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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

Slc35b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).By similarity

GO - Molecular functioni

  1. 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Source: MGI
  2. signal transducer activity Source: MGI

GO - Biological processi

  1. 3'-phospho-5'-adenylyl sulfate transmembrane transport Source: MGI
  2. 3'-phosphoadenosine 5'-phosphosulfate transport Source: MGI
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  4. signal transduction Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_273373. Transport and synthesis of PAPS.
REACT_327505. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Alternative name(s):
PAPS transporter 1
Solute carrier family 35 member B2
Gene namesi
Name:Slc35b2
Synonyms:J207, Papst1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1921086. Slc35b2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Adenosine 3'-phospho 5'-phosphosulfate transporter 1PRO_0000213375Add
BLAST

Proteomic databases

MaxQBiQ91ZN5.
PaxDbiQ91ZN5.
PRIDEiQ91ZN5.

PTM databases

PhosphoSiteiQ91ZN5.

Expressioni

Gene expression databases

BgeeiQ91ZN5.
CleanExiMM_SLC35B2.
ExpressionAtlasiQ91ZN5. baseline and differential.
GenevestigatoriQ91ZN5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000264497.
HOVERGENiHBG062347.
InParanoidiQ91ZN5.
KOiK15276.
OMAiATSPGEH.
OrthoDBiEOG79CXZC.
PhylomeDBiQ91ZN5.
TreeFamiTF105926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDARWWAVVV LATLPSLGAG GESPEAPPQS WTQLWLFRFL LNVAGYASFM
60 70 80 90 100
VPGYLLVQYL RRKNYLETGR GLCFPLVKAC VFGNEPKAPD EVLLAPRTET
110 120 130 140 150
AESTPSWQVL KLVFCASGLQ VSYLTWGILQ ERVMTGSYGA TATSPGEHFT
160 170 180 190 200
DSQFLVLMNR VLALVVAGLY CVLRKQPRHG APMYRYSFAS LSNVLSSWCQ
210 220 230 240 250
YEALKFVSFP TQVLAKASKV IPVMMMGKLV SRRSYEHWEY LTAGLISIGV
260 270 280 290 300
SMFLLSSGPE PRSSPATTLS GLVLLAGYIA FDSFTSNWQD ALFAYKMSSV
310 320 330 340 350
QMMFGVNLFS CLFTVGSLLE QGALLEGARF MGRHSEFALH ALLLSICSAF
360 370 380 390 400
GQLFIFYTIG QFGAAVFTII MTLRQAIAIL LSCLLYGHTV TVVGGLGVAV
410 420 430
VFTALLLRVY ARGRKQRGKK AVPTEPPVQK V
Length:431
Mass (Da):47,370
Last modified:November 30, 2001 - v1
Checksum:i9C83961CF403FCEB
GO
Isoform 2 (identifier: Q91ZN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:382
Mass (Da):41,979
Checksum:iEC54AAB97F414026
GO

Sequence cautioni

The sequence BAC41173.1 differs from that shown. Reason: Frameshift at positions 350 and 375. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611R → K in BAC41173 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_014085Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414190 mRNA. Translation: AAL07487.1.
AK090329 mRNA. Translation: BAC41173.1. Frameshift.
AK144403 mRNA. Translation: BAE25873.1.
AK155551 mRNA. Translation: BAE33321.1.
BC025875 mRNA. Translation: AAH25875.1.
BC036992 mRNA. Translation: AAH36992.1.
CCDSiCCDS37630.1. [Q91ZN5-2]
RefSeqiXP_006525059.1. XM_006524996.1. [Q91ZN5-1]
UniGeneiMm.289716.

Genome annotation databases

EnsembliENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089. [Q91ZN5-2]
GeneIDi73836.
KEGGimmu:73836.
UCSCiuc008cqx.1. mouse. [Q91ZN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414190 mRNA. Translation: AAL07487.1.
AK090329 mRNA. Translation: BAC41173.1. Frameshift.
AK144403 mRNA. Translation: BAE25873.1.
AK155551 mRNA. Translation: BAE33321.1.
BC025875 mRNA. Translation: AAH25875.1.
BC036992 mRNA. Translation: AAH36992.1.
CCDSiCCDS37630.1. [Q91ZN5-2]
RefSeqiXP_006525059.1. XM_006524996.1. [Q91ZN5-1]
UniGeneiMm.289716.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91ZN5.

Proteomic databases

MaxQBiQ91ZN5.
PaxDbiQ91ZN5.
PRIDEiQ91ZN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089. [Q91ZN5-2]
GeneIDi73836.
KEGGimmu:73836.
UCSCiuc008cqx.1. mouse. [Q91ZN5-1]

Organism-specific databases

CTDi347734.
MGIiMGI:1921086. Slc35b2.

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000264497.
HOVERGENiHBG062347.
InParanoidiQ91ZN5.
KOiK15276.
OMAiATSPGEH.
OrthoDBiEOG79CXZC.
PhylomeDBiQ91ZN5.
TreeFamiTF105926.

Enzyme and pathway databases

ReactomeiREACT_273373. Transport and synthesis of PAPS.
REACT_327505. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSlc35b2. mouse.
PROiQ91ZN5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZN5.
CleanExiMM_SLC35B2.
ExpressionAtlasiQ91ZN5. baseline and differential.
GenevestigatoriQ91ZN5.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene J207."
    Yang X., Wang J.-S., Han H., Li R., Wang Y.L.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Brain and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N and FVB/N-3.
    Tissue: Liver and Mammary tumor.

Entry informationi

Entry nameiS35B2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZN5
Secondary accession number(s): Q3U221, Q8BTH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2005
Last sequence update: November 30, 2001
Last modified: March 31, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.