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Protein

BMP-2-inducible protein kinase

Gene

Bmp2k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in osteoblast differentiation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76ATPPROSITE-ProRule annotation1
Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 62ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphatase regulator activity Source: MGI
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • regulation of bone mineralization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-2-inducible protein kinase (EC:2.7.11.1)
Short name:
BIKe
Gene namesi
Name:Bmp2k
Synonyms:Bike
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2155456. Bmp2k.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856641 – 1138BMP-2-inducible protein kinaseAdd BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei676PhosphoserineBy similarity1
Modified residuei733PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Modified residuei807PhosphoserineBy similarity1
Modified residuei819PhosphothreonineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1012PhosphoserineCombined sources1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1020PhosphoserineBy similarity1
Modified residuei1022PhosphoserineBy similarity1
Modified residuei1087PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91Z96.
PaxDbiQ91Z96.
PeptideAtlasiQ91Z96.
PRIDEiQ91Z96.

PTM databases

iPTMnetiQ91Z96.
PhosphoSitePlusiQ91Z96.

Expressioni

Tissue specificityi

Expressed in spleen, kidney, lung, brain, heart, diaphragm and calvaria but not in liver.

Gene expression databases

BgeeiENSMUSG00000034663.
CleanExiMM_BMP2K.
GenevisibleiQ91Z96. MM.

Interactioni

Protein-protein interaction databases

BioGridi228314. 1 interactor.
STRINGi10090.ENSMUSP00000037970.

Structurei

3D structure databases

ProteinModelPortaliQ91Z96.
SMRiQ91Z96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi421 – 546Gln/His-richAdd BLAST126

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1989. Eukaryota.
ENOG410Y515. LUCA.
GeneTreeiENSGT00810000125451.
HOGENOMiHOG000095243.
HOVERGENiHBG050703.
InParanoidiQ91Z96.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG091G02KI.
PhylomeDBiQ91Z96.
TreeFamiTF317300.

Family and domain databases

InterProiIPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91Z96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL
60 70 80 90 100
EESLAEGGFS TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS
110 120 130 140 150
GHKNIVGYLD CAVNSISDNV WEVLILMEYC RAGQVVNQMN KKLQTGFTES
160 170 180 190 200
EVLQIFCDTC EAVARLHQCK TPIIHRDLKV ENILLNDAGN YVLCDFGSAT
210 220 230 240 250
NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI TTKADIWALG
260 270 280 290 300
CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE
310 320 330 340 350
CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM
360 370 380 390 400
KARITDTIGP TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF
410 420 430 440 450
SNHKPKGALR PGNGSEVLMV QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH
460 470 480 490 500
RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ QLLQNAYLQQ YQHAMHQQHI
510 520 530 540 550
LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH QQPAQQVSPE
560 570 580 590 600
YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK
610 620 630 640 650
TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSNRL GASTPSDKTV
660 670 680 690 700
DLPPAPHSRP PEEPFASVPF ISHSGSPEKK TTEHSPNQKS ITANLTKNGG
710 720 730 740 750
SSPLCKDQRA GKKTSENPVI RGQVQKGHDD SESDFESDPP SPKSSEEEQE
760 770 780 790 800
DEDAQGEHGD FNDDDTEPEN LGHRPLLMDS EDEEEDDKHS SDSECEQAKT
810 820 830 840 850
KRGDTSSLRR DKPGVAPDTA LLTPARSPAD ALTPSQEFDV FGAVPFFAAP
860 870 880 890 900
APQSLQHRGD GKNLSQHAFP EQEDFDVFTK APFNKKVSVQ DWPAVGPDAR
910 920 930 940 950
PLPARPRSVD IFGSTPFQPF SVSASKSESK EDVFGLVPFE EITGSQQQQK
960 970 980 990 1000
VKQRSLQKLS SRQRRTKQDV SKSNGKRHHG TPTSAKKTLK PPYRTPERAR
1010 1020 1030 1040 1050
RHKKVGRRDS QSSNEFLTIS DSKENISVAL TDGKDRASVL PSDESLLDPF
1060 1070 1080 1090 1100
GAKPFHPPDL WHQPHQGLSD ICVDHTTILP GRPRQNSVHG SFHSAETLRM
1110 1120 1130
DDFGAVPFTE LVVQSVTPQQ SQPVELDPFG AAPFPSKQ
Length:1,138
Mass (Da):126,185
Last modified:December 1, 2001 - v1
Checksum:i8EDDE02F1333840D
GO
Isoform 2 (identifier: Q91Z96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-649: NRLGASTPSDKT → SKGHLKAYFASQ
     650-1138: Missing.

Show »
Length:649
Mass (Da):72,515
Checksum:i49CF3A3020D5564F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008094638 – 649NRLGA…PSDKT → SKGHLKAYFASQ in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_008095650 – 1138Missing in isoform 2. 1 PublicationAdd BLAST489

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSiCCDS39175.1. [Q91Z96-1]
RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneiMm.281490.
Mm.392853.

Genome annotation databases

EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneIDi140780.
KEGGimmu:140780.
UCSCiuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSiCCDS39175.1. [Q91Z96-1]
RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneiMm.281490.
Mm.392853.

3D structure databases

ProteinModelPortaliQ91Z96.
SMRiQ91Z96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228314. 1 interactor.
STRINGi10090.ENSMUSP00000037970.

PTM databases

iPTMnetiQ91Z96.
PhosphoSitePlusiQ91Z96.

Proteomic databases

EPDiQ91Z96.
PaxDbiQ91Z96.
PeptideAtlasiQ91Z96.
PRIDEiQ91Z96.

Protocols and materials databases

DNASUi140780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneIDi140780.
KEGGimmu:140780.
UCSCiuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Organism-specific databases

CTDi55589.
MGIiMGI:2155456. Bmp2k.

Phylogenomic databases

eggNOGiKOG1989. Eukaryota.
ENOG410Y515. LUCA.
GeneTreeiENSGT00810000125451.
HOGENOMiHOG000095243.
HOVERGENiHBG050703.
InParanoidiQ91Z96.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG091G02KI.
PhylomeDBiQ91Z96.
TreeFamiTF317300.

Miscellaneous databases

PROiQ91Z96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034663.
CleanExiMM_BMP2K.
GenevisibleiQ91Z96. MM.

Family and domain databases

InterProiIPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP2K_MOUSE
AccessioniPrimary (citable) accession number: Q91Z96
Secondary accession number(s): Q8C8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.