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Q91ZN5

- S35B2_MOUSE

UniProt

Q91ZN5 - S35B2_MOUSE

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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

Slc35b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).By similarity

GO - Molecular functioni

  1. 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Source: Ensembl
  2. signal transducer activity Source: Ensembl

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_203051. Transport of nucleotide sugars.
REACT_214239. Transport and synthesis of PAPS.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Alternative name(s):
PAPS transporter 1
Solute carrier family 35 member B2
Gene namesi
Name:Slc35b2
Synonyms:J207, Papst1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1921086. Slc35b2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Adenosine 3'-phospho 5'-phosphosulfate transporter 1PRO_0000213375Add
BLAST

Proteomic databases

MaxQBiQ91ZN5.
PaxDbiQ91ZN5.
PRIDEiQ91ZN5.

PTM databases

PhosphoSiteiQ91ZN5.

Expressioni

Gene expression databases

BgeeiQ91ZN5.
CleanExiMM_SLC35B2.
ExpressionAtlasiQ91ZN5. baseline and differential.
GenevestigatoriQ91ZN5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000264497.
HOVERGENiHBG062347.
InParanoidiQ91ZN5.
KOiK15276.
OMAiVLCKQPR.
OrthoDBiEOG79CXZC.
PhylomeDBiQ91ZN5.
TreeFamiTF105926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZN5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDARWWAVVV LATLPSLGAG GESPEAPPQS WTQLWLFRFL LNVAGYASFM
60 70 80 90 100
VPGYLLVQYL RRKNYLETGR GLCFPLVKAC VFGNEPKAPD EVLLAPRTET
110 120 130 140 150
AESTPSWQVL KLVFCASGLQ VSYLTWGILQ ERVMTGSYGA TATSPGEHFT
160 170 180 190 200
DSQFLVLMNR VLALVVAGLY CVLRKQPRHG APMYRYSFAS LSNVLSSWCQ
210 220 230 240 250
YEALKFVSFP TQVLAKASKV IPVMMMGKLV SRRSYEHWEY LTAGLISIGV
260 270 280 290 300
SMFLLSSGPE PRSSPATTLS GLVLLAGYIA FDSFTSNWQD ALFAYKMSSV
310 320 330 340 350
QMMFGVNLFS CLFTVGSLLE QGALLEGARF MGRHSEFALH ALLLSICSAF
360 370 380 390 400
GQLFIFYTIG QFGAAVFTII MTLRQAIAIL LSCLLYGHTV TVVGGLGVAV
410 420 430
VFTALLLRVY ARGRKQRGKK AVPTEPPVQK V
Length:431
Mass (Da):47,370
Last modified:December 1, 2001 - v1
Checksum:i9C83961CF403FCEB
GO
Isoform 2 (identifier: Q91ZN5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:382
Mass (Da):41,979
Checksum:iEC54AAB97F414026
GO

Sequence cautioni

The sequence BAC41173.1 differs from that shown. Reason: Frameshift at positions 350 and 375. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611R → K in BAC41173. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_014085Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414190 mRNA. Translation: AAL07487.1.
AK090329 mRNA. Translation: BAC41173.1. Frameshift.
AK144403 mRNA. Translation: BAE25873.1.
AK155551 mRNA. Translation: BAE33321.1.
BC025875 mRNA. Translation: AAH25875.1.
BC036992 mRNA. Translation: AAH36992.1.
CCDSiCCDS37630.1. [Q91ZN5-2]
RefSeqiXP_006525059.1. XM_006524996.1. [Q91ZN5-1]
UniGeneiMm.289716.

Genome annotation databases

EnsembliENSMUST00000041353; ENSMUSP00000037834; ENSMUSG00000037089. [Q91ZN5-2]
GeneIDi73836.
KEGGimmu:73836.
UCSCiuc008cqx.1. mouse. [Q91ZN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414190 mRNA. Translation: AAL07487.1 .
AK090329 mRNA. Translation: BAC41173.1 . Frameshift.
AK144403 mRNA. Translation: BAE25873.1 .
AK155551 mRNA. Translation: BAE33321.1 .
BC025875 mRNA. Translation: AAH25875.1 .
BC036992 mRNA. Translation: AAH36992.1 .
CCDSi CCDS37630.1. [Q91ZN5-2 ]
RefSeqi XP_006525059.1. XM_006524996.1. [Q91ZN5-1 ]
UniGenei Mm.289716.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91ZN5.

Proteomic databases

MaxQBi Q91ZN5.
PaxDbi Q91ZN5.
PRIDEi Q91ZN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041353 ; ENSMUSP00000037834 ; ENSMUSG00000037089 . [Q91ZN5-2 ]
GeneIDi 73836.
KEGGi mmu:73836.
UCSCi uc008cqx.1. mouse. [Q91ZN5-1 ]

Organism-specific databases

CTDi 347734.
MGIi MGI:1921086. Slc35b2.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00530000063090.
HOGENOMi HOG000264497.
HOVERGENi HBG062347.
InParanoidi Q91ZN5.
KOi K15276.
OMAi VLCKQPR.
OrthoDBi EOG79CXZC.
PhylomeDBi Q91ZN5.
TreeFami TF105926.

Enzyme and pathway databases

Reactomei REACT_203051. Transport of nucleotide sugars.
REACT_214239. Transport and synthesis of PAPS.

Miscellaneous databases

ChiTaRSi Slc35b2. mouse.
PROi Q91ZN5.
SOURCEi Search...

Gene expression databases

Bgeei Q91ZN5.
CleanExi MM_SLC35B2.
ExpressionAtlasi Q91ZN5. baseline and differential.
Genevestigatori Q91ZN5.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene J207."
    Yang X., Wang J.-S., Han H., Li R., Wang Y.L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Brain and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N and FVB/N-3.
    Tissue: Liver and Mammary tumor.

Entry informationi

Entry nameiS35B2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZN5
Secondary accession number(s): Q3U221, Q8BTH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3