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Q91Z96

- BMP2K_MOUSE

UniProt

Q91Z96 - BMP2K_MOUSE

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Protein
BMP-2-inducible protein kinase
Gene
Bmp2k, Bike
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in osteoblast differentiation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761ATP By similarity
Active sitei177 – 1771Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 629ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatase regulator activity Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of bone mineralization Source: MGI
  2. regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-2-inducible protein kinase (EC:2.7.11.1)
Short name:
BIKe
Gene namesi
Name:Bmp2k
Synonyms:Bike
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2155456. Bmp2k.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11381138BMP-2-inducible protein kinase
PRO_0000085664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei819 – 8191Phosphothreonine By similarity
Modified residuei908 – 9081Phosphoserine1 Publication
Modified residuei1010 – 10101Phosphoserine2 Publications
Modified residuei1012 – 10121Phosphoserine1 Publication
Modified residuei1013 – 10131Phosphoserine2 Publications
Modified residuei1087 – 10871Phosphoserine By similarity
Modified residuei1091 – 10911Phosphoserine By similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91Z96.
PaxDbiQ91Z96.
PRIDEiQ91Z96.

PTM databases

PhosphoSiteiQ91Z96.

Expressioni

Tissue specificityi

Expressed in spleen, kidney, lung, brain, heart, diaphragm and calvaria but not in liver.

Gene expression databases

ArrayExpressiQ91Z96.
BgeeiQ91Z96.
CleanExiMM_BMP2K.
GenevestigatoriQ91Z96.

Interactioni

Protein-protein interaction databases

BioGridi228314. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91Z96.
SMRiQ91Z96. Positions 43-375.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 313266Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi421 – 546126Gln/His-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00510000046552.
HOGENOMiHOG000095243.
HOVERGENiHBG050703.
InParanoidiQ91Z96.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG7PP566.
PhylomeDBiQ91Z96.
TreeFamiTF317300.

Family and domain databases

InterProiIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91Z96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL     50
EESLAEGGFS TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS 100
GHKNIVGYLD CAVNSISDNV WEVLILMEYC RAGQVVNQMN KKLQTGFTES 150
EVLQIFCDTC EAVARLHQCK TPIIHRDLKV ENILLNDAGN YVLCDFGSAT 200
NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI TTKADIWALG 250
CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE 300
CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM 350
KARITDTIGP TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF 400
SNHKPKGALR PGNGSEVLMV QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH 450
RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ QLLQNAYLQQ YQHAMHQQHI 500
LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH QQPAQQVSPE 550
YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK 600
TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSNRL GASTPSDKTV 650
DLPPAPHSRP PEEPFASVPF ISHSGSPEKK TTEHSPNQKS ITANLTKNGG 700
SSPLCKDQRA GKKTSENPVI RGQVQKGHDD SESDFESDPP SPKSSEEEQE 750
DEDAQGEHGD FNDDDTEPEN LGHRPLLMDS EDEEEDDKHS SDSECEQAKT 800
KRGDTSSLRR DKPGVAPDTA LLTPARSPAD ALTPSQEFDV FGAVPFFAAP 850
APQSLQHRGD GKNLSQHAFP EQEDFDVFTK APFNKKVSVQ DWPAVGPDAR 900
PLPARPRSVD IFGSTPFQPF SVSASKSESK EDVFGLVPFE EITGSQQQQK 950
VKQRSLQKLS SRQRRTKQDV SKSNGKRHHG TPTSAKKTLK PPYRTPERAR 1000
RHKKVGRRDS QSSNEFLTIS DSKENISVAL TDGKDRASVL PSDESLLDPF 1050
GAKPFHPPDL WHQPHQGLSD ICVDHTTILP GRPRQNSVHG SFHSAETLRM 1100
DDFGAVPFTE LVVQSVTPQQ SQPVELDPFG AAPFPSKQ 1138
Length:1,138
Mass (Da):126,185
Last modified:December 1, 2001 - v1
Checksum:i8EDDE02F1333840D
GO
Isoform 2 (identifier: Q91Z96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-649: NRLGASTPSDKT → SKGHLKAYFASQ
     650-1138: Missing.

Show »
Length:649
Mass (Da):72,515
Checksum:i49CF3A3020D5564F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei638 – 64912NRLGA…PSDKT → SKGHLKAYFASQ in isoform 2.
VSP_008094Add
BLAST
Alternative sequencei650 – 1138489Missing in isoform 2.
VSP_008095Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSiCCDS39175.1. [Q91Z96-1]
RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneiMm.281490.
Mm.392853.

Genome annotation databases

EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneIDi140780.
KEGGimmu:140780.
UCSCiuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050249 mRNA. Translation: AAK91585.1 .
AK046752 mRNA. Translation: BAC32854.1 .
CCDSi CCDS39175.1. [Q91Z96-1 ]
RefSeqi NP_542439.1. NM_080708.1. [Q91Z96-1 ]
UniGenei Mm.281490.
Mm.392853.

3D structure databases

ProteinModelPortali Q91Z96.
SMRi Q91Z96. Positions 43-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228314. 1 interaction.

PTM databases

PhosphoSitei Q91Z96.

Proteomic databases

MaxQBi Q91Z96.
PaxDbi Q91Z96.
PRIDEi Q91Z96.

Protocols and materials databases

DNASUi 140780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035635 ; ENSMUSP00000037970 ; ENSMUSG00000034663 . [Q91Z96-1 ]
ENSMUST00000112974 ; ENSMUSP00000108598 ; ENSMUSG00000034663 . [Q91Z96-2 ]
GeneIDi 140780.
KEGGi mmu:140780.
UCSCi uc008yfo.1. mouse. [Q91Z96-2 ]
uc008yfp.1. mouse. [Q91Z96-1 ]

Organism-specific databases

CTDi 55589.
MGIi MGI:2155456. Bmp2k.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00510000046552.
HOGENOMi HOG000095243.
HOVERGENi HBG050703.
InParanoidi Q91Z96.
KOi K08854.
OMAi VPFISHP.
OrthoDBi EOG7PP566.
PhylomeDBi Q91Z96.
TreeFami TF317300.

Miscellaneous databases

NextBioi 369977.
PROi Q91Z96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91Z96.
Bgeei Q91Z96.
CleanExi MM_BMP2K.
Genevestigatori Q91Z96.

Family and domain databases

InterProi IPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR22967:SF10. PTHR22967:SF10. 1 hit.
Pfami PF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro."
    Kearns A.E., Donohue M.M., Sanyal B., Demay M.B.
    J. Biol. Chem. 276:42213-42218(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-1010; SER-1012 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBMP2K_MOUSE
AccessioniPrimary (citable) accession number: Q91Z96
Secondary accession number(s): Q8C8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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