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Protein

Protein odd-skipped-related 2

Gene

Osr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • bone morphogenesis Source: UniProtKB
  • cell differentiation Source: BHF-UCL
  • chondrocyte differentiation Source: BHF-UCL
  • embryo development ending in birth or egg hatching Source: UniProtKB
  • embryonic digit morphogenesis Source: BHF-UCL
  • embryonic forelimb morphogenesis Source: BHF-UCL
  • embryonic hindlimb morphogenesis Source: BHF-UCL
  • embryonic skeletal joint development Source: BHF-UCL
  • embryonic skeletal joint morphogenesis Source: BHF-UCL
  • embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  • embryonic skeletal system morphogenesis Source: MGI
  • eyelid development in camera-type eye Source: UniProtKB
  • head development Source: BHF-UCL
  • mesonephros development Source: UniProtKB
  • metanephros development Source: UniProtKB
  • middle ear morphogenesis Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • odontogenesis Source: UniProtKB
  • osteoblast proliferation Source: UniProtKB
  • positive regulation of bone mineralization Source: BHF-UCL
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • pronephros development Source: UniProtKB
  • roof of mouth development Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 2
Gene namesi
Name:Osr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1930813 Osr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470081 – 312Protein odd-skipped-related 2Add BLAST312

Proteomic databases

PaxDbiQ91ZD1
PRIDEiQ91ZD1

PTM databases

iPTMnetiQ91ZD1
PhosphoSitePlusiQ91ZD1

Expressioni

Developmental stagei

First detected at E9.25, specifically in the mesonephric vesicles. By E10.0 expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022330
CleanExiMM_OSR2
GenevisibleiQ91ZD1 MM

Interactioni

Protein-protein interaction databases

IntActiQ91ZD1, 3 interactors
STRINGi10090.ENSMUSP00000022952

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi175 – 177Combined sources3
Helixi184 – 194Combined sources11
Beta strandi203 – 205Combined sources3
Helixi212 – 218Combined sources7
Helixi219 – 221Combined sources3
Beta strandi231 – 233Combined sources3
Helixi240 – 249Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE8NMR-A162-252[»]
ProteinModelPortaliQ91ZD1
SMRiQ91ZD1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91ZD1

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ91ZD1
KOiK09215
OMAiKTLHMQT
OrthoDBiEOG091G0LRE
PhylomeDBiQ91ZD1
TreeFamiTF350876

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZD1-1) [UniParc]FASTAAdd to basket
Also known as: OSR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH
60 70 80 90 100
MNHWTLGYPS VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG
110 120 130 140 150
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL
160 170 180 190 200
SKLNPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY
210 220 230 240 250
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH
260 270 280 290 300
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
310
RHSLTHTPRQ NF
Length:312
Mass (Da):35,454
Last modified:December 1, 2001 - v1
Checksum:i33B4B92B1FA11D20
GO
Isoform 2 (identifier: Q91ZD1-2) [UniParc]FASTAAdd to basket
Also known as: OSR2B

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA

Show »
Length:276
Mass (Da):30,487
Checksum:iA0E28AA0979CB1ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142G → W in BAC34859 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017122253 – 312ESPHK…PRQNF → TSSPTAASSAAKCSGETAIC GGTA in isoform 2. 3 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370121 mRNA Translation: AAL07364.1
AY038074 mRNA Translation: AAK74068.1
AK052147 mRNA Translation: BAC34859.1
BC013504 mRNA Translation: AAH13504.1
CCDSiCCDS27422.1 [Q91ZD1-2]
RefSeqiNP_473390.1, NM_054049.2 [Q91ZD1-2]
XP_006520076.1, XM_006520013.3 [Q91ZD1-1]
UniGeneiMm.46336

Genome annotation databases

EnsembliENSMUST00000022952; ENSMUSP00000022952; ENSMUSG00000022330 [Q91ZD1-2]
ENSMUST00000228152; ENSMUSP00000154286; ENSMUSG00000022330 [Q91ZD1-1]
GeneIDi107587
KEGGimmu:107587
UCSCiuc007vma.1 mouse [Q91ZD1-2]
uc007vmb.1 mouse [Q91ZD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOSR2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZD1
Secondary accession number(s): Q8BPV6, Q91V54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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