Reviewed, UniProtKB/Swiss-Prot Q91ZJ5 (UGPA_MOUSE)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
      Short name=UGPase

Gene names

Name:

Ugp2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subunit structure	Homooctamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Molecular function	Nucleotidyltransferase Transferase
PTM	Acetylation
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91ZJ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91ZJ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 508	507	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185753
Amino acid modifications
	Modified residue	438	1	N6-acetyllysine By similarity
Natural variations
	Alternative sequence	1 – 11	11	Missing in isoform 2.		VSP_012835

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7F5FB23628D631FE	FASTA	508	56,979
	10 20 30 40 50 60 MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH TKKDLDGFRK 70 80 90 100 110 120 LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS 130 140 150 160 170 180 MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH 190 200 210 220 230 240 CRVKIYTFNQ SRYPRINKES LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 250 260 270 280 290 300 EEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 310 320 330 340 350 360 KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM EIIVNPKTLD 370 380 390 400 410 420 GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 430 440 450 460 470 480 KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 490 500 NHGDRIDIPP GAVLENKIVS GNLRILDH
	Isoform 2. Checksum: 34852343B69B9BC9	FASTA	497	55,716
	10 20 30 40 50 60 MSQDGASQFQ EVILQELELS VKKELEKILT TAASHEFEHT KKDLDGFRKL FHRFLQEKGP 70 80 90 100 110 120 SVDWGKIQRP PEDSIQPYEK IKARGLPDNI SSVLNKLVVV KLNGGLGTSM GCKGPKSLIG 130 140 150 160 170 180 VRNENTFLDL TVQQIEHLNK TYNTDVPLVL MNSFNTDEDT KKILQKYNHC RVKIYTFNQS 190 200 210 220 230 240 RYPRINKESL LPIAKDVSYS GENTEAWYPP GHGDIYASFY NSGLLDTFIE EGKEYIFVSN 250 260 270 280 290 300 IDNLGATVDL YILNHLMNPP NGKRCEFVME VTNKTRADVK GGTLTQYEGK LRLVEIAQVP 310 320 330 340 350 360 KAHVDEFKSV SKFKIFNTNN LWISLGAVKR LQEQNAIDME IIVNPKTLDG GLNVIQLETA 370 380 390 400 410 420 VGAAIKSFEN SLGINVPRSR FLPVKTTSDL LLVMSNLYSL NAGSLTMSEK REFPTVPLVK 430 440 450 460 470 480 LGSSFTKVQD YLRRFESIPD MLELDHLTVS GDVTFGKNVS LKGTVIIIAN HGDRIDIPPG 490 AVLENKIVSG NLRILDH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14." Fuchs S., Resch K., Thiel C., Ulbrich M., Platzer M., Jockusch H., Schmitt-John T. BMC Genet. 3:14-14(2002) [PubMed: 12174196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Colon.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: FVB/N. Tissue: Mammary tumor and Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF424698 mRNA. Translation: AAL24807.1. AK033445 mRNA. Translation: BAC28291.1. AL772195, AL833772 Genomic DNA. Translation: CAI24602.1. AL772195, AL833772 Genomic DNA. Translation: CAI24601.1. AL833772, AL772195 Genomic DNA. Translation: CAI24172.1. AL833772, AL772195 Genomic DNA. Translation: CAI24171.1. BC023810 mRNA. Translation: AAH23810.1. BC025585 mRNA. Translation: AAH25585.1. BC061208 mRNA. Translation: AAH61208.1.
IPI	IPI00131204. IPI00279474.
RefSeq	NP_647458.1.
UniGene	Mm.28877
3D structure databases
SMR	Q91ZJ5. Positions 51-508.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91ZJ5.
PTM databases
PhosphoSite	Q91ZJ5.
Proteomic databases
PRIDE	Q91ZJ5.
Genome annotation databases
Ensembl	ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891; Mus musculus. [Genome view] ENSMUST00000109575; ENSMUSP00000105203; ENSMUSG00000001891; Mus musculus. [Genome view]
GeneID	216558.
KEGG	mmu:216558.
UCSC	uc007ids.1. mouse.
Organism-specific databases
CTD	216558.
MGI	MGI:2183447. Ugp2.
Phylogenomic databases
HOGENOM	HBG316482.
HOVERGEN	Q91ZJ5.
InParanoid	Q91ZJ5.
OMA	AEYIMEL.
PhylomeDB	Q91ZJ5.
Enzyme and pathway databases
BRENDA	2.7.7.9. 244.
Gene expression databases
ArrayExpress	Q91ZJ5.
Bgee	Q91ZJ5.
CleanEx	MM_UGP2.
Genevestigator	Q91ZJ5.
GermOnline	ENSMUSG00000001891. Mus musculus.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_sub. [Graphical view]
PANTHER	PTHR11952. UDPGP_trans. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	375212.
SOURCE	Search...

Entry information

Entry name

UGPA_MOUSE

Accession

Primary (citable) accession number: Q91ZJ5
Secondary accession number(s): Q8R3D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)