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Protein

Vacuole membrane protein 1

Gene

Vmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion (By similarity). Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.By similarity4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
Transmembrane protein 49
Gene namesi
Name:Vmp1
Synonyms:Tmem49
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi70367. Vmp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 109ExtracellularSequence analysisAdd BLAST11
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 250CytoplasmicSequence analysisAdd BLAST120
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 273ExtracellularSequence analysis2
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305CytoplasmicSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 363ExtracellularSequence analysisAdd BLAST37
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 406CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002845492 – 406Vacuole membrane protein 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ91ZQ0.
PRIDEiQ91ZQ0.

PTM databases

iPTMnetiQ91ZQ0.
PhosphoSitePlusiQ91ZQ0.

Expressioni

Tissue specificityi

Highly expressed in intestine, kidney, ovary and placenta, moderately expressed in liver, lung, stomach, thymus, brain, and testis and slightly expressed in control thyroid and retina. Strongly expressed in pancreas (acinar cells) during acute pancreatitis.1 Publication

Inductioni

Overexpressed only in pancreas during acute pancreatitis. Up-regulated by starvation. Up-regulated following MTOR-inhibition by rapamycin.1 Publication

Gene expression databases

BgeeiENSRNOG00000003967.
GenevisibleiQ91ZQ0. RN.

Interactioni

Subunit structurei

Interacts with TJP1 (By similarity). Interacts with BECN1. Interacts with TP53INP2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144576EBI-11163586,EBI-949378From a different organism.

Protein-protein interaction databases

BioGridi251330. 2 interactors.
IntActiQ91ZQ0. 2 interactors.
STRINGi10116.ENSRNOP00000005658.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni378 – 406Required for interaction with BECN11 PublicationAdd BLAST29

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ91ZQ0.
OMAiWLSWTFE.
OrthoDBiEOG091G0AKM.
PhylomeDBiQ91ZQ0.
TreeFamiTF313699.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGTNCDQ RRGAMSKEQH NGSFTDPSSV NEKKRRDREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE TLVVLKEWTS KLWHRQSMVV SFFLLLAALV ATYYVEGAHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPD EEGTEGAISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAETAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVIV TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HRSEAGTAQG ENWLSWTFEK LVVAMVCYFI LSIINSMAQS YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):45,901
Last modified:December 1, 2001 - v1
Checksum:iB87BDD5E8D06D722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411216 mRNA. Translation: AAL05859.1.
BC061721 mRNA. Translation: AAH61721.1.
PIRiJC7798.
RefSeqiNP_620194.1. NM_138839.2.
XP_006247140.1. XM_006247078.3.
XP_006247141.1. XM_006247079.3.
UniGeneiRn.109048.
Rn.167960.

Genome annotation databases

EnsembliENSRNOT00000005658; ENSRNOP00000005658; ENSRNOG00000003967.
GeneIDi192129.
KEGGirno:192129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411216 mRNA. Translation: AAL05859.1.
BC061721 mRNA. Translation: AAH61721.1.
PIRiJC7798.
RefSeqiNP_620194.1. NM_138839.2.
XP_006247140.1. XM_006247078.3.
XP_006247141.1. XM_006247079.3.
UniGeneiRn.109048.
Rn.167960.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251330. 2 interactors.
IntActiQ91ZQ0. 2 interactors.
STRINGi10116.ENSRNOP00000005658.

PTM databases

iPTMnetiQ91ZQ0.
PhosphoSitePlusiQ91ZQ0.

Proteomic databases

PaxDbiQ91ZQ0.
PRIDEiQ91ZQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005658; ENSRNOP00000005658; ENSRNOG00000003967.
GeneIDi192129.
KEGGirno:192129.

Organism-specific databases

CTDi81671.
RGDi70367. Vmp1.

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ91ZQ0.
OMAiWLSWTFE.
OrthoDBiEOG091G0AKM.
PhylomeDBiQ91ZQ0.
TreeFamiTF313699.

Miscellaneous databases

PROiQ91ZQ0.

Gene expression databases

BgeeiENSRNOG00000003967.
GenevisibleiQ91ZQ0. RN.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMP1_RAT
AccessioniPrimary (citable) accession number: Q91ZQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.