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Protein

Docking protein 5

Gene

Dok5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.1 Publication

GO - Molecular functioni

  • receptor signaling protein activity Source: MGI

GO - Biological processi

  • MAPK cascade Source: MGI
  • nervous system development Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 5
Alternative name(s):
Downstream of tyrosine kinase 5
Gene namesi
Name:Dok5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924079. Dok5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Docking protein 5PRO_0000187278Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.By similarity

Proteomic databases

MaxQBiQ91ZM9.
PaxDbiQ91ZM9.
PRIDEiQ91ZM9.

PTM databases

iPTMnetiQ91ZM9.
PhosphoSiteiQ91ZM9.

Expressioni

Tissue specificityi

Specifically expressed in the brain, with a high specificity for neurons.1 Publication

Developmental stagei

In E12.5 and E13 embryos, it is expressed in the central nervous system, e.g. in the neural tube, the dorsal root and the cranial ganglion.

Gene expression databases

BgeeiENSMUSG00000027560.
CleanExiMM_DOK5.
GenevisibleiQ91ZM9. MM.

Interactioni

Subunit structurei

Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029075.

Structurei

3D structure databases

ProteinModelPortaliQ91ZM9.
SMRiQ91ZM9. Positions 133-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105PHAdd
BLAST
Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 27311DKFBH motifAdd
BLAST

Domaini

PTB domain mediates receptor interaction.

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ91ZM9.
OMAiHAVGIYF.
OrthoDBiEOG091G0M38.
PhylomeDBiQ91ZM9.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA
60 70 80 90 100
AYFRCYHKVT ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA
110 120 130 140 150
DEWCKVLQME CVGTRINDIS LGEPDLLATG VEREQSERFN VYLMPSPNLD
160 170 180 190 200
VHGECALQIT YEYICLWDVQ NPRVKLISWP LSALRRYGRD TTWFTFEAGR
210 220 230 240 250
MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS VKNSMLQMKK
260 270 280 290 300
SERAASLSTV VPLPRSAYWQ HITRQHSTGQ LYHLQDVTSP LKLHRTETFP

TYRSEH
Length:306
Mass (Da):35,453
Last modified:December 1, 2001 - v1
Checksum:i7889802FBEAC04A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → M in BAC31799 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418208 mRNA. Translation: AAL14627.1.
AK012430 mRNA. Translation: BAB28233.1.
AK044148 mRNA. Translation: BAC31799.1.
CCDSiCCDS17125.1.
RefSeqiNP_001157158.1. NM_001163686.1.
NP_084037.3. NM_029761.4.
UniGeneiMm.41633.

Genome annotation databases

EnsembliENSMUST00000029075; ENSMUSP00000029075; ENSMUSG00000027560.
GeneIDi76829.
KEGGimmu:76829.
UCSCiuc008ocg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418208 mRNA. Translation: AAL14627.1.
AK012430 mRNA. Translation: BAB28233.1.
AK044148 mRNA. Translation: BAC31799.1.
CCDSiCCDS17125.1.
RefSeqiNP_001157158.1. NM_001163686.1.
NP_084037.3. NM_029761.4.
UniGeneiMm.41633.

3D structure databases

ProteinModelPortaliQ91ZM9.
SMRiQ91ZM9. Positions 133-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029075.

PTM databases

iPTMnetiQ91ZM9.
PhosphoSiteiQ91ZM9.

Proteomic databases

MaxQBiQ91ZM9.
PaxDbiQ91ZM9.
PRIDEiQ91ZM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029075; ENSMUSP00000029075; ENSMUSG00000027560.
GeneIDi76829.
KEGGimmu:76829.
UCSCiuc008ocg.2. mouse.

Organism-specific databases

CTDi55816.
MGIiMGI:1924079. Dok5.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ91ZM9.
OMAiHAVGIYF.
OrthoDBiEOG091G0M38.
PhylomeDBiQ91ZM9.
TreeFamiTF324994.

Miscellaneous databases

ChiTaRSiDok5. mouse.
PROiQ91ZM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027560.
CleanExiMM_DOK5.
GenevisibleiQ91ZM9. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOK5_MOUSE
AccessioniPrimary (citable) accession number: Q91ZM9
Secondary accession number(s): Q8BRI3, Q9CSM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.