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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

Celsr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

GO - Biological processi

  • axonal fasciculation Source: MGI
  • cilium assembly Source: MGI
  • dopaminergic neuron axon guidance Source: ParkinsonsUK-UCL
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • neuron migration Source: MGI
  • planar cell polarity pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • regulation of protein localization Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • serotonergic neuron axon guidance Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Gene namesi
Name:Celsr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1858236. Celsr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 2531ExtracellularSequence analysisAdd BLAST2500
Transmembranei2532 – 2552Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2553 – 2563CytoplasmicSequence analysisAdd BLAST11
Transmembranei2564 – 2584Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2585 – 2592ExtracellularSequence analysis8
Transmembranei2593 – 2613Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2614 – 2634CytoplasmicSequence analysisAdd BLAST21
Transmembranei2635 – 2655Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2656 – 2673ExtracellularSequence analysisAdd BLAST18
Transmembranei2674 – 2694Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2695 – 2716CytoplasmicSequence analysisAdd BLAST22
Transmembranei2717 – 2737Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2738 – 2744ExtracellularSequence analysis7
Transmembranei2745 – 2765Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2766 – 3301CytoplasmicSequence analysisAdd BLAST536

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001291932 – 3301Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi623N-linked (GlcNAc...)Sequence analysis1
Glycosylationi838N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1318N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1370 ↔ 1381By similarity
Disulfide bondi1375 ↔ 1412By similarity
Disulfide bondi1414 ↔ 1423By similarity
Disulfide bondi1430 ↔ 1441By similarity
Disulfide bondi1435 ↔ 1450By similarity
Disulfide bondi1452 ↔ 1459By similarity
Disulfide bondi1468 ↔ 1479By similarity
Disulfide bondi1473 ↔ 1489By similarity
Disulfide bondi1491 ↔ 1502By similarity
Glycosylationi1638N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1682 ↔ 1708By similarity
Glycosylationi1702N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1715 ↔ 1726By similarity
Disulfide bondi1720 ↔ 1735By similarity
Disulfide bondi1737 ↔ 1746By similarity
Glycosylationi1759N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1904 ↔ 1933By similarity
Disulfide bondi1939 ↔ 1950By similarity
Disulfide bondi1944 ↔ 1959By similarity
Modified residuei1952(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1961 ↔ 1970By similarity
Disulfide bondi1974 ↔ 1985By similarity
Disulfide bondi1979 ↔ 1997By similarity
Disulfide bondi1999 ↔ 2008By similarity
Disulfide bondi2016 ↔ 2029By similarity
Disulfide bondi2031 ↔ 2041By similarity
Glycosylationi2042N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2048 ↔ 2063By similarity
Disulfide bondi2050 ↔ 2066By similarity
Disulfide bondi2068 ↔ 2078By similarity
Disulfide bondi2087 ↔ 2096By similarity
Disulfide bondi2099 ↔ 2111By similarity
Modified residuei2115PhosphotyrosineBy similarity1
Glycosylationi2166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2465N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2497N-linked (GlcNAc...)Sequence analysis1
Modified residuei3042PhosphotyrosineBy similarity1
Modified residuei3090PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQBiQ91ZI0.
PaxDbiQ91ZI0.
PRIDEiQ91ZI0.

PTM databases

iPTMnetiQ91ZI0.
PhosphoSitePlusiQ91ZI0.

Expressioni

Tissue specificityi

Expressed in the CNS and in the eye.1 Publication

Developmental stagei

Predominantly expressed in the CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. No expression is detected until somite stages. Between E10 and E12, expression is strong in the marginal zone (MZ), and lower in the ventricular zone (VZ). At E15, expression is restricted to the brain and olfactory epithelium. In the brain, it is low in VZ but strong in external fields, particularly those with ongoing migration, such as the telencephalic cortical plate, the olfactory bulb, the cerebellum and the tectum. In the newborn and postnatal stages, expression is high in differentiated neuronal fields.2 Publications

Gene expression databases

BgeeiENSMUSG00000023473.
ExpressionAtlasiQ91ZI0. baseline and differential.
GenevisibleiQ91ZI0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91ZI0. 1 interactor.
STRINGi10090.ENSMUSP00000024238.

