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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

Slc35b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-174362 Transport and synthesis of PAPS
R-MMU-727802 Transport of nucleotide sugars

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Alternative name(s):
PAPS transporter 1
Solute carrier family 35 member B2
Gene namesi
Name:Slc35b2
Synonyms:J207, Papst1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1921086 Slc35b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133751 – 431Adenosine 3'-phospho 5'-phosphosulfate transporter 1Add BLAST431

Proteomic databases

PaxDbiQ91ZN5
PRIDEiQ91ZN5

PTM databases

iPTMnetiQ91ZN5
PhosphoSitePlusiQ91ZN5
SwissPalmiQ91ZN5

Expressioni

Gene expression databases

BgeeiENSMUSG00000037089
CleanExiMM_SLC35B2
ExpressionAtlasiQ91ZN5 baseline and differential
GenevisibleiQ91ZN5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037834

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1581 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00530000063090
HOGENOMiHOG000264497
HOVERGENiHBG062347
InParanoidiQ91ZN5
OMAiQMMCGVN
PhylomeDBiQ91ZN5
TreeFamiTF105926

Family and domain databases

InterProiView protein in InterPro
IPR013657 UAA
PfamiView protein in Pfam
PF08449 UAA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDARWWAVVV LATLPSLGAG GESPEAPPQS WTQLWLFRFL LNVAGYASFM
60 70 80 90 100
VPGYLLVQYL RRKNYLETGR GLCFPLVKAC VFGNEPKAPD EVLLAPRTET
110 120 130 140 150
AESTPSWQVL KLVFCASGLQ VSYLTWGILQ ERVMTGSYGA TATSPGEHFT
160 170 180 190 200
DSQFLVLMNR VLALVVAGLY CVLRKQPRHG APMYRYSFAS LSNVLSSWCQ
210 220 230 240 250
YEALKFVSFP TQVLAKASKV IPVMMMGKLV SRRSYEHWEY LTAGLISIGV
260 270 280 290 300
SMFLLSSGPE PRSSPATTLS GLVLLAGYIA FDSFTSNWQD ALFAYKMSSV
310 320 330 340 350
QMMFGVNLFS CLFTVGSLLE QGALLEGARF MGRHSEFALH ALLLSICSAF
360 370 380 390 400
GQLFIFYTIG QFGAAVFTII MTLRQAIAIL LSCLLYGHTV TVVGGLGVAV
410 420 430
VFTALLLRVY ARGRKQRGKK AVPTEPPVQK V
Length:431
Mass (Da):47,370
Last modified:December 1, 2001 - v1
Checksum:i9C83961CF403FCEB
GO
Isoform 2 (identifier: Q91ZN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):41,979
Checksum:iEC54AAB97F414026
GO

Sequence cautioni

The sequence BAC41173 differs from that shown. Reason: Frameshift at positions 350 and 375.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61R → K in BAC41173 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140851 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414190 mRNA Translation: AAL07487.1
AK090329 mRNA Translation: BAC41173.1 Frameshift.
AK144403 mRNA Translation: BAE25873.1
AK155551 mRNA Translation: BAE33321.1
BC025875 mRNA Translation: AAH25875.1
BC036992 mRNA Translation: AAH36992.1
CCDSiCCDS37630.1 [Q91ZN5-1]
RefSeqiXP_006525059.1, XM_006524996.1
UniGeneiMm.289716

Genome annotation databases

EnsembliENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089 [Q91ZN5-2]
ENSMUST00000223987; ENSMUSP00000153631; ENSMUSG00000037089 [Q91ZN5-2]
ENSMUST00000224905; ENSMUSP00000153367; ENSMUSG00000037089 [Q91ZN5-1]
GeneIDi73836
UCSCiuc008cqx.1 mouse [Q91ZN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35B2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZN5
Secondary accession number(s): Q3U221, Q8BTH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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