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Q91Z96

- BMP2K_MOUSE

UniProt

Q91Z96 - BMP2K_MOUSE

Protein

BMP-2-inducible protein kinase

Gene

Bmp2k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in osteoblast differentiation.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761ATPPROSITE-ProRule annotation
    Active sitei177 – 1771Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 629ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphatase regulator activity Source: MGI
    3. protein kinase activity Source: MGI
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of bone mineralization Source: MGI
    2. regulation of catalytic activity Source: GOC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BMP-2-inducible protein kinase (EC:2.7.11.1)
    Short name:
    BIKe
    Gene namesi
    Name:Bmp2k
    Synonyms:Bike
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2155456. Bmp2k.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11381138BMP-2-inducible protein kinasePRO_0000085664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei819 – 8191PhosphothreonineBy similarity
    Modified residuei908 – 9081Phosphoserine1 Publication
    Modified residuei1010 – 10101Phosphoserine2 Publications
    Modified residuei1012 – 10121Phosphoserine1 Publication
    Modified residuei1013 – 10131Phosphoserine2 Publications
    Modified residuei1087 – 10871PhosphoserineBy similarity
    Modified residuei1091 – 10911PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91Z96.
    PaxDbiQ91Z96.
    PRIDEiQ91Z96.

    PTM databases

    PhosphoSiteiQ91Z96.

    Expressioni

    Tissue specificityi

    Expressed in spleen, kidney, lung, brain, heart, diaphragm and calvaria but not in liver.

    Gene expression databases

    ArrayExpressiQ91Z96.
    BgeeiQ91Z96.
    CleanExiMM_BMP2K.
    GenevestigatoriQ91Z96.

    Interactioni

    Protein-protein interaction databases

    BioGridi228314. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Z96.
    SMRiQ91Z96. Positions 43-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 313266Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi421 – 546126Gln/His-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00510000046552.
    HOGENOMiHOG000095243.
    HOVERGENiHBG050703.
    InParanoidiQ91Z96.
    KOiK08854.
    OMAiVPFISHP.
    OrthoDBiEOG7PP566.
    PhylomeDBiQ91Z96.
    TreeFamiTF317300.

    Family and domain databases

    InterProiIPR026105. BMP-2-ind_kinase.
    IPR028182. BMP2K_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR22967:SF10. PTHR22967:SF10. 1 hit.
    PfamiPF15282. BMP2K_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91Z96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL     50
    EESLAEGGFS TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS 100
    GHKNIVGYLD CAVNSISDNV WEVLILMEYC RAGQVVNQMN KKLQTGFTES 150
    EVLQIFCDTC EAVARLHQCK TPIIHRDLKV ENILLNDAGN YVLCDFGSAT 200
    NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI TTKADIWALG 250
    CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE 300
    CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM 350
    KARITDTIGP TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF 400
    SNHKPKGALR PGNGSEVLMV QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH 450
    RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ QLLQNAYLQQ YQHAMHQQHI 500
    LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH QQPAQQVSPE 550
    YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK 600
    TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSNRL GASTPSDKTV 650
    DLPPAPHSRP PEEPFASVPF ISHSGSPEKK TTEHSPNQKS ITANLTKNGG 700
    SSPLCKDQRA GKKTSENPVI RGQVQKGHDD SESDFESDPP SPKSSEEEQE 750
    DEDAQGEHGD FNDDDTEPEN LGHRPLLMDS EDEEEDDKHS SDSECEQAKT 800
    KRGDTSSLRR DKPGVAPDTA LLTPARSPAD ALTPSQEFDV FGAVPFFAAP 850
    APQSLQHRGD GKNLSQHAFP EQEDFDVFTK APFNKKVSVQ DWPAVGPDAR 900
    PLPARPRSVD IFGSTPFQPF SVSASKSESK EDVFGLVPFE EITGSQQQQK 950
    VKQRSLQKLS SRQRRTKQDV SKSNGKRHHG TPTSAKKTLK PPYRTPERAR 1000
    RHKKVGRRDS QSSNEFLTIS DSKENISVAL TDGKDRASVL PSDESLLDPF 1050
    GAKPFHPPDL WHQPHQGLSD ICVDHTTILP GRPRQNSVHG SFHSAETLRM 1100
    DDFGAVPFTE LVVQSVTPQQ SQPVELDPFG AAPFPSKQ 1138
    Length:1,138
    Mass (Da):126,185
    Last modified:December 1, 2001 - v1
    Checksum:i8EDDE02F1333840D
    GO
    Isoform 2 (identifier: Q91Z96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         638-649: NRLGASTPSDKT → SKGHLKAYFASQ
         650-1138: Missing.

