ID   CP17A_PERLE             Reviewed;         509 AA.
AC   Q91Z85;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase;
DE            EC=1.14.99.9;
DE   AltName: Full=Cytochrome P450 17A1;
DE   AltName: Full=CYPXVII;
DE   AltName: Full=P450-C17;
DE            Short=P450c17;
GN   Name=Cyp17a1; Synonyms=Cyp17;
OS   Peromyscus leucopus (White-footed mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Neotominae; Peromyscus.
OX   NCBI_TaxID=10041;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gleason K.K., Hurst F.P., Powers M.A., Riddle S.W., Seashols S.,
RA   Bradley E.L.;
RT   "Genomic sequence and adrenal expression of Cyp17 during reproductive
RT   development in Peromyscus leucopus.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Conversion of pregnenolone and progesterone to their 17-
CC       alpha-hydroxylated products and subsequently to
CC       dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both
CC       the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved
CC       in sexual development during fetal life and at puberty (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: A steroid + AH(2) + O(2) = a 17-alpha-
CC       hydroxysteroid + A + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- PATHWAY: Lipid metabolism; steroid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Membrane (Potential). Membrane; Single-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; AY054747; AAL12229.1; -; Genomic_DNA.
DR   HSSP; P00179; 1DT6.
DR   HOVERGEN; Q91Z85; -.
DR   BRENDA; 1.14.99.9; 291462.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004508; F:steroid 17-alpha-monooxygenase activity; IEA:EC.
DR   GO; GO:0006700; P:C21-steroid hormone biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Steroidogenesis.
FT   CHAIN         1    509       Steroid 17-alpha-hydroxylase/17,20 lyase.
FT                                /FTId=PRO_0000051939.
FT   METAL       440    440       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   509 AA;  57722 MW;  E1BAB018B7A6661E CRC64;
     MWELVCLLLL ILAYLFWPKP KTSDAKFPRS LPFLPLVGSL PFLPRHGHMH VNFFKLQEKY
     GPIYSLRLGT IPTVIIGQYQ LAREVLIKKG KEFSGRPQMV TLGLLSNQGK GIAFADSDDA
     WQLHRKLALS SFALFRDGDQ RLETIICQEA SSLCDLLLTH NEESVDLSQP IFMSVTNIIC
     AICFSTSYEN RDPILTTIQT FTEGILNCLD NENLVDIFPW LTIFPNKTLE KIKRHVKVRD
     EVLIDMLEKC KEKFNNDSIS NLTDILIQAK MNADNNNTTD HQGSFSDSHI LSTVGDFFGA
     GIETTTSVLC WIVAFLLHNP EVKKKIQKEI DQNIGFSRTP TFNDRNHLLM LEATIREVLR
     IRPVAPMLIP HKANIDSSIG EFTIPKDTHV VINLWALHHN EKEWDQPDRF MPERFLDATG
     SHLITPSLSY LPFGAGPRAC IGEVLARQVL FLYVACLLQR FDLDVPDGAP MPCLKGDPKV
     VFLIDPFKVK VTVRQAWKDA QAEVGTWRP
//