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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei187Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1296041. Activation of G protein gated Potassium channels.
R-RNO-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Protein family/group databases

TCDBi1.A.2.1.4. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:Kcnj15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621662. Kcnj15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 93CytoplasmicBy similarityAdd BLAST93
Transmembranei94 – 118Helical; Name=M1By similarityAdd BLAST25
Topological domaini119 – 143ExtracellularBy similarityAdd BLAST25
Intramembranei144 – 155Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei156 – 162Pore-formingBy similarity7
Topological domaini163 – 171ExtracellularBy similarity9
Transmembranei172 – 193Helical; Name=M2By similarityAdd BLAST22
Topological domaini194 – 405CytoplasmicBy similarityAdd BLAST212

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549741 – 405ATP-sensitive inward rectifier potassium channel 15Add BLAST405

Proteomic databases

PaxDbiQ91ZF1.
PRIDEiQ91ZF1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001656.
GenevisibleiQ91ZF1. RN.

Interactioni

Subunit structurei

Interacts with PATJ.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002259.

Structurei

3D structure databases

ProteinModelPortaliQ91ZF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi157 – 162Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ91ZF1.
KOiK05008.
OMAiCPLAIFT.
OrthoDBiEOG091G08HC.
PhylomeDBiQ91ZF1.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZF1-1) [UniParc]FASTAAdd to basket
Also known as: Kir4.2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVARWVKGSE DAPLALQKIP DLQSGPRSLR MEAIHIGMSS APLVKHSNGV
60 70 80 90 100
GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID MKWRYKLTLF
110 120 130 140 150
AATFVMTWFL FGVVYYAIAF IHGDLELGES NSNHTPCIMK VDSLTGAFLF
160 170 180 190 200
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR
210 220 230 240 250
PKKRAETIKF SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH
260 270 280 290 300
VTKEGERILL NQATVKFHVD SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ
310 320 330 340 350
NLKEKEFELV VLLNATVEST SAVCQSRTSY IPEEIYWGFE FVPVVSLSKN
360 370 380 390 400
GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ RERELRSLLL

QQSNV
Length:405
Mass (Da):45,908
Last modified:December 1, 2001 - v1
Checksum:i77C0BEB7C6785E5D
GO
Isoform 2 (identifier: Q91ZF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:375
Mass (Da):42,606
Checksum:i8FC043B633B473FB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116871 – 30Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028455 mRNA. Translation: AAK20928.1.
RefSeqiNP_579855.1. NM_133321.2. [Q91ZF1-1]
XP_006248190.1. XM_006248128.3. [Q91ZF1-1]
XP_006248191.1. XM_006248129.3. [Q91ZF1-1]
XP_006248193.1. XM_006248131.3. [Q91ZF1-1]
XP_006248194.1. XM_006248132.3. [Q91ZF1-1]
XP_006248195.1. XM_006248133.3. [Q91ZF1-1]
XP_006248197.1. XM_006248135.2. [Q91ZF1-1]
XP_006248201.1. XM_006248139.3. [Q91ZF1-2]
XP_006248203.1. XM_006248141.3. [Q91ZF1-2]
XP_008766772.1. XM_008768550.2. [Q91ZF1-1]
XP_008766773.1. XM_008768551.2. [Q91ZF1-1]
XP_008766774.1. XM_008768552.2. [Q91ZF1-1]
XP_008766775.1. XM_008768553.2. [Q91ZF1-1]
XP_017453350.1. XM_017597861.1. [Q91ZF1-1]
XP_017453351.1. XM_017597862.1. [Q91ZF1-1]
XP_017453352.1. XM_017597863.1. [Q91ZF1-1]
UniGeneiRn.81018.

Genome annotation databases

EnsembliENSRNOT00000002259; ENSRNOP00000002259; ENSRNOG00000001656. [Q91ZF1-1]
GeneIDi170847.
KEGGirno:170847.
UCSCiRGD:621662. rat. [Q91ZF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028455 mRNA. Translation: AAK20928.1.
RefSeqiNP_579855.1. NM_133321.2. [Q91ZF1-1]
XP_006248190.1. XM_006248128.3. [Q91ZF1-1]
XP_006248191.1. XM_006248129.3. [Q91ZF1-1]
XP_006248193.1. XM_006248131.3. [Q91ZF1-1]
XP_006248194.1. XM_006248132.3. [Q91ZF1-1]
XP_006248195.1. XM_006248133.3. [Q91ZF1-1]
XP_006248197.1. XM_006248135.2. [Q91ZF1-1]
XP_006248201.1. XM_006248139.3. [Q91ZF1-2]
XP_006248203.1. XM_006248141.3. [Q91ZF1-2]
XP_008766772.1. XM_008768550.2. [Q91ZF1-1]
XP_008766773.1. XM_008768551.2. [Q91ZF1-1]
XP_008766774.1. XM_008768552.2. [Q91ZF1-1]
XP_008766775.1. XM_008768553.2. [Q91ZF1-1]
XP_017453350.1. XM_017597861.1. [Q91ZF1-1]
XP_017453351.1. XM_017597862.1. [Q91ZF1-1]
XP_017453352.1. XM_017597863.1. [Q91ZF1-1]
UniGeneiRn.81018.

3D structure databases

ProteinModelPortaliQ91ZF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002259.

Chemistry databases

GuidetoPHARMACOLOGYi439.

Protein family/group databases

TCDBi1.A.2.1.4. inward rectifier k(+) channel (irk-c) family.

Proteomic databases

PaxDbiQ91ZF1.
PRIDEiQ91ZF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002259; ENSRNOP00000002259; ENSRNOG00000001656. [Q91ZF1-1]
GeneIDi170847.
KEGGirno:170847.
UCSCiRGD:621662. rat. [Q91ZF1-1]

Organism-specific databases

CTDi3772.
RGDi621662. Kcnj15.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiQ91ZF1.
KOiK05008.
OMAiCPLAIFT.
OrthoDBiEOG091G08HC.
PhylomeDBiQ91ZF1.
TreeFamiTF313676.

Enzyme and pathway databases

ReactomeiR-RNO-1296041. Activation of G protein gated Potassium channels.
R-RNO-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

PROiQ91ZF1.

Gene expression databases

BgeeiENSRNOG00000001656.
GenevisibleiQ91ZF1. RN.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ15_RAT
AccessioniPrimary (citable) accession number: Q91ZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.