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Q91ZL1

- CCL5_SIGHI

UniProt

Q91ZL1 - CCL5_SIGHI

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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Sigmodon hispidus (Hispid cotton rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemokine-mediated signaling pathway Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. regulation of insulin secretion Source: UniProtKB
  7. regulation of neuron death Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiSigmodon hispidus (Hispid cotton rat)
Taxonomic identifieri42415 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeSigmodontinaeSigmodon

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ91ZL1.
SMRiQ91ZL1. Positions 24-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG017871.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISAAVLTV VLMAASLCAP ASASPNGSDT IPCCFAYLSA VLPRAHVKEY
60 70 80 90
FYTSSKCSNF AVVFVTRRNR QVCANPKKKW VQEYINYLEL K
Length:91
Mass (Da):10,082
Last modified:December 1, 2001 - v1
Checksum:iD0D6EAEABE4242FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421391 mRNA. Translation: AAL16932.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421391 mRNA. Translation: AAL16932.1 .

3D structure databases

ProteinModelPortali Q91ZL1.
SMRi Q91ZL1. Positions 24-90.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG017871.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats."
    Blanco J.C., Richardson J.Y., Darnell M.E., Rowzee A., Pletneva L.M., Porter D.D., Prince G.A.
    J. Infect. Dis. 185:1780-1785(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL5_SIGHI
AccessioniPrimary (citable) accession number: Q91ZL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3