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Q91ZD1

- OSR2_MOUSE

UniProt

Q91ZD1 - OSR2_MOUSE

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Protein

Protein odd-skipped-related 2

Gene

Osr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. bone morphogenesis Source: UniProtKB
  2. cell differentiation Source: BHF-UCL
  3. chondrocyte differentiation Source: BHF-UCL
  4. embryo development Source: UniProtKB
  5. embryonic digit morphogenesis Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: UniProtKB
  7. embryonic hindlimb morphogenesis Source: UniProtKB
  8. embryonic skeletal joint development Source: BHF-UCL
  9. embryonic skeletal joint morphogenesis Source: BHF-UCL
  10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  11. embryonic skeletal system morphogenesis Source: MGI
  12. eyelid development in camera-type eye Source: UniProtKB
  13. head development Source: BHF-UCL
  14. mesonephros development Source: UniProtKB
  15. metanephros development Source: UniProtKB
  16. middle ear morphogenesis Source: UniProtKB
  17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. odontogenesis Source: UniProtKB
  19. osteoblast proliferation Source: UniProtKB
  20. palate development Source: UniProtKB
  21. positive regulation of bone mineralization Source: BHF-UCL
  22. positive regulation of cell proliferation Source: MGI
  23. positive regulation of epithelial cell proliferation Source: UniProtKB
  24. positive regulation of gastrulation Source: UniProtKB
  25. positive regulation of gene expression Source: UniProtKB
  26. positive regulation of transcription, DNA-templated Source: UniProtKB
  27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  28. pronephros development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 2
Gene namesi
Name:Osr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1930813. Osr2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Protein odd-skipped-related 2PRO_0000047008Add
BLAST

Proteomic databases

PRIDEiQ91ZD1.

Expressioni

Developmental stagei

First detected at E9.25, specifically in the mesonephric vesicles. By E10.0 expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.1 Publication

Gene expression databases

BgeeiQ91ZD1.
CleanExiMM_OSR2.
GenevestigatoriQ91ZD1.

Interactioni

Protein-protein interaction databases

IntActiQ91ZD1. 2 interactions.

Structurei

Secondary structure

1
312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi175 – 1773
Helixi184 – 19411
Beta strandi203 – 2053
Helixi212 – 2187
Helixi219 – 2213
Beta strandi231 – 2333
Helixi240 – 24910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE8NMR-A162-252[»]
ProteinModelPortaliQ91ZD1.
SMRiQ91ZD1. Positions 163-309.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91ZD1.

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ91ZD1.
KOiK09215.
OMAiKTLHMQT.
OrthoDBiEOG754HQ2.
PhylomeDBiQ91ZD1.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91ZD1-1) [UniParc]FASTAAdd to Basket

Also known as: OSR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH
60 70 80 90 100
MNHWTLGYPS VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG
110 120 130 140 150
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL
160 170 180 190 200
SKLNPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY
210 220 230 240 250
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH
260 270 280 290 300
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
310
RHSLTHTPRQ NF
Length:312
Mass (Da):35,454
Last modified:December 1, 2001 - v1
Checksum:i33B4B92B1FA11D20
GO
Isoform 2 (identifier: Q91ZD1-2) [UniParc]FASTAAdd to Basket

Also known as: OSR2B

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA

Show »
Length:276
Mass (Da):30,487
Checksum:iA0E28AA0979CB1ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421G → W in BAC34859. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei253 – 31260ESPHK…PRQNF → TSSPTAASSAAKCSGETAIC GGTA in isoform 2. 3 PublicationsVSP_017122Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF370121 mRNA. Translation: AAL07364.1.
AY038074 mRNA. Translation: AAK74068.1.
AK052147 mRNA. Translation: BAC34859.1.
BC013504 mRNA. Translation: AAH13504.1.
CCDSiCCDS27422.1. [Q91ZD1-2]
RefSeqiNP_473390.1. NM_054049.2. [Q91ZD1-2]
XP_006520076.1. XM_006520013.1. [Q91ZD1-1]
UniGeneiMm.46336.

Genome annotation databases

EnsembliENSMUST00000022952; ENSMUSP00000022952; ENSMUSG00000022330. [Q91ZD1-2]
GeneIDi107587.
KEGGimmu:107587.
UCSCiuc007vma.1. mouse. [Q91ZD1-2]
uc007vmb.1. mouse. [Q91ZD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF370121 mRNA. Translation: AAL07364.1 .
AY038074 mRNA. Translation: AAK74068.1 .
AK052147 mRNA. Translation: BAC34859.1 .
BC013504 mRNA. Translation: AAH13504.1 .
CCDSi CCDS27422.1. [Q91ZD1-2 ]
RefSeqi NP_473390.1. NM_054049.2. [Q91ZD1-2 ]
XP_006520076.1. XM_006520013.1. [Q91ZD1-1 ]
UniGenei Mm.46336.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EE8 NMR - A 162-252 [» ]
ProteinModelPortali Q91ZD1.
SMRi Q91ZD1. Positions 163-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91ZD1. 2 interactions.

Proteomic databases

PRIDEi Q91ZD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022952 ; ENSMUSP00000022952 ; ENSMUSG00000022330 . [Q91ZD1-2 ]
GeneIDi 107587.
KEGGi mmu:107587.
UCSCi uc007vma.1. mouse. [Q91ZD1-2 ]
uc007vmb.1. mouse. [Q91ZD1-1 ]

Organism-specific databases

CTDi 116039.
MGIi MGI:1930813. Osr2.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119344.
HOGENOMi HOG000013107.
HOVERGENi HBG054398.
InParanoidi Q91ZD1.
KOi K09215.
OMAi KTLHMQT.
OrthoDBi EOG754HQ2.
PhylomeDBi Q91ZD1.
TreeFami TF350876.

Miscellaneous databases

EvolutionaryTracei Q91ZD1.
NextBioi 359096.
PROi Q91ZD1.
SOURCEi Search...

Gene expression databases

Bgeei Q91ZD1.
CleanExi MM_OSR2.
Genevestigatori Q91ZD1.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development."
    Lan Y., Kingsley P.D., Cho E.-S., Jiang R.
    Mech. Dev. 107:175-179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DEVELOPMENTAL STAGE.
    Tissue: Mammary gland.
  2. "Alternative splicing of the mouse Osr2 mRNA produces two protein isoforms differing in the zinc finger region."
    Jiang R., Cho E.-S., Lan Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Eye.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Colon.
  5. "Solution structure of three ZF-C2H2 domains from mouse protein odd-skipped-related 2 splicing isoform 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 162-252 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiOSR2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZD1
Secondary accession number(s): Q8BPV6, Q91V54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3