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Protein

Mas-related G-protein coupled receptor member D

Gene

Mrgprd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member D
Alternative name(s):
Beta-alanine receptor
G-protein coupled receptor TGR7
Gene namesi
Name:Mrgprd
Synonyms:Gm499, Mrgd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3033142. Mrgprd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularSequence analysis8
Transmembranei9 – 29Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini30CytoplasmicSequence analysis1
Transmembranei31 – 51Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini52 – 72ExtracellularSequence analysisAdd BLAST21
Transmembranei73 – 93Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini94 – 146CytoplasmicSequence analysisAdd BLAST53
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 181ExtracellularSequence analysisAdd BLAST14
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 220CytoplasmicSequence analysisAdd BLAST18
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 260ExtracellularSequence analysisAdd BLAST19
Transmembranei261 – 281Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini282 – 321CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697581 – 321Mas-related G-protein coupled receptor member DAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZB8.
PRIDEiQ91ZB8.

PTM databases

PhosphoSitePlusiQ91ZB8.

Expressioni

Tissue specificityi

Expressed in a subset of sensory neurons that includes nociceptors. Expressed in the subclass of non-peptidergic sensory neurons that are IB4+ and VR1-.1 Publication

Gene expression databases

BgeeiENSMUSG00000051207.
CleanExiMM_MRGPRD.
ExpressionAtlasiQ91ZB8. differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063021.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY7. Eukaryota.
ENOG41117F1. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ91ZB8.
KOiK08392.
OMAiCGMAGNS.
OrthoDBiEOG091G0EM7.
PhylomeDBiQ91ZB8.
TreeFamiTF336336.

Family and domain databases

CDDicd15108. 7tmA_MrgprD. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026232. MRGPCRD.
IPR026234. MRGPCRFAMILY.
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02110. MRGPCRD.
PR02108. MRGPCRFAMILY.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91ZB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLDSSPA PGLTISPTMD LVTWIYFSVT FLAMATCVGG MAGNSLVIWL
60 70 80 90 100
LSCNGMQRSP FCVYVLNLAV ADFLFLFCMA SMLSLETGPL LIVNISAKIY
110 120 130 140 150
EGMRRIKYFA YTAGLSLLTA ISTQRCLSVL FPIWYKCHRP RHLSSVVSGA
160 170 180 190 200
LWALAFLMNF LASFFCVQFW HPNKHQCFKV DIVFNSLILG IFMPVMILTS
210 220 230 240 250
TILFIRVRKN SLMQRRRPRR LYVVILTSIL VFLTCSLPLG INWFLLYWVD
260 270 280 290 300
VKRDVRLLYS CVSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
310 320
LRDEPEPEGR ETPSTCTNDG V
Length:321
Mass (Da):36,126
Last modified:December 1, 2001 - v1
Checksum:iB0642547A75077B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042209 Genomic DNA. Translation: AAK91800.1.
AB154412 Genomic DNA. Translation: BAD20640.1.
CCDSiCCDS22057.1.
RefSeqiNP_987075.1. NM_203490.3.
UniGeneiMm.370299.

Genome annotation databases

EnsembliENSMUST00000062163; ENSMUSP00000063021; ENSMUSG00000051207.
GeneIDi211578.
KEGGimmu:211578.
UCSCiuc009kra.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMRGRD_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families