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Q91Z85 (CP17A_PERLE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase

EC=1.14.99.9
EC=4.1.2.30
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name=Cytochrome P450c17
Gene names
Name:Cyp17a1
Synonyms:Cyp17
OrganismPeromyscus leucopus (White-footed mouse)
Taxonomic identifier10041 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeNeotominaePeromyscus

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty By similarity.

Catalytic activity

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

Membrane Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051939

Sites

Metal binding4401Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91Z85 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E1BAB018B7A6661E

FASTA50957,722
        10         20         30         40         50         60 
MWELVCLLLL ILAYLFWPKP KTSDAKFPRS LPFLPLVGSL PFLPRHGHMH VNFFKLQEKY 

        70         80         90        100        110        120 
GPIYSLRLGT IPTVIIGQYQ LAREVLIKKG KEFSGRPQMV TLGLLSNQGK GIAFADSDDA 

       130        140        150        160        170        180 
WQLHRKLALS SFALFRDGDQ RLETIICQEA SSLCDLLLTH NEESVDLSQP IFMSVTNIIC 

       190        200        210        220        230        240 
AICFSTSYEN RDPILTTIQT FTEGILNCLD NENLVDIFPW LTIFPNKTLE KIKRHVKVRD 

       250        260        270        280        290        300 
EVLIDMLEKC KEKFNNDSIS NLTDILIQAK MNADNNNTTD HQGSFSDSHI LSTVGDFFGA 

       310        320        330        340        350        360 
GIETTTSVLC WIVAFLLHNP EVKKKIQKEI DQNIGFSRTP TFNDRNHLLM LEATIREVLR 

       370        380        390        400        410        420 
IRPVAPMLIP HKANIDSSIG EFTIPKDTHV VINLWALHHN EKEWDQPDRF MPERFLDATG 

       430        440        450        460        470        480 
SHLITPSLSY LPFGAGPRAC IGEVLARQVL FLYVACLLQR FDLDVPDGAP MPCLKGDPKV 

       490        500 
VFLIDPFKVK VTVRQAWKDA QAEVGTWRP 

« Hide

References

[1]"Genomic sequence and adrenal expression of Cyp17 during reproductive development in Peromyscus leucopus."
Gleason K.K., Hurst F.P., Powers M.A., Riddle S.W., Seashols S., Bradley E.L.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY054747 Genomic DNA. Translation: AAL12229.1.

3D structure databases

ProteinModelPortalQ91Z85.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Enzyme and pathway databases

UniPathwayUPA00062.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP17A_PERLE
AccessionPrimary (citable) accession number: Q91Z85
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: December 11, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways