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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

Ugp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Binding sitei127UTPBy similarity1
Binding sitei190UTPBy similarity1
Binding sitei222UTP; via amide nitrogenBy similarity1
Binding sitei223SubstrateBy similarity1
Metal bindingi253MagnesiumBy similarity1
Binding sitei253UTPBy similarity1
Active sitei396By similarity1
Binding sitei396UTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-173599 Formation of the active cofactor, UDP-glucuronate
R-MMU-3322077 Glycogen synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:Ugp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2183447 Ugp2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857531 – 508UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei426PhosphothreonineBy similarity1
Modified residuei434PhosphoserineBy similarity1
Modified residuei438N6-acetyllysineBy similarity1
Modified residuei448PhosphoserineCombined sources1
Modified residuei461PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ91ZJ5
PeptideAtlasiQ91ZJ5
PRIDEiQ91ZJ5

2D gel databases

REPRODUCTION-2DPAGEiIPI00279474

PTM databases

iPTMnetiQ91ZJ5
PhosphoSitePlusiQ91ZJ5
SwissPalmiQ91ZJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000001891
CleanExiMM_UGP2
ExpressionAtlasiQ91ZJ5 baseline and differential
GenevisibleiQ91ZJ5 MM

Interactioni

Subunit structurei

Homooctamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2297602 interactors.
IntActiQ91ZJ5 3 interactors.
MINTiQ91ZJ5
STRINGi10090.ENSMUSP00000099939

Structurei

3D structure databases

ProteinModelPortaliQ91ZJ5
SMRiQ91ZJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116UTP bindingBy similarity4
Regioni115 – 116Substrate bindingBy similarity2
Regioni251 – 253Substrate bindingBy similarity3
Regioni457 – 508OligomerizationBy similarityAdd BLAST52
Regioni502 – 503Critical for end-to-end subunit interactionBy similarity2

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638 Eukaryota
COG4284 LUCA
GeneTreeiENSGT00390000003174
HOGENOMiHOG000113618
HOVERGENiHBG055396
InParanoidiQ91ZJ5
KOiK00963
OMAiMEIIPNG
OrthoDBiEOG091G04UI
PhylomeDBiQ91ZJ5
TreeFamiTF300567

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.101 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI EEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM
360 370 380 390 400
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,979
Last modified:January 23, 2007 - v3
Checksum:i7F5FB23628D631FE
GO
Isoform 2 (identifier: Q91ZJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:497
Mass (Da):55,716
Checksum:i34852343B69B9BC9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128351 – 11Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424698 mRNA Translation: AAL24807.1
AK033445 mRNA Translation: BAC28291.1
AL772195, AL833772 Genomic DNA Translation: CAI24602.1
AL772195, AL833772 Genomic DNA Translation: CAI24601.1
AL833772, AL772195 Genomic DNA Translation: CAI24172.1
AL833772, AL772195 Genomic DNA Translation: CAI24171.1
BC023810 mRNA Translation: AAH23810.1
BC025585 mRNA Translation: AAH25585.1
BC061208 mRNA Translation: AAH61208.1
CCDSiCCDS24464.1 [Q91ZJ5-1]
CCDS70148.1 [Q91ZJ5-2]
RefSeqiNP_001277563.1, NM_001290634.1 [Q91ZJ5-2]
NP_647458.1, NM_139297.6 [Q91ZJ5-1]
UniGeneiMm.28877

Genome annotation databases

EnsembliENSMUST00000060895; ENSMUSP00000056324; ENSMUSG00000001891 [Q91ZJ5-2]
ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891 [Q91ZJ5-1]
GeneIDi216558
KEGGimmu:216558
UCSCiuc007idr.4 mouse [Q91ZJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUGPA_MOUSE
AccessioniPrimary (citable) accession number: Q91ZJ5
Secondary accession number(s): Q8R3D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome