ID   UGPA_MOUSE              Reviewed;         508 AA.
AC   Q91ZJ5; Q8R3D2;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE            Short=UGPase;
GN   Name=Ugp2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J;
RX   MEDLINE=22325413; PubMed=12174196; DOI=10.1186/1471-2156-3-14;
RA   Fuchs S., Resch K., Thiel C., Ulbrich M., Platzer M., Jockusch H.,
RA   Schmitt-John T.;
RT   "Comparative transcription map of the wobbler critical region on mouse
RT   chromosome 11 and the homologous region on human chromosome 2p13-14.";
RL   BMC Genet. 3:14-14(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Colon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RG   The mouse genome sequencing consortium;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=FVB/N; TISSUE=Mammary tumor, and Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a central role as a glucosyl donor in cellular
CC       metabolic pathways.
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- SUBUNIT: Homooctamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q91ZJ5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q91ZJ5-2; Sequence=VSP_012835;
CC   -!- SIMILARITY: Belongs to the UDPGP type 1 family.
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DR   EMBL; AF424698; AAL24807.1; -; mRNA.
DR   EMBL; AK033445; BAC28291.1; -; mRNA.
DR   EMBL; AL772195; CAI24602.1; -; Genomic_DNA.
DR   EMBL; AL833772; CAI24602.1; JOINED; Genomic_DNA.
DR   EMBL; AL772195; CAI24601.1; -; Genomic_DNA.
DR   EMBL; AL833772; CAI24601.1; JOINED; Genomic_DNA.
DR   EMBL; AL833772; CAI24172.1; -; Genomic_DNA.
DR   EMBL; AL772195; CAI24172.1; JOINED; Genomic_DNA.
DR   EMBL; AL833772; CAI24171.1; -; Genomic_DNA.
DR   EMBL; AL772195; CAI24171.1; JOINED; Genomic_DNA.
DR   EMBL; BC023810; AAH23810.1; -; mRNA.
DR   EMBL; BC025585; AAH25585.1; -; mRNA.
DR   EMBL; BC061208; AAH61208.1; -; mRNA.
DR   IPI; IPI00131204; -.
DR   IPI; IPI00279474; -.
DR   RefSeq; NP_647458.1; -.
DR   UniGene; Mm.28877; -.
DR   PhosphoSite; Q91ZJ5; -.
DR   PRIDE; Q91ZJ5; -.
DR   Ensembl; ENSMUSG00000001891; Mus musculus.
DR   GeneID; 216558; -.
DR   KEGG; mmu:216558; -.
DR   MGI; MGI:2183447; Ugp2.
DR   HOGENOM; Q91ZJ5; -.
DR   HOVERGEN; Q91ZJ5; -.
DR   OMA; Q91ZJ5; AEYIMEL.
DR   BRENDA; 2.7.7.9; 244.
DR   NextBio; 375212; -.
DR   ArrayExpress; Q91ZJ5; -.
DR   Bgee; Q91ZJ5; -.
DR   CleanEx; MM_UGP2; -.
DR   GermOnline; ENSMUSG00000001891; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR002618; UDPGP_trans.
DR   InterPro; IPR016267; UDPGP_trans_sub.
DR   PANTHER; PTHR11952; UDPGP_trans; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   PIRSF; PIRSF000806; UDPGP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Nucleotidyltransferase; Transferase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    508       UTP--glucose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000185753.
FT   VAR_SEQ       1     11       Missing (in isoform 2).
FT                                /FTId=VSP_012835.
SQ   SEQUENCE   508 AA;  56979 MW;  7F5FB23628D631FE CRC64;
     MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH TKKDLDGFRK
     LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS
     MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH
     CRVKIYTFNQ SRYPRINKES LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI
     EEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
     KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM EIIVNPKTLD
     GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE
     KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA
     NHGDRIDIPP GAVLENKIVS GNLRILDH
//