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Q91ZL1

- CCL5_SIGHI

UniProt

Q91ZL1 - CCL5_SIGHI

Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Sigmodon hispidus (Hispid cotton rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:CCL5
    Synonyms:SCYA5
    OrganismiSigmodon hispidus (Hispid cotton rat)
    Taxonomic identifieri42415 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeSigmodontinaeSigmodon

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZL1.
    SMRiQ91ZL1. Positions 24-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG017871.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91ZL1-1 [UniParc]FASTAAdd to Basket

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    MKISAAVLTV VLMAASLCAP ASASPNGSDT IPCCFAYLSA VLPRAHVKEY   50
    FYTSSKCSNF AVVFVTRRNR QVCANPKKKW VQEYINYLEL K 91
    Length:91
    Mass (Da):10,082
    Last modified:December 1, 2001 - v1
    Checksum:iD0D6EAEABE4242FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421391 mRNA. Translation: AAL16932.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421391 mRNA. Translation: AAL16932.1 .

    3D structure databases

    ProteinModelPortali Q91ZL1.
    SMRi Q91ZL1. Positions 24-90.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017871.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats."
      Blanco J.C., Richardson J.Y., Darnell M.E., Rowzee A., Pletneva L.M., Porter D.D., Prince G.A.
      J. Infect. Dis. 185:1780-1785(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL5_SIGHI
    AccessioniPrimary (citable) accession number: Q91ZL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3