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Protein

Mas-related G-protein coupled receptor member G

Gene

Mrgprg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member G
Alternative name(s):
Evolutionary breakpoint transcript 2 protein
Gene namesi
Name:Mrgprg
Synonyms:Ebrt2, Gm1098, Mrgg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3033145. Mrgprg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence analysisAdd
BLAST
Transmembranei14 – 3421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini35 – 5218CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 785ExtracellularSequence analysis
Transmembranei79 – 9921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini100 – 12021CytoplasmicSequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini142 – 16423ExtracellularSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini186 – 19914CytoplasmicSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini221 – 2222ExtracellularSequence analysis
Transmembranei223 – 24321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini244 – 28946CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Mas-related G-protein coupled receptor member GPRO_0000069768Add
BLAST

Proteomic databases

PaxDbiQ91ZB5.
PRIDEiQ91ZB5.

Expressioni

Gene expression databases

BgeeiQ91ZB5.
CleanExiMM_MRGPRG.
GenevisibleiQ91ZB5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060411.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIKH. Eukaryota.
ENOG411199G. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB5.
KOiK08395.
OMAiQSLPMGL.
OrthoDBiEOG7F7W9T.
PhylomeDBiQ91ZB5.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF32. PTHR11334:SF32. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.

Sequencei

Sequence statusi: Complete.

Q91ZB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIFNIWGT FNKVLFFLSL TVSLAGLVGN ALLLWHLGLH IKKGPFNTYL
60 70 80 90 100
LHLAAADFLF LSCQVGFSIA TIVSGHEDTL YFPVTFLWFA VGLWLLAAFS
110 120 130 140 150
VDCCLAYMFP SFCSPNRRPR FTSVVLCLVI WALTMPAVLL PANACGLLKN
160 170 180 190 200
GMSLLVCLKY HWTSVTWLAV LSGMACGASK FLLIFGNCCS SQPPPKFCKL
210 220 230 240 250
AQCSGILLFF CRLPLVVYWC LRPVLKFLLP FFFPLATLLA CIDSSAKPLL
260 270 280
YYMKGRQLRK DPLQVALNRA LGEESQSGLG GLSLPMHQV
Length:289
Mass (Da):32,028
Last modified:December 1, 2001 - v1
Checksum:i82BD4BEA02E0864C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221T → I in CAC86130 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042212 Genomic DNA. Translation: AAK91803.1.
BC100302 mRNA. Translation: AAI00303.1.
AJ313465 mRNA. Translation: CAC86130.1.
CCDSiCCDS22045.1.
RefSeqiNP_987077.1. NM_203492.2.
UniGeneiMm.297839.

Genome annotation databases

EnsembliENSMUST00000058092; ENSMUSP00000060411; ENSMUSG00000050276.
GeneIDi381974.
KEGGimmu:381974.
UCSCiuc009kpy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042212 Genomic DNA. Translation: AAK91803.1.
BC100302 mRNA. Translation: AAI00303.1.
AJ313465 mRNA. Translation: CAC86130.1.
CCDSiCCDS22045.1.
RefSeqiNP_987077.1. NM_203492.2.
UniGeneiMm.297839.

3D structure databases

ProteinModelPortaliQ91ZB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060411.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ91ZB5.
PRIDEiQ91ZB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058092; ENSMUSP00000060411; ENSMUSG00000050276.
GeneIDi381974.
KEGGimmu:381974.
UCSCiuc009kpy.1. mouse.

Organism-specific databases

CTDi386746.
MGIiMGI:3033145. Mrgprg.

Phylogenomic databases

eggNOGiENOG410IIKH. Eukaryota.
ENOG411199G. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ91ZB5.
KOiK08395.
OMAiQSLPMGL.
OrthoDBiEOG7F7W9T.
PhylomeDBiQ91ZB5.
TreeFamiTF336336.

Miscellaneous databases

PROiQ91ZB5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZB5.
CleanExiMM_MRGPRG.
GenevisibleiQ91ZB5. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF32. PTHR11334:SF32. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
    Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
    Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The BWS region contains an evolutionary breakpoint region."
    Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V., Oshimura M., Walter J.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-156.
    Strain: C57BL/6J.

Entry informationi

Entry nameiMRGRG_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB5
Secondary accession number(s): Q498A2, Q711N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.