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Q91ZJ5

- UGPA_MOUSE

UniProt

Q91ZJ5 - UGPA_MOUSE

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

Ugp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a central role as a glucosyl donor in cellular metabolic pathways.

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271MagnesiumBy similarity
    Metal bindingi253 – 2531MagnesiumBy similarity
    Active sitei396 – 3961By similarity

    GO - Molecular functioni

    1. glucose binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. pyrimidine ribonucleotide binding Source: Ensembl
    4. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucose 1-phosphate metabolic process Source: Ensembl
    2. UDP-glucose metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_188939. Glycogen synthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Short name:
    UGPase
    Gene namesi
    Name:Ugp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2183447. Ugp2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei438 – 4381N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ91ZJ5.
    PaxDbiQ91ZJ5.
    PRIDEiQ91ZJ5.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00279474.

    PTM databases

    PhosphoSiteiQ91ZJ5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91ZJ5.
    BgeeiQ91ZJ5.
    CleanExiMM_UGP2.
    GenevestigatoriQ91ZJ5.

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    IntActiQ91ZJ5. 3 interactions.
    MINTiMINT-1856424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZJ5.
    SMRiQ91ZJ5. Positions 22-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni457 – 50852OligomerizationBy similarityAdd
    BLAST
    Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

    Sequence similaritiesi

    Belongs to the UDPGP type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG4284.
    GeneTreeiENSGT00390000003174.
    HOGENOMiHOG000113618.
    HOVERGENiHBG055396.
    InParanoidiQ91ZJ5.
    KOiK00963.
    OMAiPPNGKRC.
    OrthoDBiEOG7ZPNK4.
    PhylomeDBiQ91ZJ5.
    TreeFamiTF300567.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000806. UDPGP. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZJ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH    50
    TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN 100
    ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN 150
    KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES 200
    LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI EEGKEYIFVS 250
    NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 300
    KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM 350
    EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD 400
    LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP 450
    DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS 500
    GNLRILDH 508
    Length:508
    Mass (Da):56,979
    Last modified:January 23, 2007 - v3
    Checksum:i7F5FB23628D631FE
    GO
    Isoform 2 (identifier: Q91ZJ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:497
    Mass (Da):55,716
    Checksum:i34852343B69B9BC9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_012835Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF424698 mRNA. Translation: AAL24807.1.
    AK033445 mRNA. Translation: BAC28291.1.
    AL772195, AL833772 Genomic DNA. Translation: CAI24602.1.
    AL772195, AL833772 Genomic DNA. Translation: CAI24601.1.
    AL833772, AL772195 Genomic DNA. Translation: CAI24172.1.
    AL833772, AL772195 Genomic DNA. Translation: CAI24171.1.
    BC023810 mRNA. Translation: AAH23810.1.
    BC025585 mRNA. Translation: AAH25585.1.
    BC061208 mRNA. Translation: AAH61208.1.
    CCDSiCCDS24464.1. [Q91ZJ5-1]
    CCDS70148.1. [Q91ZJ5-2]
    RefSeqiNP_001277563.1. NM_001290634.1. [Q91ZJ5-2]
    NP_647458.1. NM_139297.6. [Q91ZJ5-1]
    UniGeneiMm.28877.

    Genome annotation databases

    EnsembliENSMUST00000060895; ENSMUSP00000056324; ENSMUSG00000001891. [Q91ZJ5-2]
    ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891. [Q91ZJ5-1]
    GeneIDi216558.
    KEGGimmu:216558.
    UCSCiuc007idr.3. mouse. [Q91ZJ5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF424698 mRNA. Translation: AAL24807.1 .
    AK033445 mRNA. Translation: BAC28291.1 .
    AL772195 , AL833772 Genomic DNA. Translation: CAI24602.1 .
    AL772195 , AL833772 Genomic DNA. Translation: CAI24601.1 .
    AL833772 , AL772195 Genomic DNA. Translation: CAI24172.1 .
    AL833772 , AL772195 Genomic DNA. Translation: CAI24171.1 .
    BC023810 mRNA. Translation: AAH23810.1 .
    BC025585 mRNA. Translation: AAH25585.1 .
    BC061208 mRNA. Translation: AAH61208.1 .
    CCDSi CCDS24464.1. [Q91ZJ5-1 ]
    CCDS70148.1. [Q91ZJ5-2 ]
    RefSeqi NP_001277563.1. NM_001290634.1. [Q91ZJ5-2 ]
    NP_647458.1. NM_139297.6. [Q91ZJ5-1 ]
    UniGenei Mm.28877.

    3D structure databases

    ProteinModelPortali Q91ZJ5.
    SMRi Q91ZJ5. Positions 22-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91ZJ5. 3 interactions.
    MINTi MINT-1856424.

    PTM databases

    PhosphoSitei Q91ZJ5.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00279474.

    Proteomic databases

    MaxQBi Q91ZJ5.
    PaxDbi Q91ZJ5.
    PRIDEi Q91ZJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060895 ; ENSMUSP00000056324 ; ENSMUSG00000001891 . [Q91ZJ5-2 ]
    ENSMUST00000102875 ; ENSMUSP00000099939 ; ENSMUSG00000001891 . [Q91ZJ5-1 ]
    GeneIDi 216558.
    KEGGi mmu:216558.
    UCSCi uc007idr.3. mouse. [Q91ZJ5-1 ]

    Organism-specific databases

    CTDi 7360.
    MGIi MGI:2183447. Ugp2.

    Phylogenomic databases

    eggNOGi COG4284.
    GeneTreei ENSGT00390000003174.
    HOGENOMi HOG000113618.
    HOVERGENi HBG055396.
    InParanoidi Q91ZJ5.
    KOi K00963.
    OMAi PPNGKRC.
    OrthoDBi EOG7ZPNK4.
    PhylomeDBi Q91ZJ5.
    TreeFami TF300567.

    Enzyme and pathway databases

    Reactomei REACT_188939. Glycogen synthesis.

    Miscellaneous databases

    ChiTaRSi UGP2. mouse.
    NextBioi 375212.
    PROi Q91ZJ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91ZJ5.
    Bgeei Q91ZJ5.
    CleanExi MM_UGP2.
    Genevestigatori Q91ZJ5.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000806. UDPGP. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14."
      Fuchs S., Resch K., Thiel C., Ulbrich M., Platzer M., Jockusch H., Schmitt-John T.
      BMC Genet. 3:14-14(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Mammary tumor and Pituitary.

    Entry informationi

    Entry nameiUGPA_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZJ5
    Secondary accession number(s): Q8R3D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3