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Protein

Transcription factor AP-2-delta

Gene

Tfap2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • inferior colliculus development Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell proliferation Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2-delta
Short name:
AP2-delta
Alternative name(s):
Activating enhancer-binding protein 2-delta
Gene namesi
Name:Tfap2d
Synonyms:Tcfap2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2153466 Tfap2d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095141 – 452Transcription factor AP-2-deltaAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei239Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91ZK0
PaxDbiQ91ZK0
PeptideAtlasiQ91ZK0
PRIDEiQ91ZK0

PTM databases

PhosphoSitePlusiQ91ZK0

Expressioni

Tissue specificityi

Expressed in both embryonic and newborn brain.1 Publication

Developmental stagei

Expression is first detected at E9.5 in the central nervous system and the developing heart. The signal detected in heart persists through to E10.5. Diffusely expressed in developing brain at E10.5 to E11.5, but by E13.5 expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at E10.5, and in retinal epithelium from E13.5 to E16.5. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000042596
CleanExiMM_TCFAP2D
GenevisibleiQ91ZK0 MM

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ash2lQ91X204EBI-15703453,EBI-1556554

Protein-protein interaction databases

BioGridi230568, 3 interactors
DIPiDIP-46108N
IntActiQ91ZK0, 3 interactors
STRINGi10090.ENSMUSP00000037699

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 410H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST131

Sequence similaritiesi

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ91ZK0
KOiK09178
OMAiHGEPADF
OrthoDBiEOG091G0PR6
PhylomeDBiQ91ZK0
TreeFamiTF313718

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01748 AP2TNSCPFCT

Sequencei

Sequence statusi: Complete.

Q91ZK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST
60 70 80 90 100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ
110 120 130 140 150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH
160 170 180 190 200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGIVL NGQGGVIRRG
210 220 230 240 250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG
260 270 280 290 300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL
310 320 330 340 350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD
360 370 380 390 400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT
410 420 430 440 450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKASE AAVKEGKTEK

TD
Length:452
Mass (Da):49,548
Last modified:December 1, 2001 - v1
Checksum:i6722342B15CDF9EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37T → A in AAI52326 (PubMed:15489334).Curated1
Sequence conflicti37T → A in AAI52325 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421891 mRNA Translation: AAL16940.1
BC152324 mRNA Translation: AAI52325.1
BC152325 mRNA Translation: AAI52326.1
CCDSiCCDS14838.1
RefSeqiNP_694794.1, NM_153154.3
UniGeneiMm.244858

Genome annotation databases

EnsembliENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596
GeneIDi226896
KEGGimmu:226896
UCSCiuc007akp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAP2D_MOUSE
AccessioniPrimary (citable) accession number: Q91ZK0
Secondary accession number(s): A7MCU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health