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Q91ZD1

- OSR2_MOUSE

UniProt

Q91ZD1 - OSR2_MOUSE

Protein

Protein odd-skipped-related 2

Gene

Osr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. bone morphogenesis Source: UniProtKB
    2. cell differentiation Source: BHF-UCL
    3. chondrocyte differentiation Source: BHF-UCL
    4. embryo development Source: UniProtKB
    5. embryonic digit morphogenesis Source: BHF-UCL
    6. embryonic forelimb morphogenesis Source: UniProtKB
    7. embryonic hindlimb morphogenesis Source: UniProtKB
    8. embryonic skeletal joint development Source: BHF-UCL
    9. embryonic skeletal joint morphogenesis Source: BHF-UCL
    10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
    11. embryonic skeletal system morphogenesis Source: MGI
    12. eyelid development in camera-type eye Source: UniProtKB
    13. head development Source: BHF-UCL
    14. mesonephros development Source: UniProtKB
    15. metanephros development Source: UniProtKB
    16. middle ear morphogenesis Source: UniProtKB
    17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    18. odontogenesis Source: UniProtKB
    19. osteoblast proliferation Source: UniProtKB
    20. palate development Source: UniProtKB
    21. positive regulation of bone mineralization Source: BHF-UCL
    22. positive regulation of cell proliferation Source: MGI
    23. positive regulation of epithelial cell proliferation Source: UniProtKB
    24. positive regulation of gastrulation Source: UniProtKB
    25. positive regulation of gene expression Source: UniProtKB
    26. positive regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. pronephros development Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein odd-skipped-related 2
    Gene namesi
    Name:Osr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1930813. Osr2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Protein odd-skipped-related 2PRO_0000047008Add
    BLAST

    Proteomic databases

    PRIDEiQ91ZD1.

    Expressioni

    Developmental stagei

    First detected at E9.25, specifically in the mesonephric vesicles. By E10.0 expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.1 Publication

    Gene expression databases

    BgeeiQ91ZD1.
    CleanExiMM_OSR2.
    GenevestigatoriQ91ZD1.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91ZD1. 2 interactions.

    Structurei

    Secondary structure

    1
    312
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi175 – 1773
    Helixi184 – 19411
    Beta strandi203 – 2053
    Helixi212 – 2187
    Helixi219 – 2213
    Beta strandi231 – 2333
    Helixi240 – 24910

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EE8NMR-A162-252[»]
    ProteinModelPortaliQ91ZD1.
    SMRiQ91ZD1. Positions 163-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ91ZD1.

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117413.
    HOGENOMiHOG000013107.
    HOVERGENiHBG054398.
    InParanoidiQ91ZD1.
    KOiK09215.
    OMAiKTLHMQT.
    OrthoDBiEOG754HQ2.
    PhylomeDBiQ91ZD1.
    TreeFamiTF350876.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91ZD1-1) [UniParc]FASTAAdd to Basket

    Also known as: OSR2A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH    50
    MNHWTLGYPS VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG 100
    AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL 150
    SKLNPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY 200
    TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH 250
    MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 300
    RHSLTHTPRQ NF 312
    Length:312
    Mass (Da):35,454
    Last modified:December 1, 2001 - v1
    Checksum:i33B4B92B1FA11D20
    GO
    Isoform 2 (identifier: Q91ZD1-2) [UniParc]FASTAAdd to Basket

    Also known as: OSR2B

    The sequence of this isoform differs from the canonical sequence as follows:
         253-312: ESPHKCPTCG...SLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA

    Show »
    Length:276
    Mass (Da):30,487
    Checksum:iA0E28AA0979CB1ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421G → W in BAC34859. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei253 – 31260ESPHK…PRQNF → TSSPTAASSAAKCSGETAIC GGTA in isoform 2. 3 PublicationsVSP_017122Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF370121 mRNA. Translation: AAL07364.1.
    AY038074 mRNA. Translation: AAK74068.1.
    AK052147 mRNA. Translation: BAC34859.1.
    BC013504 mRNA. Translation: AAH13504.1.
    CCDSiCCDS27422.1. [Q91ZD1-2]
    RefSeqiNP_473390.1. NM_054049.2. [Q91ZD1-2]
    XP_006520076.1. XM_006520013.1. [Q91ZD1-1]
    UniGeneiMm.46336.

    Genome annotation databases

    EnsembliENSMUST00000022952; ENSMUSP00000022952; ENSMUSG00000022330. [Q91ZD1-2]
    GeneIDi107587.
    KEGGimmu:107587.
    UCSCiuc007vma.1. mouse. [Q91ZD1-2]
    uc007vmb.1. mouse. [Q91ZD1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF370121 mRNA. Translation: AAL07364.1 .
    AY038074 mRNA. Translation: AAK74068.1 .
    AK052147 mRNA. Translation: BAC34859.1 .
    BC013504 mRNA. Translation: AAH13504.1 .
    CCDSi CCDS27422.1. [Q91ZD1-2 ]
    RefSeqi NP_473390.1. NM_054049.2. [Q91ZD1-2 ]
    XP_006520076.1. XM_006520013.1. [Q91ZD1-1 ]
    UniGenei Mm.46336.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EE8 NMR - A 162-252 [» ]
    ProteinModelPortali Q91ZD1.
    SMRi Q91ZD1. Positions 163-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91ZD1. 2 interactions.

    Proteomic databases

    PRIDEi Q91ZD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022952 ; ENSMUSP00000022952 ; ENSMUSG00000022330 . [Q91ZD1-2 ]
    GeneIDi 107587.
    KEGGi mmu:107587.
    UCSCi uc007vma.1. mouse. [Q91ZD1-2 ]
    uc007vmb.1. mouse. [Q91ZD1-1 ]

    Organism-specific databases

    CTDi 116039.
    MGIi MGI:1930813. Osr2.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117413.
    HOGENOMi HOG000013107.
    HOVERGENi HBG054398.
    InParanoidi Q91ZD1.
    KOi K09215.
    OMAi KTLHMQT.
    OrthoDBi EOG754HQ2.
    PhylomeDBi Q91ZD1.
    TreeFami TF350876.

    Miscellaneous databases

    EvolutionaryTracei Q91ZD1.
    NextBioi 359096.
    PROi Q91ZD1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91ZD1.
    CleanExi MM_OSR2.
    Genevestigatori Q91ZD1.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development."
      Lan Y., Kingsley P.D., Cho E.-S., Jiang R.
      Mech. Dev. 107:175-179(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DEVELOPMENTAL STAGE.
      Tissue: Mammary gland.
    2. "Alternative splicing of the mouse Osr2 mRNA produces two protein isoforms differing in the zinc finger region."
      Jiang R., Cho E.-S., Lan Y.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Eye.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Colon.
    5. "Solution structure of three ZF-C2H2 domains from mouse protein odd-skipped-related 2 splicing isoform 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 162-252 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiOSR2_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZD1
    Secondary accession number(s): Q8BPV6, Q91V54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3