarity). Interacts with BECN1. Interacts with TP53INP2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144576EBI-11163586,EBI-949378From Homo sapiens.

Protein-protein interaction databases

BioGridi251330, 2 interactors
IntActiQ91ZQ0, 2 interactors
STRINGi10116.ENSRNOP00000005658

Structurei

3D structure databases

SMRiQ91ZQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni378 – 406Required for interaction with BECN11 PublicationAdd BLAST29

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109 Eukaryota
ENOG410XQHA LUCA
GeneTreeiENSGT00390000007230
HOVERGENiHBG057290
InParanoidiQ91ZQ0
KOiK21248
OMAiMDKGKLF
OrthoDBiEOG091G0AKM
PhylomeDBiQ91ZQ0
TreeFamiTF313699

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGTNCDQ RRGAMSKEQH NGSFTDPSSV NEKKRRDREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE TLVVLKEWTS KLWHRQSMVV SFFLLLAALV ATYYVEGAHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPD EEGTEGAISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAETAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVIV TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HRSEAGTAQG ENWLSWTFEK LVVAMVCYFI LSIINSMAQS YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):45,901
Last modified:December 1, 2001 - v1
Checksum:iB87BDD5E8D06D722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411216 mRNA Translation: AAL05859.1
BC061721 mRNA Translation: AAH61721.1
PIRiJC7798
RefSeqiNP_620194.1, NM_138839.2
XP_006247140.1, XM_006247078.3
XP_006247141.1, XM_006247079.3
UniGeneiRn.109048
Rn.167960

Genome annotation databases

EnsembliENSRNOT00000005658; ENSRNOP00000005658; ENSRNOG00000003967
GeneIDi192129
KEGGirno:192129

Similar proteinsi

Entry informationi

Entry nameiVMP1_RAT
AccessioniPrimary (citable) accession number: Q91ZQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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