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Protein

Alpha-protein kinase 2

Gene

Alpk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 2 (EC:2.7.11.-)
Alternative name(s):
Heart alpha-protein kinase
Gene namesi
Name:Alpk2Imported
Synonyms:HakImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2449492. Alpk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002913831 – 2144Alpha-protein kinase 2Add BLAST2144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 98PROSITE-ProRule annotation
Disulfide bondi1781 ↔ 1831PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ91ZB0.
PaxDbiQ91ZB0.
PRIDEiQ91ZB0.

PTM databases

iPTMnetiQ91ZB0.
PhosphoSitePlusiQ91ZB0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032845.
CleanExiMM_ALPK2.
ExpressionAtlasiQ91ZB0. baseline and differential.
GenevisibleiQ91ZB0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048752.

Structurei

3D structure databases

ProteinModelPortaliQ91ZB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 105Ig-like 1Add BLAST99
Domaini1759 – 1847Ig-like 2Add BLAST89
Domaini1874 – 2106Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000033907.
HOVERGENiHBG100440.
InParanoidiQ91ZB0.
KOiK08868.
OMAiMICCSAS.
OrthoDBiEOG091G008T.
TreeFamiTF332629.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPGCPERR TLCFLSTLLS QKVPEKSDVV LRCMIAGQPK PEVTWYKNGQ
60 70 80 90 100
AIDLGGTVSS YEFFENQYIH LLHLSCCTQS DAAVYQVSAR NCVGMICCSA
110 120 130 140 150
SLEVQCLQDP QVSPDPGGGR DAAGECKTEI REEDSINHTD EKWNPCKKGE
160 170 180 190 200
STADSFLDKF NHLSSPQIVA RGDSGASNSE NPQYIKETRQ RMGQYNSNNM
210 220 230 240 250
QENSFNSNNT AEKQDVSQLW TVNATVPGLV SDGLGYEESN ESVSPSHQTP
260 270 280 290 300
KVQKYISFSL PLPETTLGPY PEDSNSINMQ PGPQVSSEDS DSDYELCPEI
310 320 330 340 350
TLTYTEEFSD DDLEYLECSD VMTDYSNAVW QRSLQGTDRV FLLESDDEEM
360 370 380 390 400
EFNECGLGGC EHFFTEMGCG PQVSGGMWSM NVATGFCSYH SQPQEVRVRS
410 420 430 440 450
SGTSGHSPLP LHSEMTLTLG PHQDETAKMT EPGRAPLPTA PEAVENDCSG
460 470 480 490 500
IRGETRDNPE AGEEFSGDNL QTMDKVETEA SVKPLSGGSD KTEVKQGLES
510 520 530 540 550
LARERTDEKY PGSKKAALRP TRARRPGMKA NTKKQLLRDS APKGTLDLLP
560 570 580 590 600
KEPTRQPLPG SYGQEPTHTE AGAPGWDSHF HAEVCIPLPA EQDSKILRPP
610 620 630 640 650
ADPLSKEEDS SFEGGGALLN KLFEASQIPD RTDHLQMQIQ ETIGESSSLD
660 670 680 690 700
QMLAFSVPAE ESSTFAGATT HSVSNLSEIN RENLSLAQYP GLESCPQSLQ
710 720 730 740 750
QEGRPNRDRD LPGALWAESA CELSLLEDNE EEESQPPASV ALPQGDGVPC
760 770 780 790 800
REPEGLSDSF PQPTAPSLPL ENVGSGSRVR EAAGGVGCFE AGDQETCYAT
810 820 830 840 850
MDLLVGAPVD KYLPQEICPE DLELTEGQSE VCDLCSPDKI LAVLQTQGSE
860 870 880 890 900
PPRSTDKRSQ DGKSAEGLLF NSTFTWDTAK EASEDAVGET AADVENPPST
910 920 930 940 950
FSSTLPYSER GFGETQPLCS ETISFVKDSE GSYRSSSLSI PAAIDTLASY
960 970 980 990 1000
SSDRECSKEQ SAESTANVDC HQVTREMEGI STNAAEVHEI KCHSVSVPQD
1010 1020 1030 1040 1050
NDFDVGADQV SCEARDEDNS QSLPDDDSQS GRSLSSSTGE ATGETLVPAP
1060 1070 1080 1090 1100
SSAGDHGHFS MPEGQGLCSR ALQMDNQPVC QSQAMEGAHS RGLEEHFQEK
1110 1120 1130 1140 1150
GSGMKHGIRP QSTSHQVSLS ANDFQEILPS IPTMQQETNV EPLEHSLADS
1160 1170 1180 1190 1200
REEIECSSDP RTSDLVVAEK TVGEDSHLVV SVPALPDILL GEKDDVGLGS
1210 1220 1230 1240 1250
WAVGGKVKII TLEAPVFEIW PPELVRHPGY KEAEAGLTMP GRSWALSDIL
1260 1270 1280 1290 1300
RAGATRSEPG ALGGAAWVPS PQADALMALG ANRDTWLGAA PDRQANCNCL
1310 1320 1330 1340 1350
SSQCLSQPRF LESSVDPVED KELEVTDSPS EVSKTGEMEM PETLNEEQEE
1360 1370 1380 1390 1400
TQQILRHPAV VNQSVNFPRI LESSVDPIDD RGELEGVWPE KPEPSDSSVE
1410 1420 1430 1440 1450
GNEFIVGNTC QRVDIQPASL QLPHPQDSGE IIPYEHTTNQ NRVDGERAEA
1460 1470 1480 1490 1500
KTSLPDKAKA EAEAVVWQAQ GPGEEGQGIP SVCSMSQTQD GGDRSLGEAG
1510 1520 1530 1540 1550
QRGTDETEVI SPLSPLSSCL TGVTHTCVKA ETNNSTGHIY GGSEPRTRQS
1560 1570 1580 1590 1600
VIPMKTEKGT IESKCGNHVR SSDDLTNTPC TSSPKGNVTR LSISHGLEEL
1610 1620 1630 1640 1650
KSEKLQIAET KPLNSSDSPT MTLALISGEC ESEKDPKSLL RRDPCPKGST
1660 1670 1680 1690 1700
LDSGKKSRDQ QQKPVAAQVS KAPGDQSAMA GSEEGKKKQE ASGSGHLTAG
1710 1720 1730 1740 1750
IKKKILSRVA ALRLRLEEKE NSRKNSIVKK TPKFERSLSR TDEKRDPKRA
1760 1770 1780 1790 1800
PCKAEGKAPV LLKRIQAEMA PEHSGNIKLS CQFSEIHEDS TVCWTKDSKS
1810 1820 1830 1840 1850
IAQAKKSAGD NSSVSLAIVQ AGQKDQGLYY CCLKNSYGKV TAEFNLTAEV
1860 1870 1880 1890 1900
LKQLSSHTEY RGCEEIEFSQ LIFKEDVFND SYFGDHLRGQ ISTEELHFGE
1910 1920 1930 1940 1950
GVHRKAFRSK VMQGLMPVFQ PGHACVLKVH NAVAHGTRNN DELVQRNYKL
1960 1970 1980 1990 2000
AAQECYVQNT ARYYAKIYAA EAQPLEGFGE VPEIIPIFLI HRPENNIPYA
2010 2020 2030 2040 2050
TVEEELIGEF VKYSIRDGKE INFLRRDSEA GQKCCTFQHW VYQKTSGCLL
2060 2070 2080 2090 2100
VTDMQGVGMK LTDVGIATLA RGYKGFKGNC SMTFIDQFRA LHQCNKYCKM
2110 2120 2130 2140
LGLKSLQNNS QKPKKPIVGK GRVPTNATQV KTPESETPPA ERKT
Length:2,144
Mass (Da):233,298
Last modified:June 13, 2012 - v3
Checksum:iACBCEA70E0BE1C26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti670 – 671TH → VD in AAK95953 (PubMed:10021370).Curated2
Sequence conflicti849S → Y in AAK95953 (PubMed:10021370).Curated1
Sequence conflicti1354I → M in AAK95953 (PubMed:10021370).Curated1
Sequence conflicti1710A → V in AAK95953 (PubMed:10021370).Curated1
Sequence conflicti2114K → R in AAK95953 (PubMed:10021370).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157910 Genomic DNA. No translation available.
AY044451 mRNA. Translation: AAK95953.1.
CCDSiCCDS50310.1.
RefSeqiNP_001032371.1. NM_001037294.1.
UniGeneiMm.296528.

Genome annotation databases

EnsembliENSMUST00000035548; ENSMUSP00000048752; ENSMUSG00000032845.
GeneIDi225638.
KEGGimmu:225638.
UCSCiuc008feu.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157910 Genomic DNA. No translation available.
AY044451 mRNA. Translation: AAK95953.1.
CCDSiCCDS50310.1.
RefSeqiNP_001032371.1. NM_001037294.1.
UniGeneiMm.296528.

3D structure databases

ProteinModelPortaliQ91ZB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048752.

PTM databases

iPTMnetiQ91ZB0.
PhosphoSitePlusiQ91ZB0.

Proteomic databases

EPDiQ91ZB0.
PaxDbiQ91ZB0.
PRIDEiQ91ZB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035548; ENSMUSP00000048752; ENSMUSG00000032845.
GeneIDi225638.
KEGGimmu:225638.
UCSCiuc008feu.3. mouse.

Organism-specific databases

CTDi115701.
MGIiMGI:2449492. Alpk2.

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000033907.
HOVERGENiHBG100440.
InParanoidiQ91ZB0.
KOiK08868.
OMAiMICCSAS.
OrthoDBiEOG091G008T.
TreeFamiTF332629.

Miscellaneous databases

PROiQ91ZB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032845.
CleanExiMM_ALPK2.
ExpressionAtlasiQ91ZB0. baseline and differential.
GenevisibleiQ91ZB0. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALPK2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZB0
Secondary accession number(s): E9QL35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 13, 2012
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.