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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei187Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: RGD
  • potassium channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

TCDBi1.A.2.1.4 the inward rectifier k(+) channel (irk-c) family

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:Kcnj15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621662 Kcnj15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 93CytoplasmicBy similarityAdd BLAST93
Transmembranei94 – 118Helical; Name=M1By similarityAdd BLAST25
Topological domaini119 – 143ExtracellularBy similarityAdd BLAST25
Intramembranei144 – 155Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei156 – 162Pore-formingBy similarity7
Topological domaini163 – 171ExtracellularBy similarity9
Transmembranei172 – 193Helical; Name=M2By similarityAdd BLAST22
Topological domaini194 – 405CytoplasmicBy similarityAdd BLAST212

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi439

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549741 – 405ATP-sensitive inward rectifier potassium channel 15Add BLAST405

Proteomic databases

PaxDbiQ91ZF1
PRIDEiQ91ZF1

Expressioni

Gene expression databases

BgeeiENSRNOG00000001656
GenevisibleiQ91ZF1 RN

Interactioni

Subunit structurei

Interacts with PATJ.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002259

Structurei

3D structure databases

ProteinModelPortaliQ91ZF1
SMRiQ91ZF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi157 – 162Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiQ91ZF1
KOiK05008
OMAiECPLAIF
OrthoDBiEOG091G08HC
PhylomeDBiQ91ZF1
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003270 K_chnl_inward-rec_Kir1.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF20 PTHR11767:SF20, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01323 KIR13CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZF1-1) [UniParc]FASTAAdd to basket
Also known as: Kir4.2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVARWVKGSE DAPLALQKIP DLQSGPRSLR MEAIHIGMSS APLVKHSNGV
60 70 80 90 100
GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID MKWRYKLTLF
110 120 130 140 150
AATFVMTWFL FGVVYYAIAF IHGDLELGES NSNHTPCIMK VDSLTGAFLF
160 170 180 190 200
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR
210 220 230 240 250
PKKRAETIKF SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH
260 270 280 290 300
VTKEGERILL NQATVKFHVD SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ
310 320 330 340 350
NLKEKEFELV VLLNATVEST SAVCQSRTSY IPEEIYWGFE FVPVVSLSKN
360 370 380 390 400
GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ RERELRSLLL

QQSNV
Length:405
Mass (Da):45,908
Last modified:December 1, 2001 - v1
Checksum:i77C0BEB7C6785E5D
GO
Isoform 2 (identifier: Q91ZF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:375
Mass (Da):42,606
Checksum:i8FC043B633B473FB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116871 – 30Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028455 mRNA Translation: AAK20928.1
RefSeqiNP_579855.1, NM_133321.2 [Q91ZF1-1]
XP_006248190.1, XM_006248128.3 [Q91ZF1-1]
XP_006248191.1, XM_006248129.3 [Q91ZF1-1]
XP_006248193.1, XM_006248131.3 [Q91ZF1-1]
XP_006248194.1, XM_006248132.3 [Q91ZF1-1]
XP_006248195.1, XM_006248133.3 [Q91ZF1-1]
XP_006248197.1, XM_006248135.2 [Q91ZF1-1]
XP_006248201.1, XM_006248139.3 [Q91ZF1-2]
XP_006248203.1, XM_006248141.3 [Q91ZF1-2]
XP_008766772.1, XM_008768550.2 [Q91ZF1-1]
XP_008766773.1, XM_008768551.2 [Q91ZF1-1]
XP_008766774.1, XM_008768552.2 [Q91ZF1-1]
XP_008766775.1, XM_008768553.2 [Q91ZF1-1]
XP_017453350.1, XM_017597861.1 [Q91ZF1-1]
XP_017453351.1, XM_017597862.1 [Q91ZF1-1]
XP_017453352.1, XM_017597863.1 [Q91ZF1-1]
UniGeneiRn.81018

Genome annotation databases

EnsembliENSRNOT00000002259; ENSRNOP00000002259; ENSRNOG00000001656 [Q91ZF1-1]
GeneIDi170847
KEGGirno:170847
UCSCiRGD:621662 rat [Q91ZF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKCJ15_RAT
AccessioniPrimary (citable) accession number: Q91ZF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health