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Protein

BMP-2-inducible protein kinase

Gene

Bmp2k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in osteoblast differentiation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761ATPPROSITE-ProRule annotation
Active sitei177 – 1771Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 629ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatase regulator activity Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of bone mineralization Source: MGI
  2. regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-2-inducible protein kinase (EC:2.7.11.1)
Short name:
BIKe
Gene namesi
Name:Bmp2k
Synonyms:Bike
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2155456. Bmp2k.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11381138BMP-2-inducible protein kinasePRO_0000085664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei819 – 8191PhosphothreonineBy similarity
Modified residuei908 – 9081Phosphoserine1 Publication
Modified residuei1010 – 10101Phosphoserine2 Publications
Modified residuei1012 – 10121Phosphoserine1 Publication
Modified residuei1013 – 10131Phosphoserine2 Publications
Modified residuei1020 – 10201PhosphoserineBy similarity
Modified residuei1087 – 10871PhosphoserineBy similarity
Modified residuei1091 – 10911PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91Z96.
PaxDbiQ91Z96.
PRIDEiQ91Z96.

PTM databases

PhosphoSiteiQ91Z96.

Expressioni

Tissue specificityi

Expressed in spleen, kidney, lung, brain, heart, diaphragm and calvaria but not in liver.

Gene expression databases

BgeeiQ91Z96.
CleanExiMM_BMP2K.
ExpressionAtlasiQ91Z96. baseline and differential.
GenevestigatoriQ91Z96.

Interactioni

Protein-protein interaction databases

BioGridi228314. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91Z96.
SMRiQ91Z96. Positions 36-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 313266Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi421 – 546126Gln/His-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00510000046552.
HOGENOMiHOG000095243.
HOVERGENiHBG050703.
InParanoidiQ91Z96.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG7PP566.
PhylomeDBiQ91Z96.
TreeFamiTF317300.

Family and domain databases

InterProiIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91Z96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL
60 70 80 90 100
EESLAEGGFS TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS
110 120 130 140 150
GHKNIVGYLD CAVNSISDNV WEVLILMEYC RAGQVVNQMN KKLQTGFTES
160 170 180 190 200
EVLQIFCDTC EAVARLHQCK TPIIHRDLKV ENILLNDAGN YVLCDFGSAT
210 220 230 240 250
NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI TTKADIWALG
260 270 280 290 300
CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE
310 320 330 340 350
CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM
360 370 380 390 400
KARITDTIGP TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF
410 420 430 440 450
SNHKPKGALR PGNGSEVLMV QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH
460 470 480 490 500
RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ QLLQNAYLQQ YQHAMHQQHI
510 520 530 540 550
LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH QQPAQQVSPE
560 570 580 590 600
YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK
610 620 630 640 650
TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSNRL GASTPSDKTV
660 670 680 690 700
DLPPAPHSRP PEEPFASVPF ISHSGSPEKK TTEHSPNQKS ITANLTKNGG
710 720 730 740 750
SSPLCKDQRA GKKTSENPVI RGQVQKGHDD SESDFESDPP SPKSSEEEQE
760 770 780 790 800
DEDAQGEHGD FNDDDTEPEN LGHRPLLMDS EDEEEDDKHS SDSECEQAKT
810 820 830 840 850
KRGDTSSLRR DKPGVAPDTA LLTPARSPAD ALTPSQEFDV FGAVPFFAAP
860 870 880 890 900
APQSLQHRGD GKNLSQHAFP EQEDFDVFTK APFNKKVSVQ DWPAVGPDAR
910 920 930 940 950
PLPARPRSVD IFGSTPFQPF SVSASKSESK EDVFGLVPFE EITGSQQQQK
960 970 980 990 1000
VKQRSLQKLS SRQRRTKQDV SKSNGKRHHG TPTSAKKTLK PPYRTPERAR
1010 1020 1030 1040 1050
RHKKVGRRDS QSSNEFLTIS DSKENISVAL TDGKDRASVL PSDESLLDPF
1060 1070 1080 1090 1100
GAKPFHPPDL WHQPHQGLSD ICVDHTTILP GRPRQNSVHG SFHSAETLRM
1110 1120 1130
DDFGAVPFTE LVVQSVTPQQ SQPVELDPFG AAPFPSKQ
Length:1,138
Mass (Da):126,185
Last modified:December 1, 2001 - v1
Checksum:i8EDDE02F1333840D
GO
Isoform 2 (identifier: Q91Z96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-649: NRLGASTPSDKT → SKGHLKAYFASQ
     650-1138: Missing.

Show »
Length:649
Mass (Da):72,515
Checksum:i49CF3A3020D5564F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei638 – 64912NRLGA…PSDKT → SKGHLKAYFASQ in isoform 2. 1 PublicationVSP_008094Add
BLAST
Alternative sequencei650 – 1138489Missing in isoform 2. 1 PublicationVSP_008095Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSiCCDS39175.1. [Q91Z96-1]
RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneiMm.281490.
Mm.392853.

Genome annotation databases

EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneIDi140780.
KEGGimmu:140780.
UCSCiuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050249 mRNA. Translation: AAK91585.1.
AK046752 mRNA. Translation: BAC32854.1.
CCDSiCCDS39175.1. [Q91Z96-1]
RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
UniGeneiMm.281490.
Mm.392853.

3D structure databases

ProteinModelPortaliQ91Z96.
SMRiQ91Z96. Positions 36-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228314. 1 interaction.

PTM databases

PhosphoSiteiQ91Z96.

Proteomic databases

MaxQBiQ91Z96.
PaxDbiQ91Z96.
PRIDEiQ91Z96.

Protocols and materials databases

DNASUi140780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
GeneIDi140780.
KEGGimmu:140780.
UCSCiuc008yfo.1. mouse. [Q91Z96-2]
uc008yfp.1. mouse. [Q91Z96-1]

Organism-specific databases

CTDi55589.
MGIiMGI:2155456. Bmp2k.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00510000046552.
HOGENOMiHOG000095243.
HOVERGENiHBG050703.
InParanoidiQ91Z96.
KOiK08854.
OMAiVPFISHP.
OrthoDBiEOG7PP566.
PhylomeDBiQ91Z96.
TreeFamiTF317300.

Miscellaneous databases

NextBioi369977.
PROiQ91Z96.
SOURCEiSearch...

Gene expression databases

BgeeiQ91Z96.
CleanExiMM_BMP2K.
ExpressionAtlasiQ91Z96. baseline and differential.
GenevestigatoriQ91Z96.

Family and domain databases

InterProiIPR026105. BMP-2-ind_kinase.
IPR028182. BMP2K_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
PfamiPF15282. BMP2K_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro."
    Kearns A.E., Donohue M.M., Sanyal B., Demay M.B.
    J. Biol. Chem. 276:42213-42218(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-1010; SER-1012 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBMP2K_MOUSE
AccessioniPrimary (citable) accession number: Q91Z96
Secondary accession number(s): Q8C8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.