Reviewed,
UniProtKB/Swiss-Prot Q91ZF0 (DJC24_MOUSE)
Last modified
January 19, 2010.
Version 71.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: DnaJ homolog subfamily C member 24 Alternative name(s): DPH4 homolog CSL-type zinc finger-containing protein 3 J domain protein DjC7 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 196 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Stimulates the ATPase activity of several Hsp70-type chaperones. Ref.1 |
| Tissue specificity | Detected in heart, brain, spleen, lung, liver, kidney and testis. Ref.1 |
| Sequence similarities | Belongs to the DPH4 family. Contains 1 DPH-type zinc finger. Contains 1 J domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Zinc-finger |
| Ligand | Metal-binding Zinc |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Molecular function | heat shock protein binding Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q91ZF0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q91ZF0-2) The sequence of this isoform differs from the canonical sequence as follows: 1-48: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||
Molecule processing | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 196 | 196 | DnaJ homolog subfamily C member 24 | PRO_0000082623 | |||||||||||||||||
Regions | |||||||||||||||||||||
| Domain | 58 – 129 | 72 | J | ||||||||||||||||||
| Zinc finger | 140 – 195 | 56 | DPH-type | ||||||||||||||||||
Natural variations | |||||||||||||||||||||
| Alternative sequence | 1 – 48 | 48 | Missing in isoform 2. | VSP_013793 | |||||||||||||||||
Experimental info | |||||||||||||||||||||
| Sequence conflict | 150 | 1 | S → F in AAK21968. Ref.1 | ||||||||||||||||||
| Sequence conflict | 194 | 1 | H → Q in AAK21968. Ref.1 | ||||||||||||||||||
Secondary structure | |||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||
| Beta strand | 52 – 55 | 4 | |||||||||||||||||||
| Helix | 59 – 62 | 4 | |||||||||||||||||||
| Helix | 71 – 80 | 10 | |||||||||||||||||||
| Beta strand | 83 – 85 | 3 | |||||||||||||||||||
| Helix | 96 – 116 | 21 | |||||||||||||||||||
| Beta strand | 117 – 120 | 4 | |||||||||||||||||||
| Helix | 121 – 128 | 8 | |||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of a new soluble murine J-domain protein that stimulates BiP, Hsc70 and DnaK ATPase activity with different efficiencies." Kroczynska B., Blond S.Y. Gene 273:267-274(2001) [PubMed: 11595173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Embryo. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J and FVB/N. Tissue: Mammary tumor and Thymus. |
| [4] | "Solution structure of J-domain of mouse DNAJ-like protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 49-129. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AY028460 mRNA. Translation: AAK21968.1. AK006521 mRNA. Translation: BAB24631.1. BC030072 mRNA. Translation: AAH30072.1. BC091774 mRNA. Translation: AAH91774.1. | ||||||||||||
| IPI | IPI00315007. IPI00605234. | ||||||||||||
| RefSeq | NP_081268.1. | ||||||||||||
| UniGene | Mm.25661 Mm.393077 Mm.401286 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| SMR | Q91ZF0. Positions 141-194. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q91ZF0. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q91ZF0. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSMUST00000028587; ENSMUSP00000028587; ENSMUSG00000027166; Mus musculus. [Genome view] ENSMUST00000102555; ENSMUSP00000099615; ENSMUSG00000027166; Mus musculus. [Genome view] | ||||||||||||
| GeneID | 99349. | ||||||||||||
| KEGG | mmu:99349. | ||||||||||||
| NMPDR | fig|10090.3.peg.6513. | ||||||||||||
| UCSC | uc008llf.1. mouse. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 99349. | ||||||||||||
| MGI | MGI:1919522. Dnajc24. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG283742. | ||||||||||||
| HOVERGEN | Q91ZF0. | ||||||||||||
| InParanoid | Q91ZF0. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q91ZF0. | ||||||||||||
| Bgee | Q91ZF0. | ||||||||||||
| Genevestigator | Q91ZF0. | ||||||||||||
| GermOnline | ENSMUSG00000027166. Mus musculus. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001623. DnaJ_N. IPR015609. Hsp40/DnaJ_Rel. IPR007872. Znf_DHP. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.287.110. DnaJ_N. 1 hit. | ||||||||||||
| PANTHER | PTHR11821. Hsp40/DnaJ_Rel. 1 hit. | ||||||||||||
| Pfam | PF00226. DnaJ. 1 hit. PF05207. zf-CSL. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS51074. ZF_DPH. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 353889. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | DJC24_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q91ZF0 Secondary accession number(s): Q9D9S7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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