ID   MRGRE_MOUSE             Reviewed;         310 AA.
AC   Q91ZB7; Q711I9;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-NOV-2011, entry version 70.
DE   RecName: Full=Mas-related G-protein coupled receptor member E;
DE   AltName: Full=Evolutionary breakpoint transcript 3 protein;
GN   Name=Mrgpre; Synonyms=Ebrt3, Mrge;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6;
RX   MEDLINE=21435808; PubMed=11551509; DOI=10.1016/S0092-8674(01)00483-4;
RA   Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT   "A diverse family of GPCRs expressed in specific subsets of
RT   nociceptive sensory neurons.";
RL   Cell 106:619-632(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6;
RA   Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V.,
RA   Oshimura M., Walter J.;
RT   "An evolutinary breakpoint region borders the imprinted Beckwith-
RT   Wiedemann syndrome (BWS) region.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
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DR   EMBL; AY042210; AAK91801.1; -; Genomic_DNA.
DR   EMBL; AJ320231; CAC86257.1; -; mRNA.
DR   EMBL; AK048528; BAC33361.1; -; mRNA.
DR   IPI; IPI00131025; -.
DR   RefSeq; NP_780743.1; NM_175534.3.
DR   UniGene; Mm.183561; -.
DR   ProteinModelPortal; Q91ZB7; -.
DR   STRING; Q91ZB7; -.
DR   PRIDE; Q91ZB7; -.
DR   Ensembl; ENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
DR   GeneID; 244238; -.
DR   KEGG; mmu:244238; -.
DR   CTD; 116534; -.
DR   MGI; MGI:2441884; Mrgpre.
DR   GeneTree; ENSGT00550000074531; -.
DR   HOGENOM; HBG403162; -.
DR   HOVERGEN; HBG102287; -.
DR   InParanoid; Q91ZB7; -.
DR   OMA; DVACADL; -.
DR   OrthoDB; EOG4NVZM3; -.
DR   PhylomeDB; Q91ZB7; -.
DR   NextBio; 386209; -.
DR   ArrayExpress; Q91ZB7; -.
DR   Bgee; Q91ZB7; -.
DR   CleanEx; MM_MRGPRE; -.
DR   Genevestigator; Q91ZB7; -.
DR   GermOnline; ENSMUSG00000048965; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   KO; K08393; -.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    310       Mas-related G-protein coupled receptor
FT                                member E.
FT                                /FTId=PRO_0000069762.
FT   TOPO_DOM      1     22       Extracellular (Potential).
FT   TRANSMEM     23     43       Helical; Name=1; (Potential).
FT   TOPO_DOM     44     60       Cytoplasmic (Potential).
FT   TRANSMEM     61     81       Helical; Name=2; (Potential).
FT   TOPO_DOM     82     92       Extracellular (Potential).
FT   TRANSMEM     93    113       Helical; Name=3; (Potential).
FT   TOPO_DOM    114    133       Cytoplasmic (Potential).
FT   TRANSMEM    134    154       Helical; Name=4; (Potential).
FT   TOPO_DOM    155    174       Extracellular (Potential).
FT   TRANSMEM    175    195       Helical; Name=5; (Potential).
FT   TOPO_DOM    196    213       Cytoplasmic (Potential).
FT   TRANSMEM    214    234       Helical; Name=6; (Potential).
FT   TOPO_DOM    235    248       Extracellular (Potential).
FT   TRANSMEM    249    269       Helical; Name=7; (Potential).
FT   TOPO_DOM    270    310       Cytoplasmic (Potential).
FT   CARBOHYD     20     20       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    237    237       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   310 AA;  34588 MW;  9E44127DCB5E9370 CRC64;
     MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY RNPFSIYLLD
     VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF FCYIVGLSLL AAISTEQCLA
     TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL
     LAALCCTMCV TSLLLLLRVE RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW
     HIPLYFYHFS FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA
     SQGGLVDMTV
//