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Q91ZJ5

- UGPA_MOUSE

UniProt

Q91ZJ5 - UGPA_MOUSE

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

Ugp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271MagnesiumBy similarity
Metal bindingi253 – 2531MagnesiumBy similarity
Active sitei396 – 3961By similarity

GO - Molecular functioni

  1. glucose binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. pyrimidine ribonucleotide binding Source: Ensembl
  4. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucose 1-phosphate metabolic process Source: Ensembl
  2. UDP-glucose metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_188939. Glycogen synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:Ugp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2183447. Ugp2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei438 – 4381N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91ZJ5.
PaxDbiQ91ZJ5.
PRIDEiQ91ZJ5.

2D gel databases

REPRODUCTION-2DPAGEIPI00279474.

PTM databases

PhosphoSiteiQ91ZJ5.

Expressioni

Gene expression databases

BgeeiQ91ZJ5.
CleanExiMM_UGP2.
ExpressionAtlasiQ91ZJ5. baseline and differential.
GenevestigatoriQ91ZJ5.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

IntActiQ91ZJ5. 3 interactions.
MINTiMINT-1856424.

Structurei

3D structure databases

ProteinModelPortaliQ91ZJ5.
SMRiQ91ZJ5. Positions 22-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 50852OligomerizationBy similarityAdd
BLAST
Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
GeneTreeiENSGT00390000003174.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiQ91ZJ5.
KOiK00963.
OMAiPPNGKRC.
OrthoDBiEOG7ZPNK4.
PhylomeDBiQ91ZJ5.
TreeFamiTF300567.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZJ5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI EEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM
360 370 380 390 400
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,979
Last modified:January 23, 2007 - v3
Checksum:i7F5FB23628D631FE
GO
Isoform 2 (identifier: Q91ZJ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:497
Mass (Da):55,716
Checksum:i34852343B69B9BC9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_012835Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424698 mRNA. Translation: AAL24807.1.
AK033445 mRNA. Translation: BAC28291.1.
AL772195, AL833772 Genomic DNA. Translation: CAI24602.1.
AL772195, AL833772 Genomic DNA. Translation: CAI24601.1.
AL833772, AL772195 Genomic DNA. Translation: CAI24172.1.
AL833772, AL772195 Genomic DNA. Translation: CAI24171.1.
BC023810 mRNA. Translation: AAH23810.1.
BC025585 mRNA. Translation: AAH25585.1.
BC061208 mRNA. Translation: AAH61208.1.
CCDSiCCDS24464.1. [Q91ZJ5-1]
CCDS70148.1. [Q91ZJ5-2]
RefSeqiNP_001277563.1. NM_001290634.1. [Q91ZJ5-2]
NP_647458.1. NM_139297.6. [Q91ZJ5-1]
UniGeneiMm.28877.

Genome annotation databases

EnsembliENSMUST00000060895; ENSMUSP00000056324; ENSMUSG00000001891. [Q91ZJ5-2]
ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891. [Q91ZJ5-1]
GeneIDi216558.
KEGGimmu:216558.
UCSCiuc007idr.3. mouse. [Q91ZJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424698 mRNA. Translation: AAL24807.1 .
AK033445 mRNA. Translation: BAC28291.1 .
AL772195 , AL833772 Genomic DNA. Translation: CAI24602.1 .
AL772195 , AL833772 Genomic DNA. Translation: CAI24601.1 .
AL833772 , AL772195 Genomic DNA. Translation: CAI24172.1 .
AL833772 , AL772195 Genomic DNA. Translation: CAI24171.1 .
BC023810 mRNA. Translation: AAH23810.1 .
BC025585 mRNA. Translation: AAH25585.1 .
BC061208 mRNA. Translation: AAH61208.1 .
CCDSi CCDS24464.1. [Q91ZJ5-1 ]
CCDS70148.1. [Q91ZJ5-2 ]
RefSeqi NP_001277563.1. NM_001290634.1. [Q91ZJ5-2 ]
NP_647458.1. NM_139297.6. [Q91ZJ5-1 ]
UniGenei Mm.28877.

3D structure databases

ProteinModelPortali Q91ZJ5.
SMRi Q91ZJ5. Positions 22-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91ZJ5. 3 interactions.
MINTi MINT-1856424.

PTM databases

PhosphoSitei Q91ZJ5.

2D gel databases

REPRODUCTION-2DPAGE IPI00279474.

Proteomic databases

MaxQBi Q91ZJ5.
PaxDbi Q91ZJ5.
PRIDEi Q91ZJ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060895 ; ENSMUSP00000056324 ; ENSMUSG00000001891 . [Q91ZJ5-2 ]
ENSMUST00000102875 ; ENSMUSP00000099939 ; ENSMUSG00000001891 . [Q91ZJ5-1 ]
GeneIDi 216558.
KEGGi mmu:216558.
UCSCi uc007idr.3. mouse. [Q91ZJ5-1 ]

Organism-specific databases

CTDi 7360.
MGIi MGI:2183447. Ugp2.

Phylogenomic databases

eggNOGi COG4284.
GeneTreei ENSGT00390000003174.
HOGENOMi HOG000113618.
HOVERGENi HBG055396.
InParanoidi Q91ZJ5.
KOi K00963.
OMAi PPNGKRC.
OrthoDBi EOG7ZPNK4.
PhylomeDBi Q91ZJ5.
TreeFami TF300567.

Enzyme and pathway databases

Reactomei REACT_188939. Glycogen synthesis.

Miscellaneous databases

ChiTaRSi UGP2. mouse.
NextBioi 375212.
PROi Q91ZJ5.
SOURCEi Search...

Gene expression databases

Bgeei Q91ZJ5.
CleanExi MM_UGP2.
ExpressionAtlasi Q91ZJ5. baseline and differential.
Genevestigatori Q91ZJ5.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14."
    Fuchs S., Resch K., Thiel C., Ulbrich M., Platzer M., Jockusch H., Schmitt-John T.
    BMC Genet. 3:14-14(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary tumor and Pituitary.

Entry informationi

Entry nameiUGPA_MOUSE
AccessioniPrimary (citable) accession number: Q91ZJ5
Secondary accession number(s): Q8R3D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3