Structurei

3D structure databases

ProteinModelPortaliQ91ZI0.
SMRiQ91ZI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 424Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini425 – 536Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini537 – 642Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini643 – 747Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini748 – 849Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini850 – 952Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini953 – 1058Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1059 – 1160Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1161 – 1257Cadherin 9PROSITE-ProRule annotationAdd BLAST97
Domaini1366 – 1424EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1426 – 1460EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST35
Domaini1464 – 1503EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1504 – 1708Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1711 – 1747EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1751 – 1933Laminin G-like 2PROSITE-ProRule annotationAdd BLAST183
Domaini1935 – 1971EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1972 – 2002EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST31
Domaini2003 – 2042EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2044 – 2079EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2066 – 2113Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2468 – 2520GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2720 – 2724Poly-Leu5

Sequence similaritiesi

Contains 9 cadherin domains.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ91ZI0.
KOiK04602.
OMAiYRFVGPP.
OrthoDBiEOG091G0039.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRPLWWGL PGPSTPVLLL LLLSLFPFSR EELGGGGDQD WDPGVATTTG
60 70 80 90 100
PRAQIGSGAV ALCPESPGVW EDGDPGLGVR EPVFMRLRVG RQNARNGRGA
110 120 130 140 150
PEQPNAEVVV QALGSREQEA GQGPGYLLCW HPEISSCGRT GPLRRGSLPL
160 170 180 190 200
DALSPGDSDL RNSSPHPSEL LAQPDGSRPV AFQRNARRSI RKRVETSRCC
210 220 230 240 250
GKLWEPGHKG QGERSATSTV DRGPFRRDCL PGSLGSGLGE DSAPRAVRTA
260 270 280 290 300
PTPGSAPRES RTAPGRMRSR GLFRRRFLFE RPGPRPPGFP TGPEAKQILS
310 320 330 340 350
TNQARPRRAA NRHPQFPQYN YQTLVPENEA AGTSVLRVVA QDPDPGEAGR
360 370 380 390 400
LIYSLAALMN SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG
410 420 430 440 450
SPRLSATTMV AVTVADRNDH APVFEQAQYR ETLRENVEEG YPILQLRATD
460 470 480 490 500
GDAPPNANLR YRFVGSPAVR TAAAAAFEID PRSGLISTSG RVDREHMESY
510 520 530 540 550
ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR YVAQVREDVR
560 570 580 590 600
PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD
610 620 630 640 650
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHAP IFVSTPFQVS
660 670 680 690 700
VLENAPLGHS VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS
710 720 730 740 750
VSGPLDRESV EHYFFGVEAR DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK
760 770 780 790 800
EYHLRLNEDA AVGTSVVSVT AVDRDANSAI SYQITGGNTR NRFAISTQGG
810 820 830 840 850
VGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT DANTHRPVFQ
860 870 880 890 900
SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD
910 920 930 940 950
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP
960 970 980 990 1000
QFVASHYTGL VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD
1010 1020 1030 1040 1050
FTIEPTSGIV RTVRRLDREA VPVYELTAYA VDRGVPPLRT PVSIQVTVQD
1060 1070 1080 1090 1100
VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI TAVDPDDGPN AHIMYQIVEG
1110 1120 1130 1140 1150
NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL VSRATVHVRL
1160 1170 1180 1190 1200
VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS
1210 1220 1230 1240 1250
FERGNELQLL VVNRTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC
1260 1270 1280 1290 1300
VLRVVIITEE LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED
1310 1320 1330 1340 1350
VFIFNIQNDT DVGGTVLNVS FSALAPRGAG AGAAGPWFSS EELQEQLYVR
1360 1370 1380 1390 1400
RAALAARSLL DVLPFDDNVC LREPCENYMK CVSVLRFDSS APFLASTSTL
1410 1420 1430 1440 1450
FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA CARREGGYTC
1460 1470 1480 1490 1500
VCRPRFTDCE LDTEAGRCVP GVCRNGGTCT NAPNGGFRCQ CPAGGAFEGP
1510 1520 1530 1540 1550
RCEVAARSFP PSSFVMFRGL RQRFHLTLSL SFATVQPSGL LFYNGRLNEK
1560 1570 1580 1590 1600
HDFLALELVA GQVRLTYSTG ESNTVVSPTV PGGLSDGQWH TVHLRYYNKP
1610 1620 1630 1640 1650
RTDALGGAQG PSKDKVAVLS VDDCNVAVAL QFGAEIGNYS CAAAGVQTSS
1660 1670 1680 1690 1700
KKSLDLTGPL LLGGVPNLPE NFPVSHKDFI GCMRDLHIDG RRMDMAAFVA
1710 1720 1730 1740 1750
NNGTMAGCQA KSHFCASGPC KNNGFCSERW GGFSCDCPVG FGGKDCRLTM
1760 1770 1780 1790 1800
AHPYHFQGNG TLSWDFGNDM AVSVPWYLGL SFRTRATKGI LMQVQLGPHS
1810 1820 1830 1840 1850
VLLCKLDRGL LSVTLNRASG HTVHLLLDQM TVSDGRWHDL RLELQEEPGG
1860 1870 1880 1890 1900
RRGHHIFMVS LDFTLFQDTM AMGGELQGLK VKQLHVGGLP PSSKEEGHQG
1910 1920 1930 1940 1950
LVGCIQGVWI GFTPFGSSAL LPPSHRVNVE PGCTVTNPCA SGPCPPHADC
1960 1970 1980 1990 2000
KDLWQTFSCT CRPGYYGPGC VDACLLNPCQ NQGSCRHLQG APHGYTCDCV
2010 2020 2030 2040 2050
SGYFGQHCEH RVDQQCPRGW WGSPTCGPCN CDVHKGFDPN CNKTNGQCHC
2060 2070 2080 2090 2100
KEFHYRPRGS DSCLPCDCYP VGSTSRSCAP HSGQCPCRPG ALGRQCNSCD
2110 2120 2130 2140 2150
SPFAEVTASG CRVLYDACPK SLRSGVWWPQ TKFGVLATVP CPRGALGAAV
2160 2170 2180 2190 2200
RLCDEDQGWL EPDLFNCTSP AFRELSLLLD GLELNKTALD TVEAKKLAQR
2210 2220 2230 2240 2250
LREVTGQTDH YFSQDVRVTA RLLAYLLAFE SHQQGFGLTA TQDAHFNENL
2260 2270 2280 2290 2300
LWAGSALLAP ETGHLWAALG QRAPGGSPGS AGLVQHLEEY AATLARNMEL
2310 2320 2330 2340 2350
TYLNPVGLVT PNIMLSIDRM EHPSSTQGAR RYPRYHSNLF RGQDAWDPHT
2360 2370 2380 2390 2400
HVLLPSQASQ PSPSEVLPTS SNAENATASS VVSPPAPLEP ESEPGISIVI
2410 2420 2430 2440 2450
LLVYRALGGL LPAQFQAERR GARLPQNPVM NSPVVSVAVF HGRNFLRGVL
2460 2470 2480 2490 2500
VSPINLEFRL LQTANRSKAI CVQWDPPGPT DQHGMWTARD CELVHRNGSH
2510 2520 2530 2540 2550
ARCRCSRTGT FGVLMDASPR ERLEGDLELL AVFTHVVVAV SVTALVLTAA
2560 2570 2580 2590 2600
VLLSLRSLKS NVRGIHANVA AALGVAELLF LLGIHRTHNQ LLCTAVAILL
2610 2620 2630 2640 2650
HYFFLSTFAW LLVQGLHLYR MQVEPRNVDR GAMRFYHALG WGVPAVLLGL
2660 2670 2680 2690 2700
AVGLDPEGYG NPDFCWISIH EPLIWSFAGP IVLVIVMNGT MFLLAARTSC
2710 2720 2730 2740 2750
STGQREAKKT SVLTLRSSFL LLLLVSASWL FGLLAVNHSI LAFHYLHAGL
2760 2770 2780 2790 2800
CGLQGLAVLL LFCVLNADAR AAWTPACLGK KAAPEETRPA PGPGSGAYNN
2810 2820 2830 2840 2850
TALFEESGLI RITLGASTVS SVSSARSGRA QDQDSQRGRS YLRDNVLVRH
2860 2870 2880 2890 2900
GSTAEHTERS LQAHAGPTDL DVAMFHRDAG ADSDSDSDLS LEEERSLSIP
2910 2920 2930 2940 2950
SSESEDNGRT RGRFQRPLRR AAQSERLLAH PKDVDGNDLL SYWPALGECE
2960 2970 2980 2990 3000
AAPCALQAWG SERRLGLDSN KDAANNNQPE LALTSGDETS LGRAQRQRKG
3010 3020 3030 3040 3050
ILKNRLQYPL VPQSRGTPEL SWCRAATLGH RAVPAASYGR IYAGGGTGSL
3060 3070 3080 3090 3100
SQPASRYSSR EQLDLLLRRQ LSKERLEEVP VPAPVLHPLS RPGSQERLDT
3110 3120 3130 3140 3150
APARLEARDR GSTLPRRQPP RDYPGTMAGR FGSRDALDLG APREWLSTLP
3160 3170 3180 3190 3200
PPRRNRDLDP QHPPLPLSPQ RQLSRDPLLP SRPLDSLSRI SNSREGLDQV
3210 3220 3230 3240 3250
PSRHPSREAL GPAPQLLRAR EDPASGPSHG PSTEQLDILS SILASFNSSA
3260 3270 3280 3290 3300
LSSVQSSSTP SGPHTTATAS ALGPSTPRSA TSHSISELSP DSEVPRSEGH

