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Q91ZB7 (MRGRE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
Evolutionary breakpoint transcript 3 protein
Gene names
Name:Mrgpre
Synonyms:Ebrt3, Mrge
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Mas-related G-protein coupled receptor member E
PRO_0000069762

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4321Helical; Name=1; Potential
Topological domain44 – 6017Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 9211Extracellular Potential
Transmembrane93 – 11321Helical; Name=3; Potential
Topological domain114 – 13320Cytoplasmic Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 17420Extracellular Potential
Transmembrane175 – 19521Helical; Name=5; Potential
Topological domain196 – 21318Cytoplasmic Potential
Transmembrane214 – 23421Helical; Name=6; Potential
Topological domain235 – 24814Extracellular Potential
Transmembrane249 – 26921Helical; Name=7; Potential
Topological domain270 – 31041Cytoplasmic Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q91ZB7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9E44127DCB5E9370

FASTA31034,588
        10         20         30         40         50         60 
MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY RNPFSIYLLD 

        70         80         90        100        110        120 
VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF FCYIVGLSLL AAISTEQCLA 

       130        140        150        160        170        180 
TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL 

       190        200        210        220        230        240 
LAALCCTMCV TSLLLLLRVE RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW 

       250        260        270        280        290        300 
HIPLYFYHFS FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA 

       310 
SQGGLVDMTV

« Hide

References

« Hide 'large scale' references
[1]"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6.
[2]"An evolutinary breakpoint region borders the imprinted Beckwith-Wiedemann syndrome (BWS) region."
Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
IPIIPI00131025.
RefSeqNP_780743.1. NM_175534.3.
UniGeneMm.183561.

3D structure databases

ProteinModelPortalQ91ZB7.
SMRQ91ZB7. Positions 12-281.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000058000.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ91ZB7.
PRIDEQ91ZB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneID244238.
KEGGmmu:244238.

Organism-specific databases

CTD116534.
MGIMGI:2441884. Mrgpre.

Phylogenomic databases

eggNOGNOG47650.
GeneTreeENSGT00550000074531.
HOGENOMHOG000015412.
HOVERGENHBG102287.
InParanoidQ91ZB7.
KOK08393.
OMATEQCLAT.
OrthoDBEOG4NVZM3.

Gene expression databases

ArrayExpressQ91ZB7.
BgeeQ91ZB7.
CleanExMM_MRGPRE.
GenevestigatorQ91ZB7.
GermOnlineENSMUSG00000048965. Mus musculus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF20. PTHR11334:SF20. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386209.
SOURCESearch...

Entry information

Entry nameMRGRE_MOUSE
AccessionPrimary (citable) accession number: Q91ZB7
Secondary accession number(s): Q711I9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents