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Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
Evolutionary breakpoint transcript 3 protein
Gene namesi
Name:Mrgpre
Synonyms:Ebrt3, Mrge
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2441884. Mrgpre.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 6017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 9211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini114 – 13320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 17420ExtracellularSequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini196 – 21318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini235 – 24814ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini270 – 31041CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Mas-related G-protein coupled receptor member EPRO_0000069762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZB7.
PRIDEiQ91ZB7.

Expressioni

Gene expression databases

BgeeiQ91ZB7.
CleanExiMM_MRGPRE.
ExpressionAtlasiQ91ZB7. baseline and differential.
GenevestigatoriQ91ZB7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058000.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47650.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB7.
KOiK08393.
OrthoDBiEOG7NCV48.
PhylomeDBiQ91ZB7.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY
60 70 80 90 100
RNPFSIYLLD VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF
110 120 130 140 150
FCYIVGLSLL AAISTEQCLA TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL
160 170 180 190 200
DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL LAALCCTMCV TSLLLLLRVE
210 220 230 240 250
RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW HIPLYFYHFS
260 270 280 290 300
FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA
310
SQGGLVDMTV
Length:310
Mass (Da):34,588
Last modified:December 1, 2001 - v1
Checksum:i9E44127DCB5E9370
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
CCDSiCCDS22046.1.
RefSeqiNP_780743.1. NM_175534.3.
UniGeneiMm.183561.

Genome annotation databases

EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneIDi244238.
KEGGimmu:244238.
UCSCiuc009kpz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
CCDSiCCDS22046.1.
RefSeqiNP_780743.1. NM_175534.3.
UniGeneiMm.183561.

3D structure databases

ProteinModelPortaliQ91ZB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058000.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ91ZB7.
PRIDEiQ91ZB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneIDi244238.
KEGGimmu:244238.
UCSCiuc009kpz.2. mouse.

Organism-specific databases

CTDi116534.
MGIiMGI:2441884. Mrgpre.

Phylogenomic databases

eggNOGiNOG47650.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB7.
KOiK08393.
OrthoDBiEOG7NCV48.
PhylomeDBiQ91ZB7.
TreeFamiTF336336.

Miscellaneous databases

NextBioi386209.
PROiQ91ZB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZB7.
CleanExiMM_MRGPRE.
ExpressionAtlasiQ91ZB7. baseline and differential.
GenevestigatoriQ91ZB7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
  2. "An evolutinary breakpoint region borders the imprinted Beckwith-Wiedemann syndrome (BWS) region."
    Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiMRGRE_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB7
Secondary accession number(s): Q711I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.