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Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
Evolutionary breakpoint transcript 3 protein
Gene namesi
Name:Mrgpre
Synonyms:Ebrt3, Mrge
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2441884. Mrgpre.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 60CytoplasmicSequence analysisAdd BLAST17
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 92ExtracellularSequence analysisAdd BLAST11
Transmembranei93 – 113Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini114 – 133CytoplasmicSequence analysisAdd BLAST20
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 174ExtracellularSequence analysisAdd BLAST20
Transmembranei175 – 195Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini196 – 213CytoplasmicSequence analysisAdd BLAST18
Transmembranei214 – 234Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini235 – 248ExtracellularSequence analysisAdd BLAST14
Transmembranei249 – 269Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini270 – 310CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697621 – 310Mas-related G-protein coupled receptor member EAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi237N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZB7.
PRIDEiQ91ZB7.

PTM databases

PhosphoSitePlusiQ91ZB7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048965.
CleanExiMM_MRGPRE.
ExpressionAtlasiQ91ZB7. baseline and differential.
GenevisibleiQ91ZB7. MM.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JC07. Eukaryota.
ENOG4111507. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB7.
KOiK08393.
OMAiTEQCLAT.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ91ZB7.
TreeFamiTF336336.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY
60 70 80 90 100
RNPFSIYLLD VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF
110 120 130 140 150
FCYIVGLSLL AAISTEQCLA TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL
160 170 180 190 200
DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL LAALCCTMCV TSLLLLLRVE
210 220 230 240 250
RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW HIPLYFYHFS
260 270 280 290 300
FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA
310
SQGGLVDMTV
Length:310
Mass (Da):34,588
Last modified:December 1, 2001 - v1
Checksum:i9E44127DCB5E9370
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
CCDSiCCDS22046.1.
RefSeqiNP_780743.1. NM_175534.3.
UniGeneiMm.183561.

Genome annotation databases

EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneIDi244238.
KEGGimmu:244238.
UCSCiuc009kpz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
CCDSiCCDS22046.1.
RefSeqiNP_780743.1. NM_175534.3.
UniGeneiMm.183561.

3D structure databases

ProteinModelPortaliQ91ZB7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ91ZB7.

Proteomic databases

PaxDbiQ91ZB7.
PRIDEiQ91ZB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneIDi244238.
KEGGimmu:244238.
UCSCiuc009kpz.2. mouse.

Organism-specific databases

CTDi116534.
MGIiMGI:2441884. Mrgpre.

Phylogenomic databases

eggNOGiENOG410JC07. Eukaryota.
ENOG4111507. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB7.
KOiK08393.
OMAiTEQCLAT.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ91ZB7.
TreeFamiTF336336.

Miscellaneous databases

PROiQ91ZB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048965.
CleanExiMM_MRGPRE.
ExpressionAtlasiQ91ZB7. baseline and differential.
GenevisibleiQ91ZB7. MM.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRE_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB7
Secondary accession number(s): Q711I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.