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Q91Z85

- CP17A_PERLE

UniProt

Q91Z85 - CP17A_PERLE

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene
Cyp17a1, Cyp17
Organism
Peromyscus leucopus (White-footed mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty By similarity.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB
  2. progesterone metabolic process Source: UniProtKB
  3. steroid biosynthetic process Source: UniProtKB-UniPathway
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:Cyp17a1
Synonyms:Cyp17
OrganismiPeromyscus leucopus (White-footed mouse)
Taxonomic identifieri10041 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeNeotominaePeromyscus

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051939Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ91Z85.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Z85-1 [UniParc]FASTAAdd to Basket

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MWELVCLLLL ILAYLFWPKP KTSDAKFPRS LPFLPLVGSL PFLPRHGHMH    50
VNFFKLQEKY GPIYSLRLGT IPTVIIGQYQ LAREVLIKKG KEFSGRPQMV 100
TLGLLSNQGK GIAFADSDDA WQLHRKLALS SFALFRDGDQ RLETIICQEA 150
SSLCDLLLTH NEESVDLSQP IFMSVTNIIC AICFSTSYEN RDPILTTIQT 200
FTEGILNCLD NENLVDIFPW LTIFPNKTLE KIKRHVKVRD EVLIDMLEKC 250
KEKFNNDSIS NLTDILIQAK MNADNNNTTD HQGSFSDSHI LSTVGDFFGA 300
GIETTTSVLC WIVAFLLHNP EVKKKIQKEI DQNIGFSRTP TFNDRNHLLM 350
LEATIREVLR IRPVAPMLIP HKANIDSSIG EFTIPKDTHV VINLWALHHN 400
EKEWDQPDRF MPERFLDATG SHLITPSLSY LPFGAGPRAC IGEVLARQVL 450
FLYVACLLQR FDLDVPDGAP MPCLKGDPKV VFLIDPFKVK VTVRQAWKDA 500
QAEVGTWRP 509
Length:509
Mass (Da):57,722
Last modified:December 1, 2001 - v1
Checksum:iE1BAB018B7A6661E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY054747 Genomic DNA. Translation: AAL12229.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY054747 Genomic DNA. Translation: AAL12229.1 .

3D structure databases

ProteinModelPortali Q91Z85.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence and adrenal expression of Cyp17 during reproductive development in Peromyscus leucopus."
    Gleason K.K., Hurst F.P., Powers M.A., Riddle S.W., Seashols S., Bradley E.L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP17A_PERLE
AccessioniPrimary (citable) accession number: Q91Z85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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