Reviewed, UniProtKB/Swiss-Prot Q91ZB7 (MRGRE_MOUSE)

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member E

Alternative name(s):
Evolutionary breakpoint transcript 3 protein

Gene names

Name:	Mrgpre
Synonyms:	Ebrt3, Mrge

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Mas-related G-protein coupled receptor member E		PRO_0000069762
Regions
	Topological domain	1 – 22	22	Extracellular Potential
	Transmembrane	23 – 43	21	1 Potential
	Topological domain	44 – 60	17	Cytoplasmic Potential
	Transmembrane	61 – 81	21	2 Potential
	Topological domain	82 – 92	11	Extracellular Potential
	Transmembrane	93 – 113	21	3 Potential
	Topological domain	114 – 133	20	Cytoplasmic Potential
	Transmembrane	134 – 154	21	4 Potential
	Topological domain	155 – 174	20	Extracellular Potential
	Transmembrane	175 – 195	21	5 Potential
	Topological domain	196 – 213	18	Cytoplasmic Potential
	Transmembrane	214 – 234	21	6 Potential
	Topological domain	235 – 248	14	Extracellular Potential
	Transmembrane	249 – 269	21	7 Potential
	Topological domain	270 – 310	41	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q91ZB7-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9E44127DCB5E9370	FASTA	310	34,588
	10 20 30 40 50 60 MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY RNPFSIYLLD 70 80 90 100 110 120 VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF FCYIVGLSLL AAISTEQCLA 130 140 150 160 170 180 TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL 190 200 210 220 230 240 LAALCCTMCV TSLLLLLRVE RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW 250 260 270 280 290 300 HIPLYFYHFS FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA 310 SQGGLVDMTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons." Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J. Cell 106:619-632(2001) [PubMed: 11551509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6.
[2]	"An evolutinary breakpoint region borders the imprinted Beckwith-Wiedemann syndrome (BWS) region." Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY042210 Genomic DNA. Translation: AAK91801.1. AJ320231 mRNA. Translation: CAC86257.1. AK048528 mRNA. Translation: BAC33361.1.
IPI	IPI00131025.
RefSeq	NP_780743.1.
UniGene	Mm.183561
3D structure databases
SMR	Q91ZB7. Positions 28-299.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91ZB7.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q91ZB7.
Genome annotation databases
Ensembl	ENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965; Mus musculus. [Genome view]
GeneID	244238.
KEGG	mmu:244238.
UCSC	uc009kpz.1. mouse.
Organism-specific databases
CTD	244238.
MGI	MGI:2441884. Mrgpre.
Phylogenomic databases
HOGENOM	HBG403162.
HOVERGEN	HBG102287.
InParanoid	Q91ZB7.
OMA	DVACADL.
OrthoDB	EOG9KD96C.
PhylomeDB	Q91ZB7.
Gene expression databases
ArrayExpress	Q91ZB7.
Bgee	Q91ZB7.
CleanEx	MM_MRGPRE.
Genevestigator	Q91ZB7.
GermOnline	ENSMUSG00000048965. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	386209.
SOURCE	Search...

Entry information

Entry name

MRGRE_MOUSE

Accession

Primary (citable) accession number: Q91ZB7
Secondary accession number(s): Q711I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	December 1, 2001
Last modified:	March 2, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)