Reviewed, UniProtKB/Swiss-Prot Q91ZA6 (SOCS4_MOUSE)

Names and origin

Protein names

Recommended name:
    Suppressor of cytokine signaling 4
      Short name=SOCS-4
Alternative name(s):
    Suppressor of cytokine signaling 7
      Short name=SOCS-7

Gene names

Name:	Socs4
Synonyms:	Socs7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Contains 1 SH2 domain. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Growth regulation Ubl conjugation pathway
Domain	SH2 domain
Molecular function	Signal transduction inhibitor
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of signal transduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Suppressor of cytokine signaling 4		PRO_0000181248
Regions
	Domain	283 – 378	96	SH2
	Domain	373 – 422	50	SOCS box

Sequences

	Sequence		Length	Mass (Da)
	Q91ZA6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4182126B510F98BD	FASTA	436	49,948
	10 20 30 40 50 60 MAENNSKNVD VWPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG TVENVEIPLR 70 80 90 100 110 120 SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF PIKNCSGRHS PGLPSKRKIH 130 140 150 160 170 180 ISELMLDKCP FPPRSDLAFR WHFIKRHTVP MSPNSDEWVS ADLSERKLRD AQLKRRNTED 190 200 210 220 230 240 DIPCFSHTNG QPCVITANSA SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK 250 260 270 280 290 300 RNKPRWEMEE EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK 310 320 330 340 350 360 PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH SPDITGLLEH 370 380 390 400 410 420 YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY DGIDALPIPS PMKLYLKEYH 430 YKSKVRLLRI DVPEQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hilton D.J. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY046322 mRNA. Translation: AAL03942.1. BC117814 mRNA. Translation: AAI17815.1.
IPI	IPI00130993.
UniGene	Mm.23957 Mm.425886
3D structure databases
HSSP	HSSP built from PDB template 1JU5 based on UniProtKB P46108.
SMR	Q91ZA6. Positions 271-426.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91ZA6.
Proteomic databases
PRIDE	Q91ZA6.
Genome annotation databases
Ensembl	ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379; Mus musculus. [Genome view] ENSMUST00000111789; ENSMUSP00000107419; ENSMUSG00000048379; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1914546. Socs4.
Phylogenomic databases
HOGENOM	Q91ZA6.
HOVERGEN	Q91ZA6.
Gene expression databases
ArrayExpress	Q91ZA6.
Bgee	Q91ZA6.
CleanEx	MM_SOCS4. MM_SOCS7.
Genevestigator	Q91ZA6.
GermOnline	ENSMUSG00000048379. Mus musculus.
Family and domain databases
InterPro	IPR000980. SH2. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
ProDom	PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

SOCS4_MOUSE

Accession

Primary (citable) accession number: Q91ZA6
Secondary accession number(s): Q149F8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	December 1, 2001
Last modified:	October 13, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)