Q91ZA6 (SOCS4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor of cytokine signaling 4
Short name=SOCS-4

Alternative name(s):
Suppressor of cytokine signaling 7
Short name=SOCS-7

Gene names

Name:	Socs4
Synonyms:	Socs7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR By similarity.
Pathway	Protein modification; protein ubiquitination.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Contains 1 SH2 domain. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Growth regulation Ubl conjugation pathway
Domain	SH2 domain
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of epidermal growth factor-activated receptor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Suppressor of cytokine signaling 4		PRO_0000181248
Regions
	Domain	283 – 378	96	SH2
	Domain	373 – 422	50	SOCS box
Experimental info
	Sequence conflict	12	1	R → W in AAL03942. Ref.1
	Sequence conflict	12	1	R → W in AAI17815. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q91ZA6 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: B64BF54C75F27A21	FASTA	436	49,918
	10 20 30 40 50 60 MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG TVENVEIPLR 70 80 90 100 110 120 SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF PIKNCSGRHS PGLPSKRKIH 130 140 150 160 170 180 ISELMLDKCP FPPRSDLAFR WHFIKRHTVP MSPNSDEWVS ADLSERKLRD AQLKRRNTED 190 200 210 220 230 240 DIPCFSHTNG QPCVITANSA SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK 250 260 270 280 290 300 RNKPRWEMEE EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK 310 320 330 340 350 360 PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH SPDITGLLEH 370 380 390 400 410 420 YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY DGIDALPIPS PMKLYLKEYH 430 YKSKVRLLRI DVPEQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hilton D.J. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY046322 mRNA. Translation: AAL03942.1. CH466605 Genomic DNA. Translation: EDL20739.1. BC117814 mRNA. Translation: AAI17815.1. BC117815 mRNA. Translation: AAI17816.1.
IPI	IPI00130993.
RefSeq	NP_543119.2. NM_080843.2.
UniGene	Mm.23957. Mm.425886.
3D structure databases
ProteinModelPortal	Q91ZA6.
SMR	Q91ZA6. Positions 271-426.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91ZA6.
PTM databases
PhosphoSite	Q91ZA6.
Proteomic databases
PRIDE	Q91ZA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379.
GeneID	67296.
KEGG	mmu:67296.
NMPDR	fig|10090.3.peg.28904.
Organism-specific databases
CTD	122809.
MGI	MGI:1914546. Socs4.
Phylogenomic databases
eggNOG	roNOG09623.
GeneTree	ENSGT00550000074283.
HOGENOM	HBG444599.
HOVERGEN	HBG054138.
InParanoid	Q91ZA6.
OrthoDB	EOG4Q58PD.
Gene expression databases
ArrayExpress	Q91ZA6.
Bgee	Q91ZA6.
CleanEx	MM_SOCS4. MM_SOCS7.
Genevestigator	Q91ZA6.
GermOnline	ENSMUSG00000048379. Mus musculus.
Family and domain databases
InterPro	IPR000980. SH2. IPR022252. SOCS. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
KO	K04697.
Pfam	PF00017. SH2. 1 hit. PF12610. SOCS. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. SM00969. SOCS_box. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	324152.
SOURCE	Search...

Entry information

Entry name

SOCS4_MOUSE

Accession

Primary (citable) accession number: Q91ZA6
Secondary accession number(s): Q149F7, Q149F8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program