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Q91ZB7

- MRGRE_MOUSE

UniProt

Q91ZB7 - MRGRE_MOUSE

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Protein

Mas-related G-protein coupled receptor member E

Gene

Mrgpre

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
Evolutionary breakpoint transcript 3 protein
Gene namesi
Name:Mrgpre
Synonyms:Ebrt3, Mrge
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2441884. Mrgpre.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Mas-related G-protein coupled receptor member EPRO_0000069762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZB7.
PRIDEiQ91ZB7.

Expressioni

Gene expression databases

BgeeiQ91ZB7.
CleanExiMM_MRGPRE.
ExpressionAtlasiQ91ZB7. baseline and differential.
GenevestigatoriQ91ZB7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058000.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Topological domaini44 – 6017CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini82 – 9211ExtracellularSequence AnalysisAdd
BLAST
Topological domaini114 – 13320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini155 – 17420ExtracellularSequence AnalysisAdd
BLAST
Topological domaini196 – 21318CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini235 – 24814ExtracellularSequence AnalysisAdd
BLAST
Topological domaini270 – 31041CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47650.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB7.
KOiK08393.
OMAiTEQCLAT.
OrthoDBiEOG7NCV48.
PhylomeDBiQ91ZB7.
TreeFamiTF336336.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY
60 70 80 90 100
RNPFSIYLLD VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF
110 120 130 140 150
FCYIVGLSLL AAISTEQCLA TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL
160 170 180 190 200
DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL LAALCCTMCV TSLLLLLRVE
210 220 230 240 250
RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW HIPLYFYHFS
260 270 280 290 300
FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA
310
SQGGLVDMTV
Length:310
Mass (Da):34,588
Last modified:December 1, 2001 - v1
Checksum:i9E44127DCB5E9370
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1.
AJ320231 mRNA. Translation: CAC86257.1.
AK048528 mRNA. Translation: BAC33361.1.
CCDSiCCDS22046.1.
RefSeqiNP_780743.1. NM_175534.3.
UniGeneiMm.183561.

Genome annotation databases

EnsembliENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
GeneIDi244238.
KEGGimmu:244238.
UCSCiuc009kpz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY042210 Genomic DNA. Translation: AAK91801.1 .
AJ320231 mRNA. Translation: CAC86257.1 .
AK048528 mRNA. Translation: BAC33361.1 .
CCDSi CCDS22046.1.
RefSeqi NP_780743.1. NM_175534.3.
UniGenei Mm.183561.

3D structure databases

ProteinModelPortali Q91ZB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000058000.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q91ZB7.
PRIDEi Q91ZB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054048 ; ENSMUSP00000058000 ; ENSMUSG00000048965 .
GeneIDi 244238.
KEGGi mmu:244238.
UCSCi uc009kpz.2. mouse.

Organism-specific databases

CTDi 116534.
MGIi MGI:2441884. Mrgpre.

Phylogenomic databases

eggNOGi NOG47650.
GeneTreei ENSGT00550000074531.
HOGENOMi HOG000015412.
HOVERGENi HBG102287.
InParanoidi Q91ZB7.
KOi K08393.
OMAi TEQCLAT.
OrthoDBi EOG7NCV48.
PhylomeDBi Q91ZB7.
TreeFami TF336336.

Miscellaneous databases

NextBioi 386209.
PROi Q91ZB7.
SOURCEi Search...

Gene expression databases

Bgeei Q91ZB7.
CleanExi MM_MRGPRE.
ExpressionAtlasi Q91ZB7. baseline and differential.
Genevestigatori Q91ZB7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view ]
PANTHERi PTHR11334. PTHR11334. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
  2. "An evolutinary breakpoint region borders the imprinted Beckwith-Wiedemann syndrome (BWS) region."
    Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiMRGRE_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB7
Secondary accession number(s): Q711I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3