Reviewed, UniProtKB/Swiss-Prot Q91ZF0 (DJC24_MOUSE)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily C member 24
Alternative name(s):
    DPH4 homolog
    CSL-type zinc finger-containing protein 3
    J domain protein DjC7

Gene names

Name:	Dnajc24
Synonyms:	Dph4, Zcsl3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the ATPase activity of several Hsp70-type chaperones. Ref.1
Tissue specificity	Detected in heart, brain, spleen, lung, liver, kidney and testis. Ref.1
Sequence similarities	Belongs to the DPH4 family. Contains 1 DPH-type zinc finger. Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91ZF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91ZF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 196

196

DnaJ homolog subfamily C member 24

PRO_0000082623

Regions

Domain

58 – 129

72

J

Zinc finger

140 – 195

56

DPH-type

Natural variations

Alternative sequence

1 – 48

48

Missing in isoform 2.

VSP_013793

Experimental info

Sequence conflict

150

1

S → F in AAK21968. Ref.1

Sequence conflict

194

1

H → Q in AAK21968. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

196

Helix Strand Turn

Details...

Beta strand

52 – 55

4

Helix

59 – 62

4

Helix

71 – 80

10

Beta strand

83 – 85

3

Helix

96 – 116

21

Beta strand

117 – 120

4

Helix

121 – 128

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2005. Version 2. Checksum: 566EA6265955CD4F	FASTA	196	22,098
	10 20 30 40 50 60 MTLCGARGRH QQGQPRWGGR LPVDAACPPS CGCFRVIREG SLLGQRTLMA LEQTLKKDWY 70 80 90 100 110 120 SILGADPSAN MSDLKQKYQK LILLYHPDKQ SADVPAGTME ECMQKFIEID QAWKILGNEE 130 140 150 160 170 180 TKKKYDLQRH EDELRNVGPV DAQVRLEEMS WNQGDESFFL SCRCGGKYTV SKDEAQEATL 190 ISCDACSLIV ELLHQS
	Isoform 2. Checksum: D0025C7A02252FC4	FASTA	148	16,922
	10 20 30 40 50 60 MALEQTLKKD WYSILGADPS ANMSDLKQKY QKLILLYHPD KQSADVPAGT MEECMQKFIE 70 80 90 100 110 120 IDQAWKILGN EETKKKYDLQ RHEDELRNVG PVDAQVRLEE MSWNQGDESF FLSCRCGGKY 130 140 TVSKDEAQEA TLISCDACSL IVELLHQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a new soluble murine J-domain protein that stimulates BiP, Hsc70 and DnaK ATPase activity with different efficiencies." Kroczynska B., Blond S.Y. Gene 273:267-274(2001) [PubMed: 11595173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Embryo.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J and FVB/N. Tissue: Mammary tumor and Thymus.
[4]	"Solution structure of J-domain of mouse DNAJ-like protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 49-129.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY028460 mRNA. Translation: AAK21968.1.
AK006521 mRNA. Translation: BAB24631.1.
BC030072 mRNA. Translation: AAH30072.1.
BC091774 mRNA. Translation: AAH91774.1.

IPI

IPI00315007.
IPI00605234.

RefSeq

NP_081268.1.

UniGene

Mm.25661
Mm.393077
Mm.401286

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WJZ	NMR	-	A	49-129	[»]

SMR

Q91ZF0. Positions 141-194.

ModBase

Search...

Protein-protein interaction databases

STRING

Q91ZF0.

Proteomic databases

PRIDE

Q91ZF0.

Genome annotation databases

Ensembl

ENSMUST00000028587; ENSMUSP00000028587; ENSMUSG00000027166; Mus musculus. [Genome view]
ENSMUST00000102555; ENSMUSP00000099615; ENSMUSG00000027166; Mus musculus. [Genome view]

GeneID

99349.

KEGG

mmu:99349.

NMPDR

fig|10090.3.peg.6513.

UCSC

uc008llf.1. mouse.

Organism-specific databases

CTD

99349.

MGI

MGI:1919522. Dnajc24.

Phylogenomic databases

HOGENOM

HBG283742.

HOVERGEN

Q91ZF0.

InParanoid

Q91ZF0.

Gene expression databases

ArrayExpress

Q91ZF0.

Bgee

Q91ZF0.

Genevestigator

Q91ZF0.

GermOnline

ENSMUSG00000027166. Mus musculus.

Family and domain databases

InterPro

IPR001623. DnaJ_N.
IPR015609. Hsp40/DnaJ_Rel.
IPR007872. Znf_DHP.
[Graphical view]

Gene3D

G3DSA:1.10.287.110. DnaJ_N. 1 hit.

PANTHER

PTHR11821. Hsp40/DnaJ_Rel. 1 hit.

Pfam

PF00226. DnaJ. 1 hit.
PF05207. zf-CSL. 1 hit.
[Graphical view]

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

PROSITE

PS00636. DNAJ_1. False negative.
PS50076. DNAJ_2. 1 hit.
PS51074. ZF_DPH. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

353889.

SOURCE

Search...

Entry information

Entry name

DJC24_MOUSE

Accession

Primary (citable) accession number: Q91ZF0
Secondary accession number(s): Q9D9S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	January 19, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)