    Show »
    Length:649
    Mass (Da):72,515
    Checksum:i49CF3A3020D5564F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei638 – 64912NRLGA…PSDKT → SKGHLKAYFASQ in isoform 2. 1 PublicationVSP_008094Add
    BLAST
    Alternative sequencei650 – 1138489Missing in isoform 2. 1 PublicationVSP_008095Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050249 mRNA. Translation: AAK91585.1.
    AK046752 mRNA. Translation: BAC32854.1.
    CCDSiCCDS39175.1. [Q91Z96-1]
    RefSeqiNP_542439.1. NM_080708.1. [Q91Z96-1]
    UniGeneiMm.281490.
    Mm.392853.

    Genome annotation databases

    EnsembliENSMUST00000035635; ENSMUSP00000037970; ENSMUSG00000034663. [Q91Z96-1]
    ENSMUST00000112974; ENSMUSP00000108598; ENSMUSG00000034663. [Q91Z96-2]
    GeneIDi140780.
    KEGGimmu:140780.
    UCSCiuc008yfo.1. mouse. [Q91Z96-2]
    uc008yfp.1. mouse. [Q91Z96-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050249 mRNA. Translation: AAK91585.1 .
    AK046752 mRNA. Translation: BAC32854.1 .
    CCDSi CCDS39175.1. [Q91Z96-1 ]
    RefSeqi NP_542439.1. NM_080708.1. [Q91Z96-1 ]
    UniGenei Mm.281490.
    Mm.392853.

    3D structure databases

    ProteinModelPortali Q91Z96.
    SMRi Q91Z96. Positions 43-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228314. 1 interaction.

    PTM databases

    PhosphoSitei Q91Z96.

    Proteomic databases

    MaxQBi Q91Z96.
    PaxDbi Q91Z96.
    PRIDEi Q91Z96.

    Protocols and materials databases

    DNASUi 140780.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035635 ; ENSMUSP00000037970 ; ENSMUSG00000034663 . [Q91Z96-1 ]
    ENSMUST00000112974 ; ENSMUSP00000108598 ; ENSMUSG00000034663 . [Q91Z96-2 ]
    GeneIDi 140780.
    KEGGi mmu:140780.
    UCSCi uc008yfo.1. mouse. [Q91Z96-2 ]
    uc008yfp.1. mouse. [Q91Z96-1 ]

    Organism-specific databases

    CTDi 55589.
    MGIi MGI:2155456. Bmp2k.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00510000046552.
    HOGENOMi HOG000095243.
    HOVERGENi HBG050703.
    InParanoidi Q91Z96.
    KOi K08854.
    OMAi VPFISHP.
    OrthoDBi EOG7PP566.
    PhylomeDBi Q91Z96.
    TreeFami TF317300.

    Miscellaneous databases

    NextBioi 369977.
    PROi Q91Z96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91Z96.
    Bgeei Q91Z96.
    CleanExi MM_BMP2K.
    Genevestigatori Q91Z96.

    Family and domain databases

    InterProi IPR026105. BMP-2-ind_kinase.
    IPR028182. BMP2K_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR22967:SF10. PTHR22967:SF10. 1 hit.
    Pfami PF15282. BMP2K_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro."
      Kearns A.E., Donohue M.M., Sanyal B., Demay M.B.
      J. Biol. Chem. 276:42213-42218(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-1010; SER-1012 AND SER-1013, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBMP2K_MOUSE
    AccessioniPrimary (citable) accession number: Q91Z96
    Secondary accession number(s): Q8C8L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3