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Q91ZN5 (S35B2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Alternative name(s):
PAPS transporter 1
Solute carrier family 35 member B2
Gene names
Name:Slc35b2
Synonyms:J207, Papst1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Sequence caution

The sequence BAC41173.1 differs from that shown. Reason: Frameshift at positions 350 and 375.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91ZN5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91ZN5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Adenosine 3'-phospho 5'-phosphosulfate transporter 1
PRO_0000213375

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane299 – 31921Helical; Potential
Transmembrane353 – 37321Helical; Potential
Transmembrane387 – 40721Helical; Potential

Natural variations

Alternative sequence1 – 4949Missing in isoform 2.
VSP_014085

Experimental info

Sequence conflict611R → K in BAC41173. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9C83961CF403FCEB

FASTA43147,370
        10         20         30         40         50         60 
MDARWWAVVV LATLPSLGAG GESPEAPPQS WTQLWLFRFL LNVAGYASFM VPGYLLVQYL 

        70         80         90        100        110        120 
RRKNYLETGR GLCFPLVKAC VFGNEPKAPD EVLLAPRTET AESTPSWQVL KLVFCASGLQ 

       130        140        150        160        170        180 
VSYLTWGILQ ERVMTGSYGA TATSPGEHFT DSQFLVLMNR VLALVVAGLY CVLRKQPRHG 

       190        200        210        220        230        240 
APMYRYSFAS LSNVLSSWCQ YEALKFVSFP TQVLAKASKV IPVMMMGKLV SRRSYEHWEY 

       250        260        270        280        290        300 
LTAGLISIGV SMFLLSSGPE PRSSPATTLS GLVLLAGYIA FDSFTSNWQD ALFAYKMSSV 

       310        320        330        340        350        360 
QMMFGVNLFS CLFTVGSLLE QGALLEGARF MGRHSEFALH ALLLSICSAF GQLFIFYTIG 

       370        380        390        400        410        420 
QFGAAVFTII MTLRQAIAIL LSCLLYGHTV TVVGGLGVAV VFTALLLRVY ARGRKQRGKK 

       430 
AVPTEPPVQK V 

« Hide

Isoform 2 [UniParc].

Checksum: EC54AAB97F414026
Show »

FASTA38241,979

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel gene J207."
Yang X., Wang J.-S., Han H., Li R., Wang Y.L.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Brain and Spinal cord.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N and FVB/N-3.
Tissue: Liver and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF414190 mRNA. Translation: AAL07487.1.
AK090329 mRNA. Translation: BAC41173.1. Frameshift.
AK144403 mRNA. Translation: BAE25873.1.
AK155551 mRNA. Translation: BAE33321.1.
BC025875 mRNA. Translation: AAH25875.1.
BC036992 mRNA. Translation: AAH36992.1.
CCDSCCDS37630.1. [Q91ZN5-2]
RefSeqXP_006525059.1. XM_006524996.1. [Q91ZN5-1]
UniGeneMm.289716.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91ZN5.

Proteomic databases

PaxDbQ91ZN5.
PRIDEQ91ZN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089. [Q91ZN5-2]
GeneID73836.
KEGGmmu:73836.
UCSCuc008cqx.1. mouse. [Q91ZN5-1]

Organism-specific databases

CTD347734.
MGIMGI:1921086. Slc35b2.

Phylogenomic databases

eggNOGCOG0697.
GeneTreeENSGT00530000063090.
HOGENOMHOG000264497.
HOVERGENHBG062347.
InParanoidQ91ZN5.
KOK15276.
OMAVLCKQPR.
OrthoDBEOG79CXZC.
PhylomeDBQ91ZN5.
TreeFamTF105926.

Gene expression databases

ArrayExpressQ91ZN5.
BgeeQ91ZN5.
CleanExMM_SLC35B2.
GenevestigatorQ91ZN5.

Family and domain databases

InterProIPR013657. UAA.
[Graphical view]
PfamPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC35B2. mouse.
PROQ91ZN5.
SOURCESearch...

Entry information

Entry nameS35B2_MOUSE
AccessionPrimary (citable) accession number: Q91ZN5
Secondary accession number(s): Q3U221, Q8BTH2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot