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Protein

Diencephalon/mesencephalon homeobox protein 1

Gene

Dmbx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 130HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: UniProtKB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • adult feeding behavior Source: MGI
  • adult locomotory behavior Source: MGI
  • brain development Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • developmental growth Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Diencephalon/mesencephalon homeobox protein 1
Alternative name(s):
Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein
Orthodenticle homolog 3
Paired-like homeobox protein DMBX1
Paired-type homeobox Atx
Gene namesi
Name:Dmbx1Imported
Synonyms:CdmxImported, Mbx1 Publication, Otx3Imported, PaxBImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2153518 Dmbx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629551 – 381Diencephalon/mesencephalon homeobox protein 1Add BLAST381

Proteomic databases

PaxDbiQ91ZK4
PRIDEiQ91ZK4

PTM databases

iPTMnetiQ91ZK4
PhosphoSitePlusiQ91ZK4

Expressioni

Tissue specificityi

Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the hindlimbs.4 Publications

Developmental stagei

Detected in embryo from E10.5 to 13.5 dpc. Strongly expressed from 9.5 to 11.5 dpc in the diencephalon, mesencephalon, metencephalon, myeloencephalon, and the developing eye.3 Publications

Gene expression databases

BgeeiENSMUSG00000028707
CleanExiMM_DMBX1
GenevisibleiQ91ZK4 MM

Interactioni

Subunit structurei

Homodimer or heterodimer. Forms heterodimers with OTX2.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi228255, 1 interactor
MINTiQ91ZK4
STRINGi10090.ENSMUSP00000120320

Structurei

3D structure databases

ProteinModelPortaliQ91ZK4
SMRiQ91ZK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 156Interaction with OTX2 and is required for repressor activity1 PublicationAdd BLAST156

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi358 – 371OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000261650
HOVERGENiHBG061416
InParanoidiQ91ZK4
OMAiQAQQVWN
OrthoDBiEOG091G0EWK
PhylomeDBiQ91ZK4
TreeFamiTF351609

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 14 Publications (identifier: Q91ZK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL
60 70 80 90 100
AGCTFQDIIL EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM
110 120 130 140 150
RERLAMCTNL PEARVQVWFK NRRAKFRKKQ RSLQKEQLQK QKEAEGSHGE
160 170 180 190 200
GKVEAPASDT QLETEQPPGL PSGDPPAELQ LSLSEQSASE SAPEDQLDRE
210 220 230 240 250
EDSRAEEPKA EKSPGSESKV PGCKRGSPKA DSPGSLAITP AAPGGGLLGP
260 270 280 290 300
SHSYSSSPLS LFRLQEQFRQ HMAATNNLMH YSSFEVGGPA PAAAAAAAAA
310 320 330 340 350
VPYLGVNMAP LSSLHCQSYY QSLSAAAAAH QGVWGSPLLP APPTGLAPAS
360 370 380
AALNSKTTSI ENLRLRAKQH AASLGLDTLP N
Length:381
Mass (Da):41,115
Last modified:December 1, 2001 - v1
Checksum:iF180D3BAE1D2CFAE
GO
Isoform 23 Publications (identifier: Q91ZK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-56: Missing.

Show »
Length:376
Mass (Da):40,578
Checksum:i48959A8120BB1B70
GO

Sequence cautioni

The sequence BAC00919 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206E → G in AAN76724 (PubMed:11914943).Curated1
Sequence conflicti279M → V in AAL66343 (PubMed:12175514).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05225252 – 56Missing in isoform 2. 4 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448118 mRNA Translation: AAN76724.1
AF499446 mRNA Translation: AAM78514.1
AB037698 mRNA Translation: BAC00919.1 Different initiation.
AF421857 mRNA Translation: AAL30508.1
AF421858 mRNA Translation: AAL30509.1
AF463513 mRNA Translation: AAL68836.1
AL627105 Genomic DNA No translation available.
BC050912 mRNA Translation: AAH50912.1
AF461039 mRNA Translation: AAL66343.1
CCDSiCCDS18500.1 [Q91ZK4-2]
RefSeqiNP_001020738.1, NM_001025567.1 [Q91ZK4-2]
NP_570935.3, NM_130865.3 [Q91ZK4-1]
XP_017175447.1, XM_017319958.1 [Q91ZK4-1]
XP_017175448.1, XM_017319959.1 [Q91ZK4-1]
UniGeneiMm.213206
Mm.413175

Genome annotation databases

EnsembliENSMUST00000064806; ENSMUSP00000134457; ENSMUSG00000028707 [Q91ZK4-2]
ENSMUST00000084338; ENSMUSP00000081366; ENSMUSG00000028707 [Q91ZK4-1]
ENSMUST00000124071; ENSMUSP00000120320; ENSMUSG00000028707 [Q91ZK4-2]
GeneIDi140477
KEGGimmu:140477
UCSCiuc008ufp.1 mouse [Q91ZK4-2]
uc008ufr.1 mouse [Q91ZK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDMBX1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZK4
Secondary accession number(s): B1ASG1
, Q8CH43, Q8K4U6, Q8VHG8, Q91ZK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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