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Protein

Transcription factor AP-2-delta

Gene

Tfap2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • inferior colliculus development Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell proliferation Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2-delta
Short name:
AP2-delta
Alternative name(s):
Activating enhancer-binding protein 2-delta
Gene namesi
Name:Tfap2d
Synonyms:Tcfap2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2153466. Tfap2d.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GO_Central
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Transcription factor AP-2-deltaPRO_0000309514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91ZK0.
PaxDbiQ91ZK0.
PeptideAtlasiQ91ZK0.
PRIDEiQ91ZK0.

PTM databases

PhosphoSiteiQ91ZK0.

Expressioni

Tissue specificityi

Expressed in both embryonic and newborn brain.1 Publication

Developmental stagei

Expression is first detected at E9.5 in the central nervous system and the developing heart. The signal detected in heart persists through to E10.5. Diffusely expressed in developing brain at E10.5 to E11.5, but by E13.5 expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at E10.5, and in retinal epithelium from E13.5 to E16.5. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000042596.
CleanExiMM_TCFAP2D.
GenevisibleiQ91ZK0. MM.

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.1 Publication

Protein-protein interaction databases

BioGridi230568. 3 interactions.
DIPiDIP-46108N.
STRINGi10090.ENSMUSP00000037699.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 410131H-S-H (helix-span-helix), dimerizationSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ91ZK0.
KOiK09178.
OMAiHGEPADF.
OrthoDBiEOG091G0PR6.
PhylomeDBiQ91ZK0.
TreeFamiTF313718.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

Q91ZK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST
60 70 80 90 100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ
110 120 130 140 150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH
160 170 180 190 200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGIVL NGQGGVIRRG
210 220 230 240 250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG
260 270 280 290 300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL
310 320 330 340 350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD
360 370 380 390 400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT
410 420 430 440 450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKASE AAVKEGKTEK

TD
Length:452
Mass (Da):49,548
Last modified:December 1, 2001 - v1
Checksum:i6722342B15CDF9EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371T → A in AAI52326 (PubMed:15489334).Curated
Sequence conflicti37 – 371T → A in AAI52325 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421891 mRNA. Translation: AAL16940.1.
BC152324 mRNA. Translation: AAI52325.1.
BC152325 mRNA. Translation: AAI52326.1.
CCDSiCCDS14838.1.
RefSeqiNP_694794.1. NM_153154.2.
UniGeneiMm.244858.

Genome annotation databases

EnsembliENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596.
GeneIDi226896.
KEGGimmu:226896.
UCSCiuc007akp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421891 mRNA. Translation: AAL16940.1.
BC152324 mRNA. Translation: AAI52325.1.
BC152325 mRNA. Translation: AAI52326.1.
CCDSiCCDS14838.1.
RefSeqiNP_694794.1. NM_153154.2.
UniGeneiMm.244858.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230568. 3 interactions.
DIPiDIP-46108N.
STRINGi10090.ENSMUSP00000037699.

PTM databases

PhosphoSiteiQ91ZK0.

Proteomic databases

MaxQBiQ91ZK0.
PaxDbiQ91ZK0.
PeptideAtlasiQ91ZK0.
PRIDEiQ91ZK0.

Protocols and materials databases

DNASUi226896.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596.
GeneIDi226896.
KEGGimmu:226896.
UCSCiuc007akp.1. mouse.

Organism-specific databases

CTDi83741.
MGIiMGI:2153466. Tfap2d.

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ91ZK0.
KOiK09178.
OMAiHGEPADF.
OrthoDBiEOG091G0PR6.
PhylomeDBiQ91ZK0.
TreeFamiTF313718.

Miscellaneous databases

PROiQ91ZK0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042596.
CleanExiMM_TCFAP2D.
GenevisibleiQ91ZK0. MM.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01748. AP2TNSCPFCT.
ProtoNetiSearch...

Entry informationi

Entry nameiAP2D_MOUSE
AccessioniPrimary (citable) accession number: Q91ZK0
Secondary accession number(s): A7MCU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.