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Protein

Protein odd-skipped-related 2

Gene

Osr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • bone morphogenesis Source: UniProtKB
  • cell differentiation Source: BHF-UCL
  • chondrocyte differentiation Source: BHF-UCL
  • embryo development Source: UniProtKB
  • embryonic digit morphogenesis Source: BHF-UCL
  • embryonic forelimb morphogenesis Source: UniProtKB
  • embryonic hindlimb morphogenesis Source: UniProtKB
  • embryonic skeletal joint development Source: BHF-UCL
  • embryonic skeletal joint morphogenesis Source: BHF-UCL
  • embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  • embryonic skeletal system morphogenesis Source: MGI
  • eyelid development in camera-type eye Source: UniProtKB
  • head development Source: BHF-UCL
  • mesonephros development Source: UniProtKB
  • metanephros development Source: UniProtKB
  • middle ear morphogenesis Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • odontogenesis Source: UniProtKB
  • osteoblast proliferation Source: UniProtKB
  • palate development Source: UniProtKB
  • positive regulation of bone mineralization Source: BHF-UCL
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • pronephros development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 2
Gene namesi
Name:Osr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1930813. Osr2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Protein odd-skipped-related 2PRO_0000047008Add
BLAST

Proteomic databases

PRIDEiQ91ZD1.

Expressioni

Developmental stagei

First detected at E9.25, specifically in the mesonephric vesicles. By E10.0 expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.1 Publication

Gene expression databases

BgeeiQ91ZD1.
CleanExiMM_OSR2.
GenevisibleiQ91ZD1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91ZD1. 2 interactions.
STRINGi10090.ENSMUSP00000022952.

Structurei

Secondary structure

1
312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi175 – 1773Combined sources
Helixi184 – 19411Combined sources
Beta strandi203 – 2053Combined sources
Helixi212 – 2187Combined sources
Helixi219 – 2213Combined sources
Beta strandi231 – 2333Combined sources
Helixi240 – 24910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE8NMR-A162-252[»]
ProteinModelPortaliQ91ZD1.
SMRiQ91ZD1. Positions 163-309.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91ZD1.

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ91ZD1.
KOiK09215.
OMAiKTLHMQT.
OrthoDBiEOG754HQ2.
PhylomeDBiQ91ZD1.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZD1-1) [UniParc]FASTAAdd to basket

Also known as: OSR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH
60 70 80 90 100
MNHWTLGYPS VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG
110 120 130 140 150
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL
160 170 180 190 200
SKLNPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY
210 220 230 240 250
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH
260 270 280 290 300
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
310
RHSLTHTPRQ NF
Length:312
Mass (Da):35,454
Last modified:December 1, 2001 - v1
Checksum:i33B4B92B1FA11D20
GO
Isoform 2 (identifier: Q91ZD1-2) [UniParc]FASTAAdd to basket

Also known as: OSR2B

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA

Show »
Length:276
Mass (Da):30,487
Checksum:iA0E28AA0979CB1ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421G → W in BAC34859 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei253 – 31260ESPHK…PRQNF → TSSPTAASSAAKCSGETAIC GGTA in isoform 2. 3 PublicationsVSP_017122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370121 mRNA. Translation: AAL07364.1.
AY038074 mRNA. Translation: AAK74068.1.
AK052147 mRNA. Translation: BAC34859.1.
BC013504 mRNA. Translation: AAH13504.1.
CCDSiCCDS27422.1. [Q91ZD1-2]
RefSeqiNP_473390.1. NM_054049.2. [Q91ZD1-2]
XP_006520076.1. XM_006520013.2. [Q91ZD1-1]
UniGeneiMm.46336.

Genome annotation databases

EnsembliENSMUST00000022952; ENSMUSP00000022952; ENSMUSG00000022330. [Q91ZD1-2]
GeneIDi107587.
KEGGimmu:107587.
UCSCiuc007vma.1. mouse. [Q91ZD1-2]
uc007vmb.1. mouse. [Q91ZD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370121 mRNA. Translation: AAL07364.1.
AY038074 mRNA. Translation: AAK74068.1.
AK052147 mRNA. Translation: BAC34859.1.
BC013504 mRNA. Translation: AAH13504.1.
CCDSiCCDS27422.1. [Q91ZD1-2]
RefSeqiNP_473390.1. NM_054049.2. [Q91ZD1-2]
XP_006520076.1. XM_006520013.2. [Q91ZD1-1]
UniGeneiMm.46336.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE8NMR-A162-252[»]
ProteinModelPortaliQ91ZD1.
SMRiQ91ZD1. Positions 163-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZD1. 2 interactions.
STRINGi10090.ENSMUSP00000022952.

Proteomic databases

PRIDEiQ91ZD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022952; ENSMUSP00000022952; ENSMUSG00000022330. [Q91ZD1-2]
GeneIDi107587.
KEGGimmu:107587.
UCSCiuc007vma.1. mouse. [Q91ZD1-2]
uc007vmb.1. mouse. [Q91ZD1-1]

Organism-specific databases

CTDi116039.
MGIiMGI:1930813. Osr2.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ91ZD1.
KOiK09215.
OMAiKTLHMQT.
OrthoDBiEOG754HQ2.
PhylomeDBiQ91ZD1.
TreeFamiTF350876.

Miscellaneous databases

EvolutionaryTraceiQ91ZD1.
NextBioi359096.
PROiQ91ZD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZD1.
CleanExiMM_OSR2.
GenevisibleiQ91ZD1. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development."
    Lan Y., Kingsley P.D., Cho E.-S., Jiang R.
    Mech. Dev. 107:175-179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DEVELOPMENTAL STAGE.
    Tissue: Mammary gland.
  2. "Alternative splicing of the mouse Osr2 mRNA produces two protein isoforms differing in the zinc finger region."
    Jiang R., Cho E.-S., Lan Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Eye.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Colon.
  5. "Solution structure of three ZF-C2H2 domains from mouse protein odd-skipped-related 2 splicing isoform 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 162-252 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiOSR2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZD1
Secondary accession number(s): Q8BPV6, Q91V54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.