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Protein

Suppressor of cytokine signaling 4

Gene

Socs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:Socs4
Synonyms:Socs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914546. Socs4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Suppressor of cytokine signaling 4PRO_0000181248Add
BLAST

Proteomic databases

PaxDbiQ91ZA6.
PRIDEiQ91ZA6.

PTM databases

iPTMnetiQ91ZA6.
PhosphoSiteiQ91ZA6.

Expressioni

Gene expression databases

BgeeiQ91ZA6.
CleanExiMM_SOCS4.
MM_SOCS7.
GenevisibleiQ91ZA6. MM.

Interactioni

Protein-protein interaction databases

BioGridi212083. 3 interactions.
STRINGi10090.ENSMUSP00000066031.

Structurei

3D structure databases

ProteinModelPortaliQ91ZA6.
SMRiQ91ZA6. Positions 86-155, 271-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini283 – 37896SH2PROSITE-ProRule annotationAdd
BLAST
Domaini373 – 42250SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiQ91ZA6.
KOiK04697.
OMAiESCSDAE.
OrthoDBiEOG7XH6QR.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF77. PTHR24369:SF77. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91ZA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG
60 70 80 90 100
TVENVEIPLR SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF
110 120 130 140 150
PIKNCSGRHS PGLPSKRKIH ISELMLDKCP FPPRSDLAFR WHFIKRHTVP
160 170 180 190 200
MSPNSDEWVS ADLSERKLRD AQLKRRNTED DIPCFSHTNG QPCVITANSA
210 220 230 240 250
SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK RNKPRWEMEE
260 270 280 290 300
EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK
310 320 330 340 350
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH
360 370 380 390 400
SPDITGLLEH YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY
410 420 430
DGIDALPIPS PMKLYLKEYH YKSKVRLLRI DVPEQQ
Length:436
Mass (Da):49,918
Last modified:July 27, 2011 - v2
Checksum:iB64BF54C75F27A21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121R → W in AAL03942 (Ref. 1) Curated
Sequence conflicti12 – 121R → W in AAI17815 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046322 mRNA. Translation: AAL03942.1.
CH466605 Genomic DNA. Translation: EDL20739.1.
BC117814 mRNA. Translation: AAI17815.1.
BC117815 mRNA. Translation: AAI17816.1.
CCDSiCCDS26985.1.
RefSeqiNP_543119.2. NM_080843.2.
UniGeneiMm.23957.
Mm.425886.

Genome annotation databases

EnsembliENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379.
GeneIDi67296.
KEGGimmu:67296.
UCSCiuc007thx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046322 mRNA. Translation: AAL03942.1.
CH466605 Genomic DNA. Translation: EDL20739.1.
BC117814 mRNA. Translation: AAI17815.1.
BC117815 mRNA. Translation: AAI17816.1.
CCDSiCCDS26985.1.
RefSeqiNP_543119.2. NM_080843.2.
UniGeneiMm.23957.
Mm.425886.

3D structure databases

ProteinModelPortaliQ91ZA6.
SMRiQ91ZA6. Positions 86-155, 271-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212083. 3 interactions.
STRINGi10090.ENSMUSP00000066031.

PTM databases

iPTMnetiQ91ZA6.
PhosphoSiteiQ91ZA6.

Proteomic databases

PaxDbiQ91ZA6.
PRIDEiQ91ZA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379.
GeneIDi67296.
KEGGimmu:67296.
UCSCiuc007thx.1. mouse.

Organism-specific databases

CTDi122809.
MGIiMGI:1914546. Socs4.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
GeneTreeiENSGT00760000119136.
HOGENOMiHOG000027791.
HOVERGENiHBG054138.
InParanoidiQ91ZA6.
KOiK04697.
OMAiESCSDAE.
OrthoDBiEOG7XH6QR.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ91ZA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91ZA6.
CleanExiMM_SOCS4.
MM_SOCS7.
GenevisibleiQ91ZA6. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028416. SOCS4.
IPR022252. SOCS4/SOCS5_dom.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF77. PTHR24369:SF77. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12610. SOCS. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hilton D.J.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSOCS4_MOUSE
AccessioniPrimary (citable) accession number: Q91ZA6
Secondary accession number(s): Q149F7, Q149F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.