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Protein

Calcium-binding protein 7

Gene

Cabp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi46 – 57121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi82 – 93122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 7
Short name:
CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene namesi
Name:Cabp7
Synonyms:Caln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2183437. Cabp7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 188188CytoplasmicSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini210 – 2156ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Calcium-binding protein 7PRO_0000073527Add
BLAST

Proteomic databases

PaxDbiQ91ZM8.
PRIDEiQ91ZM8.

PTM databases

iPTMnetiQ91ZM8.
PhosphoSiteiQ91ZM8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009075.
CleanExiMM_CABP7.
ExpressionAtlasiQ91ZM8. baseline and differential.
GenevisibleiQ91ZM8. MM.

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009219.

Structurei

3D structure databases

ProteinModelPortaliQ91ZM8.
SMRiQ91ZM8. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini69 – 10436EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.By similarity

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ91ZM8.
OMAiCPVEVET.
OrthoDBiEOG091G0IOW.
PhylomeDBiQ91ZM8.
TreeFamiTF331025.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN
60 70 80 90 100
GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP
110 120 130 140 150
KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI
160 170 180 190 200
ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS
210
VMLIAANQVL RSGMK
Length:215
Mass (Da):24,453
Last modified:December 1, 2001 - v1
Checksum:i9C254C955F7AFFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419324 mRNA. Translation: AAL14997.1.
CCDSiCCDS24390.1.
RefSeqiNP_620398.1. NM_138948.3.
UniGeneiMm.207056.

Genome annotation databases

EnsembliENSMUST00000009219; ENSMUSP00000009219; ENSMUSG00000009075.
GeneIDi192650.
KEGGimmu:192650.
UCSCiuc007hve.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419324 mRNA. Translation: AAL14997.1.
CCDSiCCDS24390.1.
RefSeqiNP_620398.1. NM_138948.3.
UniGeneiMm.207056.

3D structure databases

ProteinModelPortaliQ91ZM8.
SMRiQ91ZM8. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009219.

PTM databases

iPTMnetiQ91ZM8.
PhosphoSiteiQ91ZM8.

Proteomic databases

PaxDbiQ91ZM8.
PRIDEiQ91ZM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009219; ENSMUSP00000009219; ENSMUSG00000009075.
GeneIDi192650.
KEGGimmu:192650.
UCSCiuc007hve.1. mouse.

Organism-specific databases

CTDi164633.
MGIiMGI:2183437. Cabp7.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
HOVERGENiHBG050762.
InParanoidiQ91ZM8.
OMAiCPVEVET.
OrthoDBiEOG091G0IOW.
PhylomeDBiQ91ZM8.
TreeFamiTF331025.

Miscellaneous databases

PROiQ91ZM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009075.
CleanExiMM_CABP7.
ExpressionAtlasiQ91ZM8. baseline and differential.
GenevisibleiQ91ZM8. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCABP7_MOUSE
AccessioniPrimary (citable) accession number: Q91ZM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.