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Protein

Mas-related G-protein coupled receptor member D

Gene

Mrgprd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member D
Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7
Gene namesi
Name:Mrgprd
Synonyms:Gm499, Mrgd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3033142. Mrgprd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88ExtracellularSequence analysis
Transmembranei9 – 2921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini30 – 301CytoplasmicSequence analysis
Transmembranei31 – 5121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini52 – 7221ExtracellularSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini94 – 14653CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 18114ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini203 – 22018CytoplasmicSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini242 – 26019ExtracellularSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 32140CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Mas-related G-protein coupled receptor member DPRO_0000069758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZB8.
PRIDEiQ91ZB8.

Expressioni

Tissue specificityi

Expressed in a subset of sensory neurons that includes nociceptors. Expressed in the subclass of non-peptidergic sensory neurons that are IB4+ and VR1-.1 Publication

Gene expression databases

BgeeiQ91ZB8.
CleanExiMM_MRGPRD.
ExpressionAtlasiQ91ZB8. differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063021.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB8.
SMRiQ91ZB8. Positions 22-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ91ZB8.
KOiK08392.
OMAiPSTCTND.
OrthoDBiEOG78SQJK.
PhylomeDBiQ91ZB8.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLDSSPA PGLTISPTMD LVTWIYFSVT FLAMATCVGG MAGNSLVIWL
60 70 80 90 100
LSCNGMQRSP FCVYVLNLAV ADFLFLFCMA SMLSLETGPL LIVNISAKIY
110 120 130 140 150
EGMRRIKYFA YTAGLSLLTA ISTQRCLSVL FPIWYKCHRP RHLSSVVSGA
160 170 180 190 200
LWALAFLMNF LASFFCVQFW HPNKHQCFKV DIVFNSLILG IFMPVMILTS
210 220 230 240 250
TILFIRVRKN SLMQRRRPRR LYVVILTSIL VFLTCSLPLG INWFLLYWVD
260 270 280 290 300
VKRDVRLLYS CVSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
310 320
LRDEPEPEGR ETPSTCTNDG V
Length:321
Mass (Da):36,126
Last modified:December 1, 2001 - v1
Checksum:iB0642547A75077B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042209 Genomic DNA. Translation: AAK91800.1.
AB154412 Genomic DNA. Translation: BAD20640.1.
CCDSiCCDS22057.1.
RefSeqiNP_987075.1. NM_203490.3.
UniGeneiMm.370299.

Genome annotation databases

EnsembliENSMUST00000062163; ENSMUSP00000063021; ENSMUSG00000051207.
GeneIDi211578.
KEGGimmu:211578.
UCSCiuc009kra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042209 Genomic DNA. Translation: AAK91800.1.
AB154412 Genomic DNA. Translation: BAD20640.1.
CCDSiCCDS22057.1.
RefSeqiNP_987075.1. NM_203490.3.
UniGeneiMm.370299.

3D structure databases

ProteinModelPortaliQ91ZB8.
SMRiQ91ZB8. Positions 22-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063021.

Chemistry

GuidetoPHARMACOLOGYi152.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ91ZB8.
PRIDEiQ91ZB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062163; ENSMUSP00000063021; ENSMUSG00000051207.
GeneIDi211578.
KEGGimmu:211578.
UCSCiuc009kra.1. mouse.

Organism-specific databases

CTDi116512.
MGIiMGI:3033142. Mrgprd.

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ91ZB8.
KOiK08392.
OMAiPSTCTND.
OrthoDBiEOG78SQJK.
PhylomeDBiQ91ZB8.
TreeFamiTF336336.

Miscellaneous databases

PROiQ91ZB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZB8.
CleanExiMM_MRGPRD.
ExpressionAtlasiQ91ZB8. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMRGRD_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.