Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91Z96 (BMP2K_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BMP-2-inducible protein kinase

Short name=BIKe
EC=2.7.11.1
Gene names
Name:Bmp2k
Synonyms:Bike
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1138 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in osteoblast differentiation.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus.

Tissue specificity

Expressed in spleen, kidney, lung, brain, heart, diaphragm and calvaria but not in liver.

Post-translational modification

Autophosphorylated.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91Z96-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91Z96-2)

The sequence of this isoform differs from the canonical sequence as follows:
     638-649: NRLGASTPSDKT → SKGHLKAYFASQ
     650-1138: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11381138BMP-2-inducible protein kinase
PRO_0000085664

Regions

Domain48 – 313266Protein kinase
Nucleotide binding54 – 629ATP By similarity
Compositional bias421 – 546126Gln/His-rich

Sites

Active site1771Proton acceptor By similarity
Binding site761ATP By similarity

Amino acid modifications

Modified residue8191Phosphothreonine By similarity
Modified residue9081Phosphoserine Ref.4
Modified residue10101Phosphoserine Ref.3 Ref.4
Modified residue10121Phosphoserine Ref.4
Modified residue10131Phosphoserine Ref.3 Ref.4
Modified residue10871Phosphoserine By similarity
Modified residue10911Phosphoserine By similarity

Natural variations

Alternative sequence638 – 64912NRLGA…PSDKT → SKGHLKAYFASQ in isoform 2.
VSP_008094
Alternative sequence650 – 1138489Missing in isoform 2.
VSP_008095

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8EDDE02F1333840D

FASTA1,138126,185
        10         20         30         40         50         60 
MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL EESLAEGGFS 

        70         80         90        100        110        120 
TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS GHKNIVGYLD CAVNSISDNV 

       130        140        150        160        170        180 
WEVLILMEYC RAGQVVNQMN KKLQTGFTES EVLQIFCDTC EAVARLHQCK TPIIHRDLKV 

       190        200        210        220        230        240 
ENILLNDAGN YVLCDFGSAT NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI 

       250        260        270        280        290        300 
TTKADIWALG CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE 

       310        320        330        340        350        360 
CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM KARITDTIGP 

       370        380        390        400        410        420 
TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF SNHKPKGALR PGNGSEVLMV 

       430        440        450        460        470        480 
QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ 

       490        500        510        520        530        540 
QLLQNAYLQQ YQHAMHQQHI LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH 

       550        560        570        580        590        600 
QQPAQQVSPE YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK 

       610        620        630        640        650        660 
TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSNRL GASTPSDKTV DLPPAPHSRP 

       670        680        690        700        710        720 
PEEPFASVPF ISHSGSPEKK TTEHSPNQKS ITANLTKNGG SSPLCKDQRA GKKTSENPVI 

       730        740        750        760        770        780 
RGQVQKGHDD SESDFESDPP SPKSSEEEQE DEDAQGEHGD FNDDDTEPEN LGHRPLLMDS 

       790        800        810        820        830        840 
EDEEEDDKHS SDSECEQAKT KRGDTSSLRR DKPGVAPDTA LLTPARSPAD ALTPSQEFDV 

       850        860        870        880        890        900 
FGAVPFFAAP APQSLQHRGD GKNLSQHAFP EQEDFDVFTK APFNKKVSVQ DWPAVGPDAR 

       910        920        930        940        950        960 
PLPARPRSVD IFGSTPFQPF SVSASKSESK EDVFGLVPFE EITGSQQQQK VKQRSLQKLS 

       970        980        990       1000       1010       1020 
SRQRRTKQDV SKSNGKRHHG TPTSAKKTLK PPYRTPERAR RHKKVGRRDS QSSNEFLTIS 

      1030       1040       1050       1060       1070       1080 
DSKENISVAL TDGKDRASVL PSDESLLDPF GAKPFHPPDL WHQPHQGLSD ICVDHTTILP 

      1090       1100       1110       1120       1130 
GRPRQNSVHG SFHSAETLRM DDFGAVPFTE LVVQSVTPQQ SQPVELDPFG AAPFPSKQ 

« Hide

Isoform 2 [UniParc].

Checksum: 49CF3A3020D5564F
Show »

FASTA64972,515

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro."
Kearns A.E., Donohue M.M., Sanyal B., Demay M.B.
J. Biol. Chem. 276:42213-42218(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Thymus.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-1010; SER-1012 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSCCDS39175.1. [Q91Z96-1]
RefSeqNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneMm.281490.
Mm.392853.

3D structure databases

ProteinModelPortalQ91Z96.
SMRQ91Z96. Positions 43-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid228314. 1 interaction.

PTM databases

PhosphoSiteQ91Z96.

Proteomic databases

MaxQBQ91Z96.
PaxDbQ91Z96.
PRIDEQ91Z96.

Protocols and materials databases

DNASU140780.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneID140780.
KEGGmmu:140780.
UCSCuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Organism-specific databases

CTD55589.
MGIMGI:2155456. Bmp2k.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00510000046552.
HOGENOMHOG000095243.
HOVERGENHBG050703.
InParanoidQ91Z96.
KOK08854.
OMAVPFISHP.
OrthoDBEOG7PP566.
PhylomeDBQ91Z96.
TreeFamTF317300.

Gene expression databases

ArrayExpressQ91Z96.
BgeeQ91Z96.
CleanExMM_BMP2K.
GenevestigatorQ91Z96.

Family and domain databases

InterProIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369977.
PROQ91Z96.
SOURCESearch...

Entry information

Entry nameBMP2K_MOUSE
AccessionPrimary (citable) accession number: Q91Z96
Secondary accession number(s): Q8C8L7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot