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Q91ZN5

- S35B2_MOUSE

UniProt

Q91ZN5 - S35B2_MOUSE

Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

Slc35b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi By similarity.By similarity

    GO - Molecular functioni

    1. 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Source: Ensembl
    2. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_203051. Transport of nucleotide sugars.
    REACT_214239. Transport and synthesis of PAPS.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Alternative name(s):
    PAPS transporter 1
    Solute carrier family 35 member B2
    Gene namesi
    Name:Slc35b2
    Synonyms:J207, Papst1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1921086. Slc35b2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Adenosine 3'-phospho 5'-phosphosulfate transporter 1PRO_0000213375Add
    BLAST

    Proteomic databases

    PaxDbiQ91ZN5.
    PRIDEiQ91ZN5.

    PTM databases

    PhosphoSiteiQ91ZN5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91ZN5.
    BgeeiQ91ZN5.
    CleanExiMM_SLC35B2.
    GenevestigatoriQ91ZN5.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00530000063090.
    HOGENOMiHOG000264497.
    HOVERGENiHBG062347.
    InParanoidiQ91ZN5.
    KOiK15276.
    OMAiVLCKQPR.
    OrthoDBiEOG79CXZC.
    PhylomeDBiQ91ZN5.
    TreeFamiTF105926.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZN5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDARWWAVVV LATLPSLGAG GESPEAPPQS WTQLWLFRFL LNVAGYASFM    50
    VPGYLLVQYL RRKNYLETGR GLCFPLVKAC VFGNEPKAPD EVLLAPRTET 100
    AESTPSWQVL KLVFCASGLQ VSYLTWGILQ ERVMTGSYGA TATSPGEHFT 150
    DSQFLVLMNR VLALVVAGLY CVLRKQPRHG APMYRYSFAS LSNVLSSWCQ 200
    YEALKFVSFP TQVLAKASKV IPVMMMGKLV SRRSYEHWEY LTAGLISIGV 250
    SMFLLSSGPE PRSSPATTLS GLVLLAGYIA FDSFTSNWQD ALFAYKMSSV 300
    QMMFGVNLFS CLFTVGSLLE QGALLEGARF MGRHSEFALH ALLLSICSAF 350
    GQLFIFYTIG QFGAAVFTII MTLRQAIAIL LSCLLYGHTV TVVGGLGVAV 400
    VFTALLLRVY ARGRKQRGKK AVPTEPPVQK V 431
    Length:431
    Mass (Da):47,370
    Last modified:December 1, 2001 - v1
    Checksum:i9C83961CF403FCEB
    GO
    Isoform 2 (identifier: Q91ZN5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:382
    Mass (Da):41,979
    Checksum:iEC54AAB97F414026
    GO

    Sequence cautioni

    The sequence BAC41173.1 differs from that shown. Reason: Frameshift at positions 350 and 375.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611R → K in BAC41173. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_014085Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF414190 mRNA. Translation: AAL07487.1.
    AK090329 mRNA. Translation: BAC41173.1. Frameshift.
    AK144403 mRNA. Translation: BAE25873.1.
    AK155551 mRNA. Translation: BAE33321.1.
    BC025875 mRNA. Translation: AAH25875.1.
    BC036992 mRNA. Translation: AAH36992.1.
    CCDSiCCDS37630.1. [Q91ZN5-2]
    RefSeqiXP_006525059.1. XM_006524996.1. [Q91ZN5-1]
    UniGeneiMm.289716.

    Genome annotation databases

    EnsembliENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089. [Q91ZN5-2]
    GeneIDi73836.
    KEGGimmu:73836.
    UCSCiuc008cqx.1. mouse. [Q91ZN5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF414190 mRNA. Translation: AAL07487.1 .
    AK090329 mRNA. Translation: BAC41173.1 . Frameshift.
    AK144403 mRNA. Translation: BAE25873.1 .
    AK155551 mRNA. Translation: BAE33321.1 .
    BC025875 mRNA. Translation: AAH25875.1 .
    BC036992 mRNA. Translation: AAH36992.1 .
    CCDSi CCDS37630.1. [Q91ZN5-2 ]
    RefSeqi XP_006525059.1. XM_006524996.1. [Q91ZN5-1 ]
    UniGenei Mm.289716.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91ZN5.

    Proteomic databases

    PaxDbi Q91ZN5.
    PRIDEi Q91ZN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041353 ; ENSMUSP00000037834 ; ENSMUSG00000037089 . [Q91ZN5-2 ]
    GeneIDi 73836.
    KEGGi mmu:73836.
    UCSCi uc008cqx.1. mouse. [Q91ZN5-1 ]

    Organism-specific databases

    CTDi 347734.
    MGIi MGI:1921086. Slc35b2.

    Phylogenomic databases

    eggNOGi COG0697.
    GeneTreei ENSGT00530000063090.
    HOGENOMi HOG000264497.
    HOVERGENi HBG062347.
    InParanoidi Q91ZN5.
    KOi K15276.
    OMAi VLCKQPR.
    OrthoDBi EOG79CXZC.
    PhylomeDBi Q91ZN5.
    TreeFami TF105926.

    Enzyme and pathway databases

    Reactomei REACT_203051. Transport of nucleotide sugars.
    REACT_214239. Transport and synthesis of PAPS.

    Miscellaneous databases

    ChiTaRSi SLC35B2. mouse.
    PROi Q91ZN5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91ZN5.
    Bgeei Q91ZN5.
    CleanExi MM_SLC35B2.
    Genevestigatori Q91ZN5.

    Family and domain databases

    InterProi IPR013657. UAA.
    [Graphical view ]
    Pfami PF08449. UAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene J207."
      Yang X., Wang J.-S., Han H., Li R., Wang Y.L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Brain and Spinal cord.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N and FVB/N-3.
      Tissue: Liver and Mammary tumor.

    Entry informationi

    Entry nameiS35B2_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZN5
    Secondary accession number(s): Q3U221, Q8BTH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3