S
Length:3,301
Mass (Da):358,478
Last modified:July 27, 2011 - v2
Checksum:i29EA6A0D1E5A75AF
GO

Sequence cautioni

The sequence AAG17057 differs from that shown. Reason: Frameshift at positions 2575 and 2578.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221D → E in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti537S → G in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti2713L → LR in AAG17057 (PubMed:11677057).Curated1
Sequence conflicti3024R → P in AAG17057 (PubMed:11677057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427498 mRNA. Translation: AAL25099.1.
AC168054 Genomic DNA. No translation available.
AF188752 mRNA. Translation: AAG17057.1. Frameshift.
CCDSiCCDS23539.1.
RefSeqiNP_536685.2. NM_080437.2.
UniGeneiMm.39945.

Genome annotation databases

EnsembliENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473.
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269.
GeneIDi107934.
KEGGimmu:107934.
UCSCiuc009rrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427498 mRNA. Translation: AAL25099.1.
AC168054 Genomic DNA. No translation available.
AF188752 mRNA. Translation: AAG17057.1. Frameshift.
CCDSiCCDS23539.1.
RefSeqiNP_536685.2. NM_080437.2.
UniGeneiMm.39945.

3D structure databases

ProteinModelPortaliQ91ZI0.
SMRiQ91ZI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZI0. 1 interactor.
STRINGi10090.ENSMUSP00000024238.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ91ZI0.
PhosphoSitePlusiQ91ZI0.

Proteomic databases

MaxQBiQ91ZI0.
PaxDbiQ91ZI0.
PRIDEiQ91ZI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473.
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269.
GeneIDi107934.
KEGGimmu:107934.
UCSCiuc009rrb.1. mouse.

Organism-specific databases

CTDi1951.
MGIiMGI:1858236. Celsr3.

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ91ZI0.
KOiK04602.
OMAiYRFVGPP.
OrthoDBiEOG091G0039.
TreeFamiTF323983.

Miscellaneous databases

PROiQ91ZI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023473.
ExpressionAtlasiQ91ZI0. baseline and differential.
GenevisibleiQ91ZI0. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
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Entry informationi

Entry nameiCELR3_MOUSE
AccessioniPrimary (citable) accession number: Q91ZI0
Secondary accession number(s): E9QLD7, Q9ESD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.