Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91ZB7

- MRGRE_MOUSE

UniProt

Q91ZB7 - MRGRE_MOUSE

Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mas-related G-protein coupled receptor member E
    Alternative name(s):
    Evolutionary breakpoint transcript 3 protein
    Gene namesi
    Name:Mrgpre
    Synonyms:Ebrt3, Mrge
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2441884. Mrgpre.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Mas-related G-protein coupled receptor member EPRO_0000069762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ91ZB7.
    PRIDEiQ91ZB7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91ZB7.
    BgeeiQ91ZB7.
    CleanExiMM_MRGPRE.
    GenevestigatoriQ91ZB7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000058000.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91ZB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini44 – 6017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 9211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 17420ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 21318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 24814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 31041CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47650.
    GeneTreeiENSGT00550000074531.
    HOGENOMiHOG000015412.
    HOVERGENiHBG102287.
    InParanoidiQ91ZB7.
    KOiK08393.
    OMAiTEQCLAT.
    OrthoDBiEOG7NCV48.
    PhylomeDBiQ91ZB7.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026230. MRGPCRE.
    IPR026234. MRGPCRFAMILY.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR02111. MRGPCRE.
    PR02108. MRGPCRFAMILY.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91ZB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY    50
    RNPFSIYLLD VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF 100
    FCYIVGLSLL AAISTEQCLA TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL 150
    DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL LAALCCTMCV TSLLLLLRVE 200
    RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW HIPLYFYHFS 250
    FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA 300
    SQGGLVDMTV 310
    Length:310
    Mass (Da):34,588
    Last modified:December 1, 2001 - v1
    Checksum:i9E44127DCB5E9370
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY042210 Genomic DNA. Translation: AAK91801.1.
    AJ320231 mRNA. Translation: CAC86257.1.
    AK048528 mRNA. Translation: BAC33361.1.
    CCDSiCCDS22046.1.
    RefSeqiNP_780743.1. NM_175534.3.
    UniGeneiMm.183561.

    Genome annotation databases

    EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
    GeneIDi244238.
    KEGGimmu:244238.
    UCSCiuc009kpz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY042210 Genomic DNA. Translation: AAK91801.1 .
    AJ320231 mRNA. Translation: CAC86257.1 .
    AK048528 mRNA. Translation: BAC33361.1 .
    CCDSi CCDS22046.1.
    RefSeqi NP_780743.1. NM_175534.3.
    UniGenei Mm.183561.

    3D structure databases

    ProteinModelPortali Q91ZB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000058000.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi Q91ZB7.
    PRIDEi Q91ZB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054048 ; ENSMUSP00000058000 ; ENSMUSG00000048965 .
    GeneIDi 244238.
    KEGGi mmu:244238.
    UCSCi uc009kpz.2. mouse.

    Organism-specific databases

    CTDi 116534.
    MGIi MGI:2441884. Mrgpre.

    Phylogenomic databases

    eggNOGi NOG47650.
    GeneTreei ENSGT00550000074531.
    HOGENOMi HOG000015412.
    HOVERGENi HBG102287.
    InParanoidi Q91ZB7.
    KOi K08393.
    OMAi TEQCLAT.
    OrthoDBi EOG7NCV48.
    PhylomeDBi Q91ZB7.
    TreeFami TF336336.

    Miscellaneous databases

    NextBioi 386209.
    PROi Q91ZB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91ZB7.
    Bgeei Q91ZB7.
    CleanExi MM_MRGPRE.
    Genevestigatori Q91ZB7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026230. MRGPCRE.
    IPR026234. MRGPCRFAMILY.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR02111. MRGPCRE.
    PR02108. MRGPCRFAMILY.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
      Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
      Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6.
    2. "An evolutinary breakpoint region borders the imprinted Beckwith-Wiedemann syndrome (BWS) region."
      Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.

    Entry informationi

    Entry nameiMRGRE_MOUSE
    AccessioniPrimary (citable) accession number: Q91ZB7
    Secondary accession number(s): Q711I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3